LOCUS       NP_001385653             623 aa            linear   ROD 31-MAR-2024
DEFINITION  E3 ubiquitin-protein ligase Praja-1 isoform 3 [Rattus norvegicus].
ACCESSION   NP_001385653 XP_006257167
VERSION     NP_001385653.1
DBSOURCE    REFSEQ: accession NM_001398724.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 623)
  AUTHORS   Watabe,K., Kato,Y., Sakuma,M., Murata,M., Niida-Kawaguchi,M.,
            Takemura,T., Hanagata,N., Tada,M., Kakita,A. and Shibata,N.
  TITLE     Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal
            cytoplasmic TDP-43 aggregate formation
  JOURNAL   Neuropathology 40 (6), 570-586 (2020)
   PUBMED   32686212
  REMARK    GeneRIF: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal
            cytoplasmic TDP-43 aggregate formation.
REFERENCE   2  (residues 1 to 623)
  AUTHORS   Sasaki,A., Masuda,Y., Iwai,K., Ikeda,K. and Watanabe,K.
  TITLE     A RING finger protein Praja1 regulates Dlx5-dependent transcription
            through its ubiquitin ligase activity for the Dlx/Msx-interacting
            MAGE/Necdin family protein, Dlxin-1
  JOURNAL   J Biol Chem 277 (25), 22541-22546 (2002)
   PUBMED   11959851
REFERENCE   3  (residues 1 to 623)
  AUTHORS   Mishra,L., Tully,R.E., Monga,S.P., Yu,P., Cai,T., Makalowski,W.,
            Mezey,E., Pavan,W.J. and Mishra,B.
  TITLE     Praja1, a novel gene encoding a RING-H2 motif in mouse development
  JOURNAL   Oncogene 15 (19), 2361-2368 (1997)
   PUBMED   9393880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 22, 2021 this sequence version replaced XP_006257167.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1575898.1,
                                           SRR26643299.68132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     Protein         1..623
                     /product="E3 ubiquitin-protein ligase Praja-1 isoform 3"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase Praja-1; praja ring
                     finger 1, E3 ubiquitin protein ligase"
                     /calculated_mol_wt=68594
     Region          574..619
                     /region_name="RING-H2_PJA1_2"
                     /note="RING finger, H2 subclass, found in protein E3
                     ubiquitin-protein ligase Praja-1, Praja-2, and similar
                     proteins; cd16465"
                     /db_xref="CDD:438128"
     CDS             1..623
                     /gene="Pja1"
                     /coded_by="NM_001398724.1:267..2138"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:683077"
                     /db_xref="RGD:1591532"
ORIGIN      
        1 mgqgsskpvr pppaggyqsg pgrsygrrha yvsfrpsmsq qeriasqrrt tsevpmhrst
       61 anqskrsrsp fastrrrwed negsgaslav enedysrypp reyrasgsrr gmayghidtl
      121 vardseeega gpvdrlpvrg ktgkfkddpe kgarssrfss vnhdvkeerg kvesppaarc
      181 sarraelskq ngslasqiss aegraavkgn hslererqnl parpsrapvs icgggentpk
      241 saeepvvrpk vrnvaapncm kpkvffdtdd dddvphstsr wrdaadaeea hadglarrgr
      301 geaaggssep ryaedqdarn eqakpekvsr rrrtmadpdf waysddyyry yeedsdsdke
      361 wmaalrrkyr srdqpqsssg esweplpgke dqepqqargn vntagagsla gagsngsgyp
      421 eevqepslqe eeqasleege ipwlrynene sssegdnest helmqpgmfm ldgnnnledd
      481 ssvsedlevd wslfdgfadg lgvaeaisyv dpqfltymal eerlaqamet alahleslav
      541 dvevanppas kesidalpei lvtedhgavg qemccpiccs eyvkgevate lpchhyfhkp
      601 cvsiwlqksg tcpvcrcmfp ppl
//
