LOCUS       NM_001108853            4048 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus piwi-like RNA-mediated gene silencing 1 (Piwil1),
            mRNA.
ACCESSION   NM_001108853 XM_001078557 XM_017598411 XM_344105
VERSION     NM_001108853.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4048)
  AUTHORS   Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu
            Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ and Liu
            MF.
  TITLE     Ubiquitination-Deficient Mutations in Human Piwi Cause Male
            Infertility by Impairing Histone-to-Protamine Exchange during
            Spermiogenesis
  JOURNAL   Cell 169 (6), 1090-1104 (2017)
   PUBMED   28552346
REFERENCE   2  (bases 1 to 4048)
  AUTHORS   Tarabay Y, Achour M, Teletin M, Ye T, Teissandier A, Mark M,
            Bourc'his D and Viville S.
  TITLE     Tex19 paralogs are new members of the piRNA pathway controlling
            retrotransposon suppression
  JOURNAL   J Cell Sci 130 (8), 1463-1474 (2017)
   PUBMED   28254886
REFERENCE   3  (bases 1 to 4048)
  AUTHORS   Zhao PP, Yao MJ, Chang SY, Gou LT, Liu MF, Qiu ZL and Yuan XB.
  TITLE     Novel function of PIWIL1 in neuronal polarization and migration via
            regulation of microtubule-associated proteins
  JOURNAL   Mol Brain 8, 39 (2015)
   PUBMED   26104391
  REMARK    GeneRIF: PIWIL1 regulates neuronal polarization and radial
            migration partly via modulating the expression of
            microtubule-associated proteins.
            Erratum:[Mol Brain. 2016;9:21. PMID: 26907587]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4048)
  AUTHORS   Rizzo F, Hashim A, Marchese G, Ravo M, Tarallo R, Nassa G, Giurato
            G, Rinaldi A, Cordella A, Persico M, Sulas P, Perra A,
            Ledda-Columbano GM, Columbano A and Weisz A.
  TITLE     Timed regulation of P-element-induced wimpy testis-interacting RNA
            expression during rat liver regeneration
  JOURNAL   Hepatology 60 (3), 798-806 (2014)
   PUBMED   24930433
  REMARK    GeneRIF: RNAs encoding PIWIL2/HILI, PIWIL4/HIWI2 and other
            components of the piRNA biogenesis pathways are identified in the
            normal rat liver during regenerative proliferation.
REFERENCE   5  (bases 1 to 4048)
  AUTHORS   Zhao S, Gou LT, Zhang M, Zu LD, Hua MM, Hua Y, Shi HJ, Li Y, Li J,
            Li D, Wang ED and Liu MF.
  TITLE     piRNA-triggered MIWI ubiquitination and removal by APC/C in late
            spermatogenesis
  JOURNAL   Dev Cell 24 (1), 13-25 (2013)
   PUBMED   23328397
REFERENCE   6  (bases 1 to 4048)
  AUTHORS   Girard A, Sachidanandam R, Hannon GJ and Carmell MA.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 4048)
  AUTHORS   Grivna ST, Beyret E, Wang Z and Lin H.
  TITLE     A novel class of small RNAs in mouse spermatogenic cells
  JOURNAL   Genes Dev 20 (13), 1709-1714 (2006)
   PUBMED   16766680
REFERENCE   8  (bases 1 to 4048)
  AUTHORS   Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita
            Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y and Nakano T.
  TITLE     Mili, a mammalian member of piwi family gene, is essential for
            spermatogenesis
  JOURNAL   Development 131 (4), 839-849 (2004)
   PUBMED   14736746
REFERENCE   9  (bases 1 to 4048)
  AUTHORS   Deng W and Lin H.
  TITLE     miwi, a murine homolog of piwi, encodes a cytoplasmic protein
            essential for spermatogenesis
  JOURNAL   Dev Cell 2 (6), 819-830 (2002)
   PUBMED   12062093
REFERENCE   10 (bases 1 to 4048)
  AUTHORS   Kuramochi-Miyagawa S, Kimura T, Yomogida K, Kuroiwa A, Tadokoro Y,
            Fujita Y, Sato M, Matsuda Y and Nakano T.
  TITLE     Two mouse piwi-related genes: miwi and mili
  JOURNAL   Mech Dev 108 (1-2), 121-133 (2001)
   PUBMED   11578866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000227.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001108853.3.
            
            On or before Apr 13, 2021 this sequence version replaced
            XM_017598411.2, NM_001108853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JACYVU010000227.1  9240211-9240321     c
            112-188             JACYVU010000227.1  9238950-9239026     c
            189-269             JACYVU010000227.1  9237345-9237425     c
            270-384             JACYVU010000227.1  9236933-9237047     c
            385-510             JACYVU010000227.1  9235572-9235697     c
            511-725             JACYVU010000227.1  9234954-9235168     c
            726-847             JACYVU010000227.1  9234517-9234638     c
            848-928             JACYVU010000227.1  9233305-9233385     c
            929-1126            JACYVU010000227.1  9232526-9232723     c
            1127-1238           JACYVU010000227.1  9232152-9232263     c
            1239-1365           JACYVU010000227.1  9230788-9230914     c
            1366-1483           JACYVU010000227.1  9230578-9230695     c
            1484-1598           JACYVU010000227.1  9230145-9230259     c
            1599-1786           JACYVU010000227.1  9228901-9229088     c
            1787-1859           JACYVU010000227.1  9228461-9228533     c
            1860-2060           JACYVU010000227.1  9225349-9225549     c
            2061-2164           JACYVU010000227.1  9225132-9225235     c
            2165-2235           JACYVU010000227.1  9224639-9224709     c
            2236-2389           JACYVU010000227.1  9224365-9224518     c
            2390-2515           JACYVU010000227.1  9222669-9222794     c
            2516-2663           JACYVU010000227.1  9220986-9221133     c
            2664-4048           JACYVU010000227.1  9219483-9220867     c
FEATURES             Location/Qualifiers
     source          1..4048
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..4048
                     /gene="Piwil1"
                     /note="piwi-like RNA-mediated gene silencing 1"
                     /db_xref="GeneID:363912"
                     /db_xref="RGD:1306980"
     exon            1..111
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..188
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..269
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2780
                     /gene="Piwil1"
                     /note="piwi like homolog 1; piwi-like 1"
                     /codon_start=1
                     /product="piwi-like protein 1"
                     /protein_id="NP_001102323.1"
                     /db_xref="GeneID:363912"
                     /db_xref="RGD:1306980"
                     /translation="MTGRARARARGRARGQETVQHVGAAASQQPGYIPPRPQQSPTEG
                     DLVGRGRQRGMVVGATSKSQELQISAGFQELSLAERGGRRRDFHDLGVNTRQNLDHVK
                     ESKTGSSGIIVKLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGR
                     CHAFDGTILFLPKRLQHKVTEVFSQTRNGEHVRITITLTNELPPTSPTCLQFYNIIFR
                     RLLKIMNLQQIGRNYYNPSDPIDIPNHRLVIWPGFTTSILQYENNIMLCTDVSHKVLR
                     SETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTKYNNKTYRVDDIDWDQNPKSTFK
                     KADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTG
                     LTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKDDNVQRELRDWGLSFDSNL
                     LSFSGRILQSEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEA
                     ANSLIQNLFKVTPAMGIQMKKAIMIEVDDRTEAYLRALQQKVTSDTQIVVCLLSSNRK
                     DKYDAIKKYLCTDCPTPSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDMPL
                     KLAMIVGIDCYHDTTAGRRSIAGFVASINEGMTRWFSRCVFQDRGQELVDGLKVCLQA
                     ALRAWSGCNEYMPSRVIVYRDGVGDGQLKTLVNYEVPQFLDCLKSVGRGYNPRLTVIV
                     VKKRVNARFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVI
                     YDSSGLKPDHIQRLTYKLCHVYYNWPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLS
                     NRLYYL"
     exon            270..384
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..510
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..725
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..847
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..928
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1126
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1238
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1365
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1483
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1598
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1786
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1859
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2060
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2164
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2235
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2389
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2515
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2663
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..4048
                     /gene="Piwil1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagcctg ctgcagcgac ccggcgtgag gagcctcagg ggctgcggac ctaagcgtgc
       61 tgagcacggg gccaagatag gaccagacgc tgctggacca cgacgatcag ggcgcgacca
      121 caccggcatc cagcctgcga cacacgtagg attggaagga ggccaagctg aacacctgag
      181 ctgactggaa aatgactgga cgagcccgag cccgggcccg tggcagggcc cgaggtcagg
      241 agacggtgca gcatgttggg gctgctgcaa gccagcaacc tgggtacatc ccgccgagac
      301 cccagcagtc gcccacagag ggggacttgg ttggccgagg acgacagagg ggaatggtag
      361 tcggagccac gtccaagtca caagaactgc agatctcagc cgggtttcag gagctgtcac
      421 tggcagagag aggagggcgt cgccgagact tccatgacct tggtgtgaac accagacaga
      481 accttgacca tgtcaaagag tcaaagacag gctcctctgg catcattgtg aagctgagca
      541 ccaaccactt ccggctgacc tcgcgcccac agtgggccct gtaccagtac cacattgact
      601 ataaccccct gatggaggcc cgcaggctgc gctctgccct gctcttccag cacgaagacc
      661 tcattggaag gtgtcatgct ttcgacggga caatattgtt tttacctaag agactacagc
      721 acaaggtcac ggaagtattc agtcagactc ggaatgggga acacgtgcgg attaccatca
      781 ccctgaccaa cgagctgccg cccacctcac ccacctgcct gcagttctat aacatcatct
      841 tcaggaggct cttgaaaatc atgaatttgc aacaaattgg acggaattat tacaacccaa
      901 gtgacccgat tgatattcca aatcacaggt tggtgatctg gcccggcttc accacctcca
      961 tacttcaata tgagaacaac atcatgcttt gcacagacgt cagccacaag gtcctccgca
     1021 gcgagaccgt tctagacttc atgttcaatc tgtaccagca gacggaggag cacaagttcc
     1081 aggagcaagt gtccaaggag ctcataggcc tcatcgtcct caccaagtac aacaacaaga
     1141 cctacagggt ggatgacatc gactgggacc agaatccaaa gagcaccttc aagaaggcag
     1201 atggctcgga ggtcagcttc ctggagtact acaggaagca atacaaccag gagatcacag
     1261 acttgaagca gccagtgcta gtgagccagc ccaagcggag gagaggccct ggcggcaccc
     1321 tgcctggccc agccatgctc atcccagagc tctgctacct cacaggcctg actgataaaa
     1381 tgcgcaatga tttcaacgtg atgaaggacc tggcggtgca cacacggctg acccctgagc
     1441 agcggcagcg ggaggtgggc cgcctcatcg actacatcca caaggatgac aatgtgcaga
     1501 gagagcttcg agactggggc ctaagcttcg attcgaactt gctgtccttc tcaggaagaa
     1561 tcttacaatc cgagaagatc caccagggtg gaaagacgtt tgattacaac ccacaatttg
     1621 cagactggtc caaagaaacg agaggcgcgc cgctgatcag cgtgaagccg ttggataact
     1681 ggctgctgat ctatacccgc aggaattatg aagcggccaa ctcgctgata cagaacctgt
     1741 tcaaagtgac tccggccatg ggcatccaga tgaaaaaggc catcatgatc gaggtggacg
     1801 acagaacaga agcttatctg agagccttgc agcagaaggt gacatcagac actcagatag
     1861 ttgtctgtct cttgtcaagt aatcggaagg acaagtatga tgccatcaag aagtatttgt
     1921 gcacagactg ccccacccca agtcagtgtg tggtggcccg gacgctgggc aagcagcaaa
     1981 cagtcatggc cattgccacc aagatcgccc tgcagatgaa ctgcaagatg ggaggcgagc
     2041 tctggcgggt ggacatgcct ctgaagctgg caatgatcgt gggcattgac tgttaccatg
     2101 acaccacagc tgggcggagg tccatcgcag gattcgttgc cagcatcaat gaagggatga
     2161 cccgttggtt ctcccgctgc gtctttcagg accgtggaca ggagctggta gacggtctga
     2221 aggtgtgctt gcaagctgcc ctgagggctt ggagtggctg caatgaatat atgcccagcc
     2281 gagtcattgt gtaccgagac ggtgtggggg acgggcagct gaagaccctg gtcaattatg
     2341 aggtcccaca gttcctagac tgcctcaagt cagtcgggag aggttacaac ccaagactga
     2401 ccgtgatcgt agtgaagaag cgagtcaatg ccaggttttt tgctcagtct gggggaagac
     2461 ttcagaaccc tcttccgggg acagtcatcg atgtggaagt caccagacca gagtggtatg
     2521 actttttcat cgtgagccag gcagtgagaa gtgggagtgt gtccccaaca cactacaatg
     2581 tcatctacga cagcagtggc ctgaagcccg accacatcca gcggctgacg tacaagctgt
     2641 gtcacgtgta ctacaattgg cctggagtca tccgagtccc tgcaccttgc cagtatgcac
     2701 acaagctggc cttcctcgtg ggccagagca tccacagaga gccgaacctc tccctgtcca
     2761 accgtctcta ctacctctaa ccagcagcga gggcctacat gctggtttcc tccagagctc
     2821 tgccaacctt tagttctgtt tctcatatga tgttgttcta gcgggatgct gggggtgggg
     2881 gttgggggcc gcggtttcgt tttttttttt tttttttagt tggtttgtag tggttataga
     2941 gttaactaag gttcactgtt tgctttgttt ctcatagagc gttgtgacaa tttgcttggc
     3001 agagtggtgg cagggggccg tggtaccaca gatagacttt cctaaagcag ccgagtcggc
     3061 aggttctcgg aggtgctcct gggagcacgt cctactgtac gctgcgctct ctctctctct
     3121 ctctctctct ctctctctct ctctctctct ctctctctgc atgtttgaat ttaaaggagg
     3181 aaaagacgca aggcaaaaat acccagagca tcctaggctg atgctatgtg ggactctgac
     3241 cctctgacac ctcagatcct aaagataaaa aggccggggg tgcctctctg aatttctttt
     3301 aagagttagg ttatagggaa tgaaaagaat tgttgagggt tggggattta gctcagtggt
     3361 agagcgcttg cctagcaagc gcaaggccct gggttcggtc cccagctccg aaaaaaaaga
     3421 aaaaagaaaa aaaaataata attgttgaaa gttttaaact tttctccatg aaagtgtttt
     3481 aagactgatg aggccggtgg tggaacgagt gttgttttct ttcgcaattt tctcaccgag
     3541 tgaaattagc gaccctcact ttatttaaac agtttttagt tttcgaaggc ccgtgttttc
     3601 tttgttttta aactgcagaa gaccactctg ggataggatt ccactcccga aagtaaggtg
     3661 tcgggcgtgg tggcacacac ctgtgatctc agcacttggg aggtgaagcc cggggaaccc
     3721 caagttcccg gtcagcctag gctacatagt gagaccttgt cttaacaaac aggaaaataa
     3781 aagaaaaatg gagcagttat gagttatggg tgtcagtttc tgcaggagac tctgggagta
     3841 agagctgccc ctgtccccag aggcagctgg tgggccaatt caggtgccag gcaaggtatg
     3901 gccacatatg tttgtctggc tctttggcag tgaaggaggc ttggagttat gtcacgagag
     3961 cagcttgaag tggctacagt gtgatgagtt ttacacaatg gcagtgtgtg cccccggcac
     4021 agctcaataa agtttctgtc tcacttta
//
