LOCUS       NM_019334               1716 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus paired-like homeodomain 2 (Pitx2), transcript
            variant 2, mRNA.
ACCESSION   NM_019334
VERSION     NM_019334.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Tian,L., Li,X., Ying,Y., Wang,L., Qiao,Y., Wang,D., Song,Y., Li,N.
            and Liu,X.
  TITLE     Pitx2 suppression at meiotic stages associates with seasonal
            inhibition of testis development in Rattus norvegicus caraco
  JOURNAL   Integr Zool 18 (3), 543-551 (2023)
   PUBMED   35639924
  REMARK    GeneRIF: Pitx2 suppression at meiotic stages associates with
            seasonal inhibition of testis development in Rattus norvegicus
            caraco.
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Scridon,A., Fouilloux-Meugnier,E., Loizon,E., Rome,S., Julien,C.,
            Barres,C. and Chevalier,P.
  TITLE     Long-standing arterial hypertension is associated with Pitx2
            down-regulation in a rat model of spontaneous atrial
            tachyarrhythmias
  JOURNAL   Europace 17 (1), 160-165 (2015)
   PUBMED   24908044
  REMARK    GeneRIF: The present study suggests the presence of age-dependent
            left atrial Pitx2 down-regulation in SHRs
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Li,X., Venugopalan,S.R., Cao,H., Pinho,F.O., Paine,M.L.,
            Snead,M.L., Semina,E.V. and Amendt,B.A.
  TITLE     A model for the molecular underpinnings of tooth defects in
            Axenfeld-Rieger syndrome
  JOURNAL   Hum Mol Genet 23 (1), 194-208 (2014)
   PUBMED   23975681
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Welsh,I.C., Thomsen,M., Gludish,D.W., Alfonso-Parra,C., Bai,Y.,
            Martin,J.F. and Kurpios,N.A.
  TITLE     Integration of left-right Pitx2 transcription and Wnt signaling
            drives asymmetric gut morphogenesis via Daam2
  JOURNAL   Dev Cell 26 (6), 629-644 (2013)
   PUBMED   24091014
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Ma,H.Y., Xu,J., Eng,D., Gross,M.K. and Kioussi,C.
  TITLE     Pitx2-mediated cardiac outflow tract remodeling
  JOURNAL   Dev Dyn 242 (5), 456-468 (2013)
   PUBMED   23361844
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Lindberg,C., Wunderlich,M., Ratliff,J., Dinsmore,J. and Jacoby,D.B.
  TITLE     Regulated expression of the homeobox gene, rPtx2, in the developing
            rat
  JOURNAL   Brain Res Dev Brain Res 110 (2), 215-226 (1998)
   PUBMED   9748586
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Yoshioka,H., Meno,C., Koshiba,K., Sugihara,M., Itoh,H.,
            Ishimaru,Y., Inoue,T., Ohuchi,H., Semina,E.V., Murray,J.C.,
            Hamada,H. and Noji,S.
  TITLE     Pitx2, a bicoid-type homeobox gene, is involved in a
            lefty-signaling pathway in determination of left-right asymmetry
  JOURNAL   Cell 94 (3), 299-305 (1998)
   PUBMED   9708732
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Amendt,B.A., Sutherland,L.B., Semina,E.V. and Russo,A.F.
  TITLE     The molecular basis of Rieger syndrome. Analysis of Pitx2
            homeodomain protein activities
  JOURNAL   J Biol Chem 273 (32), 20066-20072 (1998)
   PUBMED   9685346
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Kulak,S.C., Kozlowski,K., Semina,E.V., Pearce,W.G. and Walter,M.A.
  TITLE     Mutation in the RIEG1 gene in patients with iridogoniodysgenesis
            syndrome
  JOURNAL   Hum Mol Genet 7 (7), 1113-1117 (1998)
   PUBMED   9618168
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Alward,W.L., Semina,E.V., Kalenak,J.W., Heon,E., Sheth,B.P.,
            Stone,E.M. and Murray,J.C.
  TITLE     Autosomal dominant iris hypoplasia is caused by a mutation in the
            Rieger syndrome (RIEG/PITX2) gene
  JOURNAL   Am J Ophthalmol 125 (1), 98-100 (1998)
   PUBMED   9437321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF039832.1.
            
            On Jul 1, 2006 this sequence version replaced NM_019334.1.
            
            Transcript Variant: This variant (2) represents the shorter
            transcript and encodes the shorter protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039832.1, AJ222972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1483              AF039832.1         1-1483
            1484-1716           AF039832.1         1485-1717
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1716
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /note="paired-like homeodomain 2"
                     /db_xref="GeneID:54284"
                     /db_xref="RGD:3331"
     exon            1..198
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..254
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1024
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     paired-like homeodomain transcription factor 2; pituitary
                     homeobox 2; rPtx2; homeobox protein PITX2"
                     /codon_start=1
                     /product="pituitary homeobox 2 isoform 2"
                     /protein_id="NP_062207.1"
                     /db_xref="GeneID:54284"
                     /db_xref="RGD:3331"
                     /translation="METNCRKLVSACVQLEKDKGQQGKNEDVGAEDPSKKKRQRRQRT
                     HFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQ
                     AELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLS
                     SQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPY
                     APPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV"
     exon            255..460
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..1716
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagacaga aactgcccgc acccgctagc tttagcagcc ctcagcgtgg accctctcgc
       61 aacttggcac cctcaagatc cctgcggttc caaccagacc cgctccacgg cgctggctgt
      121 gcagcccgag cctcggccgc ctggcagtca ccctgggaag cggtgggacg gggagacagc
      181 cgttctctct ggtagccgat aacggggaat ggagaccaat tgtcgcaaac tagtgtcggc
      241 ctgtgtgcaa ttagagaaag ataagggcca gcagggaaag aatgaggatg tgggcgcaga
      301 ggacccgtcc aagaagaagc ggcaacgccg gcagaggact cactttacta gtcagcagct
      361 ccaggagctg gaagccactt tccagagaaa ccgctaccca gacatgtcca ctcgcgaaga
      421 aatcgccgtg tggaccaacc ttacggaagc ccgagtccgg gtttggttca agaatcgccg
      481 ggccaaatgg agaaagcggg agcgcaacca gcaggccgag ctgtgtaaga atggcttcgg
      541 gccgcagttc aatgggctca tgcagccgta cgatgacatg taccccggct actcgtacaa
      601 caattgggct gccaagggcc tcacgtcagc gtctctgtcc accaagagct tccccttctt
      661 caactctatg aacgtcaatc ccctatcctc ccagagcatg ttttccccgc ccaactccat
      721 ctcatccatg agtatgtcgt ccagcatggt gccgtccgcg gtgaccggcg tcccgggctc
      781 cagcctcaat agcctgaata acttgaacaa cctgagcagc ccgtcgctga attccgcggt
      841 gcccacgccc gcctgtcctt acgcgccgcc gactcctccg tacgtttata gggacacatg
      901 taactcgagc ctggccagtc tgagactaaa agcaaagcaa cactccagct tcggctacgc
      961 cagcgtgcag aacccggcct ccaacctgag cgcttgccag tatgcggtcg accggccggt
     1021 gtgaaccgcg cccagggcgc gggattccga ggactgtcgg agtgggcaac tctgcccgag
     1081 aaagactgag aattgtgcta gaaggtcgtg cgcactacgg ggagaaagag ggggggacaa
     1141 aagagatcag aggaaaagaa accactgaat tcaaagagag agagcgcctt tgatttcaaa
     1201 ggaatgcccc caagtgtctg ccatcttccg ctgaaagtat tcccaacagt tggaggacgc
     1261 gtgcaccaac aaatgtttga ctggatatga cattttaaca ttactataag cttgttattt
     1321 tttaagttta gcattgttaa cattaaaatg actgaaagga tgtatatata tcgaaatgtc
     1381 aaattaattt tataaaagca gttgttagta ctctcacgac agtgttttta aaggctaggc
     1441 tttaaaataa agcatgttat ccagaatcag ttaggatttt tcgcttgcga gcaaaggaat
     1501 gtatatacta aatgccacac tgtatgtttc taacatatta ttattataaa aaatgtgtga
     1561 atataagttt tagagtagtt tctctggtgg atgccttgtt tctgaaactg ctacgtacaa
     1621 cctatcctgt gtataacatt tcgtacgata ttgttttact tttcagcaaa tatgaaaaaa
     1681 tgtgttttat ttcttgggag taaaatatac cgcata
//
