LOCUS       NM_001042505            2019 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus paired-like homeodomain 2 (Pitx2), transcript
            variant 1, mRNA.
ACCESSION   NM_001042505
VERSION     NM_001042505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Tian,L., Li,X., Ying,Y., Wang,L., Qiao,Y., Wang,D., Song,Y., Li,N.
            and Liu,X.
  TITLE     Pitx2 suppression at meiotic stages associates with seasonal
            inhibition of testis development in Rattus norvegicus caraco
  JOURNAL   Integr Zool 18 (3), 543-551 (2023)
   PUBMED   35639924
  REMARK    GeneRIF: Pitx2 suppression at meiotic stages associates with
            seasonal inhibition of testis development in Rattus norvegicus
            caraco.
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Scridon,A., Fouilloux-Meugnier,E., Loizon,E., Rome,S., Julien,C.,
            Barres,C. and Chevalier,P.
  TITLE     Long-standing arterial hypertension is associated with Pitx2
            down-regulation in a rat model of spontaneous atrial
            tachyarrhythmias
  JOURNAL   Europace 17 (1), 160-165 (2015)
   PUBMED   24908044
  REMARK    GeneRIF: The present study suggests the presence of age-dependent
            left atrial Pitx2 down-regulation in SHRs
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Li,X., Venugopalan,S.R., Cao,H., Pinho,F.O., Paine,M.L.,
            Snead,M.L., Semina,E.V. and Amendt,B.A.
  TITLE     A model for the molecular underpinnings of tooth defects in
            Axenfeld-Rieger syndrome
  JOURNAL   Hum Mol Genet 23 (1), 194-208 (2014)
   PUBMED   23975681
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Welsh,I.C., Thomsen,M., Gludish,D.W., Alfonso-Parra,C., Bai,Y.,
            Martin,J.F. and Kurpios,N.A.
  TITLE     Integration of left-right Pitx2 transcription and Wnt signaling
            drives asymmetric gut morphogenesis via Daam2
  JOURNAL   Dev Cell 26 (6), 629-644 (2013)
   PUBMED   24091014
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Ma,H.Y., Xu,J., Eng,D., Gross,M.K. and Kioussi,C.
  TITLE     Pitx2-mediated cardiac outflow tract remodeling
  JOURNAL   Dev Dyn 242 (5), 456-468 (2013)
   PUBMED   23361844
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   Lindberg,C., Wunderlich,M., Ratliff,J., Dinsmore,J. and Jacoby,D.B.
  TITLE     Regulated expression of the homeobox gene, rPtx2, in the developing
            rat
  JOURNAL   Brain Res Dev Brain Res 110 (2), 215-226 (1998)
   PUBMED   9748586
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Yoshioka,H., Meno,C., Koshiba,K., Sugihara,M., Itoh,H.,
            Ishimaru,Y., Inoue,T., Ohuchi,H., Semina,E.V., Murray,J.C.,
            Hamada,H. and Noji,S.
  TITLE     Pitx2, a bicoid-type homeobox gene, is involved in a
            lefty-signaling pathway in determination of left-right asymmetry
  JOURNAL   Cell 94 (3), 299-305 (1998)
   PUBMED   9708732
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Amendt,B.A., Sutherland,L.B., Semina,E.V. and Russo,A.F.
  TITLE     The molecular basis of Rieger syndrome. Analysis of Pitx2
            homeodomain protein activities
  JOURNAL   J Biol Chem 273 (32), 20066-20072 (1998)
   PUBMED   9685346
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Kulak,S.C., Kozlowski,K., Semina,E.V., Pearce,W.G. and Walter,M.A.
  TITLE     Mutation in the RIEG1 gene in patients with iridogoniodysgenesis
            syndrome
  JOURNAL   Hum Mol Genet 7 (7), 1113-1117 (1998)
   PUBMED   9618168
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Alward,W.L., Semina,E.V., Kalenak,J.W., Heon,E., Sheth,B.P.,
            Stone,E.M. and Murray,J.C.
  TITLE     Autosomal dominant iris hypoplasia is caused by a mutation in the
            Rieger syndrome (RIEG/PITX2) gene
  JOURNAL   Am J Ophthalmol 125 (1), 98-100 (1998)
   PUBMED   9437321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and 5'
            coding region compared to variant 2. The resulting protein (isoform
            1) is longer and has a distinct N-terminus compared to isoform 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222971.1, SRR26360172.2865035.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               JAXUCZ010000002.1  220406223-220406775
            554-759             JAXUCZ010000002.1  220407643-220407848
            760-2019            JAXUCZ010000002.1  220410329-220411588
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2019
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /note="paired-like homeodomain 2"
                     /db_xref="GeneID:54284"
                     /db_xref="RGD:3331"
     exon            1..553
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1323
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paired-like homeodomain transcription factor 2; pituitary
                     homeobox 2; rPtx2; homeobox protein PITX2"
                     /codon_start=1
                     /product="pituitary homeobox 2 isoform 1"
                     /protein_id="NP_001035970.1"
                     /db_xref="GeneID:54284"
                     /db_xref="RGD:3331"
                     /translation="MNCMKGPLPLEHRAAGTKLSAASSPFCHHTQALAMASVLAPGQP
                     RSLDASKHRLEVHTISDTSSPEVAEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQ
                     QLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCK
                     NGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMF
                     SPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTP
                     PYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV"
     exon            554..759
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..2019
                     /gene="Pitx2"
                     /gene_synonym="Pitx-2; Pitx2c; Ptx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctaggggag ggagggaggc aagaaaaggg tctttgccca ttcttgtttc gctttggatc
       61 gtggaagtcg gctccctaaa gacgcttgca gcggttccct tctgcccacg tccccaagtc
      121 tccgttggcc ccctgacttt cggctgccga actctgtttg gctggagtct gcagttagaa
      181 gagacagggg cagtttggct ggaggaccct gcagtttgcg tcccctggct ctacaagtct
      241 cggctaacac agggacactt ggcgcctaga gcgctaccca gaaccggcgg ccaccggggc
      301 tcgacaggcg ggagccctgg actcgtaggg caccgcactc cctcgtccat gaactgcatg
      361 aaaggcccgc tgcccttgga gcaccgagca gccgggacta agctgtcggc cgcttcctca
      421 cccttctgtc accataccca ggcgttagcc atggcttcgg tcctagctcc tggtcagccc
      481 cgctccctgg acgcctccaa acatagactg gaggtgcata caatctccga tacgtccagc
      541 cctgaagtcg cagagaaaga taagggccag cagggaaaga atgaggatgt gggcgcagag
      601 gacccgtcca agaagaagcg gcaacgccgg cagaggactc actttactag tcagcagctc
      661 caggagctgg aagccacttt ccagagaaac cgctacccag acatgtccac tcgcgaagaa
      721 atcgccgtgt ggaccaacct tacggaagcc cgagtccggg tttggttcaa gaatcgccgg
      781 gccaaatgga gaaagcggga gcgcaaccag caggccgagc tgtgtaagaa tggcttcggg
      841 ccgcagttca atgggctcat gcagccgtac gatgacatgt accccggcta ctcgtacaac
      901 aattgggctg ccaagggcct cacgtcagcg tctctgtcca ccaagagctt ccccttcttc
      961 aactctatga acgtcaatcc cctatcctcc cagagcatgt tttccccgcc caactccatc
     1021 tcatccatga gtatgtcgtc cagcatggtg ccgtccgcgg tgaccggcgt cccgggctcc
     1081 agcctcaata gcctgaataa cttgaacaac ctgagcagcc cgtcgctgaa ttccgcggtg
     1141 cccacgcccg cctgtcctta cgcgccgccg actcctccgt acgtttatag ggacacatgt
     1201 aactcgagcc tggccagtct gagactaaaa gcaaagcaac actccagctt cggctacgcc
     1261 agcgtgcaga acccggcctc caacctgagc gcttgccagt atgcggtcga ccggccggtg
     1321 tgaaccgcgc ccagggcgcg ggattccgag gactgtcgga gtgggcaact ctgcccgaga
     1381 aagactgaga attgtgctag aaggtcgtgc gcactacggg gagaaagagg gggggacaaa
     1441 agagatcaga ggaaaagaaa ccactgaatt caaagagaga gagcgccttt gatttcaaag
     1501 gaatgccccc aagtgtctgc catcttccgc tgaaagtatt cccaacagtt ggaggacgcg
     1561 tgcaccaaca aatgtttgac tggatatgac attttaacat tactataagc ttgttatttt
     1621 ttaagtttag cattgttaac attaaaatga ctgaaaggat gtatatatat cgaaatgtca
     1681 aattaatttt ataaaagcag ttgttagtac tctcacgaca gtgtttttaa aggctaggct
     1741 ttaaaataaa gcatgttatc cagaatcagt taggattttt cgcttgcgag caaaggaatg
     1801 tatatactaa atgccacact gtatgtttct aacatattat tattataaaa aatgtgtgaa
     1861 tataagtttt agagtagttt ctctggtgga tgccttgttt ctgaaactgc tacgtacaac
     1921 ctatcctgtg tataacattt cgtacgatat tgttttactt ttcagcaaat atgaaaaaat
     1981 gtgttttatt tcttgggagt aaaatatacc gcatacaaa
//
