LOCUS       NM_053624               2287 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus paired-like homeodomain 1 (Pitx1), mRNA.
ACCESSION   NM_053624
VERSION     NM_053624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Zhao,X. and Yang,X.
  TITLE     Retinoic Acid Promotes Retinoic Acid Signaling by Suppression of
            Pitx1 In Tendon Cells: A Possible Mechanism of a Clubfoot-Like
            Phenotype Induced by Retinoic Acid
  JOURNAL   Med Sci Monit 25, 6980-6989 (2019)
   PUBMED   31527569
  REMARK    GeneRIF: Pitx1 binds to the promoter region of SIRT1 and promotes
            the transcription of SIRT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Sobrier,M.L., Tsai,Y.C., Perez,C., Leheup,B., Bouceba,T.,
            Duquesnoy,P., Copin,B., Sizova,D., Penzo,A., Stanger,B.Z.,
            Cooke,N.E., Liebhaber,S.A. and Amselem,S.
  TITLE     Functional characterization of a human POU1F1 mutation associated
            with isolated growth hormone deficiency: a novel etiology for IGHD
  JOURNAL   Hum Mol Genet 25 (3), 472-483 (2016)
   PUBMED   26612202
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   Simpson,M.T., Venkatesh,I., Callif,B.L., Thiel,L.K., Coley,D.M.,
            Winsor,K.N., Wang,Z., Kramer,A.A., Lerch,J.K. and Blackmore,M.G.
  TITLE     The tumor suppressor HHEX inhibits axon growth when prematurely
            expressed in developing central nervous system neurons
  JOURNAL   Mol Cell Neurosci 68, 272-283 (2015)
   PUBMED   26306672
  REMARK    GeneRIF: This study idnetifed that the PITX1 as inhibitors of
            neurite outgrowth.
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Gajewska,A., Herman,A.P., Wolinska-Witort,E., Kochman,K. and
            Zwierzchowski,L.
  TITLE     In vivo oestrogenic modulation of Egr1 and Pitx1 gene expression in
            female rat pituitary gland
  JOURNAL   J Mol Endocrinol 53 (3), 355-366 (2014)
   PUBMED   25258388
  REMARK    GeneRIF: Orchestrated Egr1 and Pitx1 activities depending on
            specific central and peripheral regulatory inputs could be
            responsible for physiologically variable Lhb gene promoter
            activation in vivo.
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   Duboc,V. and Logan,M.P.
  TITLE     Pitx1 is necessary for normal initiation of hindlimb outgrowth
            through regulation of Tbx4 expression and shapes hindlimb
            morphologies via targeted growth control
  JOURNAL   Development 138 (24), 5301-5309 (2011)
   PUBMED   22071103
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Lanctot,C., Moreau,A., Chamberland,M., Tremblay,M.L. and Drouin,J.
  TITLE     Hindlimb patterning and mandible development require the Ptx1 gene
  JOURNAL   Development 126 (9), 1805-1810 (1999)
   PUBMED   10101115
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Szeto,D.P., Rodriguez-Esteban,C., Ryan,A.K., O'Connell,S.M.,
            Liu,F., Kioussi,C., Gleiberman,A.S., Izpisua-Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     Role of the Bicoid-related homeodomain factor Pitx1 in specifying
            hindlimb morphogenesis and pituitary development
  JOURNAL   Genes Dev 13 (4), 484-494 (1999)
   PUBMED   10049363
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Potter,M., Wax,J. and Jones,G.M.
  TITLE     Indomethacin is a potent inhibitor of pristane and plastic disc
            induced plasmacytomagenesis in a hypersusceptible BALB/c congenic
            strain
  JOURNAL   Blood 90 (1), 260-269 (1997)
   PUBMED   9207461
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   Lamonerie,T., Tremblay,J.J., Lanctot,C., Therrien,M., Gauthier,Y.
            and Drouin,J.
  TITLE     Ptx1, a bicoid-related homeo box transcription factor involved in
            transcription of the pro-opiomelanocortin gene
  JOURNAL   Genes Dev 10 (10), 1284-1295 (1996)
   PUBMED   8675014
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061966.1.
            
            On Dec 20, 2003 this sequence version replaced NM_053624.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061966.1, AB047298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2287
                     /gene="Pitx1"
                     /gene_synonym="Bft"
                     /note="paired-like homeodomain 1"
                     /db_xref="GeneID:113983"
                     /db_xref="RGD:69253"
     exon            1..460
                     /gene="Pitx1"
                     /gene_synonym="Bft"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1239
                     /gene="Pitx1"
                     /gene_synonym="Bft"
                     /note="homeobox protein PITX1; paired-like homeodomain
                     transcription factor 1"
                     /codon_start=1
                     /product="pituitary homeobox 1"
                     /protein_id="NP_446076.1"
                     /db_xref="GeneID:113983"
                     /db_xref="RGD:69253"
                     /translation="MDAFKGGMSLERLPEGLRPPPPPPHDMGPSFHLARTADPREPLE
                     NSASESSDADLPDKERGGEAKVPEDGGAGSAGCGSAEDPAKKKKQRRQRTHFTSQQLQ
                     ELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGY
                     VPQFSGLVQPYEDVYAAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAP
                     SSISSMTMPSSMGPGSVPGMPNSGLNNINNLTGSSLNSAMSPGACPYGTPASPYSVYR
                     DTCNSSLASLRLKSKQHSSFGYGGLQGPASGLNACQYNS"
     exon            461..693
                     /gene="Pitx1"
                     /gene_synonym="Bft"
                     /inference="alignment:Splign:2.1.0"
     exon            694..2256
                     /gene="Pitx1"
                     /gene_synonym="Bft"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgggctc cgacccgagc cttagaaacc ggcctcgaat cgggactggg acccgggcct
       61 gccgggcagc tgaggccgga gcggcgggag cgcgtggcgc agcctcgagc cctgagcccc
      121 gtcctgcagc cccgagagat cgatggagcg cgggcgtcgt cgctgtgggc gcgggcagcc
      181 ctggggggca gccgcttagg cgccgctctc ttgtccccaa caggtcgcag cccgggtggc
      241 cgggcgctcc cagctccggc tcctggagcg ccctttgcgg tccccacctc catggacgcc
      301 ttcaagggag gcatgagcct ggagaggcta ccggaggggc tgcggccacc gccaccgccg
      361 ccacacgaca tggggcccag cttccacctg gcccgcaccg ccgacccccg ggagccgctg
      421 gagaactcag ccagcgagtc atccgacgcc gatctgccag acaaggagcg cggtggagag
      481 gccaaggtgc ctgaggatgg cggcgcgggc agcgctggct gcggcagcgc ggaagaccca
      541 gccaagaaga agaaacagcg gcgtcaacgc actcacttca caagccagca gttgcaagag
      601 ctggaggcca cgttccaaag gaaccgctac ccggacatga gcatgagaga ggagatcgcg
      661 gtgtggacca acctcactga gccgcgagtg cgggtctggt tcaagaaccg gcgagccaag
      721 tggcgcaaga gggagcggaa ccagcagttg gacctgtgca agggcggcta cgtgccgcag
      781 ttcagcggct tggtgcagcc ctacgaggac gtgtacgccg ccgccggcta ctcctacaac
      841 aactgggccg ccaagagctt ggcaccggcg ccgctgtcca ccaagagctt taccttcttc
      901 aactccatga gtccgctatc ctctcagtcc atgttctcgg cccccagctc catctcttcc
      961 atgaccatgc catccagcat gggcccgggc tccgtgcccg gcatgcccaa ctcgggcctc
     1021 aacaacatca acaacctcac gggctcctcg ctcaactcgg ccatgtcgcc gggcgcctgc
     1081 ccctacggca cccccgcctc gccctacagc gtctaccggg acacgtgcaa ctcgagcctc
     1141 gccagcctgc ggctcaagtc caagcagcac tcctcgtttg gctacggcgg tctgcagggt
     1201 ccagcgtcgg gcctcaacgc ctgccagtat aacagctgac cgccccgccg ggtccccggg
     1261 gccgccggcc ggcaaggcgc agcgggagcg cgcggagcac acggggcgct cgcagcacct
     1321 gggacctcac ctctgcgcag ccccttcctc cccaccctgc ctccaggttg gttttgtgtt
     1381 tgcttttccg gaccccgctc tgcccccaat gaataaaaaa gggaaaaaaa tcaagccaag
     1441 ggagggggtg ggggagagaa agcaaaaaaa ataaaaaaat tttaaaaaaa ggacatcgga
     1501 gaaaaatgct gggggtgggg gtgagttgca atgtccctgg cgatggcgca ggtggtgcgt
     1561 tcgaaccctc gacccccaac tgtccactac accaagggga tgtggcgtgg gggaagccag
     1621 cgccaaagtg gctcggagaa gacgccgttc gtccctgccg gagcgcctca acccgtgaac
     1681 tgaatgtagg gagcctggag gccctgggat cgttcacccg atcaaaaacc cgaggcaccc
     1741 tctcctagcc tgggccgtcc gagtgcatgc agcgcggatc actgttggag cttgagcctg
     1801 gctggggatg acagcgctga tggggatccg gtgtgccgga ttagcctaag gccccgggat
     1861 gccagaagag cccagcagcc ctgagctctg gagccgcaca cttcaggcca ctgagccgca
     1921 gctggccgtg gccagtccgc agcaggaggg gaagggctca gctctgagtt ccccagcccc
     1981 agcttagccg ccagcccggc cctctgctcc actacgggtc caggaggtgg cccagtgaac
     2041 agccccttcc tcactgctca cccgtgcaag agtcgagcca ggagagcgcg gggccacagc
     2101 cccagggccc ccgcccactt tgcacacccg ctctctggcc cgcgcccgtt tacagcgtcc
     2161 ctgtgtatgt cggactgact gtatagaatt ataaatctgt ctatatcgac ttgtccatgt
     2221 acgtctatta aaaccatagt cggagcgtgc taagcaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaa
//
