LOCUS       NM_053742               2670 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol transfer protein, beta
            (Pitpnb), mRNA.
ACCESSION   NM_053742
VERSION     NM_053742.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Shadan,S., Holic,R., Carvou,N., Ee,P., Li,M., Murray-Rust,J. and
            Cockcroft,S.
  TITLE     Dynamics of lipid transfer by phosphatidylinositol transfer
            proteins in cells
  JOURNAL   Traffic 9 (10), 1743-1756 (2008)
   PUBMED   18636990
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Chalimoniuk,M., Snoek,G.T., Adamczyk,A., Malecki,A. and
            Strosznajder,J.B.
  TITLE     Phosphatidylinositol transfer protein expression altered by aging
            and Parkinson disease
  JOURNAL   Cell Mol Neurobiol 26 (7-8), 1153-1166 (2006)
   PUBMED   16779671
  REMARK    GeneRIF: Lower protein expression of PI-TP(alpha and beta) in aged
            brain and in PD.
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Morgan,C.P., Allen-Baume,V., Radulovic,M., Li,M., Skippen,A. and
            Cockcroft,S.
  TITLE     Differential expression of a C-terminal splice variant of
            phosphatidylinositol transfer protein beta lacking the
            constitutive-phosphorylated Ser262 that localizes to the Golgi
            compartment
  JOURNAL   Biochem J 398 (3), 411-421 (2006)
   PUBMED   16780419
  REMARK    GeneRIF: in rat liver, the single gene for PITPbeta gives rise to
            seven distinct protein species that can be resolved on the basis of
            their charge differences
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Vordtriede,P.B., Doan,C.N., Tremblay,J.M., Helmkamp,G.M. Jr. and
            Yoder,M.D.
  TITLE     Structure of PITPbeta in complex with phosphatidylcholine:
            comparison of structure and lipid transfer to other PITP isoforms
  JOURNAL   Biochemistry 44 (45), 14760-14771 (2005)
   PUBMED   16274224
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Alb,J.G. Jr., Phillips,S.E., Rostand,K., Cui,X., Pinxteren,J.,
            Cotlin,L., Manning,T., Guo,S., York,J.D., Sontheimer,H.,
            Collawn,J.F. and Bankaitis,V.A.
  TITLE     Genetic ablation of phosphatidylinositol transfer protein function
            in murine embryonic stem cells
  JOURNAL   Mol Biol Cell 13 (3), 739-754 (2002)
   PUBMED   11907258
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Tanaka,S. and Hosaka,K.
  TITLE     Cloning of a cDNA encoding a second phosphatidylinositol transfer
            protein of rat brain by complementation of the yeast sec14 mutation
  JOURNAL   J Biochem 115 (5), 981-984 (1994)
   PUBMED   7961615
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053742.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D21132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000012.1  50958068-50958111   c
            45-75               JAXUCZ010000012.1  50953963-50953993   c
            76-221              JAXUCZ010000012.1  50951460-50951605   c
            222-313             JAXUCZ010000012.1  50943918-50944009   c
            314-321             JAXUCZ010000012.1  50943362-50943369   c
            322-396             JAXUCZ010000012.1  50942521-50942595   c
            397-480             JAXUCZ010000012.1  50940875-50940958   c
            481-558             JAXUCZ010000012.1  50926993-50927070   c
            559-669             JAXUCZ010000012.1  50916887-50916997   c
            670-792             JAXUCZ010000012.1  50914294-50914416   c
            793-876             JAXUCZ010000012.1  50911897-50911980   c
            877-2670            JAXUCZ010000012.1  50909143-50910936   c
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2670
                     /gene="Pitpnb"
                     /note="phosphatidylinositol transfer protein, beta"
                     /db_xref="GeneID:114561"
                     /db_xref="RGD:620143"
     exon            1..44
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..840
                     /gene="Pitpnb"
                     /note="PI-TP-beta; ptdIns transfer protein beta; ptdInsTP
                     beta; phosphotidylinositol transfer protein, beta"
                     /codon_start=1
                     /product="phosphatidylinositol transfer protein beta
                     isoform"
                     /protein_id="NP_446194.1"
                     /db_xref="GeneID:114561"
                     /db_xref="RGD:620143"
                     /translation="MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLK
                     NEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEY
                     MKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDP
                     ALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEK
                     RIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA"
     exon            45..75
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            76..221
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            222..313
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            314..321
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            322..396
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            397..480
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            481..558
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            559..669
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            670..792
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            793..876
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
     exon            877..2670
                     /gene="Pitpnb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctgtga gggcttcccg gaagatggtg ctgattaagg aattccgtgt agttttgccg
       61 tgttctgttc aagagtatca ggttggacag ctttactctg ttgcagaagc gagtaagaat
      121 gaaactggtg gtggagaagg aatcgaagtc ttgaagaatg aaccttatga aaatgatggc
      181 gagaagggac agtacacaca caaaatctac cacctgaaga gcaaagtccc tgcgttcgtg
      241 aggatgattg ctcccgaggg ctccttggtg ttccatgaga aagcctggaa tgcttacccc
      301 tactgcagaa caattgtaac gaatgagtac atgaaagatg acttcttcat caaaatcgaa
      361 acatggcaca aacctgactt gggaacatta gaaaatgttc acggtttaga tccaaacacg
      421 tggaaaaccg ttgaaattgt ccacatagac attgcagatc gaagtcaggt tgaaccagca
      481 gactacaaag ctgatgagga ccctgcgtta ttccagtcag tcaagaccaa gagaggcccc
      541 ctgggaccta actggaagaa ggagctggca aacacccctg actgtcctaa gatgtgtgcc
      601 tataagctgg tgaccatcaa gttcaagtgg tgggggctgc agagcaaagt agagaacttc
      661 atccagaagc aagaaaaacg gatatttaca aacttacatc gccagctctt ttgttggatt
      721 gacaagtgga ttgacctgac aatggaagac attaggagaa tggaggacga gactcagaaa
      781 gaactagaaa caatgcgtaa gaagggttcc gtccgaggca cgtcggctgc tgatgcctag
      841 atgagcccct gtaggtcaga gacattatca aactgtctac ggagtcaagg ccaagtgagg
      901 gggaccagtg cggcctgcga cgactaaagc caccagcgtc tcagtgttga cggatgtttc
      961 cagtgtgtgc ctctgacggc tcgggcacac ttgtgcacac tcgagggcac acacacaccc
     1021 atgcacacac actcacactg tatgtatgtc tgtagctgta tgtaaagcac atatggctac
     1081 aggcctagat acacacgagt gtatatatat atgtacatgt gaagatggat cagtaccttt
     1141 tctccaaagt actgcacctg tcttcagcag aaatactaaa gaaaatattt tcaatatata
     1201 tacctggaac agatattaat acccatcaac atgatgccct ggatggacaa acggactgcc
     1261 atgtggtgcc ctgtggtgct ggctggcgtg cttcgtgaat gccaggtgtg gaccagtgtg
     1321 tacagccttt ggttaggttt ctgttttttt caagtcacca cacacacaca cacgtttagt
     1381 ctcaacccat cagcaacaac tcctacagaa agattttttc aaatttttag atactccagt
     1441 gactctggaa tgtaaactct ggatgtattt ataactattt atttctgggt ggccactatc
     1501 ttccagccaa atccaacaat atctgtcaag taaggagtga aagctcttta ttggtttgcc
     1561 cgagggttgg ggatatcctt ttttaaaaaa ttgccacttt ttattggatt tttgtatttt
     1621 gaatttcaag tatttttcta tatcaaatct agcaaaaaac ggtgatgacg gtttgtgatt
     1681 tataataaac actgacaata ttcagattct ggctaagcaa acagggtgat caggcaatta
     1741 acctgagtgg cactggaggc tgtgcagagc acttctgtgg agttttgttt ctgaaatggc
     1801 ttttctggaa ttacggcctg gagactggat ggtctgtatt gctctcagtt cacagggtag
     1861 gagagtggtc ccgcccggct gtttccagtt acagtccaag ctaggaggaa atgctgatgg
     1921 gagcaggcac agcttgagca tgacacaggc ctgtccccgt cctgaggccc agctagacct
     1981 gggccttgcc gacagctctg cttcctcctc ctgtatctcc tcctcctccc ccttcctctt
     2041 ctgtctctac tttctccttt ttttttaaga gaaaggagca gtagctggga aggattttct
     2101 tttttttacc tttccgtctg atgctattct cctctcgtca gtcctggaac cctgaccagc
     2161 atcacactgt tgaatccttc aggttacaca ctgcctttta acctccaccc tgcagtcaga
     2221 gcacggtggt gacacccctt tgttgacagg cttgaccttc atgtcccttc tgccctgccc
     2281 tgtgtcccat gggggaaatg gcagagagtc ccactgcatc acactgccct gttagcctca
     2341 gcaacaagcc ctgggttcca tgtcctctaa gctctagata aaggtggtta ttccctgggc
     2401 actgctggaa gctgggaagg tcaccaccag aagggtcatt gccagccttg tctcctccag
     2461 tgaaaccaga tcacagacat ccatagtttc tctgagagct ggggcacaca aggaaaccag
     2521 agcccagtat ggattcttgt gttgctctag cagctgtgga gattgaggga tgtggtgaat
     2581 gcaaagaacc cagtttactt ggcagtctcc tgtgtaaatc acagtaaaac aaagtgaaat
     2641 cgaaacaaga ataaatttga tctcaaaatg
//
