LOCUS       NM_001009967            4343 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 5-kinase type 1
            gamma (Pip5k1c), transcript variant c, mRNA.
ACCESSION   NM_001009967 XM_234925
VERSION     NM_001009967.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Tan,X., Sun,Y., Thapa,N., Liao,Y., Hedman,A.C. and Anderson,R.A.
  TITLE     LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling,
            lysosomal sorting, and degradation
  JOURNAL   EMBO J 34 (4), 475-490 (2015)
   PUBMED   25588945
REFERENCE   2  (bases 1 to 4343)
  AUTHORS   Wang,Y., Zhao,L., Suzuki,A., Lian,L., Min,S.H., Wang,Z.,
            Litvinov,R.I., Stalker,T.J., Yago,T., Klopocki,A.G.,
            Schmidtke,D.W., Yin,H., Choi,J.K., McEver,R.P., Weisel,J.W.,
            Hartwig,J.H. and Abrams,C.S.
  TITLE     Platelets lacking PIP5KIgamma have normal integrin activation but
            impaired cytoskeletal-membrane integrity and adhesion
  JOURNAL   Blood 121 (14), 2743-2752 (2013)
   PUBMED   23372168
REFERENCE   3  (bases 1 to 4343)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4343)
  AUTHORS   Unoki,T., Matsuda,S., Kakegawa,W., Van,N.T., Kohda,K., Suzuki,A.,
            Funakoshi,Y., Hasegawa,H., Yuzaki,M. and Kanaho,Y.
  TITLE     NMDA receptor-mediated PIP5K activation to produce PI(4,5)P is
            essential for AMPA receptor endocytosis during LTD
  JOURNAL   Neuron 73 (1), 135-148 (2012)
   PUBMED   22243752
REFERENCE   5  (bases 1 to 4343)
  AUTHORS   Volpicelli-Daley,L.A., Lucast,L., Gong,L.W., Liu,L., Sasaki,J.,
            Sasaki,T., Abrams,C.S., Kanaho,Y. and De Camilli,P.
  TITLE     Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol
            4,5-bisphosphate synthesis in the brain
  JOURNAL   J Biol Chem 285 (37), 28708-28714 (2010)
   PUBMED   20622009
REFERENCE   6  (bases 1 to 4343)
  AUTHORS   Di Paolo,G., Moskowitz,H.S., Gipson,K., Wenk,M.R., Voronov,S.,
            Obayashi,M., Flavell,R., Fitzsimonds,R.M., Ryan,T.A. and De
            Camilli,P.
  TITLE     Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces
            defects in synaptic vesicle trafficking
  JOURNAL   Nature 431 (7007), 415-422 (2004)
   PUBMED   15386003
REFERENCE   7  (bases 1 to 4343)
  AUTHORS   Giudici,M.L., Emson,P.C. and Irvine,R.F.
  TITLE     A novel neuronal-specific splice variant of Type I
            phosphatidylinositol 4-phosphate 5-kinase isoform gamma
  JOURNAL   Biochem J 379 (Pt 2), 489-496 (2004)
   PUBMED   14741049
REFERENCE   8  (bases 1 to 4343)
  AUTHORS   Krauss,M., Kinuta,M., Wenk,M.R., De Camilli,P., Takei,K. and
            Haucke,V.
  TITLE     ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by
            activating phosphatidylinositol phosphate kinase type Igamma
  JOURNAL   J Cell Biol 162 (1), 113-124 (2003)
   PUBMED   12847086
REFERENCE   9  (bases 1 to 4343)
  AUTHORS   Wenk,M.R., Pellegrini,L., Klenchin,V.A., Di Paolo,G., Chang,S.,
            Daniell,L., Arioka,M., Martin,T.F. and De Camilli,P.
  TITLE     PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at
            the synapse
  JOURNAL   Neuron 32 (1), 79-88 (2001)
   PUBMED   11604140
REFERENCE   10 (bases 1 to 4343)
  AUTHORS   Ishihara,H., Shibasaki,Y., Kizuki,N., Wada,T., Yazaki,Y., Asano,T.
            and Oka,Y.
  TITLE     Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the
            third isoform and deletion/substitution analysis of members of this
            novel lipid kinase family
  JOURNAL   J Biol Chem 273 (15), 8741-8748 (1998)
   PUBMED   9535851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB557931.1,
            AY850259.1, CK366332.1, BC101909.1, CB581409.1 and CB696331.1.
            
            On Aug 5, 2006 this sequence version replaced NM_001009967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                CB557931.1         12-72
            62-507              AY850259.1         1-446
            508-630             CK366332.1         497-619
            631-714             AY850259.1         570-653
            715-716             CK366332.1         705-706
            717-1133            AY850259.1         656-1072
            1134-1536           BC101909.1         1106-1508
            1537-2057           AY850259.1         1476-1996
            2058-2125           CB581409.1         143-210
            2126-2400           BC101909.1         1942-2216
            2401-2561           CB696331.1         265-425
            2562-4343           BC101909.1         2378-4159
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4343
                     /gene="Pip5k1c"
                     /note="phosphatidylinositol-4-phosphate 5-kinase type 1
                     gamma"
                     /db_xref="GeneID:314641"
                     /db_xref="RGD:1309938"
     exon            1..155
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2128
                     /gene="Pip5k1c"
                     /EC_number="2.7.1.68"
                     /note="isoform c is encoded by transcript variant c;
                     PIP5KIgamma; ptdInsPKIgamma; ptdIns(4)P-5-kinase gamma;
                     PIP5K1-gamma; ptdIns(4)P-5-kinase 1 gamma;
                     phosphatidylinositol 4-phosphate 5-kinase type I gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     gamma isoform c"
                     /protein_id="NP_001009967.2"
                     /db_xref="GeneID:314641"
                     /db_xref="RGD:1309938"
                     /translation="MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAP
                     LVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDV
                     LMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLC
                     NEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLP
                     KFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYK
                     DLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQ
                     AEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLL
                     HIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSL
                     KSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLL
                     PCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELH
                     AEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQAS
                     DEEDAPSTDIYFFAHGRYWLFSPRRRRLRAVTPSHTGAPTDERSWVYSPLHYSARPAS
                     DGESDT"
     exon            156..187
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            188..280
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            281..411
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            412..529
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            530..682
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            683..982
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1188
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1272
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1321
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1406
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1568
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1707
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1740
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1842
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1969
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2047
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2125
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..4333
                     /gene="Pip5k1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagctcg ggtgcatcct cgggcccgcc gccgccgccg ctgccgccgg agcgcgcggc
       61 catggagcta gaggtgccgg acgaggcaga gagcgccgaa gcaggggccg tgacagcgga
      121 ggcggcctgg tctgcggaga gtggggcggc ggcaggtatg acccagaaga aggctatcct
      181 tgcagaggcc ccgttggtga cagggcagcc aggccctggc catgggaaga agctgggcca
      241 tcgaggcgtg gatgcgtctg gagagactac gtataagaag accacctcgt ccaccctgaa
      301 gggtgccatc caactgggga ttgggtacac ggtgggcaac ctcagctcta agccagaacg
      361 cgatgtgctc atgcaggact tctatgtggt ggagagcatc ttctttccca gcgaagggag
      421 caaccttacc cccgcccacc acttccagga tttccgtttc aagacctatg cacctgttgc
      481 cttccgttac ttccgggagc tctttggtat ccgtccggac gattacttgt actcactctg
      541 caacgagcca ctcattgagc tgtccaaccc gggtgccagt ggctccgtct tctacgtcac
      601 cagcgatgac gagttcatca ttaagactgt catgcacaag gaggcggagt tcctgcagaa
      661 actgctgcct ggctactata tgaacctcaa ccagaacccc cggaccttgc tgcccaagtt
      721 ctatgggctg tactgtgtgc agtccggcgg caagaacatt cgagtggtgg tcatgaacaa
      781 tgtgctgccc cgtgtcgtca agatgcacct caagttcgac ctcaagggct ccacgtacaa
      841 gcgcagggcc agcaagaagg agaaggagaa gagcctgccc acctacaagg acctggactt
      901 catgcaggac atgccagagg ggctgctact ggactctgac acctttggcg ccctggtcaa
      961 gacgctgcag cgagactgcc tggtgttgga gagcttcaag ataatggact acagcctgct
     1021 gctgggtgtg cacaacattg accagcagga gcgggagcgc caggccgagg gcgcccagag
     1081 caaggctgac gagaagcggc cggtggccca gaaggccctc tactccacag ccatggagtc
     1141 cattcagggc ggagctgccc gtggggaggc cattgagaca gatgacacga tgggtgggat
     1201 cccagccgtg aatgggcgtg gggagcgctt gctcctacac atcggaatca ttgacattct
     1261 gcagtcctac aggttcatca agaagttaga acacacctgg aaggccctcg tccacgatgg
     1321 ggataccgtc tcagtccacc ggcccagctt ctatgccgag cgcttcttca agttcatgag
     1381 cagcacggtc ttccggaaga gttcctccct caagtcctct ccatctaaga aagggcgtgg
     1441 cgccctgctc gcagtcaagc ccctggggcc caccgcagcc ttctcagcta gccagatccc
     1501 cagtgagaga gaggatgtgc agtacgacct gcggggggcc cgcagctacc ccacgctgga
     1561 ggatgaaggc cggcctgacc tcctgccctg caccccaccg tcctttgagg aagccaccac
     1621 agcctctatc gccaccaccc tgtcatccac ctccctctcc atcccagagc ggtccccttc
     1681 agacacatca gagcagcccc ggtacaggcg gcgtacgcag tcttcaggcc aggatggccg
     1741 gccccaggag gagctgcatg cggaagacct gcagaagata actgtgcagg tggagccagt
     1801 gtgtggtgtg ggggttgtcg tccccaagga gcagggtgca ggagtggagg ttcccccatc
     1861 tggggcatcg gcagcagcca cggtggaagt agacgctgcc agccaggcct cagagcccgc
     1921 cagccaagcc tctgatgagg aagatgcgcc ttccacagac atctattttt tcgcccacgg
     1981 gagatactgg cttttctctc cccgtcgtcg ccgactgcgg gccgtgacac caagccacac
     2041 aggcgctccc accgacgaga ggagctgggt gtactccccg cttcactata gcgcacggcc
     2101 cgcctccgac ggcgagagcg acacataact tctatgcagt ccccaatctg gagcccagcg
     2161 tccttctgcc accccagcca cttcctggag gcgctgcccc ccactggggc tcagagctca
     2221 gcgacatcac cccgatggcc ctggcccgac cttgttctct ccctccccac tgacggacgc
     2281 cattggccag gcccagcccc aggataggtc aggcctccat ctgctgctac ctgtgcctgt
     2341 tggggcggca agatttggag tgcacattct gtatttattt tgggtccacc cctccccccc
     2401 ctttttttgg acggagaggg agcacaggag tgtttttcta ggaaaaagac aagacacaaa
     2461 aaacccagga agaggctgca gccaccagcc ttggtggatc aggttctatg tgtctcagta
     2521 ccctggggac agtggccagg tagctccagt aaaccccaca cactccagag ctcgttatga
     2581 ctggcagagg agacaggccc tggagccgcg gcttgccgtc ccgggtctgt gttcctgagt
     2641 tgggtcgcct caacagagcc cctccttcac ctcaggtttg ggacccaagc aaaccaggac
     2701 tagtcatgcc ctgtggtctt tctgcatctg tttactgcca ctggaaggat gtccctacgc
     2761 atgtcttgtg gctacaatca cctgatgctg actgggaggt tccatattgt ctgcctctca
     2821 tccccatgaa accctgagct ggtgctgtgg gtcccctcaa ctcccaggga aatctctgcc
     2881 cccaagaagg gcacagccag gcttcaggct gcagagtgag agtttggtcc ttaccttggt
     2941 tgaagagagt aagaaaggga catcacctca gcaaagccaa ccatatctac tgaccaccag
     3001 ggagatcgca gcaagcattc tccgctgggc agaccccagt gtgttgggtg cagtccagct
     3061 atgctatgcc tctgtttcgt ggatgttcca cccacggtag gcggagtcaa gcaggaatgt
     3121 tctgaaagca cgcagccaca ggacacaacc tttgggtcag cttcatgggc ctcttgggtt
     3181 gcaccttcag ggacaggggc tatctggctt ccaaggactg tagcagcctg tggaggcagt
     3241 gtggagcatg acactgccat cgtggccaga aaaggcatgg ccagggagag gacccctgga
     3301 gggggagagt aggagagatg ggcagatgcc tgtccctgga cctcacatca gcccccttcc
     3361 tgttgaggaa tgcacagtga acacaccgtg gggagctgct gcatgagtta actaaggggt
     3421 tggggcttgc acacaccagg caagcatgtc acacctgcca tccctgaact tggaaagtta
     3481 aggcaggagg gttgtggcaa gttccaggct cgcgtgggtt agagtaaaac gagaccaaaa
     3541 ggaaaaaaaa aatcacaggg ctggccctac cactcagtgg gcagaactca cccagctgca
     3601 taaaccctga gttccattcc agcaccacag aaaccagatt gggaggcaca cagctgccat
     3661 ccctcgcttg ggaaacaggc agaaagagca ggagtgcaag gccatccttg gctgtatcca
     3721 gttgaaggcc agcctgggct acatgagact ctctcaaaag agaatctgta aatatcttcg
     3781 tgaccccacc tcccatcctg ttctctatga tggccgctat cgccccaccg tggacggtgt
     3841 gtgaactgta ctgtaaaggc ctgcctgggg gcgcctccaa ggctgaagag gtgccctccc
     3901 cggcccgcct ctgttctcct caagccatcc cagcaagtcc cctgtccagc cccacaccaa
     3961 cctcagtgca atatgccctt cccgtggggt cccctggcac ggtactgtct ctgcagcccc
     4021 ttgtctctta cccctagctc ctctctccca gtggttaaaa atcacatcgc acatcctccc
     4081 ccacatcctg tttttattgt tgaatccatt ctgtaaacta caaacctcct gtgtcttact
     4141 catcaggaat agggatcccg ggtcctcagc ccatgtgatc tggtgtttga caatccaagt
     4201 acagtgtccc cttggcacca accagtgggg cctgtccctc cagcgcagcc ggcaaatgta
     4261 tgcagcccag gttcccgctc cacctgtcac acccctcttt ttgagatctg taataaatct
     4321 ctaataagaa acaaaaaaaa aaa
//
