LOCUS       NM_001012743            2915 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 5-kinase type 1
            beta (Pip5k1b), mRNA.
ACCESSION   NM_001012743 XM_219913
VERSION     NM_001012743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Liu,T. and Lee,S.Y.
  TITLE     Phosphatidylinositol 4-phosphate 5-kinase alpha negatively
            regulates nerve growth factor-induced neurite outgrowth in PC12
            cells
  JOURNAL   Exp Mol Med 45 (3), e16 (2013)
   PUBMED   23538529
  REMARK    GeneRIF: PIP5Kalpha acts as a negative regulator of nerve growth
            factor-induced neurite outgrowth by inhibiting PI3K/Akt signaling
            pathway in PC12 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Lee,S.Y., Kim,B., Yoon,S., Kim,Y.J., Liu,T., Woo,J.H., Chwae,Y.J.,
            Joe,E.H. and Jou,I.
  TITLE     Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in
            ganglioside-stimulated brain astrocytes and contributes to
            inflammatory responses
  JOURNAL   Exp Mol Med 42 (9), 662-673 (2010)
   PUBMED   20720456
  REMARK    GeneRIF: Ganglioside treatment of primary astrocytes enhances
            PIP5Kalpha expression. PIP5Kalpha knockdown attenuates
            ganglioside-induced inflammatory responses.
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Volpicelli-Daley,L.A., Lucast,L., Gong,L.W., Liu,L., Sasaki,J.,
            Sasaki,T., Abrams,C.S., Kanaho,Y. and De Camilli,P.
  TITLE     Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol
            4,5-bisphosphate synthesis in the brain
  JOURNAL   J Biol Chem 285 (37), 28708-28714 (2010)
   PUBMED   20622009
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Manes,S., Fuentes,G., Peregil,R.M., Rojas,A.M. and Lacalle,R.A.
  TITLE     An isoform-specific PDZ-binding motif targets type I PIP5 kinase
            beta to the uropod and controls polarization of neutrophil-like
            HL60 cells
  JOURNAL   FASEB J 24 (9), 3381-3392 (2010)
   PUBMED   20442317
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Vasudevan,L., Jeromin,A., Volpicelli-Daley,L., De Camilli,P.,
            Holowka,D. and Baird,B.
  TITLE     The beta- and gamma-isoforms of type I PIP5K regulate distinct
            stages of Ca2+ signaling in mast cells
  JOURNAL   J Cell Sci 122 (Pt 14), 2567-2574 (2009)
   PUBMED   19549683
  REMARK    GeneRIF: The beta- and gamma-isoforms of type I PIP5K regulate
            distinct stages of Ca2+ signaling in mast cells.
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Ishihara,H., Shibasaki,Y., Kizuki,N., Katagiri,H., Yazaki,Y.,
            Asano,T. and Oka,Y.
  TITLE     Cloning of cDNAs encoding two isoforms of 68-kDa type I
            phosphatidylinositol-4-phosphate 5-kinase
  JOURNAL   J Biol Chem 271 (39), 23611-23614 (1996)
   PUBMED   8798574
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090349.1.
            
            On Apr 20, 2005 this sequence version replaced XM_219913.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090349.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..2915
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /note="phosphatidylinositol-4-phosphate 5-kinase type 1
                     beta"
                     /db_xref="GeneID:309419"
                     /db_xref="RGD:1310914"
     exon            1..440
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            441..527
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..2147
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /EC_number="2.7.1.68"
                     /note="PIP5KIbeta; PIP5KIalpha; ptdIns(4)P-5-kinase beta;
                     PIP5K1-beta; ptdIns(4)P-5-kinase 1 beta;
                     phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha;
                     phosphatidylinositol 4-phosphate 5-kinase type I beta;
                     phosphatidylinositol 4-phosphate 5-kinase type I alpha"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     beta"
                     /protein_id="NP_001012761.1"
                     /db_xref="GeneID:309419"
                     /db_xref="RGD:1310914"
                     /translation="MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNL
                     TSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKP
                     DDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLN
                     QNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKER
                     EKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHIL
                     DHSLKDKEEEPLQNAPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPA
                     KSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMN
                     SRVFKKIQALKASPSKKRCNSIAALKATSQEILSSISQEWKDEKQDLLTEGQSFSSLD
                     EEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSS
                     TFTLEEGTIYLTAEPNALETQDDASVLDVYL"
     exon            528..596
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            597..727
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            728..845
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            846..998
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1298
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1510
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1594
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1643
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1728
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1884
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2029
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2144
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2888
                     /gene="Pip5k1b"
                     /gene_synonym="Pip5k1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgtgcag cctgctcgct gcccgccccg ctcggactcc ggcacgccgt gcgggggccc
       61 gaggctgcgg ggtgccacca ctcctcggcc tccatcccgg atctcgcctc gccgcgctgc
      121 cgggggctgc ctggtcctag tggtccgctt gccgttctgc cggccagagg agcggcggga
      181 aggggaacgc ggggacacgc acaccggccg cggcgcgcgc gcattgcaca ctcgcagccg
      241 cgcgtccccg tcaccgcgcg tccgagccca gtgtggcccc gcggcagagc ccggcacctg
      301 cccgcccccc ttccccggcc gctgccccag ctccgccccg cctgcagcag ccacccggga
      361 acccacgaca tcccgacaac ttgcccgcgg tggcgcaact ggtctcggcc gccaaggctc
      421 cagcacgccg gccggaggag caacctgggg gcacaaaagc agtgtcaacg atgagcaggc
      481 cacccgtcac caccaactac agatgacttg ccactttact tacaaagatg tcgtcaactg
      541 ctgaaaatgg agacgccgta cctggaaaac aaaacgaaga aaaaacctac aaaaagactg
      601 catcatcagc tattaaaggt gccattcagc tgggaatagg atacacagtg ggtaatctca
      661 cttccaagcc agaacgcgat gtcctcatgc aagactttta tgtggtggaa agtgtattcc
      721 tccccagtga agggagcaat ctgaccccag cacatcacta cccagacttc aggtttaaga
      781 catacgcccc gctggctttc cgctacttcc gagaactctt tggtatcaag cccgacgatt
      841 acttgtactc catctgcagt gaaccgctga tagaactgtc caatcctgga gccagtggat
      901 ccttgttttt cttgaccagc gatgatgaat ttattatcaa aactgttcag cataaggaag
      961 ccgagttcct gcagaagctg ctgccaggct attacatgaa tctaaaccag aatccaagga
     1021 ctctcctgcc gaaattctat ggtctgtatt gcatgcagtc aggaggcatc aacatccgca
     1081 tcgtggtgat gaacaacgtg ctgccgcgtg ccatgaggat gcacttgacc tatgacctga
     1141 aaggctccac gtacaaacga agggcgtccc gaaaagagag ggagaaaccc aaccccacgt
     1201 ttaaggacct ggacttcctg caggacatgc atgaggggct gtatttcgat acagaaacat
     1261 acaatgccct tatgaagaca ctacagagag actgccgggt gctggaaagc ttcaagatca
     1321 tggactacag ccttttgctg ggtatccaca tcttggacca ttccctcaaa gacaaagaag
     1381 aggagcccct ccaaaatgca cccgacgcaa agcggccggg gatgcagaaa gtcctctact
     1441 ccacagccat ggagtccatc cagggtccag gcaagtccgc agatgggatc attgcagaga
     1501 acccagacac aatgggaggc attccagcta aaagccataa gggagaaaag ctgcttctat
     1561 tcatgggcat tattgatatt ctccaatcat ataggttaat gaagaagtta gaacactcct
     1621 ggaaagctct tgtgtatgat ggggacaccg tttcagttca tagaccaagt ttttatgcag
     1681 atagattttt aaagtttatg aattccagag ttttcaagaa aattcaagct ctgaaggcct
     1741 caccttctaa gaaacggtgc aactccatcg ctgcactgaa ggcaacctcc caggagattc
     1801 tgtcctccat cagccaagaa tggaaggatg agaagcagga tctgttaacc gaagggcaga
     1861 gtttcagcag cctggatgaa gaagccctgg gatcccgaca caggcctgac ctggtgccca
     1921 gcacgccgtc attatttgaa gctgcttcct tagcaaccac aatatcatct tcttccttat
     1981 atgtcggtga gcactatcca cacgacagga ctacgcttta ctcaaacagc aaagggttac
     2041 cttccagttc aaccttcacc ttggaagagg ggaccatcta cctgactgct gagccaaacg
     2101 ccctggaaac gcaggatgac gcctccgtgc tggatgtcta tttataagtg aaagtggtaa
     2161 ccacctgagc acaggaatgg gacctgaaca caactatggg agagaacttc ccccactgca
     2221 gaattcttca gaagagctgg gccgaacccc agcacacata gtgagaatca gcaggacctt
     2281 gaagcttgcg agatgtcggg gagcctgggt ccatggcccg tcagcagatg gatgtgaaaa
     2341 gcccacaccg ttctgtgggt gctgttgctt gctgactgtg aagaactgca tgaactctgt
     2401 ctaagctgct tttctctacc attgctgatc acccccttgg actgggaagt gctgtttccc
     2461 cataggctct ctcggtgttt cattctgcat gcatagagta attacaaata agcaacctat
     2521 ggaacctgct tctatatttt ttaaaaatcc atccatgcca aatgatgaat aagatataaa
     2581 tcctctctct ttgtttcaga gattcgaatc ataacaagct tcgatctgtt ttcctttcaa
     2641 gatcagtata ataggtctgc ctttccttta tagaaagcta gcttctataa agattttttt
     2701 cactgtttac tagtgaagtg agaaaagcaa agctgtttat aaaaggcctt atgtcttgta
     2761 tatacattgt ctttgaaaat atttgtgatt tagtttattg ctcgtaaaag agaaattata
     2821 taatttattt agtaaatacg actgtaaact atagttttat tgaaagaaat aaaatatttt
     2881 gttctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
