LOCUS       NM_001042621            3474 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 5-kinase, type
            1, alpha (Pip5k1a), mRNA.
ACCESSION   NM_001042621
VERSION     NM_001042621.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3474)
  AUTHORS   Wu,P.F., Bhore,N., Lee,Y.L., Chou,J.Y., Chen,Y.W., Wu,P.Y.,
            Hsu,W.M., Lee,H., Huang,Y.S., Lu,P.J. and Liao,Y.F.
  TITLE     Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates
            Abeta production by promoting non-amyloidogenic processing of
            amyloid precursor protein
  JOURNAL   FASEB J 34 (9), 12127-12146 (2020)
   PUBMED   32686865
  REMARK    GeneRIF: Phosphatidylinositol-4-phosphate 5-kinase type 1alpha
            attenuates Abeta production by promoting non-amyloidogenic
            processing of amyloid precursor protein.
REFERENCE   2  (bases 1 to 3474)
  AUTHORS   Liu,T., Yu,B., Kakino,M., Fujimoto,H., Ando,Y., Hakuno,F. and
            Takahashi,S.I.
  TITLE     A novel IRS-1-associated protein, DGKzeta regulates GLUT4
            translocation in 3T3-L1 adipocytes
  JOURNAL   Sci Rep 6, 35438 (2016)
   PUBMED   27739494
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3474)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   4  (bases 1 to 3474)
  AUTHORS   Volpicelli-Daley,L.A., Lucast,L., Gong,L.W., Liu,L., Sasaki,J.,
            Sasaki,T., Abrams,C.S., Kanaho,Y. and De Camilli,P.
  TITLE     Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol
            4,5-bisphosphate synthesis in the brain
  JOURNAL   J Biol Chem 285 (37), 28708-28714 (2010)
   PUBMED   20622009
REFERENCE   5  (bases 1 to 3474)
  AUTHORS   Chao,W.T., Daquinag,A.C., Ashcroft,F. and Kunz,J.
  TITLE     Type I PIPK-alpha regulates directed cell migration by modulating
            Rac1 plasma membrane targeting and activation
  JOURNAL   J Cell Biol 190 (2), 247-262 (2010)
   PUBMED   20660631
  REMARK    Erratum:[J Cell Biol. 2010 Aug 9;190(3):479]
REFERENCE   6  (bases 1 to 3474)
  AUTHORS   Gonzales,M.L., Mellman,D.L. and Anderson,R.A.
  TITLE     CKIalpha is associated with and phosphorylates star-PAP and is also
            required for expression of select star-PAP target messenger RNAs
  JOURNAL   J Biol Chem 283 (18), 12665-12673 (2008)
   PUBMED   18305108
REFERENCE   7  (bases 1 to 3474)
  AUTHORS   Mellman,D.L., Gonzales,M.L., Song,C., Barlow,C.A., Wang,P.,
            Kendziorski,C. and Anderson,R.A.
  TITLE     A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls
            expression of select mRNAs
  JOURNAL   Nature 451 (7181), 1013-1017 (2008)
   PUBMED   18288197
REFERENCE   8  (bases 1 to 3474)
  AUTHORS   Kisseleva,M., Feng,Y., Ward,M., Song,C., Anderson,R.A. and
            Longmore,G.D.
  TITLE     The LIM protein Ajuba regulates phosphatidylinositol
            4,5-bisphosphate levels in migrating cells through an interaction
            with and activation of PIPKI alpha
  JOURNAL   Mol Cell Biol 25 (10), 3956-3966 (2005)
   PUBMED   15870270
REFERENCE   9  (bases 1 to 3474)
  AUTHORS   Luo,B., Prescott,S.M. and Topham,M.K.
  TITLE     Diacylglycerol kinase zeta regulates phosphatidylinositol
            4-phosphate 5-kinase Ialpha by a novel mechanism
  JOURNAL   Cell Signal 16 (8), 891-897 (2004)
   PUBMED   15157668
REFERENCE   10 (bases 1 to 3474)
  AUTHORS   Ishihara,H., Shibasaki,Y., Kizuki,N., Katagiri,H., Yazaki,Y.,
            Asano,T. and Oka,Y.
  TITLE     Cloning of cDNAs encoding two isoforms of 68-kDa type I
            phosphatidylinositol-4-phosphate 5-kinase
  JOURNAL   J Biol Chem 271 (39), 23611-23614 (1996)
   PUBMED   8798574
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001042621.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               JAXUCZ010000002.1  185360073-185360476 c
            405-436             JAXUCZ010000002.1  185339469-185339500 c
            437-517             JAXUCZ010000002.1  185335973-185336053 c
            518-648             JAXUCZ010000002.1  185332982-185333112 c
            649-766             JAXUCZ010000002.1  185331741-185331858 c
            767-919             JAXUCZ010000002.1  185331152-185331304 c
            920-1219            JAXUCZ010000002.1  185329784-185330083 c
            1220-1425           JAXUCZ010000002.1  185326927-185327132 c
            1426-1509           JAXUCZ010000002.1  185325993-185326076 c
            1510-1558           JAXUCZ010000002.1  185324510-185324558 c
            1559-1643           JAXUCZ010000002.1  185324142-185324226 c
            1644-1790           JAXUCZ010000002.1  185323056-185323202 c
            1791-1920           JAXUCZ010000002.1  185322277-185322406 c
            1921-1966           JAXUCZ010000002.1  185319221-185319266 c
            1967-3474           JAXUCZ010000002.1  185317319-185318826 c
FEATURES             Location/Qualifiers
     source          1..3474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3474
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /note="phosphatidylinositol-4-phosphate 5-kinase, type 1,
                     alpha"
                     /db_xref="GeneID:365865"
                     /db_xref="RGD:1306127"
     exon            1..404
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1969
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /EC_number="2.7.1.68"
                     /note="phosphatidylinositol-4-phosphate 5-kinase, type 1
                     beta; PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1
                     alpha; phosphatidylinositol 4-phosphate 5-kinase type I
                     alpha; 68 kDa type I phosphatidylinositol 4-phosphate
                     5-kinase"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     alpha"
                     /protein_id="NP_001036086.2"
                     /db_xref="GeneID:365865"
                     /db_xref="RGD:1306127"
                     /translation="MASASSGPAAAGFSPLDSGVPAGTAASGIKRGTVSEGPYASLMP
                     VKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVES
                     IFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELSNS
                     GASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQA
                     GGKNIRIVVMNNLLPRSVKMHMKYDLKGSTYKRRASQKEREKTLPTFKDLDFLQDIPD
                     GLFLDADMYSALCKTLQRDCLVLQSFKIMDYSLLMSIHNMDHAQREPMNSETQYSIDT
                     RRPAPQKALYSTAMESIQGEARRGGTVETEDHMGGIPARNNKGERLLLYIGIIDILQS
                     YRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPTKKFRSG
                     PSFSRRSGPSGNSCTPSQPTASGEHKAQVTTKAEVEPDIHLGRPDVLPQTPPLEEISE
                     GSPVPGPSFSPAVGQPLQILNLSSTLEKLDVAESELTH"
     exon            405..436
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            437..517
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            518..648
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            649..766
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            767..919
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1219
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1425
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1509
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1558
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1643
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1790
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1920
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1966
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..3474
                     /gene="Pip5k1a"
                     /gene_synonym="Pip5k1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggacctc aggtgcctgg gtttttcttt aggtttgttc tatccgagac gcgggacccc
       61 cggggcccgg cttgagtgtt cctgtctagt gagagaaggt agcttttgcg gagagcagtt
      121 caagttgcta ggaaggtgcc agactggatc tctcccccat gccgggcaag tggtgcggtc
      181 ctgagcttgt cctggagcct gaacaacgcc tgtgagaagc ccgccgaacg cgggttctgt
      241 gaagagacgt ggggaagatt cgattccgag aaaaggaaaa gtcggattga aagggagtga
      301 agccgctgag ggggaggggg ctgccaagat ggcgtccgcc tcctcagggc cagcggcggc
      361 ggggttttca ccccttgatt ccggggtccc tgccggtacc gcagcatctg gaatcaagag
      421 aggcacagta tctgagggac cttatgcctc tctcatgcct gtcaagaaaa taggccatcg
      481 aagtgttgat tcctctggag agactacata caaaaagaca acttcatcag ccttgaaagg
      541 tgccatccag ttaggtatca ctcacactgt gggcagcctt agcaccaaac cagagcggga
      601 cgtcctcatg caagacttct acgtggtgga gagcatcttc ttccccagtg aaggcagcaa
      661 cctgacaccg gctcaccatt acaatgactt tcggttcaag acctatgcac ctgtcgcctt
      721 ccgttacttc agagagctat ttggcatccg gcctgacgat tacttgtact ccctttgcag
      781 tgagccattg attgaactct ccaattctgg agctagcggt tccctcttct acgtgtccag
      841 tgatgatgaa ttcatcatta agaccgtcca gcataaagag gcagaatttc tgcaaaaatt
      901 gcttccagga tactacatga atcttaacca aaaccctcgt actttgctgc ccaaatttta
      961 tggactgtac tgtgtgcaag caggcggcaa gaacatacga attgtggtga tgaacaatct
     1021 cttgcctcgg tcagtcaaaa tgcatatgaa atatgatctc aagggttcaa cttacaagcg
     1081 gcgggcttct cagaaagaac gagagaagac tctccccacc tttaaagacc tggacttcct
     1141 acaagatatc cccgatggcc tttttttaga tgctgacatg tacagtgctc tatgtaagac
     1201 tctgcagcgt gactgtctgg tgctgcagag cttcaagatt atggactata gcctgttgat
     1261 gtccatccac aacatggatc atgcccagcg agagcccatg aacagcgaaa cacaatactc
     1321 aattgacact cgcagaccag ccccgcagaa ggctctctat tccacagcta tggagtccat
     1381 ccagggcgag gctcgccggg gcggcactgt ggagactgag gaccacatgg gtggcatccc
     1441 tgccagaaac aacaaagggg aaaggctcct gctttacatt ggcatcattg atattctgca
     1501 gtcctacagg tttgttaaga agttggagca ctcttggaaa gccctggtcc atgatgggga
     1561 cacggtgtca gtacatcgtc caggcttcta tgctgaacgg ttccagcgct tcatgtgcaa
     1621 cacagtgttc aagaagattc ccttgaagcc ttctcctacc aaaaagtttc ggtctggccc
     1681 atctttctct cggcgatcag gccccagcgg caactcctgc actccttccc agccgacagc
     1741 ctctggggaa cacaaagcac aagtgactac gaaggcggaa gtggagccag atatacacct
     1801 tgggcgtcct gatgtcttac ctcagactcc accgttggag gagataagtg agggttcacc
     1861 tgttcctggt cccagtttct cacctgcagt tggacaacct ttgcaaatac taaatttgag
     1921 ttcaaccttg gaaaagcttg atgttgcaga gtcagaactc acccattgag cagcgagcct
     1981 tggaagacct gagacaagac tccgctatgg ctttgatccc aagatggcag cccttgcccc
     2041 aggaatgctg agtcgtcttc tcggtcatca acagaggaga gaatgtggag ctagcagggc
     2101 tctgtctctg tctccccttc ctctgggcag tagtgccttt gacagttgag gacaacatcg
     2161 tccccaccac tccagagtgg gtggcatgaa ttttccactg cctgccatgg cttctatagc
     2221 tgactatttt caaaccccca ttctttgtgc tggacgcggg gttgctggcc taggtggttt
     2281 cctcctcttt acctttcacc tggagctgga ctcttaatct cctcaggaca gactggctgg
     2341 acattgctcc taccttcgat cctcccgctg gtctttgaga ctcccaatga ttttatgaag
     2401 gtgtttggga ggagagtgag gacggtcctt actcccaggc tagttttttc cttaaaaaag
     2461 gaaagaaaca caaagagcac acagtgtaag tttgagccag tctcagataa acgttcttgt
     2521 atagaagagc ccgagtgttc gtgaagtaga aaggctgggg ctgccccgcc agcagctgct
     2581 ctctgtctcc ctcacttagg gctgagggag tagacagggg cgtggctaca cgtacccttt
     2641 tttaaagaca gtggggcagc catgttagga gagtggacct tagcaggacc ctactcactg
     2701 ccaggtcata cagttactac ttactattct gcgatttgga atgtatccta atagtttttc
     2761 taaatataaa gaattatcaa atgattttag accattctcc aaaggagatt tctttgttct
     2821 tcctatattt tccaacagta ttctgctctt tgtggagcta cggtggaggg agatgtttgt
     2881 gtctgtttaa caggcagtcc gtatctatga ggctagagaa tattttctta aactcctggg
     2941 gagccacaga cttccttctg taaggttgtc gccatgccac ctggcctgcc ccttcctctg
     3001 tagagaagct ggaaacaggg ccacggagcc ctctccttcc tctcagttac ggcccatctg
     3061 gtcctacggt ggggcagtgc atggtgtttg aggccagctg tggaaatccc acattagctc
     3121 cttctccatc ccgtctcacc ctgacagcag gttagccagc cccacgtaac tgtctatatt
     3181 agacgcccca gccggcttcc ggctgcctgt ctttgctgcc atgttctttt ttacaagaag
     3241 gaaagaaaca gtttcttgct attttttttc ataatttact atttatgatg tatttaagtg
     3301 ttttattcag gacagagttc tgtaaggggt gggagggagt atttgaggga gggctgggga
     3361 cttagagagg acatgggatt cagcattttt atggagtgtt actatttgcc tctactttgt
     3421 attgttgaga aatgacaaat gcagtataaa taataaatat ctggttttac tgta
//
