LOCUS       NM_080480               3194 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-5-phosphate 4-kinase type 2
            gamma (Pip4k2c), mRNA.
ACCESSION   NM_080480
VERSION     NM_080480.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3194)
  AUTHORS   Clarke,J.H., Giudici,M.L., Burke,J.E., Williams,R.L., Maloney,D.J.,
            Marugan,J. and Irvine,R.F.
  TITLE     The function of phosphatidylinositol 5-phosphate 4-kinase gamma
            (PI5P4Kgamma) explored using a specific inhibitor that targets the
            PI5P-binding site
  JOURNAL   Biochem J 466 (2), 359-367 (2015)
   PUBMED   25495341
REFERENCE   2  (bases 1 to 3194)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   3  (bases 1 to 3194)
  AUTHORS   Clarke,J.H. and Irvine,R.F.
  TITLE     Evolutionarily conserved structural changes in phosphatidylinositol
            5-phosphate 4-kinase (PI5P4K) isoforms are responsible for
            differences in enzyme activity and localization
  JOURNAL   Biochem J 454 (1), 49-57 (2013)
   PUBMED   23758345
REFERENCE   4  (bases 1 to 3194)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 3194)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 3194)
  AUTHORS   Gao,J., Li,W.X., Feng,S.Q., Yuan,Y.S., Wan,D.F., Han,W. and Yu,Y.
  TITLE     A protein-protein interaction network of transcription factors
            acting during liver cell proliferation
  JOURNAL   Genomics 91 (4), 347-355 (2008)
   PUBMED   18255255
REFERENCE   7  (bases 1 to 3194)
  AUTHORS   Itoh,T., Ijuin,T. and Takenawa,T.
  TITLE     A novel phosphatidylinositol-5-phosphate 4-kinase
            (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated
            in the endoplasmic reticulum in response to mitogenic signals
  JOURNAL   J Biol Chem 273 (32), 20292-20299 (1998)
   PUBMED   9685379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF030558.1, CO400462.1, DN934555.1, CV115612.1, BF556960.1 and
            BI275922.1.
            
            On Oct 23, 2007 this sequence version replaced NM_080480.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030558.1, SRR8487231.65072.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1163              AF030558.1         1-1163
            1164-1419           CO400462.1         432-687
            1420-1875           DN934555.1         227-682
            1876-2460           CV115612.1         170-754
            2461-2524           BF556960.1         373-436
            2525-3194           BI275922.1         1-670               c
FEATURES             Location/Qualifiers
     source          1..3194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3194
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /note="phosphatidylinositol-5-phosphate 4-kinase type 2
                     gamma"
                     /db_xref="GeneID:140607"
                     /db_xref="RGD:621711"
     exon            1..249
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1341
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /EC_number="2.7.1.149"
                     /note="PIP4KII-gamma; PI(5)P 4-kinase type II gamma;
                     phosphatidylinositol-4-phosphate 5-kinase, type II, gamma;
                     phosphatidylinositol 5-phosphate 4-kinase type II gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     gamma"
                     /protein_id="NP_536728.2"
                     /db_xref="GeneID:140607"
                     /db_xref="RGD:621711"
                     /translation="MASSSVPPATAPAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAA
                     DPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKE
                     YCPQVFRNLRDRFAIDDHDYLVSLTRSPPSETEGSDGRFLISYDRTLVIKEVSSEDIA
                     DMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYD
                     LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQL
                     KIMDYSLLLGIHDIIRGSEPEEEGPVREEESEWDGDCNLTGPPALVGSYGTSPEGIGG
                     YIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTV
                     KHGAGAEISTVHPEQYAKRFLDFISNIFA"
     exon            250..347
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            348..444
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            445..588
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            589..735
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            736..774
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            775..888
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1156
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1260
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..3179
                     /gene="Pip4k2c"
                     /gene_synonym="Pip5k2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagcaccgc ttccgggtcg ggcttcggag tcgcggccgg ctcccgcttc cactcgcttg
       61 ggtgcgcggg agattatggc gtcttcctcc gtccctcccg ccaccgcacc cgcggcagct
      121 ggaggccccg gcccgggatt cggcttcgcc tccaaaacca agaagaagca tttcgtgcag
      181 cagaaagtga aggtgttccg ggccgccgac ccactggtgg gcgtgttcct gtggggcgtc
      241 gcccactcga tcaacgagct cagtcaggtg ccacccccag tgatgctgct gccagacgac
      301 tttaaagcca gctccaagat caaggtcaac aatcaccttt tccatagaga aaatcttccc
      361 agtcatttca agttcaagga gtattgtccc caggtcttca ggaacctgcg agatcggttt
      421 gccattgatg atcatgatta cttggtgtcc cttactcgaa gccccccaag cgaaaccgaa
      481 ggcagtgatg gccgcttcct tatctcctat gaccgcactc tggtcatcaa agaagtatcc
      541 agtgaggaca tcgcggacat gcacagcaac ctctccaatt accaccagta catagtgaag
      601 tgtcacggca acacccttct gccccagttc ctgggcatgt accgggtcag tgtagaaaat
      661 gaagatagct atatgctcgt gatgcgcaat atgtttagtc accgtcttcc tgtgcatagg
      721 aagtatgacc tcaagggctc tctggtatcc cgggaagcca gcgataagga aaaggttaaa
      781 gaactgccaa cactgaagga tatggacttt cttaacaaaa accagaaagt gtatattggt
      841 gaagaagaga agaaagtgtt cctggaaaag ctgaagcgag atgtggagtt tctagtgcag
      901 ctgaagatca tggactacag ccttctactg ggcatccacg acatcattcg gggctctgaa
      961 ccggaggaag aggggcctgt gagggaggag gagtcagagt gggatgggga ctgtaacctg
     1021 actggacctc ctgctctggt aggctcctat ggcacctccc ctgagggcat tggaggctac
     1081 attcattccc accggcccct gggcccagga gagtttgagt ccttcatcga tgtctatgct
     1141 atccggagtg ctgagggggc cccccagaag gaggtgtatt tcatgggcct cattgacatt
     1201 ctaacacagt atgatgccaa gaagaaagca gctcatgcag ccaaaaccgt caagcatggg
     1261 gcaggggcgg agatctccac tgtccatcct gagcagtacg ctaagcgatt cctggatttt
     1321 atttccaaca tctttgccta agtggccgcc tgaccggggt gatcgctgct ttatgttgga
     1381 ggtggcaggt tctgagaggc ttaggggagc tggatttggc cattacttct ctttgctaaa
     1441 ttcaggctac aggctccttc catccaaata cctttgttct ggcggataat gttttcctgt
     1501 cccagaacta cactgtcctt tctcccctca tccatctctc tgccctccct ccttgctccc
     1561 agtaagcccg cctgcttcat tagagtgtta ttgtcaactc tcctaagtgc cttgatcttt
     1621 gaaaaatacc ttgtttctgt gaattaggag gagctggggg caggggctgt ttgccatctt
     1681 cagggcctga ctggacggtg gatatggcgc acgcaactgc cctggtgcac tttgcagtag
     1741 tatggaagga actaaatgtg tgggttctgc tgacaccttt ctggggcact ttgtggcatg
     1801 cattgcttcc ttcctggtaa gccctggaac ggagggcttt caggacactc cagtgtgggt
     1861 gcaggcattc acgtagggac agtctggcct ggaggtcagg ggaatgctca gcaggctggt
     1921 acctacctca caaggcagga cctaagtgga cttttgcgat tatgcagagg atggagaagg
     1981 tccttgtcaa gcattggctg ttcccattct ccttccccac cctactttca cctcttccca
     2041 tgagtcctgg gtgccagagc cttgaggcca gaggtgccca agcttaggtg cagggagagc
     2101 atagaggctg ggaggacagg tcggagtgca gggttcattc cctgtgtgac accctttctt
     2161 cccgtctact tactcccagg acttcattct agcagagggg aataatagct ctatctggtc
     2221 tgtctccata attttgagag gatagcgatc ttgagtatgg gaacctccct gtccccagga
     2281 cgtgtatgcc tagcacttgc tcctccttct ctccactatc cacccccaga gaggagtcag
     2341 agccataact cagtcaccca gtcccctcca aagatgtaca atatcctcag actagagagg
     2401 aactgctagg cctggtagct cctgcctgta aatccagcac tcaggaggct gagtcagaat
     2461 tactcaaggg agttcaaggc cagcctgggc tactgagacc tggtctcagg acaactcaaa
     2521 actaggcttg ggtttgagca ctggagacga tagcttagtc ggtagtgtgc ttgcctggca
     2581 tgtacaaagc tgggctccac cccagcgcca cataagccag gtgaaagcct tgggaaaaag
     2641 tggtaaggag gatcaggcat tcaaggtcac catcagttac ctggcagggt tgaggccagc
     2701 caaggataca tgagacttct tgaggaaaac aattctgaga tgagatagat tgtctttgtc
     2761 tctgcccaaa gcctttggaa gcaagacact catccttgct gttctgctcc cctgcggagc
     2821 tcagcgctct ggaggtgagg tgggcattga gggcaagaag ctactttgct gtgtgacctc
     2881 agggtcctca aggagaagcc cacctgtctt cctctacacc aaaggaggca gcaagaggtg
     2941 tgtccagttg gggtgagagg gtcccggtga gtcacttcaa tcccacaacc aacctttcca
     3001 tggttgaatg caataaagtg acaccagcag ctgttcttta gaactgggtt tctgaccatg
     3061 aggttatggt catgggcagt attaccacct tcacttattg cttctgttat ccatcatttt
     3121 tgttttgtta ataaaatatc tatttactcc caatatcaca ataaattatt tgatctaaaa
     3181 aaaaaaaaaa aaaa
//
