LOCUS       NM_053550               1983 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-5-phosphate 4-kinase type 2
            beta (Pip4k2b), mRNA.
ACCESSION   NM_053550
VERSION     NM_053550.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Clarke,J.H., Giudici,M.L., Burke,J.E., Williams,R.L., Maloney,D.J.,
            Marugan,J. and Irvine,R.F.
  TITLE     The function of phosphatidylinositol 5-phosphate 4-kinase gamma
            (PI5P4Kgamma) explored using a specific inhibitor that targets the
            PI5P-binding site
  JOURNAL   Biochem J 466 (2), 359-367 (2015)
   PUBMED   25495341
REFERENCE   2  (bases 1 to 1983)
  AUTHORS   Vicinanza,M., Korolchuk,V.I., Ashkenazi,A., Puri,C., Menzies,F.M.,
            Clarke,J.H. and Rubinsztein,D.C.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   3  (bases 1 to 1983)
  AUTHORS   Clarke,J.H. and Irvine,R.F.
  TITLE     Evolutionarily conserved structural changes in phosphatidylinositol
            5-phosphate 4-kinase (PI5P4K) isoforms are responsible for
            differences in enzyme activity and localization
  JOURNAL   Biochem J 454 (1), 49-57 (2013)
   PUBMED   23758345
REFERENCE   4  (bases 1 to 1983)
  AUTHORS   Rao,V.D., Misra,S., Boronenkov,I.V., Anderson,R.A. and Hurley,J.H.
  TITLE     Structure of type IIbeta phosphatidylinositol phosphate kinase: a
            protein kinase fold flattened for interfacial phosphorylation
  JOURNAL   Cell 94 (6), 829-839 (1998)
   PUBMED   9753329
REFERENCE   5  (bases 1 to 1983)
  AUTHORS   Itoh,T., Ijuin,T. and Takenawa,T.
  TITLE     A novel phosphatidylinositol-5-phosphate 4-kinase
            (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated
            in the endoplasmic reticulum in response to mitogenic signals
  JOURNAL   J Biol Chem 273 (32), 20292-20299 (1998)
   PUBMED   9685379
REFERENCE   6  (bases 1 to 1983)
  AUTHORS   Castellino,A.M., Parker,G.J., Boronenkov,I.V., Anderson,R.A. and
            Chao,M.V.
  TITLE     A novel interaction between the juxtamembrane region of the p55
            tumor necrosis factor receptor and phosphatidylinositol-4-phosphate
            5-kinase
  JOURNAL   J Biol Chem 272 (9), 5861-5870 (1997)
   PUBMED   9038203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053550.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033355.1, SRR26643429.38769.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000010.1  83231021-83231292   c
            273-370             JAXUCZ010000010.1  83219550-83219647   c
            371-467             JAXUCZ010000010.1  83216374-83216470   c
            468-620             JAXUCZ010000010.1  83213430-83213582   c
            621-767             JAXUCZ010000010.1  83211691-83211837   c
            768-806             JAXUCZ010000010.1  83210552-83210590   c
            807-920             JAXUCZ010000010.1  83210002-83210115   c
            921-1179            JAXUCZ010000010.1  83208012-83208270   c
            1180-1283           JAXUCZ010000010.1  83207538-83207641   c
            1284-1983           JAXUCZ010000010.1  83205478-83206177   c
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1983
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /note="phosphatidylinositol-5-phosphate 4-kinase type 2
                     beta"
                     /db_xref="GeneID:89812"
                     /db_xref="RGD:621710"
     exon            1..272
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1364
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /EC_number="2.7.1.149"
                     /note="1-phosphatidylinositol-5-phosphate 4-kinase B;
                     PIPKIIgamma; PIP4KII-beta; diphosphoinositide kinase
                     2-beta; phosphatidylinositol-phosphate kinase IIgamma;
                     PI(5)P 4-kinase type II beta;
                     phosphatidylinositol-4-phosphate 5-kinase, type II, beta;
                     1-phosphatidylinositol 5-phosphate 4-kinase 2-beta;
                     phosphatidylinositol 5-phosphate 4-kinase type II beta"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     beta"
                     /protein_id="NP_446002.1"
                     /db_xref="GeneID:89812"
                     /db_xref="RGD:621710"
                     /translation="MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILS
                     VLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMV
                     FRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEM
                     HNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLK
                     GSTVAREASDKEKAKDLPTFKDNDFLNEGQKLRVGEESKKNFLEKLKRDVEFLAQLKI
                     MDYSLLVGIHDVDRAEQEETEVEDRAEEEECENDGVGGGLLCSYGTPPDSPGNLLSFP
                     RFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAG
                     AEISTVNPEQYSKRFNEFMSNILT"
     exon            273..370
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            371..467
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            468..620
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            621..767
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            768..806
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            807..920
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1179
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1283
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1983
                     /gene="Pip4k2b"
                     /gene_synonym="Pip5k2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgtgag gcagcggggg tggggatcgg ttcgggggag gcctggggcc gctcgctggt
       61 gcgctgactc cgccgccccc cctttcgccg ccgccgccgc cgccgccccg ggcatgtcgt
      121 ccaactgcac cagcaccacg gcggtggcgg tggcgccgct cagcgccagc aaaaccaaga
      181 ccaagaagaa gcatttcgtg tgccagaaag tgaagctatt ccgggccagc gagccgattc
      241 tcagcgtcct gatgtggggg gtgaaccaca cgatcaatga gctgagcaat gtccccgtcc
      301 ctgtcatgct aatgccagat gacttcaaag cttacagcaa gatcaaggtg gacaatcatc
      361 tcttcaataa ggaaaacctc cccagccgct tcaagttcaa ggaatactgc cccatggtgt
      421 tccgaaacct cagggagagg tttggcatcg atgaccagga ttaccagaat tcagtgacac
      481 gcagtgcgcc catcaacagt gacagccagg gcaggtgcgg cacacgcttc ctcaccacct
      541 atgaccggcg ttttgtcatc aagactgtgt caagtgagga tgtggcagag atgcacaaca
      601 tcctaaagaa ataccaccag ttcatagtgg agtgtcacgg caataccctc ttgccacagt
      661 tcctgggcat gtaccgcctg accgtggacg gtgtggaaac ctacatggtg gtcaccagga
      721 atgtattcag tcatcggctt actgtacatc gcaaatatga cctcaagggt tccaccgttg
      781 ccagagaagc cagtgacaag gaaaaggcca aggacttgcc cacgttcaaa gacaatgact
      841 tcctcaatga agggcagaag ctacgtgtgg gagaagagag taaaaagaac ttcctagaaa
      901 aactgaagcg ggatgtggag ttcctggccc agctgaagat catggactac agcctcctgg
      961 tgggcatcca cgacgtagac cgggcagagc aggaggagac ggaggtggaa gaccgagcgg
     1021 aggaggagga gtgtgagaac gatggggtgg gcggtggcct gctctgctcc tacggcacgc
     1081 ctccagacag ccccggcaac ctcctgagct tcccccggtt ctttggccca ggagagttcg
     1141 acccctccgt cgacgtctat gccatgaaaa gccatgagag tgcccctaag aaggaggtct
     1201 atttcatggc catcattgac atccttacac cgtatgacgc taagaagaaa gctgcacatg
     1261 ccgccaagac agtgaaacat ggggcagggg ctgagatctc cactgtgaac ccggagcagt
     1321 actcaaaacg cttcaatgag ttcatgtcca acatcctgac gtagtcgtct ctaccttctg
     1381 ccagagccag actgctggac aaggggtcgg ggatcgggag agggaaaggg tgtatttggg
     1441 ctggaaggga gggcggggag cagagtcggg gctcatgagg gctttagtaa agggactgca
     1501 gcctgtgacc caaagcaact ctagaaagga agaaggagct ggctgttggc acacgtgctc
     1561 acagcgtggc agccttactt ccccagcacc ctggatgcgc cccttttgtc cctgggttaa
     1621 aacaaggttt cctctttggt atctttgtaa ccctttatga tccctagggg ctggagttga
     1681 ctttgtgggt tgatttgggt ttgtttctta aattcattgc tccaggatcg ctctttataa
     1741 cgctgtatgt catcacccca ggcaccctcc ctattctggt caggctctca gtgcccttca
     1801 attaaggcca gcacaaggga cgtgaacagc acttgctctg acaccatgag aggtcagaca
     1861 cctcagtcag cgacgtttta atctcccctc gatggacttt ttattttctg gagtattgtg
     1921 cataattccc tccatgtctc caccttggat ccaagtgaaa cattacattg gctccttcat
     1981 ccc
//
