LOCUS       NM_001083337            1362 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PIN2/TERF1 interacting, telomerase inhibitor 1
            (Pinx1), mRNA.
ACCESSION   NM_001083337 XM_001065542 XM_224282
VERSION     NM_001083337.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Li,S., Jiang,B., Yu,H. and Song,D.
  TITLE     Regulation of PINX1 expression ameliorates
            lipopolysaccharide-induced lung injury and alleviates cell
            senescence during the convalescent phase through affecting the
            telomerase activity
  JOURNAL   Aging (Albany NY) 13 (7), 10175-10186 (2021)
   PUBMED   33819185
  REMARK    GeneRIF: Regulation of PINX1 expression ameliorates
            lipopolysaccharide-induced lung injury and alleviates cell
            senescence during the convalescent phase through affecting the
            telomerase activity.
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Sriprapun,M., Chuaypen,N., Khlaiphuengsin,A., Pinjaroen,N.,
            Payungporn,S. and Tangkijvanich,P.
  TITLE     Association of PINX1 but not TEP1 Polymorphisms with Progression to
            Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B
            Virus Infection
  JOURNAL   Asian Pac J Cancer Prev 17 (4), 2019-2025 (2016)
   PUBMED   27221889
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   Yoo,J.E., Park,Y.N. and Oh,B.K.
  TITLE     PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting
            protein, maintains telomere integrity by modulating TRF1
            homeostasis, the process in which human telomerase reverse
            Transcriptase (hTERT) plays dual roles
  JOURNAL   J Biol Chem 289 (10), 6886-6898 (2014)
   PUBMED   24415760
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   Cheung,D.H., Kung,H.F., Huang,J.J. and Shaw,P.C.
  TITLE     PinX1 is involved in telomerase recruitment and regulates
            telomerase function by mediating its localization
  JOURNAL   FEBS Lett 586 (19), 3166-3171 (2012)
   PUBMED   22749911
REFERENCE   5  (bases 1 to 1362)
  AUTHORS   Soohoo,C.Y., Shi,R., Lee,T.H., Huang,P., Lu,K.P. and Zhou,X.Z.
  TITLE     Telomerase inhibitor PinX1 provides a link between TRF1 and
            telomerase to prevent telomere elongation
  JOURNAL   J Biol Chem 286 (5), 3894-3906 (2011)
   PUBMED   21119197
REFERENCE   6  (bases 1 to 1362)
  AUTHORS   Yoo,J.E., Oh,B.K. and Park,Y.N.
  TITLE     Human PinX1 mediates TRF1 accumulation in nucleolus and enhances
            TRF1 binding to telomeres
  JOURNAL   J Mol Biol 388 (5), 928-940 (2009)
   PUBMED   19265708
REFERENCE   7  (bases 1 to 1362)
  AUTHORS   Chen,Y., Yang,Y., van Overbeek,M., Donigian,J.R., Baciu,P., de
            Lange,T. and Lei,M.
  TITLE     A shared docking motif in TRF1 and TRF2 used for differential
            recruitment of telomeric proteins
  JOURNAL   Science 319 (5866), 1092-1096 (2008)
   PUBMED   18202258
REFERENCE   8  (bases 1 to 1362)
  AUTHORS   Oh,B.K., Yoon,S.M., Lee,C.H. and Park,Y.N.
  TITLE     Rat homolog of PinX1 is a nucleolar protein involved in the
            regulation of telomere length
  JOURNAL   Gene 400 (1-2), 35-43 (2007)
   PUBMED   17624691
REFERENCE   9  (bases 1 to 1362)
  AUTHORS   Banik,S.S. and Counter,C.M.
  TITLE     Characterization of interactions between PinX1 and human telomerase
            subunits hTERT and hTR
  JOURNAL   J Biol Chem 279 (50), 51745-51748 (2004)
   PUBMED   15381700
REFERENCE   10 (bases 1 to 1362)
  AUTHORS   Zhou,X.Z. and Lu,K.P.
  TITLE     The Pin2/TRF1-interacting protein PinX1 is a potent telomerase
            inhibitor
  JOURNAL   Cell 107 (3), 347-359 (2001)
   PUBMED   11701125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced NM_001083337.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158553.1, EF446165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000015.1  42273805-42273954
            151-260             JAXUCZ010000015.1  42277640-42277749
            261-353             JAXUCZ010000015.1  42279673-42279765
            354-432             JAXUCZ010000015.1  42281631-42281709
            433-525             JAXUCZ010000015.1  42285398-42285490
            526-602             JAXUCZ010000015.1  42291386-42291462
            603-1362            JAXUCZ010000015.1  42332288-42333047
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1362
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /note="PIN2/TERF1 interacting, telomerase inhibitor 1"
                     /db_xref="GeneID:305963"
                     /db_xref="RGD:1566025"
     exon            1..150
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1127
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /note="Pin2-interacting protein X1; PIN2-interacting
                     protein 1"
                     /codon_start=1
                     /product="PIN2/TERF1-interacting telomerase inhibitor 1"
                     /protein_id="NP_001076806.1"
                     /db_xref="GeneID:305963"
                     /db_xref="RGD:1566025"
                     /translation="MSMLAERRRKQKWAVDPRNTAWSNDDSKFGQKMLEKMGWSKGKG
                     LGAQEQGATEHIKVKVKNNHLGLGATNNNEDNWIAHQDDFNQLLAALNTCHGQETADS
                     SDNKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSETDLDCIFGKRRNKKLAQDGC
                     SNSTADEADTSLTTTTTTTSAFTIQEYFAKRMAQLKSKSQAAAPGSDLSETPIEWKKG
                     KKKTKEAAGTDIENSPQHKAKRHKKKKRVEAERGPAAKKRDQVELQPGGPSGDECSDA
                     SVEAAEDRVQTPDTQDDVPKPRKRRAKKTLQRPGGVAVDTAPDSAPVKKKKKVSR"
     exon            151..260
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
     exon            261..353
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
     exon            354..432
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
     exon            433..525
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
     exon            526..602
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
     exon            603..1362
                     /gene="Pinx1"
                     /gene_synonym="RGD1566025"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagtatgc gccccagtga aactcttgga cccggcgtgc tctgtgagcc ggcttcttcc
       61 ctaactgcac ttcaggctcc tcataaccgc tgggcgccag accagaggca gcgctcgaca
      121 gacttgcgac aatgtcgatg ctagcggagc gtcggcggaa gcagaaatgg gctgtggatc
      181 ccagaaatac tgcgtggagt aatgatgatt ccaagtttgg ccagaagatg cttgagaaga
      241 tggggtggtc taaaggaaag ggtttggggg ctcaggagca aggagccaca gaacatatta
      301 aagttaaagt taaaaataac cacctgggac ttggagctac aaacaataat gaagacaact
      361 ggattgctca ccaggatgac ttcaaccagc ttttggcagc actcaacact tgccatggtc
      421 aggaaacagc agattcctca gacaacaagg aaaagaaatc ttttagcctt gaagaaaaat
      481 ccaaaatctc caaaaaccgg gttcattata tgaaattcac caaagggaag gacctgtcct
      541 ctcggagcga aaccgacctg gattgtattt ttggaaaaag gaggaacaag aagcttgctc
      601 aggacggctg cagcaactcc actgcggatg aggcggacac ctccctgacc acgaccacaa
      661 ccacaaccag tgccttcacc atccaggaat attttgccaa gaggatggcc cagttaaaga
      721 gcaagtcaca ggccgcagct ccagggtctg acctttcaga gacccccatt gaatggaaaa
      781 agggaaagaa aaaaaccaaa gaggcagcag gcacagatat agagaactct ccccaacaca
      841 aggccaagcg gcataaaaag aagaagcgag tggaagcaga gagggggcct gcggccaaga
      901 agagagacca agtcgagctg cagcctggag gccccagtgg ggacgagtgt tccgacgcct
      961 ctgtggaggc tgcagaggat cgtgtgcaga caccagacac ccaggatgat gtcccaaagc
     1021 ccaggaagag gagagcaaag aagacgctgc agaggccagg aggagtggca gtagacactg
     1081 caccggacag cgcaccagtg aagaagaaga agaaagtttc cagatagcgt gtggctagca
     1141 gggtctccag ccactcagca caccacaggg cagaacgctc tggcctgctc agagtgcagc
     1201 gagccccagc agctcagcat ctttcaactg cccacaggtt gctggctcta tgccccacat
     1261 ctccctcaag ccaccttcct aggagaactg atttgaatgt tccagatcgt gactttcaat
     1321 aaataaaata actttcaata aacaaataga ttctttttta aa
//
