LOCUS       NM_001106694            1146 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus PTEN induced kinase 1 (Pink1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001106694 XM_001071148 XM_216565
VERSION     NM_001106694.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Hoffmeister,J.D., Broadfoot,C.K., Schaen-Heacock,N.E.,
            Lechner,S.A., Krasko,M.N., Nisbet,A.F., Russell,J., Szot,J.,
            Glass,T.J., Connor,N.P., Kelm-Nelson,C.A. and Ciucci,M.R.
  TITLE     Vocal and tongue exercise in early to mid-stage Parkinson disease
            using the Pink1-/- rat
  JOURNAL   Brain Res 1837, 148958 (2024)
   PUBMED   38685371
  REMARK    GeneRIF: Vocal and tongue exercise in early to mid-stage Parkinson
            disease using the Pink1-/- rat.
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Zhao,L., Chen,Y., Li,H., Ding,X. and Li,J.
  TITLE     Deciphering the neuroprotective mechanisms of RACK1 in cerebral
            ischemia-reperfusion injury: Pioneering insights into mitochondrial
            autophagy and the PINK1/Parkin axis
  JOURNAL   CNS Neurosci Ther 30 (8), e14836 (2024)
   PUBMED   39097918
  REMARK    GeneRIF: Deciphering the neuroprotective mechanisms of RACK1 in
            cerebral ischemia-reperfusion injury: Pioneering insights into
            mitochondrial autophagy and the PINK1/Parkin axis.
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Soto,I., McManus,R., Navarrete,W., Kasanga,E.A., Doshier,K.,
            Nejtek,V.A. and Salvatore,M.F.
  TITLE     Aging accelerates locomotor decline in PINK1 knockout rats in
            association with decreased nigral, but not striatal, dopamine and
            tyrosine hydroxylase expression
  JOURNAL   Exp Neurol 376, 114771 (2024)
   PUBMED   38580154
  REMARK    GeneRIF: Aging accelerates locomotor decline in PINK1 knockout rats
            in association with decreased nigral, but not striatal, dopamine
            and tyrosine hydroxylase expression.
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Lechner,S.A., Barnett,D.G.S., Gammie,S.C. and Kelm-Nelson,C.A.
  TITLE     Prodromal Parkinson disease signs are predicted by a whole-blood
            inflammatory transcriptional signature in young Pink1-/- rats
  JOURNAL   BMC Neurosci 25 (1), 11 (2024)
   PUBMED   38438964
  REMARK    GeneRIF: Prodromal Parkinson disease signs are predicted by a
            whole-blood inflammatory transcriptional signature in young
            Pink1[-/-] rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Wang,J., Sun,Z., Jiang,L., Xuan,L., Ma,Y., Wang,J., Gu,Y. and
            Zhang,Y.
  TITLE     Activation of Pink1/Parkin-mediated mitochondrial autophagy
            alleviates exertional heat stroke-induced acute lung injury in rats
  JOURNAL   Clin Hemorheol Microcirc 88 (1), 13-31 (2024)
   PUBMED   38788061
  REMARK    GeneRIF: Activation of Pink1/Parkin-mediated mitochondrial
            autophagy alleviates exertional heat stroke-induced acute lung
            injury in rats.
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Gandhi,S., Muqit,M.M., Stanyer,L., Healy,D.G., Abou-Sleiman,P.M.,
            Hargreaves,I., Heales,S., Ganguly,M., Parsons,L., Lees,A.J.,
            Latchman,D.S., Holton,J.L., Wood,N.W. and Revesz,T.
  TITLE     PINK1 protein in normal human brain and Parkinson's disease
  JOURNAL   Brain 129 (Pt 7), 1720-1731 (2006)
   PUBMED   16702191
REFERENCE   7  (bases 1 to 1146)
  AUTHORS   Tang,B., Xiong,H., Sun,P., Zhang,Y., Wang,D., Hu,Z., Zhu,Z., Ma,H.,
            Pan,Q., Xia,J.H., Xia,K. and Zhang,Z.
  TITLE     Association of PINK1 and DJ-1 confers digenic inheritance of
            early-onset Parkinson's disease
  JOURNAL   Hum Mol Genet 15 (11), 1816-1825 (2006)
   PUBMED   16632486
REFERENCE   8  (bases 1 to 1146)
  AUTHORS   Beilina,A., Van Der Brug,M., Ahmad,R., Kesavapany,S., Miller,D.W.,
            Petsko,G.A. and Cookson,M.R.
  TITLE     Mutations in PTEN-induced putative kinase 1 associated with
            recessive parkinsonism have differential effects on protein
            stability
  JOURNAL   Proc Natl Acad Sci U S A 102 (16), 5703-5708 (2005)
   PUBMED   15824318
REFERENCE   9  (bases 1 to 1146)
  AUTHORS   Valente,E.M., Abou-Sleiman,P.M., Caputo,V., Muqit,M.M., Harvey,K.,
            Gispert,S., Ali,Z., Del Turco,D., Bentivoglio,A.R., Healy,D.G.,
            Albanese,A., Nussbaum,R., Gonzalez-Maldonado,R., Deller,T.,
            Salvi,S., Cortelli,P., Gilks,W.P., Latchman,D.S., Harvey,R.J.,
            Dallapiccola,B., Auburger,G. and Wood,N.W.
  TITLE     Hereditary early-onset Parkinson's disease caused by mutations in
            PINK1
  JOURNAL   Science 304 (5674), 1158-1160 (2004)
   PUBMED   15087508
REFERENCE   10 (bases 1 to 1146)
  AUTHORS   Nakajima,A., Kataoka,K., Hong,M., Sakaguchi,M. and Huh,N.H.
  TITLE     BRPK, a novel protein kinase showing increased expression in mouse
            cancer cell lines with higher metastatic potential
  JOURNAL   Cancer Lett 201 (2), 195-201 (2003)
   PUBMED   14607334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216565.4, XM_001071148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1146
                     /gene="Pink1"
                     /note="PTEN induced kinase 1"
                     /db_xref="GeneID:298575"
                     /db_xref="RGD:1305769"
     exon            1..423
                     /gene="Pink1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..810
                     /gene="Pink1"
                     /EC_number="2.7.11.1"
                     /note="PTEN induced putative kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PINK1,
                     mitochondrial"
                     /protein_id="NP_001100164.1"
                     /db_xref="GeneID:298575"
                     /db_xref="RGD:1305769"
                     /translation="MAVRQALGRGLQLGRALLLRFAPKPGPVSGWGKPGPGAAWGRGE
                     RPGRVSSPGAQPRPLGLPLPDRYRFFRQSVAGLAARIQRQFVVRARGGAGPCGRAVFL
                     AFGLGLGLIEEKQAESRRAASACQEIQAIFTQKNKQVSDPLDTRRWQGFRLEDYLIGQ
                     AIGKGCNAAVYEATMPTLPQHLEKAKHLGLLGKGPDVVSKGADGEQAPGAPAFPFAIK
                     MMWNISAGSSSEAILSKMSQELEALGSANRKGTLQQFRR"
     exon            424..708
                     /gene="Pink1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..756
                     /gene="Pink1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1146
                     /gene="Pink1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcggtgg cagctggctc cggtcgccgc gccaccatgg cggtgcgaca ggcactgggc
       61 cgaggcctgc agctgggtcg ggcgctgctg ctgcgcttcg ctcccaagcc gggcccggtg
      121 tcaggctggg gcaagcccgg ccccggtgcg gcctggggcc gcggagagcg tcccggccgg
      181 gtctcaagcc cgggagcaca gccgcgtccg ctcgggctcc ccctcccgga ccgctaccgc
      241 ttcttccgcc agtcggtggc tgggctggcg gcgcgaatcc agcggcagtt cgtggtgcgg
      301 gcccgaggcg gcgcagggcc ttgcggccga gcagtcttcc tggccttcgg actggggttg
      361 gggctgatcg aggagaagca ggcggagagc cggagggccg cctcggcctg tcaggagatc
      421 caggcaattt ttacacagaa aaacaagcaa gtgtctgacc cactggacac acgacgttgg
      481 cagggcttcc gcctggagga ttatctgata ggacaggcca tcggcaaggg ctgcaatgcc
      541 gctgtgtatg aagccaccat gcccacactg ccccagcacc tggagaaggc caaacacctt
      601 ggccttctag gaaaaggccc agatgtcgtc tcaaagggag cagatgggga gcaggctcca
      661 ggggcccccg ccttcccctt tgccatcaaa atgatgtgga atatctcggc aggatcctcc
      721 agcgaagcca tcttaagcaa aatgagccag gagctggaag ccttgggttc agcaaacagg
      781 aagggcaccc ttcaacagtt caggcggtag acagtcacta cctatgccca tccatctaag
      841 ttctagggca gaactcagac gtcaggccag accaggagtc agtaaactgt acaggaaatt
      901 aagtagttgt gatgacttag ctgtcaccga ggcagaagga caaacacgga tgacactgaa
      961 ctttacttgt cactatactc ttctcatttt tcccgaccac ttagaaatgc aaaataacca
     1021 ggtttagttt gtaagtggcc agtgtggctc acagccaagt ttgccccatc ctgggctaaa
     1081 tgcattctca atgtctaacg cttaaaagat gctatcatta aagacagtct ccaagccaaa
     1141 gccatg
//
