LOCUS       NM_001106701             946 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Rattus norvegicus peptidylprolyl cis/trans isomerase,
            NIMA-interacting 1 (Pin1), mRNA.
ACCESSION   NM_001106701 XM_001077069 XM_216609
VERSION     NM_001106701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 946)
  AUTHORS   Ren,Q.X., Zhuang,Q.S. and Shen,G.L.
  TITLE     Expression and significance of pin1 in the wound healing
  JOURNAL   Arch Dermatol Res 316 (6), 235 (2024)
   PUBMED   38795154
  REMARK    GeneRIF: Expression and significance of pin1 in the wound healing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 946)
  AUTHORS   Yuan,J., Li,S., Han,Y., Li,F., Shi,H., Shi,W. and Cui,W.
  TITLE     Restoration of miR-328a-5p function curtails hypoxic pulmonary
            hypertension through a mechanism involving
            PIN1/GSK3beta/beta-catenin axis
  JOURNAL   Int Immunopharmacol 123, 110599 (2023)
   PUBMED   37567011
  REMARK    GeneRIF: Restoration of miR-328a-5p function curtails hypoxic
            pulmonary hypertension through a mechanism involving
            PIN1/GSK3beta/beta-catenin axis.
REFERENCE   3  (bases 1 to 946)
  AUTHORS   Rai,N., Sydykov,A., Kojonazarov,B., Wilhelm,J., Manaud,G.,
            Veeroju,S., Ruppert,C., Perros,F., Ghofrani,H.A., Weissmann,N.,
            Seeger,W., Schermuly,R.T. and Novoyatleva,T.
  TITLE     Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary
            arterial hypertension
  JOURNAL   Eur Respir J 60 (2), 2101698 (2022)
   PUBMED   35058248
  REMARK    GeneRIF: Targeting peptidyl-prolyl isomerase 1 in experimental
            pulmonary arterial hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 946)
  AUTHORS   Zhang,X., Sun,W., Wu,W., Chen,M., Ji,T., Xu,H. and Wang,Y.
  TITLE     Pin1-mediated regulation of articular cartilage stem/progenitor
            cell aging
  JOURNAL   Tissue Cell 76, 101765 (2022)
   PUBMED   35227974
  REMARK    GeneRIF: Pin1-mediated regulation of articular cartilage
            stem/progenitor cell aging.
REFERENCE   5  (bases 1 to 946)
  AUTHORS   Yu,H., Jiang,G., Hu,W. and Xu,C.
  TITLE     Pin1 aggravates renal injury induced by ischemia and reperfusion in
            rats via Nrf2/HO-1 mediated endoplasmic reticulum stress
  JOURNAL   Acta Cir Bras 37 (1), e370101 (2022)
   PUBMED   35416857
  REMARK    GeneRIF: Pin1 aggravates renal injury induced by ischemia and
            reperfusion in rats via Nrf2/HO-1 mediated endoplasmic reticulum
            stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 946)
  AUTHORS   Pastorino,L., Sun,A., Lu,P.J., Zhou,X.Z., Balastik,M., Finn,G.,
            Wulf,G., Lim,J., Li,S.H., Li,X., Xia,W., Nicholson,L.K. and Lu,K.P.
  TITLE     The prolyl isomerase Pin1 regulates amyloid precursor protein
            processing and amyloid-beta production
  JOURNAL   Nature 440 (7083), 528-534 (2006)
   PUBMED   16554819
  REMARK    Erratum:[Nature. 2007 Mar 15;446(7133):342]
REFERENCE   7  (bases 1 to 946)
  AUTHORS   Becker,E.B. and Bonni,A.
  TITLE     Pin1 mediates neural-specific activation of the mitochondrial
            apoptotic machinery
  JOURNAL   Neuron 49 (5), 655-662 (2006)
   PUBMED   16504941
REFERENCE   8  (bases 1 to 946)
  AUTHORS   Atchison,F.W., Capel,B. and Means,A.R.
  TITLE     Pin1 regulates the timing of mammalian primordial germ cell
            proliferation
  JOURNAL   Development 130 (15), 3579-3586 (2003)
   PUBMED   12810604
REFERENCE   9  (bases 1 to 946)
  AUTHORS   Ryo,A., Nakamura,M., Wulf,G., Liou,Y.C. and Lu,K.P.
  TITLE     Pin1 regulates turnover and subcellular localization of
            beta-catenin by inhibiting its interaction with APC
  JOURNAL   Nat Cell Biol 3 (9), 793-801 (2001)
   PUBMED   11533658
REFERENCE   10 (bases 1 to 946)
  AUTHORS   Lu,P.J., Zhou,X.Z., Shen,M. and Lu,K.P.
  TITLE     Function of WW domains as phosphoserine- or
            phosphothreonine-binding modules
  JOURNAL   Science 283 (5406), 1325-1328 (1999)
   PUBMED   10037602
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158867.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001106701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158867.1, CF114202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..946
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..946
                     /gene="Pin1"
                     /note="peptidylprolyl cis/trans isomerase,
                     NIMA-interacting 1"
                     /db_xref="GeneID:298696"
                     /db_xref="RGD:1310299"
     exon            1..64
                     /gene="Pin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..504
                     /gene="Pin1"
                     /EC_number="5.2.1.8"
                     /note="protein (peptidyl-prolyl cis/trans isomerase)
                     NIMA-interacting 1"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase
                     NIMA-interacting 1"
                     /protein_id="NP_001100171.1"
                     /db_xref="GeneID:298696"
                     /db_xref="RGD:1310299"
                     /translation="MADEEKLPSGWEKRMSRSSGRVYYFNHITNASQWERPSGGSTVG
                     GGSKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRSKEEALELINGYIQKIKSGE
                     EDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHI
                     ILRTE"
     exon            65..283
                     /gene="Pin1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..394
                     /gene="Pin1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..925
                     /gene="Pin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagatgg cggacgagga gaagctgccg tccgggtggg agaagcgtat gagtcgcagc
       61 tcaggccgtg tctactactt caatcacatc accaacgcca gccagtggga gcggcccagc
      121 ggaggcagca ccgttggagg cggcagcaag aatggccagg gtgagcctgc cagggtgcgc
      181 tgctcacacc tgctggtgaa gcacagccaa tctcggaggc cctcatcctg gcggcaggaa
      241 aagatcacca ggagcaaaga ggaggccttg gagctgatca atggctacat ccagaagatt
      301 aagtcaggag aggaggactt tgaatctctg gcctcacagt tcagtgactg cagctctgcc
      361 aaagccaggg gagacctggg tgccttcagc agaggtcaga tgcagaaacc gttcgaagat
      421 gcatcgtttg ctctacggac cggggaaatg agtgggccgg tgttcacgga ttcaggcatc
      481 catatcatcc tacgcacaga atgagggcag gcacctggcc agcctgcttg ggctgccaca
      541 catacagccc atggacgccc ttcctgctac tgtcacacag tatttattgt tcctaaaatg
      601 actgggaggg gggctctgag aaggggactc tgagcatccc gctccctgtt tgcccccatt
      661 tggggctgtc ctagctaggc tccttctgga ggaatcgact tcagaagggc agtggaggtg
      721 gggaggcccc caggctcagg gggtcagagg tgacctgatc ccccggtctc agaggcaggc
      781 aggagggcct ttttcttgtt agttgtatgc tcagttcttc tgttccgttg cgaaaagcag
      841 acgctccata cctggcgctg cagcagctcg gcctcagggt gcgaagcagc gcaccgtgca
      901 ccttccatta aatctggaac cgctgaaaaa aaaaaaaaaa aaaaaa
//
