LOCUS       NP_001100171             165 aa            linear   ROD 10-JUN-2024
DEFINITION  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Rattus
            norvegicus].
ACCESSION   NP_001100171 XP_001077069 XP_216609
VERSION     NP_001100171.1
DBSOURCE    REFSEQ: accession NM_001106701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 165)
  AUTHORS   Ren,Q.X., Zhuang,Q.S. and Shen,G.L.
  TITLE     Expression and significance of pin1 in the wound healing
  JOURNAL   Arch Dermatol Res 316 (6), 235 (2024)
   PUBMED   38795154
  REMARK    GeneRIF: Expression and significance of pin1 in the wound healing.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 165)
  AUTHORS   Yuan,J., Li,S., Han,Y., Li,F., Shi,H., Shi,W. and Cui,W.
  TITLE     Restoration of miR-328a-5p function curtails hypoxic pulmonary
            hypertension through a mechanism involving
            PIN1/GSK3beta/beta-catenin axis
  JOURNAL   Int Immunopharmacol 123, 110599 (2023)
   PUBMED   37567011
  REMARK    GeneRIF: Restoration of miR-328a-5p function curtails hypoxic
            pulmonary hypertension through a mechanism involving
            PIN1/GSK3beta/beta-catenin axis.
REFERENCE   3  (residues 1 to 165)
  AUTHORS   Rai,N., Sydykov,A., Kojonazarov,B., Wilhelm,J., Manaud,G.,
            Veeroju,S., Ruppert,C., Perros,F., Ghofrani,H.A., Weissmann,N.,
            Seeger,W., Schermuly,R.T. and Novoyatleva,T.
  TITLE     Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary
            arterial hypertension
  JOURNAL   Eur Respir J 60 (2), 2101698 (2022)
   PUBMED   35058248
  REMARK    GeneRIF: Targeting peptidyl-prolyl isomerase 1 in experimental
            pulmonary arterial hypertension.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 165)
  AUTHORS   Zhang,X., Sun,W., Wu,W., Chen,M., Ji,T., Xu,H. and Wang,Y.
  TITLE     Pin1-mediated regulation of articular cartilage stem/progenitor
            cell aging
  JOURNAL   Tissue Cell 76, 101765 (2022)
   PUBMED   35227974
  REMARK    GeneRIF: Pin1-mediated regulation of articular cartilage
            stem/progenitor cell aging.
REFERENCE   5  (residues 1 to 165)
  AUTHORS   Yu,H., Jiang,G., Hu,W. and Xu,C.
  TITLE     Pin1 aggravates renal injury induced by ischemia and reperfusion in
            rats via Nrf2/HO-1 mediated endoplasmic reticulum stress
  JOURNAL   Acta Cir Bras 37 (1), e370101 (2022)
   PUBMED   35416857
  REMARK    GeneRIF: Pin1 aggravates renal injury induced by ischemia and
            reperfusion in rats via Nrf2/HO-1 mediated endoplasmic reticulum
            stress.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 165)
  AUTHORS   Pastorino,L., Sun,A., Lu,P.J., Zhou,X.Z., Balastik,M., Finn,G.,
            Wulf,G., Lim,J., Li,S.H., Li,X., Xia,W., Nicholson,L.K. and Lu,K.P.
  TITLE     The prolyl isomerase Pin1 regulates amyloid precursor protein
            processing and amyloid-beta production
  JOURNAL   Nature 440 (7083), 528-534 (2006)
   PUBMED   16554819
  REMARK    Erratum:[Nature. 2007 Mar 15;446(7133):342]
REFERENCE   7  (residues 1 to 165)
  AUTHORS   Becker,E.B. and Bonni,A.
  TITLE     Pin1 mediates neural-specific activation of the mitochondrial
            apoptotic machinery
  JOURNAL   Neuron 49 (5), 655-662 (2006)
   PUBMED   16504941
REFERENCE   8  (residues 1 to 165)
  AUTHORS   Atchison,F.W., Capel,B. and Means,A.R.
  TITLE     Pin1 regulates the timing of mammalian primordial germ cell
            proliferation
  JOURNAL   Development 130 (15), 3579-3586 (2003)
   PUBMED   12810604
REFERENCE   9  (residues 1 to 165)
  AUTHORS   Ryo,A., Nakamura,M., Wulf,G., Liou,Y.C. and Lu,K.P.
  TITLE     Pin1 regulates turnover and subcellular localization of
            beta-catenin by inhibiting its interaction with APC
  JOURNAL   Nat Cell Biol 3 (9), 793-801 (2001)
   PUBMED   11533658
REFERENCE   10 (residues 1 to 165)
  AUTHORS   Lu,P.J., Zhou,X.Z., Shen,M. and Lu,K.P.
  TITLE     Function of WW domains as phosphoserine- or
            phosphothreonine-binding modules
  JOURNAL   Science 283 (5406), 1325-1328 (1999)
   PUBMED   10037602
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158867.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001077069.1, XP_216609.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158867.1, CF114202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     Protein         1..165
                     /product="peptidyl-prolyl cis-trans isomerase
                     NIMA-interacting 1"
                     /EC_number="5.2.1.8"
                     /note="protein (peptidyl-prolyl cis/trans isomerase)
                     NIMA-interacting 1"
                     /calculated_mol_wt=18201
     Region          7..37
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          53..164
                     /region_name="Rotamase_2"
                     /note="PPIC-type PPIASE domain; cl29122"
                     /db_xref="CDD:452928"
     CDS             1..165
                     /gene="Pin1"
                     /coded_by="NM_001106701.2:7..504"
                     /db_xref="GeneID:298696"
                     /db_xref="RGD:1310299"
ORIGIN      
        1 madeeklpsg wekrmsrssg rvyyfnhitn asqwerpsgg stvgggskng qgeparvrcs
       61 hllvkhsqsr rpsswrqeki trskeealel ingyiqkiks geedfeslas qfsdcssaka
      121 rgdlgafsrg qmqkpfedas falrtgemsg pvftdsgihi ilrte
//
