LOCUS       NM_022602               2133 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus Pim-3 proto-oncogene, serine/threonine kinase
            (Pim3), mRNA.
ACCESSION   NM_022602
VERSION     NM_022602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Li,T., Liu,F., Tan,Y., Peng,Y., Xu,X. and Yang,Y.
  TITLE     PIM3 regulates myocardial ischemia/reperfusion injury via
            ferroptosis
  JOURNAL   Genes Genomics 46 (2), 161-170 (2024)
   PUBMED   38148455
  REMARK    GeneRIF: PIM3 regulates myocardial ischemia/reperfusion injury via
            ferroptosis.
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Yang,C., Li,L., Guo,J., Zhang,W., Zhu,W., Rao,X. and Huang,W.
  TITLE     Up-regulation of Pim-3 in Chronic Obstructive Pulmonary Disease
            (COPD) patients and its potential therapeutic role in COPD rat
            modeling
  JOURNAL   Pathol Res Pract 213 (4), 322-326 (2017)
   PUBMED   28214201
  REMARK    GeneRIF: Our study suggests that up-regulation of Pim-3
            successfully accelerated Chronic Obstructive Pulmonary Disease
            development, and aggravated lung damage
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Liu,L.H., Lai,Q.N., Chen,J.Y., Zhang,J.X. and Cheng,B.
  TITLE     Overexpression of pim-3 and protective role in
            lipopolysaccharide-stimulated hepatic stellate cells
  JOURNAL   World J Gastroenterol 21 (29), 8858-8867 (2015)
   PUBMED   26269675
  REMARK    GeneRIF: Overexpression of pim-3 plays a protective role in
            LPS-stimulated hepatic stellate cells.
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Zhao,L., Wang,Y., Min,X., Yang,H., Zhang,P. and Zeng,Q.
  TITLE     Ischemia-reperfusion injury up-regulates Pim-3 gene expression in
            myocardial tissue
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 30 (6), 704-708 (2010)
   PUBMED   21181358
  REMARK    GeneRIF: Ischemia-reperfusion injury up-regulated Pim-3 gene
            expression through oxidative stress signaling pathway in myocardial
            tissues.
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Vlacich,G., Nawijn,M.C., Webb,G.C. and Steiner,D.F.
  TITLE     Pim3 negatively regulates glucose-stimulated insulin secretion
  JOURNAL   Islets 2 (5), 308-317 (2010)
   PUBMED   21099329
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Liu,D., He,M., Yi,B., Guo,W.H., Que,A.L. and Zhang,J.X.
  TITLE     Pim-3 protects against cardiomyocyte apoptosis in
            anoxia/reoxygenation injury via p38-mediated signal pathway
  JOURNAL   Int J Biochem Cell Biol 41 (11), 2315-2322 (2009)
   PUBMED   19505587
  REMARK    GeneRIF: Anoxic preconditioning could act to protect the heart from
            anoxia/reoxygenation injury with cooperation from the
            proto-oncogene Pim-3; in addition, it up-regulates Pim-3 expression
            through a p38 MAPK signaling pathway.
REFERENCE   7  (bases 1 to 2133)
  AUTHORS   Zhang,P., Wang,H., Min,X., Wang,Y., Tang,J., Cheng,J., Li,D.,
            Chen,X., Cheng,F., Wang,N. and Yang,H.
  TITLE     Pim-3 is expressed in endothelial cells and promotes vascular tube
            formation
  JOURNAL   J Cell Physiol 220 (1), 82-90 (2009)
   PUBMED   19229879
  REMARK    GeneRIF: Pim-3 is expressed in endothelial cells and promotes
            vascular tube formation.
REFERENCE   8  (bases 1 to 2133)
  AUTHORS   Morishita,D., Katayama,R., Sekimizu,K., Tsuruo,T. and Fujita,N.
  TITLE     Pim kinases promote cell cycle progression by phosphorylating and
            down-regulating p27Kip1 at the transcriptional and
            posttranscriptional levels
  JOURNAL   Cancer Res 68 (13), 5076-5085 (2008)
   PUBMED   18593906
REFERENCE   9  (bases 1 to 2133)
  AUTHORS   Popivanova,B.K., Li,Y.Y., Zheng,H., Omura,K., Fujii,C.,
            Tsuneyama,K. and Mukaida,N.
  TITLE     Proto-oncogene, Pim-3 with serine/threonine kinase activity, is
            aberrantly expressed in human colon cancer cells and can prevent
            Bad-mediated apoptosis
  JOURNAL   Cancer Sci 98 (3), 321-328 (2007)
   PUBMED   17270021
REFERENCE   10 (bases 1 to 2133)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Tocco,G., Marcheselli,V.L.,
            Bazan,N.G., Baudry,M. and Herschman,H.R.
  TITLE     KID-1, a protein kinase induced by depolarization in brain
  JOURNAL   J Biol Chem 273 (26), 16535-16543 (1998)
   PUBMED   9632723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF057026.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF057026.1, AF086624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2133
                     /gene="Pim3"
                     /note="Pim-3 proto-oncogene, serine/threonine kinase"
                     /db_xref="GeneID:64534"
                     /db_xref="RGD:620462"
     exon            1..270
                     /gene="Pim3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1166
                     /gene="Pim3"
                     /EC_number="2.7.11.1"
                     /note="protein kinase Kid-1; kinase induced by
                     depolarization; serine threonine kinase pim3; proviral
                     integration site 3; pim-3 oncogene; serine threonine
                     kinase-like"
                     /codon_start=1
                     /product="serine/threonine-protein kinase pim-3"
                     /protein_id="NP_072124.1"
                     /db_xref="GeneID:64534"
                     /db_xref="RGD:620462"
                     /translation="MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGA
                     VLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGMAVPLEVVLLRKVGAAGG
                     ARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRH
                     CHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRY
                     HRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSL
                     RPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL"
     exon            271..380
                     /gene="Pim3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..431
                     /gene="Pim3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..801
                     /gene="Pim3"
                     /inference="alignment:Splign:2.1.0"
     exon            802..978
                     /gene="Pim3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..2133
                     /gene="Pim3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcggcca gctgccgtct acgggcttcc gcgcggccac cgggcaactg cgccgcgcgg
       61 ctgccccact gagcgctcgg cctcggggcc gtgggatccg ccgcgctgtc tgcggtcagg
      121 aagaccgccc tcccgcgtcc gtgccggacg ggtcagaggc ggcgccgcac gcgaggccac
      181 ccgcgatgct gctgtccaag ttcggctccc tggcgcacct ctgcgggcct ggcggcgtgg
      241 accacctccc agtgaagatc ctacagccag ccaaggcgga caaggagagc ttcgagaagg
      301 tgtaccaggt gggcgccgtg ctcggcagcg gcggcttcgg cacggtctac gcgggcagcc
      361 gcatcgccga cggactcccg gtggctgtga agcacgtggt gaaggagcgg gtgaccgagt
      421 ggggcagtct cggcggaatg gccgtgcccc tggaggtggt gctgctgcgc aaggtgggcg
      481 cggcgggcgg cgcgcgcggc gtcatccgcc tgctggactg gttcgagcgg cccgacggct
      541 tcctgctggt gctggagcga cccgagccgg cacaggacct cttcgacttc atcactgaac
      601 gcggcgccct ggacgagcct ctggctcgtc gcttcttcgc gcaggtgctc gccgctgtgc
      661 ggcactgcca caattgtggg gtcgtgcacc gcgacatcaa ggacgagaac ctgctggtgg
      721 acttgcgctc gggcgagctg aagctcatcg acttcggctc gggcgcggtg ctcaaggaca
      781 cggtctacac tgactttgat ggcacccgtg tgtacagccc cccagagtgg atccggtatc
      841 atcgatatca cgggcggtct gccactgtgt ggtctctggg tgtactgctc tacgacatgg
      901 tgtgtgggga cattcccttt gagcaggatg aggagatctt gcgcggcagg ctctttttcc
      961 ggaggagggt ctccccagag tgccagcagc ttattgagtg gtgtctctcc ctgcggccct
     1021 cagagaggcc ctcgctggac caaattgctg cccatccctg gatgctgggg acagagggca
     1081 gcgttccaga gaactgtgac cttcggctct gtgccctgga tactgatgac ggagccagta
     1141 ccacttccag cagtgagagc ttgtgaggag gaggaggggc ctggactcca cactgggggc
     1201 ctgggctcag cctagccagc cctctcccag aatgaacatt ttctgcctgg gatgtctcct
     1261 gcaaaagcag tgacctctga cccctggtga cctttgctct cggcaccggg cctgtttcct
     1321 ttgctttgag tgcctttttg aacgctgctc cacagggcct gggttttctt gagctcttct
     1381 gtccaaagat ggctgcgggc taagcaaggt cccgcctgcc ctgggtggat acttgaaccc
     1441 gagaccctac cctgctgctc catcttgcgg cagccttcct gaccaagtgt gtttgacatg
     1501 gagcgccctg tggtgcccac ctccaaccct ccagtctcct ggtcttcgtc tgggcatgtc
     1561 tgcacaagca atgcaacgct gggccactgc tgcccgcctg cctccctggc accgcacgca
     1621 acgagcgtgc cacggtctct tatttatggt gtgatcaccc tggagggcgc ccctgccctg
     1681 ctggggctat ttattgttta atttatttgc tgaggttact tcctccaagc aaccaccttc
     1741 tccaggcccc tggggtgttc aggaaagcca agggtggccg ttcagtccac agacggcatc
     1801 ctggttcctg cacctgcagt aggtccctaa ccccatgttt gtgggaggag gaatttgtac
     1861 agtggctaat ttaaggggag tgggagaccc tgtcaccctg ggcactctgc gctggggagg
     1921 gggtttaaat tattgacctt gtacagtctg cttgctggct ctgaaagctg gggtggggga
     1981 cagagtctca agcccttaat ttattttagc aactgtgttc tgtgaccctg gtgtgagtag
     2041 gcatcagggg tggggttgta taagttcaaa agtgtgaaat gtctggagat catatttttt
     2101 atacaggtat ttcaattaaa tgttttggta tat
//
