LOCUS       NM_017034               1302 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Pim-1 proto-oncogene, serine/threonine kinase
            (Pim1), mRNA.
ACCESSION   NM_017034
VERSION     NM_017034.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Xia,X., Liang,Y., Zheng,W., Lin,D. and Sun,S.
  TITLE     miR-410-5p promotes the development of diabetic cardiomyopathy by
            suppressing PIM1-induced anti-apoptosis
  JOURNAL   Mol Cell Probes 52, 101558 (2020)
   PUBMED   32145290
  REMARK    GeneRIF: miR-410-5p promotes the development of diabetic
            cardiomyopathy by suppressing PIM1-induced anti-apoptosis.
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Lampron,M.C., Vitry,G., Nadeau,V., Grobs,Y., Paradis,R., Samson,N.,
            Tremblay,E., Boucherat,O., Meloche,J., Bonnet,S., Provencher,S.,
            Potus,F. and Paulin,R.
  TITLE     PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition
            Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling
            Pathway in Pulmonary Hypertension
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (3), 783-801 (2020)
   PUBMED   31969012
  REMARK    GeneRIF: PIM1 phosphorylates KU70 and initiates DNA repair
            signaling in pulmonary artery hypertension-pulmonary artery smooth
            muscle cells. PIM1 inhibitors represent a therapeutic option for
            patients with PAH.
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Zhang,S., Wang,D., Huang,T., Liu,F., Shuai,L. and Xu,J.
  TITLE     Pim-1 Expression in Rat Retina and its Changes after Optic Nerve
            Crush
  JOURNAL   Anat Rec (Hoboken) 301 (11), 1968-1976 (2018)
   PUBMED   30299595
  REMARK    GeneRIF: Overexpression of Pim1 in retinal ganglion cells is
            related to optic nerve repair following optic nerve crush.
REFERENCE   4  (bases 1 to 1302)
  AUTHORS   Zhu,H.H., Wang,X.T., Sun,Y.H., He,W.K., Liang,J.B., Mo,B.H. and
            Li,L.
  TITLE     Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After
            Exposure to Hypoxia and Oxidative Stress via Upregulating Cell
            Autophagy
  JOURNAL   Cell Physiol Biochem 49 (6), 2138-2150 (2018)
   PUBMED   30257237
  REMARK    GeneRIF: Pim1 overexpression prevented NRVM apoptosis via
            upregulation of autophagy after hypoxia and oxidative stress,
            partly via activation of the AMPK/mTOR/ATG5 autophagy pathway.
REFERENCE   5  (bases 1 to 1302)
  AUTHORS   Zhu,N., Yi,B., Guo,Z., Zhang,G., Huang,S., Qin,Y., Zhao,X. and
            Sun,J.
  TITLE     Pim-1 Kinase Phosphorylates Cardiac Troponin I and Regulates
            Cardiac Myofilament Function
  JOURNAL   Cell Physiol Biochem 45 (6), 2174-2186 (2018)
   PUBMED   29544221
  REMARK    GeneRIF: Pim-1 is a novel kinase that phosphorylates cTnI primarily
            at Ser23/24 and Ser150 in cardiomyocytes, which in turn may
            modulate myofilament function under a variety of physiological and
            pathophysiological conditions.
REFERENCE   6  (bases 1 to 1302)
  AUTHORS   Chen,W.W., Chan,D.C., Donald,C., Lilly,M.B. and Kraft,A.S.
  TITLE     Pim family kinases enhance tumor growth of prostate cancer cells
  JOURNAL   Mol Cancer Res 3 (8), 443-451 (2005)
   PUBMED   16123140
  REMARK    GeneRIF: Pim on PP2A activity may mediate the levels of c-Myc and
            the phosphorylation of proteins needed for increased protein
            synthesis, which could have a significant impact on tumor growth
REFERENCE   7  (bases 1 to 1302)
  AUTHORS   Katakami,N., Kaneto,H., Hao,H., Umayahara,Y., Fujitani,Y.,
            Sakamoto,K., Gorogawa,S., Yasuda,T., Kawamori,D., Kajimoto,Y.,
            Matsuhisa,M., Yutani,C., Hori,M. and Yamasaki,Y.
  TITLE     Role of pim-1 in smooth muscle cell proliferation
  JOURNAL   J Biol Chem 279 (52), 54742-54749 (2004)
   PUBMED   15471855
  REMARK    GeneRIF: Pim-1 expression was observed in the neointima of
            balloon-injured rat carotid arteries and in human thoracic aortas
            and coronary arteries showing intimal thickening suggesting that
            Pim-1 plays a role in vascular smooth muscle proliferation
REFERENCE   8  (bases 1 to 1302)
  AUTHORS   Krishnan,N., Pan,H., Buckley,D.J. and Buckley,A.
  TITLE     Prolactin-regulated pim-1 transcription: identification of critical
            promoter elements and Akt signaling
  JOURNAL   Endocrine 20 (1-2), 123-130 (2003)
   PUBMED   12668877
  REMARK    GeneRIF: the DE and NF-1 half-site mediate prolactin responsiveness
            of the pim-1 promoter
REFERENCE   9  (bases 1 to 1302)
  AUTHORS   Wingett,D., Reeves,R. and Magnuson,N.S.
  TITLE     Characterization of the testes-specific pim-1 transcript in rat
  JOURNAL   Nucleic Acids Res 20 (12), 3183-3189 (1992)
   PUBMED   1620615
REFERENCE   10 (bases 1 to 1302)
  AUTHORS   Saris,C.J., Domen,J. and Berns,A.
  TITLE     The pim-1 oncogene encodes two related protein-serine/threonine
            kinases by alternative initiation at AUG and CUG
  JOURNAL   EMBO J 10 (3), 655-664 (1991)
   PUBMED   1825810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X63675.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1302
                     /gene="Pim1"
                     /note="Pim-1 proto-oncogene, serine/threonine kinase"
                     /db_xref="GeneID:24649"
                     /db_xref="RGD:3330"
     exon            1..85
                     /gene="Pim1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..945
                     /gene="Pim1"
                     /EC_number="2.7.11.1"
                     /note="proto-oncogene serine/threonine-protein kinase
                     Pim-1; non-specific serine/threonine protein kinase;
                     proviral integration site 1; pim-1 oncogene"
                     /codon_start=1
                     /product="serine/threonine-protein kinase pim-1"
                     /protein_id="NP_058730.1"
                     /db_xref="GeneID:24649"
                     /db_xref="RGD:3330"
                     /translation="MLLSKINSLAHLRAAPCNDLHANKLAPGKEKEPLESQYQVGPLL
                     GSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG
                     VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN
                     CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRY
                     HGRSAAVWSLGILLYDMVCGDIPFEHDEEIVKGQVYFRQRVSSECQHLIRWCLSLRPS
                     DRPSFEEIQNHPWMQDVLLPQATAEIHLHSLSPSPSK"
     exon            86..192
                     /gene="Pim1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..243
                     /gene="Pim1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..610
                     /gene="Pim1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..787
                     /gene="Pim1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1302
                     /gene="Pim1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatgctct tgtccaagat caactccctg gcccacctgc gcgcagcccc ttgcaacgac
       61 ctgcacgcca acaagctggc gccgggcaaa gagaaggagc ccctggagtc gcagtaccag
      121 gtgggcccgc tgttgggcag cggtggcttc ggctcggtct actcgggcat ccgcgtcgcc
      181 gacaacttgc cggtggccat caagcacgtg gagaaggacc ggatttccga ctggggggaa
      241 ctgcccaacg gcacccgagt gcccatggaa gtggtcctgc tgaagaaggt gagctcgggc
      301 ttctcgggcg tcattagact tctggactgg ttcgagaggc ccgatagttt cgtgctgatc
      361 ctggagaggc ccgaacccgt gcaagacctc ttcgacttca tcaccgagcg aggagccctc
      421 caggaggagc tggcccggag cttcttctgg caggtgctgg aggccgtgcg gcattgccac
      481 aactgcgggg ttctccaccg cgacatcaag gacgagaaca tcttaatcga cctgaaccgc
      541 ggcgaactca aactcatcga cttcgggtcg ggggcgctgc tcaaggacac agtctacacg
      601 gactttgacg gaacccgagt gtacagtcct ccagagtgga ttcgctacca tcgctaccac
      661 ggcaggtcgg ctgctgtttg gtccctgggg atcctgctct atgacatggt ctgcggagat
      721 attccatttg agcacgacga agagatcgtc aagggccaag tgtactttag gcaaagggtc
      781 tcttcagaat gtcaacatct tattagatgg tgcctgtccc tgagaccatc ggaccggccc
      841 tcctttgaag aaatccagaa ccatccgtgg atgcaggatg ttctcctgcc ccaggccacc
      901 gccgagattc atctgcacag cctgtcacca tcacccagca aatagcagcc attctgtcag
      961 accctccagg gaagagagag cttgtctgct ggcctccaac aggaccctgc tctacgatgc
     1021 agggacagaa atgacaactc attccaggct ccggggtccc tggagcaacc tccctcaagg
     1081 agaagagact agttcactcg tcctggaccc cgctttgccc ctcacagact cagtggcgtc
     1141 cagtgtggct ggcgtccgca gagtcccggg tgttgggggg ggaggtggga gtgggtcaga
     1201 gccctgtcat ggaactttag tcaccatgga gactgtgggt caccaagatg ggccagggta
     1261 ggggaaaaac atttgggggg tgggattaaa aactagcacc at
//
