LOCUS       NM_001081444            3121 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 6
            (Pik3r6), mRNA.
ACCESSION   NM_001081444 XM_001078999 XM_017597455 XM_573119
VERSION     NM_001081444.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3121)
  AUTHORS   Liu,M., Liao,L., Gao,Y., Yin,Y., Wei,X., Xu,Q., Gao,L. and Zhou,R.
  TITLE     BCAM Deficiency May Contribute to Preeclampsia by Suppressing the
            PIK3R6/p-STAT3 Signaling
  JOURNAL   Hypertension 79 (12), 2830-2842 (2022)
   PUBMED   36252138
  REMARK    GeneRIF: BCAM Deficiency May Contribute to Preeclampsia by
            Suppressing the PIK3R6/p-STAT3 Signaling.
REFERENCE   2  (bases 1 to 3121)
  AUTHORS   Wilson,L.S., Baillie,G.S., Pritchard,L.M., Umana,B., Terrin,A.,
            Zaccolo,M., Houslay,M.D. and Maurice,D.H.
  TITLE     A phosphodiesterase 3B-based signaling complex integrates exchange
            protein activated by cAMP 1 and phosphatidylinositol 3-kinase
            signals in human arterial endothelial cells
  JOURNAL   J Biol Chem 286 (18), 16285-16296 (2011)
   PUBMED   21393242
REFERENCE   3  (bases 1 to 3121)
  AUTHORS   Kurig,B., Shymanets,A., Bohnacker,T., Prajwal, Brock,C.,
            Ahmadian,M.R., Schaefer,M., Gohla,A., Harteneck,C., Wymann,M.P.,
            Jeanclos,E. and Nurnberg,B.
  TITLE     Ras is an indispensable coregulator of the class IB
            phosphoinositide 3-kinase p87/p110gamma
  JOURNAL   Proc Natl Acad Sci U S A 106 (48), 20312-20317 (2009)
   PUBMED   19906996
REFERENCE   4  (bases 1 to 3121)
  AUTHORS   Tannert,A., Voigt,P., Burgold,S., Tannert,S. and Schaefer,M.
  TITLE     Signal amplification between Gbetagamma release and
            PI3Kgamma-mediated PI(3,4,5)P3 formation monitored by a fluorescent
            Gbetagamma biosensor protein and repetitive two component total
            internal reflection/fluorescence redistribution after
            photobleaching analysis
  JOURNAL   Biochemistry 47 (43), 11239-11250 (2008)
   PUBMED   18831540
REFERENCE   5  (bases 1 to 3121)
  AUTHORS   Suire,S., Coadwell,J., Ferguson,G.J., Davidson,K., Hawkins,P. and
            Stephens,L.
  TITLE     p84, a new Gbetagamma-activated regulatory subunit of the type IB
            phosphoinositide 3-kinase p110gamma
  JOURNAL   Curr Biol 15 (6), 566-570 (2005)
   PUBMED   15797027
REFERENCE   6  (bases 1 to 3121)
  AUTHORS   Rodriguez-Borlado,L., Barber,D.F., Hernandez,C.,
            Rodriguez-Marcos,M.A., Sanchez,A., Hirsch,E., Wymann,M.,
            Martinez-A,C. and Carrera,A.C.
  TITLE     Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell
            differentiation ratio
  JOURNAL   J Immunol 170 (9), 4475-4482 (2003)
   PUBMED   12707323
REFERENCE   7  (bases 1 to 3121)
  AUTHORS   Jiang,K., Zhong,B., Gilvary,D.L., Corliss,B.C., Hong-Geller,E.,
            Wei,S. and Djeu,J.Y.
  TITLE     Pivotal role of phosphoinositide-3 kinase in regulation of
            cytotoxicity in natural killer cells
  JOURNAL   Nat Immunol 1 (5), 419-425 (2000)
   PUBMED   11062502
  REMARK    Erratum:[Nat Immunol 2000 Dec;1(6):541]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 31, 2022 this sequence version replaced
            XM_017597455.2, NM_001081444.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.28072.1,
                                           SRR26643285.42995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000010.1  53704703-53704829
            128-224             JAXUCZ010000010.1  53719951-53720047
            225-308             JAXUCZ010000010.1  53725512-53725595
            309-400             JAXUCZ010000010.1  53726228-53726319
            401-469             JAXUCZ010000010.1  53726982-53727050
            470-602             JAXUCZ010000010.1  53728383-53728515
            603-672             JAXUCZ010000010.1  53728686-53728755
            673-856             JAXUCZ010000010.1  53729886-53730069
            857-1019            JAXUCZ010000010.1  53731405-53731567
            1020-1106           JAXUCZ010000010.1  53732454-53732540
            1107-1521           JAXUCZ010000010.1  53733526-53733940
            1522-1612           JAXUCZ010000010.1  53734253-53734343
            1613-1735           JAXUCZ010000010.1  53736008-53736130
            1736-1846           JAXUCZ010000010.1  53739734-53739844
            1847-1934           JAXUCZ010000010.1  53743304-53743391
            1935-2005           JAXUCZ010000010.1  53743689-53743759
            2006-2096           JAXUCZ010000010.1  53744472-53744562
            2097-2215           JAXUCZ010000010.1  53746853-53746971
            2216-2328           JAXUCZ010000010.1  53752704-53752816
            2329-3121           JAXUCZ010000010.1  53753321-53754113
FEATURES             Location/Qualifiers
     source          1..3121
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3121
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /note="phosphoinositide-3-kinase, regulatory subunit 6"
                     /db_xref="GeneID:497932"
                     /db_xref="RGD:1560850"
     exon            1..127
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            128..224
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2482
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /note="p87 phosphoinositide 3-kinase gamma adapter"
                     /codon_start=1
                     /product="phosphoinositide 3-kinase regulatory subunit 6"
                     /protein_id="NP_001074913.2"
                     /db_xref="GeneID:497932"
                     /db_xref="RGD:1560850"
                     /translation="MESSDVELDFQRSVQAVLRELNTPNPALQSNQGMWRWSLHKKME
                     RNPGKSSVLVRILLRELEKAESEDARRVIIPLLLTLMSVLTKATGITEDLYHRAYTFC
                     TRLLTLPAPYSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVD
                     PELVSASVCSALLLEIQAAQEQQTPEACMRHVVSHALQAALGEACHTGALNRKLQASS
                     RRVLEYYFHAVVAAIEQVASEDSPSRLGHLERMEEIYCSLLGTATTRRRCVGDLLQDR
                     LPSIPLPSPYITFHLWTDQEQLWKELVLFLRPRSQLRLSADLDALDLQGFRPDRDLAR
                     VSTDSGIERDLPLGNDELPDPSSSEMERAALQRKGGIKKRVWPPDFFMPGSWDGPPGL
                     HRRTGRPSGDGELLPGVSRVHTARVLVLGDDRMVGRLAQAYYRLRKRETKKFCLTPRL
                     SLQFYYIPVLAPQGTGQDPEASRKPELGELASFLGRVDPWYESTVNTLCPAILKLAEM
                     PPCLDTSRTVDPFILDVITYYVRMGTQPIYFQLYKVKIFTNLSHDPIEDIFLMELKVK
                     TQDSKSPKEGSSPRRRGAAEGTGAELSMCYQKALLSHRPRKVTVSLRATGLVLKAIPA
                     GDTEVSGFSHCTSPNAASAADCSCLHVSVTEVVKTSNLAGRSFTTSTNTFRTSSIQVQ
                     SQDQRLLTLWLDKDGRRTFRDVVRFEAGPCPEPCSRAQKSKMSAFNSHGQETEKSMTK
                     PNSLLMPINTFSGIIQ"
     exon            225..308
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            309..400
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            401..469
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            470..602
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            603..672
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            673..856
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1019
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1106
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1521
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1612
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1735
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1846
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1934
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2005
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2096
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2215
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2328
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..3121
                     /gene="Pik3r6"
                     /gene_synonym="RGD1560850"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtagacagt caggagtaca aggtctcctt ggctcctttg ggacacctgg tccctggggt
       61 tgctggcctt ctggacagga gctcaggagc tcatcgactg aaggatctgg acaggtggac
      121 agctgagaac aatctctgtg tagaaaccac cattctgctt tccactctgc tgcttgagac
      181 aaccacatcc ttcccttaca ggacaggctc catggagagc tcagatgtgg agctggactt
      241 ccagaggagt gtacaggctg tgctgcgaga gctcaacacc ccaaacccag ccctccagag
      301 taatcagggc atgtggagat ggtctctgca caagaagatg gagagaaatc caggaaagag
      361 ctccgttctg gtccgaattc tgctcagaga gctggagaag gcagaaagcg aggacgcacg
      421 gcgtgtcatc atacccttgc tgctcactct aatgtcagtg ctcactaagg cgaccggcat
      481 cacggaagat ctataccata gagcttacac cttctgcacc aggctgctga ccttgccagc
      541 cccctactct acagtcgcct tggactgtgc cataaggctg aaaacagaga cggctgtccc
      601 aggtacgctg tatcagcgga ctgtcattgc ggagcagaac ctgataagtg agctctaccc
      661 ttaccaggag agagtgtttc tgtttgtgga ccccgagctg gtttctgcct ccgtgtgcag
      721 tgccctgctg ctggagatcc aggcagccca agagcagcag acacccgagg cctgcatgcg
      781 ccacgtggtc tcccatgcct tacaggcagc tctgggagaa gcctgtcaca caggtgctct
      841 gaacaggaag ctgcaggcca gctcccgtcg cgtactagaa tactatttcc acgctgtcgt
      901 ggctgccata gagcaggtgg ctagcgagga cagccccagc cggctgggac acctggagag
      961 gatggaggag atttactgct cgctgctagg aactgcgacc acaagaaggc gctgcgtcgg
     1021 tgacctcctc caagaccgac tgccaagcat ccccctgccc agtccctaca tcaccttcca
     1081 cctgtggact gaccaggagc agctctggaa agaactggta ctcttcctcc gcccacgctc
     1141 ccagctccgt ctcagtgctg atctggatgc cttggatcta caaggattta ggccagaccg
     1201 ggacttggcc cgggtgtcca ccgacagtgg aattgaacgg gaccttcctt tggggaacga
     1261 tgagctccca gaccccagca gctctgagat ggagcgagct gcacttcaac gcaagggggg
     1321 catcaagaag cgtgtgtggc cccctgactt cttcatgccc gggagctggg atggaccccc
     1381 agggttgcat cggaggactg gaaggcctag tggggatggg gagctgctac ctggagtctc
     1441 cagagtgcat accgcccgcg tgctcgtgct gggggatgac aggatggtag ggcgcttggc
     1501 ccaggcttac tacagactca ggaaacggga gaccaagaag ttctgcctca ctcctagact
     1561 cagcctacag ttctactaca tccctgtgct ggcacctcag gggactggac aggatccaga
     1621 agcatccagg aaacctgagc tgggagagct ggcttccttc ctgggtcgag ttgacccttg
     1681 gtatgaaagc actgtcaaca ccctgtgtcc tgccatcctc aagcttgctg agatgcctcc
     1741 ctgtttggac acatccagga ccgtggaccc cttcatcctg gatgtcatca cttactatgt
     1801 tcgcatgggc acccaaccca tctatttcca gctctacaag gttaagatct tcaccaactt
     1861 gagtcatgac cctatagagg acattttcct catggagctg aaggtgaaga cccaagattc
     1921 caagtccccc aaagagggct cttcaccccg aaggagaggg gcggctgagg gcacaggagc
     1981 tgaactgtcc atgtgctacc agaaggccct gctcagccac agacccagaa aggtcactgt
     2041 ttctctgcgg gccaccgggc tggtcctgaa ggccattcca gcaggtgaca ctgaagtttc
     2101 agggttctcc cactgtacct caccaaatgc tgcttctgct gcagactgct cctgtctgca
     2161 cgtcagtgtg acagaggtgg tcaagacctc caatctggca ggaaggtcgt tcacgacatc
     2221 gacgaacacc ttccgaacat ccagtatcca agtccagagc caagaccaga ggctgctcac
     2281 actgtggctg gacaaggatg gccggcggac tttcagggat gtggtcagat ttgaggctgg
     2341 tccctgccca gagccatgtt ctcgggccca gaaatccaag atgtcagcgt tcaattcaca
     2401 tgggcaggag acagaaaaga gcatgaccaa acccaattct cttctgatgc ccatcaacac
     2461 attctctggc atcatccagt gagcctgcca ggacagtggg agatctggat ccagggacag
     2521 cagacccaag aaggaaacac tacctaccca cctacaacat tcacacggac agcctcactg
     2581 ggcgtctgtg cttggaccag gagtcagaga atgcctggga actaaaagag cctggattgt
     2641 agtgaataag aggggcaagt gataaagaag gacccatccc aaggctgcca gattgctgga
     2701 cgaagctgga gtgagacgag ctgatgcaat tccagaacca tcttgcttgt gatgatgttc
     2761 atttcccatt tctcatgcac ttcatcatcc acgccggctc cctagggagt cctgagaact
     2821 ggtgacaagc agctgcaggt acagctggcg gttcaccagt agagcacttg cctcgtgtat
     2881 gggaggcctt gggtttgaac ccaggataga aaaggaggtc agagctgatg ggttcaatat
     2941 ctatacagag tcctgtggct gaggaaggaa caggaagtag gtaaggactg ctgattctgc
     3001 ttcctttgag tccgtaccac tctttccagc tcttaggcca cggttcacct gtgctgaggt
     3061 gggtctgtct gtctcagtag agatgagact gatagtatca ataaaggcac actaaagtgt
     3121 t
//
