LOCUS       NM_001401214            4878 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 4
            (Pik3r4), mRNA.
ACCESSION   NM_001401214 XM_006243800
VERSION     NM_001401214.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4878)
  AUTHORS   Pampliega,O., Orhon,I., Patel,B., Sridhar,S., Diaz-Carretero,A.,
            Beau,I., Codogno,P., Satir,B.H., Satir,P. and Cuervo,A.M.
  TITLE     Functional interaction between autophagy and ciliogenesis
  JOURNAL   Nature 502 (7470), 194-200 (2013)
   PUBMED   24089209
REFERENCE   2  (bases 1 to 4878)
  AUTHORS   Kim,J., Kim,Y.C., Fang,C., Russell,R.C., Kim,J.H., Fan,W., Liu,R.,
            Zhong,Q. and Guan,K.L.
  TITLE     Differential regulation of distinct Vps34 complexes by AMPK in
            nutrient stress and autophagy
  JOURNAL   Cell 152 (1-2), 290-303 (2013)
   PUBMED   23332761
REFERENCE   3  (bases 1 to 4878)
  AUTHORS   Sun,Q., Zhang,J., Fan,W., Wong,K.N., Ding,X., Chen,S. and Zhong,Q.
  TITLE     The RUN domain of rubicon is important for hVps34 binding, lipid
            kinase inhibition, and autophagy suppression
  JOURNAL   J Biol Chem 286 (1), 185-191 (2011)
   PUBMED   21062745
REFERENCE   4  (bases 1 to 4878)
  AUTHORS   Thoresen,S.B., Pedersen,N.M., Liestol,K. and Stenmark,H.
  TITLE     A phosphatidylinositol 3-kinase class III sub-complex containing
            VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and
            degradative endocytic traffic
  JOURNAL   Exp Cell Res 316 (20), 3368-3378 (2010)
   PUBMED   20643123
REFERENCE   5  (bases 1 to 4878)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   6  (bases 1 to 4878)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 4878)
  AUTHORS   Stein,M.P., Feng,Y., Cooper,K.L., Welford,A.M. and
            Wandinger-Ness,A.
  TITLE     Human VPS34 and p150 are Rab7 interacting partners
  JOURNAL   Traffic 4 (11), 754-771 (2003)
   PUBMED   14617358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 4, 2022 this sequence version replaced XM_006243800.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168984.1, SRR26360194.1243677.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000008.1  115146687-115147081
            396-1169            JAXUCZ010000008.1  115147868-115148641
            1170-1303           JAXUCZ010000008.1  115152264-115152397
            1304-1886           JAXUCZ010000008.1  115155158-115155740
            1887-2021           JAXUCZ010000008.1  115158641-115158775
            2022-2243           JAXUCZ010000008.1  115160093-115160314
            2244-2417           JAXUCZ010000008.1  115164454-115164627
            2418-2563           JAXUCZ010000008.1  115168003-115168148
            2564-2767           JAXUCZ010000008.1  115169740-115169943
            2768-2969           JAXUCZ010000008.1  115174285-115174486
            2970-3157           JAXUCZ010000008.1  115175849-115176036
            3158-3368           JAXUCZ010000008.1  115176563-115176773
            3369-3534           JAXUCZ010000008.1  115179382-115179547
            3535-3699           JAXUCZ010000008.1  115183964-115184128
            3700-3911           JAXUCZ010000008.1  115186012-115186223
            3912-4043           JAXUCZ010000008.1  115189801-115189932
            4044-4144           JAXUCZ010000008.1  115192668-115192768
            4145-4233           JAXUCZ010000008.1  115193779-115193867
            4234-4342           JAXUCZ010000008.1  115193990-115194098
            4343-4878           JAXUCZ010000008.1  115194791-115195326
FEATURES             Location/Qualifiers
     source          1..4878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4878
                     /gene="Pik3r4"
                     /note="phosphoinositide-3-kinase, regulatory subunit 4"
                     /db_xref="GeneID:363131"
                     /db_xref="RGD:1311809"
     exon            1..395
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            396..1169
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..4513
                     /gene="Pik3r4"
                     /EC_number="2.7.11.1"
                     /note="PI3-kinase regulatory subunit 4;
                     phosphoinositide-3-kinase, regulatory subunit 4, p150"
                     /codon_start=1
                     /product="phosphoinositide 3-kinase regulatory subunit 4"
                     /protein_id="NP_001388143.1"
                     /db_xref="GeneID:363131"
                     /db_xref="RGD:1311809"
                     /translation="MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAK
                     HREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCLPFQKAAEKASEKAAMLF
                     RQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWN
                     WVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDP
                     STPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQ
                     VLNKIEDRSIRELVTQMIQREPGQRLEADDYLKQQRGNAFPEVFYTFLQPYMAQFAKE
                     TFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGESKASGLVVLVSVITSCLQTLKSC
                     DSKLAALELILHLAPRLSVEILLDRITPYLLHFSNNSVPRVRAEALRTLTKVLALVQE
                     VPRNDVNIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKTLNME
                     NEPDSEEVDEATRPNGDYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCV
                     FFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGL
                     SDAEEFVIVKALNALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVV
                     AHQISTADVYCKLMPYLDPYITQPVIQIERKLVLLSVLKEPVSRSIFDYALRSKDIAS
                     LFRHLHMRQKKRNGSLLDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSN
                     RAKANAVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDEKRARKHVKQDSNVN
                     EEWKSMFGSLEPPNIPQALPKTSDHEVVPTGKSPRSESSAGVCVPLSTSPQVSEAAHI
                     PSKKPVIPVVSSTVLPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWES
                     KPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHLLFATCSNDGTVKIWNSQKMEGKTT
                     TTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSR
                     ILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITS
                     FAVDIHQCWLCIGTSSGAMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAV
                     QGNNEVSMWDMETGDRRLTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSD
                     MKIRFWDLVSPERSYVVAGSTGSPSVSYYKKIIEGTEVVQEIQNKQKVGPSDDTPRRG
                     PESLPVGHHDIITDIATFQTTQGFIVTASRDGIVKVWK"
     exon            1170..1303
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1886
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2021
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2243
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2417
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2563
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2767
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2969
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3157
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3368
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3534
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3699
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3911
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4043
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4144
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4233
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            4234..4342
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4878
                     /gene="Pik3r4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcggct ttcccgggag ttcagcgttc gccgcaggtg aagtagtctt cctggacggg
       61 tgctggcact gtcccccgtc cagggctggc gcaaaggccc ggggatccgg ggactcgaac
      121 acgcgcgggc ccagggcggc aggggaggag cctcaggcga ggctgctggt tgtccggagt
      181 cccgagtatg cttgctctcc cagttgttca cccccagctc tagatttcgg acatttctgc
      241 gctcctcccc caacgacccc aggtcctctg tctgaaagga agacccctca cagaaaacac
      301 tctcctcgcc gacttctgtt cacgcccaag cccctcagct ctgccaagac ctccctggga
      361 tctttcagcg acttttgagt tgccagaggc ctggggtatt gtgtgttaac ctgccaaccc
      421 aggggtgccc atcattatgg gaaaccaact agctggtatt gctccttccc agatcctgtc
      481 cgtagagagc tacttctcag acatccatga ctttgaatat gataagagtc tgggaagtac
      541 tcggtttttt aaagttgctc gagcgaagca ccgggagggc ctggtggttg tgaaggtctt
      601 tgcaatccag gatcccacgt tgcctttaac tagttataaa caggagctgg aggaactgaa
      661 aatcaggctc cattcggccc agaactgctt acctttccag aaagcagcag aaaaagcatc
      721 ggagaaagcg gccatgctgt tcaggcagta cgtgagggac aacctctacg accgtatcag
      781 tacccgtccc ttcttaaata acatcgagaa gcgctggatc gccttccaga tcctgacagc
      841 tgtggaccaa gcacacaagt ctggagtccg ccacggtgac atcaagacag agaacgtgat
      901 ggtcaccagt tggaactggg ttctcctcac tgattttgcc agttttaagc ccacttatct
      961 tccagaggac aacccagcag atttcaacta tttctttgac acctcgagga ggaggacttg
     1021 ctacatcgcc cctgagcgtt tcgtggatgg cggtatgttc gccaccgagt tagaatacat
     1081 gagagatccc tcaactcctc ttgtcgacct aaatagcaat cagagaacac ggggagagtt
     1141 gaagagggcc atggacatct tttcagcagg ttgcgtgata gccgagctct tcacggaagg
     1201 cgtgccgttg ttcgatctct cacaactgtt ggcatacaga aatggacatt ttttccctga
     1261 gcaagtgcta aataaaatcg aagatcgcag tatcagagaa ttggtaactc agatgatcca
     1321 gcgggagccg ggacagcgtt tggaagctga cgactacctg aagcagcagc gtggcaatgc
     1381 tttccccgag gtattctata ctttccttca gccgtacatg gctcagttcg ccaaggagac
     1441 ctttctctct gcagatgagc ggattttggt tatacggaaa gacttgggca atatcattca
     1501 caacctctgt ggacatgact tgccagagaa agcagaaggg gagtccaagg ctagcgggct
     1561 ggttgtcctg gtgtcagtga taacgtcctg cctgcagaca ctgaagtcct gcgactccaa
     1621 actggctgcc ttggagctca ttctgcattt ggccccgagg ctgagcgtag agatccttct
     1681 ggatcgcatc accccctact tgttgcattt cagcaacaac tctgttcctc gagtgcgggc
     1741 tgaagccctg aggacactca ccaaagtcct tgcccttgtc caagaagttc ctcgcaatga
     1801 tgtcaatatc tacccagagt acattctccc cggcatagct cacctggccc aggacgacgc
     1861 caccatcgtc agactggcct acgctgaaaa catagctctg ttggccgaga cggctctgcg
     1921 attcctggaa ctagtgcagc taaaaactct caacatggag aacgagccgg acagtgaaga
     1981 ggtagatgaa gccacgcgtc ctaacggaga ctatgacaca gagctccagg ccctacacga
     2041 aatggtccag cagaaggttg tcactttgtt aagtgaccct gagaatattg tgaaacagac
     2101 attgatggag aatgggatca cacgcttgtg cgtcttcttt ggacggcaga aagccaacga
     2161 cgttctcttg tcccacatga tcacgttcct gaatgataag aatgactggc acctgcgtgg
     2221 agctttcttc gatagcatag tcggtgtggc tgcctatgtt ggctggcaga gctcctccat
     2281 cctcaagccc ctgctccagc aaggcctcag cgatgccgag gagttcgtca ttgtgaaagc
     2341 tctcaatgcc ctgacctgta tgtgccagtt agggctgctg cagaaacctc atgtctatga
     2401 attcgccagt gatattgctc ccttcctgtg tcaccctaat ctgtggatac gctatggtgc
     2461 cgtgggattc atcaccgtgg tagctcatca gatcagcact gctgacgtct actgcaagct
     2521 catgccgtat cttgacccgt atattacaca accagtaata cagattgaaa ggaagcttgt
     2581 cttgcttagc gttctaaaag agccggtgag tcgctctata tttgattatg ctctgaggtc
     2641 caaagacatc gctagcttgt tcagacatct tcacatgcgt cagaagaagc ggaatggctc
     2701 tcttcttgac tgccctccgc ccgaggaccc tgccatagca cagcttctga agaaactgct
     2761 ctcccagggg atgaccgaag aagaggaaga taaacttctg gctctgaagg acttcatgat
     2821 gaaatcaaat cgagcaaaag ctaatgcagt agaccagagc cacctgcatg acagcagcca
     2881 gaaaggtgta attgacttgg cagccttggg catcactggg agacaagttg accttgttaa
     2941 aaccaagcaa gagcccgatg agaaacgggc taggaagcat gtgaaacaag actccaatgt
     3001 aaatgaagaa tggaaaagca tgtttgggtc actggaacca ccgaatatcc cacaggccct
     3061 gcctaaaacc agtgaccatg aggtggttcc aacggggaag tcacctcgct ctgagtcctc
     3121 tgctggtgtc tgtgtccctt tgtcaacctc tccacaggtt tccgaagcag cacacatccc
     3181 cagtaagaag ccggtgattc cggttgtaag tagcacggtc ctgccatcca cttaccagat
     3241 ccggatcacc acttgcaaga ctgaacttca gcagctcata caacagaagc gtgagcagtg
     3301 taacgcagag cgcatagcca agcagatgat ggagaacgcc gagtgggaga gcaagccacc
     3361 tccacctggg tggcgtccta aagggctcct agttgcacat cttcatgagc acaaatctgc
     3421 tgtaaatcga atcagagtct ccgatgaaca cttactcttt gcaacgtgct caaatgatgg
     3481 tacagtgaaa atctggaaca gtcagaagat ggaggggaag accactacga cgaggtctat
     3541 tctgacatac agccgaattg gagggcgagt caagacacta acattttgcc aaggctccca
     3601 ctacttggcc atagcatctg ataatggtgc tgtccagctt cttggaattg aggcttctaa
     3661 gttacccaag tctcctaaaa tccaccctct acaaagcagg attctggatc agaaggaaga
     3721 cggatgtgtg gtggacatgc atcacttcaa ctcgggggca cagtctgttc ttgcctatgc
     3781 cacagtgaat ggctctctgg ttggatggga tctcaggtca tcaagcaacg catggacatt
     3841 aaagcatgac ctgaagtcag gcctcatcac ctcctttgct gtggacatcc accagtgctg
     3901 gctgtgcata ggcacgagca gcggggccat ggcgtgttgg gacatgaggt tccagttgcc
     3961 aatttccagt cactgtcatc cctccagagc tcgtatccgg cgcctctcca tgcacccctt
     4021 gtaccagtcc tgggtaattg cagctgttca gggcaacaat gaagtctcca tgtgggacat
     4081 ggagaccgga gacaggagac tgactctctg ggctagcagt gcgcctcccc tgtctgagtt
     4141 acagccctca ccgcacagcg tccatggcat ctactgcagc cctgcggatg gcaaccctat
     4201 cctgctgacc gctggctcag acatgaaaat aaggttctgg gacttggttt ccccagagag
     4261 gtcctatgtt gtagcgggaa gcacgggttc cccgtctgta tcctactaca agaagataat
     4321 agaaggcacg gaggttgtcc aggaaattca gaataagcag aaggttggac caagtgatga
     4381 cacccctcga aggggcccgg agtctctgcc tgtgggacat catgacatca tcacagatat
     4441 tgccaccttc cagaccactc agggcttcat tgtgactgct tctagagatg ggattgtgaa
     4501 ggtgtggaaa taaatcctgc tgacttgtat aaaatgctgt aaaattagaa atgtaccata
     4561 attcaagaca aaaggatttc tagagaagaa acgtcatttt tgaagtgtct gtattactgt
     4621 ttcatggctg aaccagtccc agccacagtg ggtaaggatg tgggcttggt gattttcttc
     4681 atgtacatct ctgaagagtt ggccagatag cagaacctgg gagtgcctgc tgtatatgga
     4741 acagaacagg tgagaagtgt aaaaaggaaa gaggatatga tgccagctta ttttatatgg
     4801 aaatgattgt aagtcactat gtaaacactt ttgttgttat aaatgctatt caaaccgcaa
     4861 gtaaactcta ttcaagca
//
