LOCUS       NM_022213               4732 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase regulatory subunit 3
            (Pik3r3), mRNA.
ACCESSION   NM_022213
VERSION     NM_022213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4732)
  AUTHORS   Luo,C., Wang,F., Ren,X., Ke,T., Xu,C., Tang,B., Qin,S., Yao,Y.,
            Chen,Q. and Wang,Q.K.
  TITLE     Identification of a molecular signaling gene-gene regulatory
            network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for
            coronary artery disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (6), 1640-1653 (2017)
   PUBMED   28341552
REFERENCE   2  (bases 1 to 4732)
  AUTHORS   Zhu,Y., Zhao,H., Rao,M. and Xu,S.
  TITLE     MicroRNA-365 inhibits proliferation, migration and invasion of
            glioma by targeting PIK3R3
  JOURNAL   Oncol Rep 37 (4), 2185-2192 (2017)
   PUBMED   28260020
REFERENCE   3  (bases 1 to 4732)
  AUTHORS   Zhang,C.L., Zeng,T., Zhao,X.L. and Xie,K.Q.
  TITLE     Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma
            in Rats by Inhibiting PI3K-AKT-NF-kappaB Pathway
  JOURNAL   Int J Biol Sci 11 (6), 643-651 (2015)
   PUBMED   25999787
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4732)
  AUTHORS   Li,G., Xie,N., Yao,Y., Zhang,Y., Guo,J., Feng,Y., Lv,F., Xiao,R.P.
            and Cao,C.M.
  TITLE     Identification of PI3K regulatory subunit p55gamma as a novel
            inhibitor of vascular smooth muscle cell proliferation and
            neointimal formation
  JOURNAL   Cardiovasc Res 105 (1), 75-85 (2015)
   PUBMED   25388664
  REMARK    GeneRIF: Western blot and mRNA analyses showed that p55gamma
            expression declined in balloon-injured carotid arteries.
REFERENCE   5  (bases 1 to 4732)
  AUTHORS   Wang,G., Yang,X., Li,C., Cao,X., Luo,X. and Hu,J.
  TITLE     PIK3R3 induces epithelial-to-mesenchymal transition and promotes
            metastasis in colorectal cancer
  JOURNAL   Mol Cancer Ther 13 (7), 1837-1847 (2014)
   PUBMED   24837077
REFERENCE   6  (bases 1 to 4732)
  AUTHORS   Nowakowska-Zajdel,E., Mazurek,U., Ziolko,E., Niedworok,E.,
            Fatyga,E., Kokot,T. and Muc-Wierzgon,M.
  TITLE     Analysis of expression profile of gene encoding proteins of signal
            cascades activated by insulin-like growth factors in colorectal
            cancer
  JOURNAL   Int J Immunopathol Pharmacol 24 (3), 781-787 (2011)
   PUBMED   21978709
REFERENCE   7  (bases 1 to 4732)
  AUTHORS   Mehlitz,A., Banhart,S., Maurer,A.P., Kaushansky,A., Gordus,A.G.,
            Zielecki,J., Macbeath,G. and Meyer,T.F.
  TITLE     Tarp regulates early Chlamydia-induced host cell survival through
            interactions with the human adaptor protein SHC1
  JOURNAL   J Cell Biol 190 (1), 143-157 (2010)
   PUBMED   20624904
REFERENCE   8  (bases 1 to 4732)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   9  (bases 1 to 4732)
  AUTHORS   Inukai,K., Anai,M., Van Breda,E., Hosaka,T., Katagiri,H.,
            Funaki,M., Fukushima,Y., Ogihara,T., Yazaki,Y., Kikuchi, Oka,Y. and
            Asano,T.
  TITLE     A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase
            structurally similar to p55PIK Is generated by alternative splicing
            of the p85alpha gene
  JOURNAL   J Biol Chem 271 (10), 5317-5320 (1996)
   PUBMED   8621382
REFERENCE   10 (bases 1 to 4732)
  AUTHORS   Pons,S., Asano,T., Glasheen,E., Miralpeix,M., Zhang,Y.,
            Fisher,T.L., Myers,M.G. Jr., Sun,X.J. and White,M.F.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_022213.3.
            
            On Nov 30, 2020 this sequence version replaced NM_022213.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2987497.1,
                                           SRR26360172.194841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000005.1  134938606-134938715
            111-219             JAXUCZ010000005.1  134968991-134969099
            220-318             JAXUCZ010000005.1  134972093-134972191
            319-499             JAXUCZ010000005.1  134983537-134983717
            500-625             JAXUCZ010000005.1  134985202-134985327
            626-768             JAXUCZ010000005.1  134994956-134995098
            769-945             JAXUCZ010000005.1  134995847-134996023
            946-1020            JAXUCZ010000005.1  134999064-134999138
            1021-1191           JAXUCZ010000005.1  134999488-134999658
            1192-4732           JAXUCZ010000005.1  135005763-135009303
FEATURES             Location/Qualifiers
     source          1..4732
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..4732
                     /gene="Pik3r3"
                     /note="phosphoinositide-3-kinase regulatory subunit 3"
                     /db_xref="GeneID:60664"
                     /db_xref="RGD:621042"
     exon            1..110
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1390
                     /gene="Pik3r3"
                     /note="p55PIK; ptdIns-3-kinase p85-gamma; PI3-kinase p85
                     subunit gamma; PI3-kinase subunit p55-gamma; PI3K
                     regulatory subunit gamma; phosphoinositide-3-kinase,
                     regulatory subunit 3 (gamma); PI3-kinase regulatory
                     subunit gamma; ptdIns-3-kinase regulatory subunit gamma;
                     ptdIns-3-kinase regulatory subunit p55-gamma;
                     phosphatidylinositol 3-kinase 55 kDa regulatory subunit
                     gamma; phosphatidylinositol 3 kinase, regulatory subunit,
                     polypeptide 3 (p55); phosphatidylinositol 3-kinase p55
                     subunit"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     gamma"
                     /protein_id="NP_071549.2"
                     /db_xref="GeneID:60664"
                     /db_xref="RGD:621042"
                     /translation="MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKP
                     VTSAVTNGMKDCFVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTL
                     TLRKGGNNKLIKIYHRDGKYGFSEPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPV
                     SRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEA
                     FNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVR
                     LEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKS
                     EDTDGGYFINEDDESLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYA
                     CSVVADGEVKHCVIYSTARGYGFAEPYNLYGSLKELVLHYQQTSLVQHNDSLNVTLAY
                     PVHAQMPSLCR"
     exon            111..219
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            220..318
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            319..499
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..625
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..768
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..945
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1020
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1191
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..4732
                     /gene="Pik3r3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgatgtac aatacggtgt ggagtatgga ccgcgatgac gcagactgga gggaggtgat
       61 gatgccctat tcgacagaac tgatatttta tattgaaatg gatcctccag ctcttccacc
      121 aaagccacct aagccagtga cgtcagcagt tacaaacgga atgaaggact gtttcgtttc
      181 tcttcaagat gcagagtggt actggggaga catttccagg gaagaggtaa atgacaaatt
      241 gcgggacatg ccagacggta ctttcttagt tcgagatgcc tcaacaaaaa tgcagggaga
      301 ctatacactg actttgagga agggaggaaa taataaatta ataaagatct atcatcggga
      361 tggtaaatat ggcttttctg agcccctgac gtttaattct gtggtggagc tcattaacca
      421 ctatcaccat gaatctctcg ctcagtacaa tcccaaactt gatgtgaagc tgatgtaccc
      481 agtgtccaga taccaacagg atcagttggt aaaagaagat aacattgatg cggtaggtaa
      541 aaacctgcaa gaattccact ctcagtacca ggagaagagt aaagagtacg ataggctgta
      601 tgaagagtac accaggacgt cacaggaaat acaaatgaag agaactgcca ttgaagcctt
      661 taatgaaacg attaaaatat ttgaggagca gtgtcatacc caagaacaac acagtaaaga
      721 ctatattgag cggtttcgca gagaggggaa tgagaaggag attgagcgga ttatgatgaa
      781 ttacgataaa ttgaaatccc gtctgggtga gattcacgat agcaaagtgc gtcttgagca
      841 ggacttgaag aaacaagctt tggacaaccg ggaaatagat aaaaaaatga atagcatcaa
      901 gcctgacctg atccagctgc gtaagatccg agaccagcac ctcgtatggc tcaatcacag
      961 gggagtgagg cagaggcgcc tgaacgcctg gctggggatc aagagtgagg acacagatgg
     1021 aggctatttt atcaatgagg acgatgagag cctgccgcat tatgatgaga agacctggtt
     1081 tgtggaggat gtgaaccgag tacaggcaga ggacctgctt tatgggaagc cagacggtgc
     1141 attcttaatt cgtgagagta gcaagaaagg atgttacgct tgttctgtgg ttgcagacgg
     1201 ggaggtgaag cactgtgtca tctacagcac tgctcgagga tatggctttg cagaacccta
     1261 caacctgtac ggctcgctga aggagctggt gctccactac cagcagacat ccctggtcca
     1321 gcacaacgac tccctcaacg tcacgctcgc ctaccctgtc cacgcacaga tgccctctct
     1381 ctgcagataa gcagagtgga agagacatgc tctccagcag ttctttccta tggtttttat
     1441 tagactacga tgagggcact ctttcgacgt agactgcctg ttttgcacaa gtgattctgt
     1501 gaatgtgaag tggagaggcc aagcagtagc ttggatttgg ggagaaatga ggcccgggtc
     1561 tctggcctcg gcgtgctgct gcactgatgg actaagctgg aagcagttat tggtttcatg
     1621 gggttcggtt ttgttgtcag gcacctttga aagaagttag acttgtgggt cggcgtgggg
     1681 tttatgtgga agcctctgaa gagtccgtgt ctccttgtcc tcaacttgga gaacgcagca
     1741 gattgtagtt ctgctggcag ttgtttcgct tccacagtct ctccccttcc cccgaataag
     1801 gagccgattt ggctctgtgg taaaatggga tttggtttgg gagggaaaac aaccaaagga
     1861 aaatagggag gtgtgggatt acatttacag aatctaaacc aaggaggcaa aagacccctt
     1921 cagttgatgt tacttcaatt tcaccaacgt aatttaggct tcagcatctt aaccagctcc
     1981 tccctctaaa gcactgtgtt tataagccaa caaggcagca ctgcagacca aggctatggg
     2041 aggacagtag tagctgaatg gacactgtac caaaacttga aagaaactag aaatgtgagt
     2101 ttgaacaaac actacaattg gtcagtgtgt ttccctctgc cctggcctcc tctctcagat
     2161 gaggaataga atattttgtg gagatagtaa gctgtgagtc atgaaaagtt ggtgctcgtg
     2221 tggtgtttct ttagactaaa gatgtttgaa accctcgtaa gttgttttat gagtcaagaa
     2281 aaggtgcaat ccagtgcttt tagatggctt gatataccaa ataatgatcg agaacagcat
     2341 tgttgcgtgc gtcctcaagt ttaaagcctt gccaaactat tcaagggtta atttgccttc
     2401 atttcccttc cttctctgga tagggtttag ggagctatag ttagctaaag gaggactcac
     2461 gtttgtggtc agagacctca gtaaatcaca tgggcccgtc acattacatg ttattccata
     2521 ctgtgggtga agcttttgcc agaagaaggg atcgcttagc gtggagttca gactatctgg
     2581 gaaaataatc cacaagcttt cctatttgcc ctttttgtga gcctgcggtt aaggcagtgt
     2641 gcatagcctg cccagcctgc cctcaggctt ccatggctgg gattttaggc catgagtctg
     2701 ctccatgtgg tttaagcctt ccagctaagt gaagttagac agaggagagg gcaggcatct
     2761 gtttctggct tcatagtcat ttaagagtcc agctgcgcca gagtcaatcc tggagccata
     2821 acaggctcag tatgactcag ttgcttgagc ccagagattt gcagtcaggc actctagata
     2881 tgcagcctgt acctgggtct tggctcataa ggcttacaat cagggaagtt ggagtttggg
     2941 ggccaaaata aagacgaata tgactttccc tgagcacttc ctttggtgac agtgtctaga
     3001 atgaacaacc gtatagagat aggtcaaaag ctttgggtaa tggttgtcac aggtgagggt
     3061 agggtatgct attgcttttc ttgttcatgc tccagtatga aatgagagga aatcgggggt
     3121 tggggattta gctcagtggt agagcgcttg cctaggaagc gcaaggccct gggttcggtc
     3181 cccagctccg gaaaaaaaaa aaaaaagaaa aaaaaaaaaa aagaaatgag aggaaatcga
     3241 ccaccctcag ctgctgttta aggcccagta tttttcaaaa tagccagctt gaaatcttgc
     3301 tcagtttacc aagtaatgcc aggctacttg ttgattggta tacctatgtg gcgctgtact
     3361 gacgttggac ttgctgaagc ggttatatgc tcaaaattag gtgggaggaa tccctctggt
     3421 ccagcactaa aattttagta tgtcctgatg ctgttttttt ttttttttaa atctcttcca
     3481 agtaagtcag aatggaagaa tacacagctt tagtgttgaa caatgtcctt actttgcagg
     3541 cagacgtgga agacgttcag gagaaagcat cttagctcca tacccagact ggactgtgga
     3601 gaacggctgt ttttcagtcc tacattcctt tcctttgaac gctttttgag atctgagact
     3661 agggatcatt taattaattg gaagctatcc ttttctgaca agttgcttca tgatttatct
     3721 gaccctgagc tgtggaagtg gcataaagac cagtttccta accgtggcct tggtgtctga
     3781 gggagccatc atggctcgga agcacatctt ggtcttcttc ccagagctca aagttttgtc
     3841 ccatgatcca ggtcctggga ctgtctcctt tggcatccta gctgtagtct cactgactaa
     3901 agcagagggt agagacagag caaaccgtag ggcacgccag ccagctcccc agcagggaag
     3961 cagcttgggc ttggtgagat acattttttt tttttaaaaa ataaaaacaa aacaaggctg
     4021 tttgcacccg acacagttca agcataggta ggtatttacg ttctcattgc tgctccagga
     4081 tagaagacat cctgtagctc cactcctaag acatacaatc tccacattca cttgagactc
     4141 cttaagccag tgtggggtct cccttgtgtg ccttctctgc aaggtaccag ctccacccat
     4201 tctcttcaac ttaaaaagaa atgtatctga gcaggctctg atttctagga tgatctctac
     4261 tgccaggtag atctttgtga ggtttccatg gcatcataga ccgggggtcc attcttggtc
     4321 ctttgctgcc aactgctcac tcttgactta gctctagcca tttgtgacaa ccacccttgt
     4381 ttccttacaa atcctcgcat gtaaccttgg tactcctgtt gtttcttgtg aagaatctat
     4441 tctgttgtct ttgatgtaat aaaaaaaatc catgtagttt atgtaaaaat aactgactca
     4501 gaaggaagcc aactgtgtct tgtgttggaa caattcataa tgtaatttct agaccacttt
     4561 tgcaaattgt tcttgtcacc aaatgtgttc agacattgct gtgcagttgt ggggaagggg
     4621 tggggggggg aaggtaagat gagaagattg ttgggctttt tttttaaacc ttctccaaat
     4681 gtggaatggt ctggccaact tgctccggat gcaataaaga caatgcagtg aa
//
