LOCUS       NM_022185               3137 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase regulatory subunit 2
            (Pik3r2), mRNA.
ACCESSION   NM_022185 XM_346488
VERSION     NM_022185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Ge,J., Jiao,X. and Li,H.
  TITLE     MicroRNA-126-3P targets PIK3R2 to ameliorate autophagy and
            apoptosis of cortex in hypoxia-reoxygenation treated neonatal rats
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 210-217 (2023)
   PUBMED   38063094
  REMARK    GeneRIF: MicroRNA-126-3P targets PIK3R2 to ameliorate autophagy and
            apoptosis of cortex in hypoxia-reoxygenation treated neonatal rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Wang,H., Chen,F.S., Zhang,Z.L., Zhou,H.X., Ma,H. and Li,X.Q.
  TITLE     MiR-126-3p-Enriched Extracellular Vesicles from
            Hypoxia-Preconditioned VSC 4.1 Neurons Attenuate
            Ischaemia-Reperfusion-Induced Pain Hypersensitivity by Regulating
            the PIK3R2-Mediated Pathway
  JOURNAL   Mol Neurobiol 58 (2), 821-834 (2021)
   PUBMED   33029740
  REMARK    GeneRIF: MiR-126-3p-Enriched Extracellular Vesicles from
            Hypoxia-Preconditioned VSC 4.1 Neurons Attenuate
            Ischaemia-Reperfusion-Induced Pain Hypersensitivity by Regulating
            the PIK3R2-Mediated Pathway.
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Xi,T., Jin,F., Zhu,Y., Wang,J., Tang,L., Wang,Y., Liebeskind,D.S.
            and He,Z.
  TITLE     MicroRNA-126-3p attenuates blood-brain barrier disruption, cerebral
            edema and neuronal injury following intracerebral hemorrhage by
            regulating PIK3R2 and Akt
  JOURNAL   Biochem Biophys Res Commun 494 (1-2), 144-151 (2017)
   PUBMED   29042193
  REMARK    GeneRIF: in vitro assays confirmed upregulation of PIK3R2 upon
            knockdown of miR-126-3p in brain microvascular endothelial cells
            (BMECs), and silencing of miR-126-3p resulted in impaired BMEC
            barrier permeability and reversed vascular endothelial growth
            factor- and angiopoietin-1-induced activation of Akt and inhibition
            of BMEC apoptosis
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Song,L., Xie,X., Yu,S., Peng,F. and Peng,L.
  TITLE     MicroRNA-126 inhibits proliferation and metastasis by targeting
            pik3r2 in prostate cancer
  JOURNAL   Mol Med Rep 13 (2), 1204-1210 (2016)
   PUBMED   26677064
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Zhang,C.L., Zeng,T., Zhao,X.L. and Xie,K.Q.
  TITLE     Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma
            in Rats by Inhibiting PI3K-AKT-NF-kappaB Pathway
  JOURNAL   Int J Biol Sci 11 (6), 643-651 (2015)
   PUBMED   25999787
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Huynh,H., Alpert,L., Alaoui-Jamali,M.A., Ng,C.Y. and Chan,T.W.
  TITLE     Co-administration of finasteride and the pure anti-oestrogen ICI
            182,780 act synergistically in modulating the IGF system in rat
            prostate
  JOURNAL   J Endocrinol 171 (1), 109-118 (2001)
   PUBMED   11572795
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Kessler,A., Uphues,I., Ouwens,D.M., Till,M. and Eckel,J.
  TITLE     Diversification of cardiac insulin signaling involves the p85
            alpha/beta subunits of phosphatidylinositol 3-kinase
  JOURNAL   Am J Physiol Endocrinol Metab 280 (1), E65-E74 (2001)
   PUBMED   11120660
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Lan,Z., Wu,H., Li,W., Wu,S., Lu,L., Xu,M. and Dai,W.
  TITLE     Transforming activity of receptor tyrosine kinase tyro3 is
            mediated, at least in part, by the PI3 kinase-signaling pathway
  JOURNAL   Blood 95 (2), 633-638 (2000)
   PUBMED   10627473
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   Kasus-Jacobi,A., Perdereau,D., Auzan,C., Clauser,E., Van
            Obberghen,E., Mauvais-Jarvis,F., Girard,J. and Burnol,A.F.
  TITLE     Identification of the rat adapter Grb14 as an inhibitor of insulin
            actions
  JOURNAL   J Biol Chem 273 (40), 26026-26035 (1998)
   PUBMED   9748281
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Inukai,K., Anai,M., Van Breda,E., Hosaka,T., Katagiri,H.,
            Funaki,M., Fukushima,Y., Ogihara,T., Yazaki,Y., Kikuchi, Oka,Y. and
            Asano,T.
  TITLE     A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase
            structurally similar to p55PIK Is generated by alternative splicing
            of the p85alpha gene
  JOURNAL   J Biol Chem 271 (10), 5317-5320 (1996)
   PUBMED   8621382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089805.1.
            
            On Feb 13, 2005 this sequence version replaced NM_022185.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089805.1, SRR8487230.124175.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3137
                     /gene="Pik3r2"
                     /note="phosphoinositide-3-kinase regulatory subunit 2"
                     /db_xref="GeneID:29741"
                     /db_xref="RGD:68341"
     exon            1..40
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            41..762
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..2609
                     /gene="Pik3r2"
                     /note="ptdIns-3-kinase p85-beta; PI3-kinase p85 subunit
                     beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit
                     beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase
                     regulatory subunit beta; ptdIns-3-kinase regulatory
                     subunit p85-beta; phosphatidylinositol 3-kinase 85 kDa
                     regulatory subunit beta; phosphatidylinositol 3-kinase,
                     regulatory subunit, polypeptide 2 (p85 beta);
                     phosphatidylinositol 3-kinase, regulartory subunit,
                     polypeptide 2; phosphoinositide-3-kinase, regulatory
                     subunit 2 (beta)"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     beta"
                     /protein_id="NP_071521.2"
                     /db_xref="GeneID:29741"
                     /db_xref="RGD:68341"
                     /translation="MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVA
                     DGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLD
                     GPSESGHTLASLAEQFSPPEPAPPILVKLIEAIEQAELDSECYSRPELPAPRTDWSLS
                     DLEQWDRTTLYDAVKGFLLALPAAVVTPEAASEAYRAMREVTGPVGLVLEPPTLPLHQ
                     ALTLQFLLQHLGRVARRAPSPATAVHALASAFGPLLLRAPPPGGEGDGSEPAPDFPVL
                     LLERLVQEHVDEQDTAPPALPPKPSKVKPAPTALANGGSTPSLQDAEWYWGDISREEV
                     NERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSV
                     VELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQVVKEDSVEAVGAQLKVYHQQYQDK
                     SREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGN
                     EKEMQRILLNSERLKSRIAEIHESRTKLEQDLRAQASDNREIDKRMNSLKPDLMQLRK
                     IRDQYLVWLTQKGARQRKINEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRT
                     QAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGS
                     LKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR"
     exon            763..855
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..906
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1038
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1237
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1323
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1432
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1531
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1712
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1838
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1981
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2158
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2230
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2401
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..3111
                     /gene="Pik3r2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcggcgg tcgtggtggc gacgacggcg gccggagtgg gctggtatcc ccctgctgag
       61 catggtagca gcctgtggtc tcagttatcc catctggtgt caggcacacc ttgaagagcc
      121 agcaagcttg ggcacctaca gcccagctaa tgacggagtg acccacctac cccagcttgg
      181 ccatctgatg ggggacacaa gccaaatgat ttgagaaaac accagggaca tcatcatcgc
      241 acaggtgact aaatggtgga ctctgtgaca agtggctttc agtaatggcc agctaggcat
      301 gtgcggcccc tgaggtcgcc tttgacttct ggaagtagag gtctgcaagc ctaccacaca
      361 ggccacacca gcccatgggg cccctggagc ccccgggagc cacctgactg tccagacccc
      421 cccacccccc gggcccagcc atggcaggtg ctgaaggctt ccagtacagg gctgtatacc
      481 cattccgccg ggagcggcct gaggacctgg agcttcttcc tggtgacctc ctggtggtga
      541 gccgggtggc tctgcaggca ctaggtgtgg ctgatggagg agagcgctgc ccacacaacg
      601 tgggctggat gcctggcttc aatgagcgca cccgacagcg aggggacttc cctggaacat
      661 atgtggagtt cctaggacct gtggctctgg ctcgaccagg ccctcgccca cgggggcccc
      721 gtccgttgcc tgccaggccc ttggatggac cttctgagtc aggtcacaca ctggcaagcc
      781 tggcagagca gttctcccca cctgagcctg cgcccccgat tctggtgaag ctgatagaag
      841 ccattgagca agcagagctg gacagtgaat gctacagtag gccggagctg cccgcaccac
      901 ggacagactg gtccctgagt gacttggagc agtgggaccg caccaccttg tacgatgctg
      961 ttaagggctt cctgctggca ttgcctgcag ctgtggtgac tcctgaggct gcatcggagg
     1021 cttatcgggc gatgcgggag gttacggggc ctgtggggct ggtgctggaa cccccaacgc
     1081 tgccgttgca ccaggccctc actctgcagt tcctgctgca gcacctgggc cgcgtggccc
     1141 gcagagcacc ctcaccagct acagctgtcc acgcactggc cagtgccttc gggccgctgc
     1201 tgctgcgtgc gcctccgcca gggggcgagg gtgatgggag tgagcctgca cctgacttcc
     1261 ctgtgctgct tctagagagg ctggtgcagg agcatgtgga tgagcaagac accgccccgc
     1321 cagcactgcc acccaaaccc tctaaggtaa agccggcacc cacagccctg gccaatggag
     1381 ggagtacacc ctcgcttcag gatgcagagt ggtactgggg ggacatttcc agggaagagg
     1441 tgaatgagag gctccgagac acacctgatg gtaccttctt agtccgagat gcatccagca
     1501 agatccaagg agagtacacg ctcaccctca ggaaaggcgg gaacaacaag ctaatcaaag
     1561 tcttccaccg ggacggtcac tatggcttct cagagcccct taccttctgc tccgtggtag
     1621 agctcatctc ccactaccga catgagtcac tggcccagta caacgccaag ctggacacgc
     1681 gccttctcta ccctgtgtcc aagtaccagc aagaccaggt ggtgaaggag gacagtgtag
     1741 aggctgtggg tgcccagctc aaggtctacc accagcagta ccaggacaag agccgcgagt
     1801 atgaccagct ctatgaggaa tacacacgaa cctcccagga gcttcagatg aagcgcacag
     1861 ccatagaggc cttcaacgag accatcaaga tcttcgaaga acagggccag acacaggaaa
     1921 agtgcagcaa ggagtatttg gagcgcttcc ggcgagaggg caatgagaag gagatgcaga
     1981 ggatcctgct gaactcggag cgactcaagt ctcgaatcgc ggagatacat gaaagccgca
     2041 cgaagctgga gcaggatctg cgggcgcagg cctcggacaa tcgagagatt gacaagcgca
     2101 tgaacagcct caagcctgat ctcatgcagc tgcgcaagat cagggaccag tacctcgtgt
     2161 ggctcaccca gaaaggtgcc cgacagagga agatcaacga gtggctggga atcaagaatg
     2221 agactgagga ccagtattca ctgatggagg atgaggacgc cctcccccac catgaggagc
     2281 gcacgtggta cgtgggcaag atcaaccgca cacaggcgga ggagatgctg agtggcaaac
     2341 gagacgggac cttcctcatc cgggagagca gccagcgggg ctgttacgca tgctctgtgg
     2401 tggtggatgg cgacacgaag cactgtgtca tctaccgcac agccactggc tttggcttcg
     2461 cagagcccta taacctgtac ggatccctga aggagctggt attgcactac cagcacgcat
     2521 cacttgtgca gcacaatgac gcgctcaccg tcaccctcgc acaccctgtg cgtgcccccg
     2581 ggcctggccc gccccctgca gcacgctgag cgccccacct cacctgcctc cctgtccatg
     2641 tctgtcttct aatcccttcc cctggtgaac acacgcagga tgccatcctc ccgctgcgtc
     2701 tgccatgttt acagaggctg cggggccact ggcctgggcc ccccgagttc ttcaagccat
     2761 atctccgatt tagaaaggaa ctgtgctagg tggtttccag gaactcagcc ctggacactt
     2821 ggggctgggc gggacccgcc ccgtggaccc caacttcccc tcttaaggtc gaagtgaaac
     2881 cagtcacggg gttaccccgc agctgccgag aagctccccc tctggagggc aaaatacaaa
     2941 ctagccctcg tccaggccct gcgctgttct cctgactgtg caatgcctcc cctttgggac
     3001 aagggccctg agtgtgtccc tgctccctga accccatacc tgcccagggt tgatgggcag
     3061 caggttttgt acggtacgtt tattgatacg aatatgaaac attgtacctg taaaaaaaaa
     3121 aaaaaaaaaa aaaaaaa
//
