LOCUS       NM_013005               6789 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase regulatory subunit 1
            (Pik3r1), mRNA.
ACCESSION   NM_013005 XM_017590649 XM_346613
VERSION     NM_013005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6789)
  AUTHORS   Yao,R.D., Li,H.L., Liu,Y. and Sun,L.T.
  TITLE     MiRNA-1 promotes pyroptosis of cardiomyocytes and release of
            inflammatory factors by downregulating the expression level of
            PIK3R1 through the FoxO3a pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (21), 11243-11250 (2020)
   PUBMED   33215443
  REMARK    GeneRIF: MiRNA-1 promotes pyroptosis of cardiomyocytes and release
            of inflammatory factors by downregulating the expression level of
            PIK3R1 through the FoxO3a pathway.
REFERENCE   2  (bases 1 to 6789)
  AUTHORS   Li,H., Xie,S., Li,H., Zhang,R. and Zhang,H.
  TITLE     LncRNA MALAT1 mediates proliferation of LPS treated-articular
            chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis
  JOURNAL   Life Sci 254, 116801 (2020)
   PUBMED   31472145
REFERENCE   3  (bases 1 to 6789)
  AUTHORS   Li,N., Men,W., Zheng,Y., Wang,H. and Meng,X.
  TITLE     Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221
            Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver
            Cancer
  JOURNAL   Molecules 24 (23), 4384 (2019)
   PUBMED   31801250
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6789)
  AUTHORS   Jiang,W., Zhang,W., Wu,L., Liu,L., Men,Y., Wang,J., Liang,J.,
            Hui,Z., Zhou,Z., Bi,N. and Wang,L.
  TITLE     MicroRNA-Related Polymorphisms in PI3K/Akt/mTOR Pathway Genes Are
            Predictive of Limited-Disease Small Cell Lung Cancer Treatment
            Outcomes
  JOURNAL   Biomed Res Int 2017, 6501385 (2017)
   PUBMED   28280736
REFERENCE   5  (bases 1 to 6789)
  AUTHORS   Varghese,R.T., Liang,Y., Guan,T., Franck,C.T., Kelly,D.F. and
            Sheng,Z.
  TITLE     Survival kinase genes present prognostic significance in
            glioblastoma
  JOURNAL   Oncotarget 7 (15), 20140-20151 (2016)
   PUBMED   26956052
REFERENCE   6  (bases 1 to 6789)
  AUTHORS   Craparo,A., O'Neill,T.J. and Gustafson,T.A.
  TITLE     Non-SH2 domains within insulin receptor substrate-1 and SHC mediate
            their phosphotyrosine-dependent interaction with the NPEY motif of
            the insulin-like growth factor I receptor
  JOURNAL   J Biol Chem 270 (26), 15639-15643 (1995)
   PUBMED   7541045
REFERENCE   7  (bases 1 to 6789)
  AUTHORS   Argetsinger,L.S., Hsu,G.W., Myers,M.G. Jr., Billestrup,N.,
            White,M.F. and Carter-Su,C.
  TITLE     Growth hormone, interferon-gamma, and leukemia inhibitory factor
            promoted tyrosyl phosphorylation of insulin receptor substrate-1
  JOURNAL   J Biol Chem 270 (24), 14685-14692 (1995)
   PUBMED   7782332
REFERENCE   8  (bases 1 to 6789)
  AUTHORS   Gustafson,T.A., He,W., Craparo,A., Schaub,C.D. and O'Neill,T.J.
  TITLE     Phosphotyrosine-dependent interaction of SHC and insulin receptor
            substrate 1 with the NPEY motif of the insulin receptor via a novel
            non-SH2 domain
  JOURNAL   Mol Cell Biol 15 (5), 2500-2508 (1995)
   PUBMED   7537849
REFERENCE   9  (bases 1 to 6789)
  AUTHORS   Rottapel,R., Turck,C.W., Casteran,N., Liu,X., Birnbaum,D.,
            Pawson,T. and Dubreuil,P.
  TITLE     Substrate specificities and identification of a putative binding
            site for PI3K in the carboxy tail of the murine Flt3 receptor
            tyrosine kinase
  JOURNAL   Oncogene 9 (6), 1755-1765 (1994)
   PUBMED   8183574
REFERENCE   10 (bases 1 to 6789)
  AUTHORS   Gout,I., Dhand,R., Hiles,I.D., Fry,M.J., Panayotou,G., Das,P.,
            Truong,O., Totty,N.F., Hsuan,J., Booker,G.W. et al.
  TITLE     The GTPase dynamin binds to and is activated by a subset of SH3
            domains
  JOURNAL   Cell 75 (1), 25-36 (1993)
   PUBMED   8402898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_013005.3.
            
            On or before Jun 1, 2021 this sequence version replaced
            XM_017590649.2, NM_013005.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: D64045.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JACYVU010000065.1  25468744-25468938   c
            196-907             JACYVU010000065.1  25458144-25458855   c
            908-1000            JACYVU010000065.1  25412768-25412860   c
            1001-1075           JACYVU010000065.1  25412046-25412120   c
            1076-1207           JACYVU010000065.1  25405884-25406015   c
            1208-1409           JACYVU010000065.1  25404908-25405109   c
            1410-1489           JACYVU010000065.1  25404639-25404718   c
            1490-1592           JACYVU010000065.1  25393562-25393664   c
            1593-1691           JACYVU010000065.1  25392625-25392723   c
            1692-1872           JACYVU010000065.1  25392343-25392523   c
            1873-1998           JACYVU010000065.1  25391999-25392124   c
            1999-2141           JACYVU010000065.1  25390850-25390992   c
            2142-2318           JACYVU010000065.1  25390507-25390683   c
            2319-2387           JACYVU010000065.1  25390348-25390416   c
            2388-2558           JACYVU010000065.1  25389597-25389767   c
            2559-6789           JACYVU010000065.1  25384212-25388442   c
FEATURES             Location/Qualifiers
     source          1..6789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..6789
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /note="phosphoinositide-3-kinase regulatory subunit 1"
                     /db_xref="GeneID:25513"
                     /db_xref="RGD:3329"
     exon            1..195
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            196..907
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..2748
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /note="ptdIns-3-kinase p85-alpha; PI3-kinase p85 subunit
                     alpha; PI3-kinase subunit p85-alpha; PI3K regulatory
                     subunit alpha; PI3-kinase regulatory subunit alpha;
                     phosphoinositide-3-kinase, regulatory subunit 1 (alpha);
                     ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase
                     regulatory subunit p85-alpha; phosphatidylinositol
                     3-kinase 85 kDa regulatory subunit alpha; Phosphoinositide
                     3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);
                     phosphatidylinositol 3-kinase, regulatory subunit,
                     polypeptide 1 (p85 alpha); Phosphoinositide 3-kinase p85
                     (other splicing variants: p55 and p50);
                     phosphatidylinositol 3-kinase p85 alpha"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     alpha"
                     /protein_id="NP_037137.2"
                     /db_xref="GeneID:25513"
                     /db_xref="RGD:3329"
                     /translation="MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSD
                     GQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSS
                     KTEADTEQPVLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAE
                     LRQLLDCDAASVDLDVFDVHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSED
                     YIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFP
                     AASSDNTEHLIKAVELLISTEWSERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWY
                     WGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF
                     SDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
                     EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEY
                     IEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSI
                     KPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTW
                     NVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFA
                     EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR"
     exon            908..1000
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1075
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1207
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1409
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1489
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1592
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1691
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1872
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1998
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2141
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2318
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2387
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2558
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..6789
                     /gene="Pik3r1"
                     /gene_synonym="PI3KA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctagcagc tggagccgag ttggaggaag cagcggcaac ggcagcggca gcagcgagga
       61 cggctgtgca gccaaggaac cgggacagct aagcaacggc cggtcgtagc tggatcgaag
      121 gaacctggga gctgggagct tgagaggccg ctgaagccct ggccgggcag aggaaggaag
      181 cgagccgacc cggaggtgaa tgaagccggg agcggagtgt gacagtaaaa tcagacgacc
      241 gatggacagt gtgacaagaa cgtcagagag gattgggcct cgctgtgaga gtcagcctga
      301 agtcaaggtg ttgacaagtt gctgaggaca cgtgggagga cggtggcgcg cagagggaga
      361 gccctgtctt cagtcacacc attgatggag gacagatgga cacccggatg gccagtcacc
      421 tctcttaaac ctttggatag tggtcctttg tgctctgacg gacacctgtt agggattcta
      481 gcccgttctc tgaactcact ttcccttaag acgtaaactc ggactgcagc gtgtgagccg
      541 gcttctccgt agcggggcac cagagctgca gacatgagcg cagaggggta ccagtacaga
      601 gcgctgtatg actacaaaaa ggaacgagag gaagacatcg acctacactt gggggacatc
      661 ctgactgtga ataaaggctc cttagtggca cttggattca gtgatggcca ggaagcccgg
      721 ccagaagata ttggctggtt aaatggttac aatgaaacta ctggggagag gggagacttt
      781 ccaggaactt atgttgagta cattggaagg aaaagaattt caccccccac tcctaagcca
      841 cggccccctc gacctcttcc tgtagcaccc ggttcttcaa aaactgaagc agacactgag
      901 caaccagtgt tgacccttcc tgatctggcc gagcagtttg cccctcctga tgttgccccg
      961 cctctcctta taaagctcct ggaagccatt gagaagaaag gactggaatg ttcaactcta
     1021 tacagaacac agagctccag caaccctgca gagttacgac agcttcttga ttgtgatgcc
     1081 gcctcagtgg acttggatgt gttcgatgta cacgttttag cagatgcttt caaacgctat
     1141 ctcgccgact taccaaatcc tgtcattcca gtagctgttt acaatgagat gatgtcttta
     1201 gcccaagaag taccaagctc cgaagactac atccagctgt tgaagaagct cattaggtcg
     1261 cctaatatac ctcatcagta ttggcttacg ctccagtatt tgctcaagca cttcttcaag
     1321 ctctctcaag cctccagcaa gaaccttctg aatgcaagag ccctctctga aattttcagc
     1381 cacgtgcttt tcagattccc agcagccagc tctgataata ctgaacacct cataaaagcg
     1441 gtagagcttt taatctcaac ggagtggagt gagcgacagc cagcaccagc actgccccct
     1501 aaaccaccca agcccacttc tatagccaac aacagcatga acaacaatat gtccttacag
     1561 gatgctgaat ggtactgggg agatatctca agggaagaag taaatgaaaa actccgagac
     1621 actgctgatg ggacctttct ggtacgagat gcatccacta aaatgcacgg cgactacact
     1681 ctcacactaa ggaaaggagg aaataacaaa ttaatcaaaa tctttcaccg agatgggaaa
     1741 tacggcttct ctgatccatt aaccttcaac tctgtggttg aattaataaa ccactaccgg
     1801 aatgagtcct tagctcagta caatcccaag ctggatgtga agttactcta cccagtgtct
     1861 aaataccagc aggatcaagt tgtcaaagaa gataatattg aagctgtagg gaaaaaatta
     1921 catgaatata atactcaatt tcaagaaaaa agtcgggaat atgatagatt atatgaggaa
     1981 tacactcgta cttcccagga aatacagatg aaaagaacag ctatcgaagc atttaatgaa
     2041 accataaaaa tattcgaaga gcagtgccaa acccaggagc ggtacagcaa agaatacata
     2101 gagaagttta aacgcgaagg caacgagaag gaaattcaaa ggataatgca taatcacgat
     2161 aagctgaagt ctcggatcag cgagatcatc gacagcagga ggagactgga ggaagacttg
     2221 aagaagcagg cagccgagta tcgcgagatc gacaagcgca tgaatagcat taagccggac
     2281 ctcattcagc tgagaaagac aagagatcaa tacttgatgt ggctgacgca gaaaggggtc
     2341 cggcagaaga agctgaacga atggttggga aacgaaaaca cagaagacca atactcactg
     2401 gtagaagatg acgaggattt gccccaccat gatgagaaga cgtggaatgt ggggagcagc
     2461 aaccgaaaca aagccgagaa cctattgcga gggaaacgag atggcacttt cctggtccgg
     2521 gagagcagta agcagggctg ctatgcctgc tctgtagtgg tagatggcga agtcaaacat
     2581 tgcgtcatca acaagactgc caccggctat ggcttcgccg agccctacaa cctgtacagc
     2641 tccctgaaag agctggtgct acattaccaa cacacctccc tggtgcagca caatgactcc
     2701 ctcaatgtca cactagcata cccagtatat gcacaacaga ggcgatgaag cgctgccctc
     2761 cctcggatac agttcctcac cttcaagcca cccaaggcct ctgggaagca aagggctcct
     2821 ctccagcccg acctgtgaac tgagctgcgg aatcgaagcc ggatgtctgc acatgggact
     2881 agagctttct tggacaaaaa gaagtcgggg aagacatgca gcctagggct gttggatgac
     2941 cagacgtttc taaccttatc tttctttttt tttttttttt ttttctttta atttaaagcc
     3001 acaatacaca gaggaaaaag aaatgcaaaa aaatctctcc gtgcaaggac aaagaggcct
     3061 ttaaccatgg tgcttgtgaa cgctttctga agctttacca gctacaagtt gggactttgg
     3121 agaccagaag gtagacaggg ccgaggagcc tgcacctggg gccgctcggt ccagcctggt
     3181 ttagcctggg tgtcactggg tgtggtgatc ccagacacat cgcactgtgg attgtttcct
     3241 ttttaaatga acggatgaca tgtagcagag agccgcgtct gctcagagag agaacatcga
     3301 tgcagtgcgt tcggaggaaa aacaaaaaca ccagaaaacc tttttgttca agcttgtcaa
     3361 accaacaacc tgccaacaga gaaaaagagt gtggacaagg ggacttaaaa atgacattca
     3421 gtatataaaa catgtacata ataacgagtg actaactatc aaatagatgg atttgtatca
     3481 ataccaaata gcttctgttt ttgttttgct aaaggctgaa cgtgcagcgc tatgcaattc
     3541 tcgattttta ttacgttgtt accagtttcc gatcaccttc agagtaagct ttcctcaccc
     3601 caggattttg ttgcttgaaa atactgtccc tgacttttgt taatatttgt ttttgttatt
     3661 cttacttttt tttaaaaaaa ataaaataaa ataaatgtac aggatgccag aaaggaaaaa
     3721 tggcttcaga attaaaacta tgaaatattt tacagttttt cttgtacaga gtacttggct
     3781 gttagcccaa ggttaaaaag ttcataacag attttttttt ttttctcgga ctaaatgttg
     3841 ggcagggccc tgataagctt caaagctgct ttattcaata aaaaaaaaga aaaagaaaaa
     3901 gaaaacgata tatgatatga caaagtatgg ctgagtccaa cagtgtgaag actcttgaaa
     3961 tacggtacct ggcaatgttt gtttccttat caattgtgaa cttgttgaat ctggagggag
     4021 gggaggcagt catgggttgt aacaggcagg gttaagggga ggggggtggt aaggtggtgt
     4081 gcactttctt gggatcccag agaaggggag aatcgaggct gtgtgtctcc cgtctttccc
     4141 catctgagtt tattaccagt aactccagac ccagtatgta acttgaaccc agcacagctg
     4201 gccagcatct ccattctcct gagggaaatg ctgagttcat tctggggttc ctgggacgcg
     4261 ccctttctcg ttgtccttgt aacacactgg cctcaaggtt gaatccctgc atttagaaaa
     4321 tgtgttcttt tctctttgca gcattggact agtcacagca gccagtcacc attcatttca
     4381 gcaaaggcat gatctgaaaa acagtacttc tagctggata cttgttactt tcctagctct
     4441 ctgttcagtt ccgcttagat cggaagacaa gtagacccaa gtgggcggtc cctgtgctct
     4501 gtggagattg ttaaatgcaa actgacagtt ctgacggtcc ttctcgttag cataaaggtg
     4561 catgttgtat acgtcagggt gtgagaaggg agcagttggt gacatcctta atttaggaca
     4621 agagtttgag tttgcccacc ctcatgtacg tgtgcaaaag ctggtgtgat cgtggggaat
     4681 cacggtcaca gcctaggtag attcaccagc catcctcagt ttctctttct caattaccag
     4741 atgcaccccc agctttacct cttcccttta tagactaagg tgaaggtgtt tgcaggtctc
     4801 gtaatgtcgt tcttgtttga atcttagaat ttgcagccca gtggccaggt taatggtctg
     4861 tcgaatgtat tcttttcctt cctgtgaagc cactgctcat cctcaagagg aagagtcagt
     4921 cagcgagact gtcagcctgc agacttgacc tgcccacctc ctgactgcca ggccattgat
     4981 ccctggcttc accccaggct ttgcaacttc cagtggtagc gttctgccat gccacatgtg
     5041 actgaagact taacacttgt ttgtaagcta ggttggtggt taattggatt ctgtttcttc
     5101 tttctttctc tctttccttc ccccttttcc tttttgcagc acatcacgta tgctatcaaa
     5161 cacaactaac tttaatttta aaaatggatc tgagattgca ccgttacaag ttctgttcaa
     5221 tggtttttct tttctttttt tttttttttc ttccttcagc actctttgca ggatgacttg
     5281 caacttttag gcagttgcct caatttctca tctcaccaac acacgtacaa tagagctttc
     5341 atttgtcaga aggcaggagc cactgagtta agtcactcag cgtcctgctg aatgcctttt
     5401 tgatgacagg ctggtatgct caccggctct gtccttagag aagcttgacc tgattctatc
     5461 caggcctcct ctagtagcat gatcgaagat agagagggca tggctgaggt gtgagcattc
     5521 ccgcatcggt ttttctcaca acctgtcaca tcctagagcc agcagacact aagctgctga
     5581 gagacagagc taggctgtag acgtgggagg gttgggacct cgtgttccac accagagtga
     5641 tcataaccac gtgatgaggc agcaagcatg ttttgcaaca tttgacaact tcacagccct
     5701 ggatatatgt atatatgtat agtgtgcatg gactgtttcc agtacacctt tcagccacgc
     5761 agatccacag tggagttcaa gtatgtaaca agcggatgtc cagtacaggt cttgtagacg
     5821 ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5881 gcgtgtgcgt gtgcgtgtgc tattgctttg ttttgtctta taaaggtaaa gcttgtcggc
     5941 acgtgaaacg agaagtccat tagttgacat tttcctgttt ttagaagcta ctcccttttg
     6001 gggagcaggt ctgcatgact tgcttacctg atgtgtccct gttgtcaggt cagagtgtgt
     6061 ttctgtgagc tgtcattgtg gggaaccaat tgctttgtca tatatctggt tccgaactat
     6121 aacttgtttg ggaagtctac tgatgttcct gctggttttc ccaagtgtgc tttcgcaatg
     6181 catggtatcc acgtcacttg gaaagtgggc tttgttgtct gtctgaattt agggtcactt
     6241 aagaaagggg cagttaaaaa taaagcacaa tgcctcacat gggacaaagt tccaaaatgc
     6301 caaattcttc tattttttac aacaacctgt agttatgtaa aataactagt actgggggag
     6361 ggaagggggt agaattggct caattggaaa gactctccca cttcacacta agcttgtttg
     6421 tcaccatgag atagcattgg ctgcccagga tgctgctatt taaaaaaaaa aaaaaagcaa
     6481 aacaaaacaa aaaaaaagaa ccctcattta tatgtgtgta ttttttaaag ctacactctg
     6541 ttcagtgttt ttacaaatct gtttatatga cattgataaa ctaaagttgg tcttttgacg
     6601 agagggagga tgtcatggtt ggttgtaatt ttgcctttac aaggtaactg gggttggggt
     6661 ggggagggag tgtgcctcct tgacattttg ttcaagttat agattcagtg aagctatgta
     6721 ttgttttaag ttgcttaatg cattgtatta ggtcctcaaa cagaataaag gttgttttga
     6781 aacttaaaa
//
