LOCUS       NM_001395158            2303 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase interacting protein 1
            (Pik3ip1), mRNA.
ACCESSION   NM_001395158 XM_006251293
VERSION     NM_001395158.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2303)
  AUTHORS   Liu,X., Yang,Y., Song,J., Li,D., Liu,X., Li,C., Ma,Z., Zhong,J. and
            Wang,L.
  TITLE     Knockdown of forkhead box protein P1 alleviates hypoxia
            reoxygenation injury in H9c2 cells through regulating
            Pik3ip1/Akt/eNOS and ROS/mPTP pathway
  JOURNAL   Bioengineered 13 (1), 1320-1334 (2022)
   PUBMED   35000528
  REMARK    GeneRIF: Knockdown of forkhead box protein P1 alleviates hypoxia
            reoxygenation injury in H9c2 cells through regulating
            Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
REFERENCE   2  (bases 1 to 2303)
  AUTHORS   He,X., Zhu,Z., Johnson,C., Stoops,J., Eaker,A.E., Bowen,W. and
            DeFrances,M.C.
  TITLE     PIK3IP1, a negative regulator of PI3K, suppresses the development
            of hepatocellular carcinoma
  JOURNAL   Cancer Res 68 (14), 5591-5598 (2008)
   PUBMED   18632611
REFERENCE   3  (bases 1 to 2303)
  AUTHORS   Zhu,Z., He,X., Johnson,C., Stoops,J., Eaker,A.E., Stoffer,D.S.,
            Bell,A., Zarnegar,R. and DeFrances,M.C.
  TITLE     PI3K is negatively regulated by PIK3IP1, a novel p110 interacting
            protein
  JOURNAL   Biochem Biophys Res Commun 358 (1), 66-72 (2007)
   PUBMED   17475214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jun 7, 2021 this sequence version replaced XM_006251293.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.49398.1,
                                           SRR26643288.52313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000014.1  82428315-82428513
            200-316             JAXUCZ010000014.1  82429360-82429476
            317-436             JAXUCZ010000014.1  82429554-82429673
            437-649             JAXUCZ010000014.1  82430668-82430880
            650-728             JAXUCZ010000014.1  82430973-82431051
            729-2303            JAXUCZ010000014.1  82438687-82440261
FEATURES             Location/Qualifiers
     source          1..2303
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2303
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /note="phosphoinositide-3-kinase interacting protein 1"
                     /db_xref="GeneID:305472"
                     /db_xref="RGD:1311203"
     exon            1..199
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..933
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /note="kringle domain-containing protein HGFL; HGFL
                     protein"
                     /codon_start=1
                     /product="phosphoinositide-3-kinase-interacting protein 1
                     precursor"
                     /protein_id="NP_001382087.1"
                     /db_xref="GeneID:305472"
                     /db_xref="RGD:1311203"
                     /translation="MLLAWVHTFLLSNMLLAEAYGSGGCFWDNGHLYREDQPSPAPGL
                     RCLNWLAAQGSGESLAQPSPGNHNYCRNPDQDPRGPWCYISSETGVPEKRPCEDLRCP
                     ETTSQAPPPPPPSSTTELEEKFGVPGDKETQVFPPANALPARSEAAEVQPVIGISQRV
                     RMNSKEKKDLGTLGYVLGVTMTVIIIAIGVGIVLGYTYKRGKDLKEQHEQKVCEREMQ
                     RITLPLSAFTNPTCEIMDEKTIIVHSNQTPADVQEGSTLLTDQAGTPGA"
     exon            200..316
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /inference="alignment:Splign:2.1.0"
     exon            317..436
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /inference="alignment:Splign:2.1.0"
     exon            437..649
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /inference="alignment:Splign:2.1.0"
     exon            650..728
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /inference="alignment:Splign:2.1.0"
     exon            729..2303
                     /gene="Pik3ip1"
                     /gene_synonym="RGD1311203; zgc:66482"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtttaccag aagagcataa taagggccgg tctgactgca aggctgggaa ctagaagaca
       61 aaactgctgc caaggagacc ccattcggac actggctgtt cagtcacctg caagccggaa
      121 gaggcgagga tgctgttggc ttgggtacac acatttcttc tcagcaacat gcttctggca
      181 gaagcctatg gatctggagg ctgcttctgg gacaacggcc acctgtaccg ggaggaccag
      241 ccctcgcccg cgccgggtct ccgctgcctc aactggttgg ccgcgcaagg cagcggcgag
      301 tcgctcgccc agcccagccc cggcaaccac aactactgcc ggaacccgga ccaggatccg
      361 cgtgggccct ggtgctacat cagcagcgag actggcgtcc ctgaaaagcg gccctgcgag
      421 gacttgcgtt gcccagagac cacttcccaa gcaccaccac caccaccacc gtcctctaca
      481 acggagctgg aagagaagtt tggtgtgccc ggtgacaaag agacacaggt gttccctcct
      541 gctaacgccc tgccagccag gagtgaggcg gcagaggtgc agccagtgat cgggatcagt
      601 cagcgtgtga ggatgaactc caaggaaaaa aaagacctgg gaactttggg ctacgtgttg
      661 ggcgttacta tgacggtaat tatcatcgct attggagttg gcatcgtctt gggctacact
      721 tacaagaggg ggaaggactt gaaagagcaa catgagcaga aagtgtgtga gagggagatg
      781 caacgaatca ccctgcccct gtctgccttc accaacccca cctgtgagat catggacgaa
      841 aagaccatca ttgtgcacag caaccagact cctgctgatg tgcaggaggg cagcaccctc
      901 ctcactgacc aggctggcac ccccggggcc tgagcccctg cagtgggcag gtgcccacat
      961 agacactggt acaggacaag ccaccctcct gcagttggga ggagctacat tttgtgttgt
     1021 ggttaaaacc ttatcccatt tttctttcgg ggggaatgtg actcctcatg acacaagaag
     1081 cagcaggtag catcaagggc gaggctgggg agggtcctat caatgctcct tttctatccc
     1141 ttagagcagg atttgcctgc ggagagagac tggcacagcg gccacagtgg tgctgtggca
     1201 aataagggct tccacattgc ctgggccagg gagacaggga gctcgctaag gctcctctgt
     1261 gctataaact gaaggtggtc tcagtctctg cctttgccat ccaggaactt gagtggcata
     1321 tactgttatt catagttaag gtcaagcatt aaaaaaacaa aactatatat ttacatatat
     1381 attcatgtga atatatagat gtatatgaat gaatgaaata tttggctgga agtcccttct
     1441 gacttctaag aaccagagat gaatttgtac taaagctaga attttgggct gcaagtgggt
     1501 tctaatgggg actgctgggc acgccccact tgctggcagc aatgtgcctt gacaactgtg
     1561 ggctggtcct gggcccaagg gtcccttcct gttttgtaag gaaagggaag aattgcacta
     1621 aaccttccac ttaggtgaag ggcccacttc tgccttcagc ctcacgcagt agatctgaat
     1681 atccagactt gtcttttcgg ggatggattg aggaacctct ccactttgtg ttgataagaa
     1741 aatagccagc caaccctggg aattacatac ttcagggtct agtgacctgc atctgaaagg
     1801 tgagcctcaa gactaagcca gaggctgggt aacaaaggca cggtgggtgg ggctggcttt
     1861 gtagtccaac ctggcttgca ggcagcccta aggcctggga cagctccttc cacaaggtta
     1921 agggtgtaac tggtacaaaa caatcactga aacactggga aggacccaaa gggttttcca
     1981 gagagggaaa agcagcttct gagtgtcctg ccgagagcgc ccagtctcct ggccttggca
     2041 gtgtccccac caggagcccc tctactcctg acactgagag caggcctcac caggctgctc
     2101 tctagagcca tttgttgagg gggcctggac ctcagggttc ccacggtggt gctgactgtg
     2161 ggagagaact gaacaacttc ctactttcct atgaaagtat ttctctgtat gttttatata
     2221 cctcattctg acacctgtgt atgaactgtg gcaaattgct ctgcattcga cttatataaa
     2281 tacaatcatg attttacctg gca
//
