LOCUS       NM_001108978            4788 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit delta (Pik3cd), mRNA.
ACCESSION   NM_001108978 XM_001075671 XM_345606
VERSION     NM_001108978.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4788)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 4788)
  AUTHORS   Wang,F., Fan,X., Kong,J., Wang,C., Ma,B., Sun,W., Ye,Z., Liu,P. and
            Wen,J.
  TITLE     Inhibition of mitochondrial fission alters neo-intimal hyperplasia
            via PI3K/Akt signaling in arteriovenous fistulas
  JOURNAL   Vascular 31 (3), 533-543 (2023)
   PUBMED   35130772
  REMARK    GeneRIF: Inhibition of mitochondrial fission alters neo-intimal
            hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
REFERENCE   3  (bases 1 to 4788)
  AUTHORS   Stark,A.K., Chandra,A., Chakraborty,K., Alam,R., Carbonaro,V.,
            Clark,J., Sriskantharajah,S., Bradley,G., Richter,A.G.,
            Banham-Hall,E., Clatworthy,M.R., Nejentsev,S., Hamblin,J.N.,
            Hessel,E.M., Condliffe,A.M. and Okkenhaug,K.
  TITLE     PI3Kdelta hyper-activation promotes development of B cells that
            exacerbate Streptococcus pneumoniae infection in an
            antibody-independent manner
  JOURNAL   Nat Commun 9 (1), 3174 (2018)
   PUBMED   30093657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4788)
  AUTHORS   Qiao,S., Zheng,N., Sun,L., Pang,G., Wang,S., Jia,P., Uzonna,J.E.,
            Bai,H. and Yang,X.
  TITLE     The p110delta isoforme of phosphatidylinositol 3-kinase plays an
            important role in host defense against chlamydial lung infection
            through influencing CD4+ T-cell function
  JOURNAL   Pathog Dis 76 (6), 5035814 (2018)
   PUBMED   29893841
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4788)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   6  (bases 1 to 4788)
  AUTHORS   Luk,S.K., Piekorz,R.P., Nurnberg,B. and Tony To,S.S.
  TITLE     The catalytic phosphoinositol 3-kinase isoform p110delta is
            required for glioma cell migration and invasion
  JOURNAL   Eur J Cancer 48 (1), 149-157 (2012)
   PUBMED   22079609
REFERENCE   7  (bases 1 to 4788)
  AUTHORS   Urick,M.E., Rudd,M.L., Godwin,A.K., Sgroi,D., Merino,M. and
            Bell,D.W.
  TITLE     PIK3R1 (p85alpha) is somatically mutated at high frequency in
            primary endometrial cancer
  JOURNAL   Cancer Res 71 (12), 4061-4067 (2011)
   PUBMED   21478295
REFERENCE   8  (bases 1 to 4788)
  AUTHORS   Randis,T.M., Puri,K.D., Zhou,H. and Diacovo,T.G.
  TITLE     Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and
            tissue localization of neutrophils
  JOURNAL   Eur J Immunol 38 (5), 1215-1224 (2008)
   PUBMED   18412166
REFERENCE   9  (bases 1 to 4788)
  AUTHORS   Hirsch,E., Costa,C. and Ciraolo,E.
  TITLE     Phosphoinositide 3-kinases as a common platform for multi-hormone
            signaling
  JOURNAL   J Endocrinol 194 (2), 243-256 (2007)
   PUBMED   17641274
  REMARK    Review article
REFERENCE   10 (bases 1 to 4788)
  AUTHORS   Clayton,E., Bardi,G., Bell,S.E., Chantry,D., Downes,C.P., Gray,A.,
            Humphries,L.A., Rawlings,D., Reynolds,H., Vigorito,E. and Turner,M.
  TITLE     A crucial role for the p110delta subunit of phosphatidylinositol
            3-kinase in B cell development and activation
  JOURNAL   J Exp Med 196 (6), 753-763 (2002)
   PUBMED   12235209
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345606.3, XM_001075671.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..4788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4788
                     /gene="Pik3cd"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit delta"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
     exon            1..126
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            127..299
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2993
                     /gene="Pik3cd"
                     /EC_number="2.7.1.153"
                     /note="catalytic phosphatidylinositol 3-kinase delta;
                     phosphatidylinositol 3-kinase catalytic delta polypeptide;
                     phosphoinositide-3-kinase, catalytic, delta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit delta isoform"
                     /protein_id="NP_001102448.1"
                     /db_xref="GeneID:366508"
                     /db_xref="RGD:1310990"
                     /translation="MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLST
                     IKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLV
                     AREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWV
                     EWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMA
                     CALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTM
                     VHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVN
                     ADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCF
                     ALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
                     ELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEM
                     LYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYE
                     SYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMK
                     VLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPS
                     TLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQL
                     MDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDA
                     LLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDF
                     GHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRH
                     GLLFLHLFALMRAAGLPELSCSKDIQTLWH"
     exon            300..528
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            529..758
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            759..938
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1088
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1178
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1400
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1497
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1628
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1679
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1801
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1945
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2045
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2224
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2337
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2416
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2584
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2708
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2854
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2977
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..4788
                     /gene="Pik3cd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttcagaca cataaggagc tgagagccag gcagaagtgg gatgaagctc cctgatggca
       61 aagcacctgt aatctcccag gcacaggggc cttggctggt ggtccttctc ggcccatccc
      121 aaacaggaga acaggcctca gagaagtaac acagcaggat gccccctggg gtagactgcc
      181 ccatggagtt ctggaccaaa gaggagagcc agagcgtggc cgttgacttc ttgctgccca
      241 caggagtcta cttgaacttc cctgtgtccc gcaatgccaa cctcagcacc atcaagcagg
      301 tgctgtggca tcgtgcacag tatgagccgt tcttccacat gctcagtgac cccgaggctt
      361 atgtgttcac ctgtgtgaac cagacagcgg agcagcagga gttggaggat gagcagcgga
      421 ggctgtgtga catccagccc ttcctgcccg tgctgcgcct ggtggcccga gagggggacc
      481 gcgtgaagaa gctcatcaac tcacagatca gcctcctcat cggcaaaggt ctccatgagt
      541 ttgattccct gcgggacccg gaagtaaacg acttccgcac taagatgcgc cagttttgcg
      601 aagaggccgc ggctcaccgc cagcagctgg gctgggtgga atggctgcag tatagcttcc
      661 ccctgcagct ggagccctca gccagaggtt ggcgggctgg cttattgcat gtcagcaacc
      721 gacccctgct ggtcaatgtg aagttcgagg gcagtgagga gagcttcacc ttccaggtat
      781 ccaccaagga catgcccctc gcactgatgg cctgtgccct ccgaaaaaag gccaccgtgt
      841 tccggcagcc tctggtggag aggcctgagg agtatgccct gcaggtgaac gggaggcacg
      901 agtacctcta cggcagctac cccctctgcc actttcagta catctgtagc tgcctgcaca
      961 gcggactgac tccccatctg accatggtcc actcctcctc catcctcgcc atgagggatg
     1021 agcagagcaa ccctgccccc caggtgcaga agccacgagt caaacctccc ccgatccctg
     1081 ccaagaagcc ctcctctgtg tccctgtggt ccctggaaca gccattctgc attgagctga
     1141 ttgagggccg caaggtgaat gcggatgaaa ggatgaagct ggttgtgcag gccgggctct
     1201 tccacggcaa tgagatgctg tgcaagactg tgtcgagctc agaggtgaat gtgtgctcag
     1261 agcccgtgtg gaagcagcga ctagaattcg acatcagcat ctgtgacctc ccccgaatgg
     1321 cccggctctg ctttgcactc tatgctgtcg tggagaaggc taagaaggcg cgctccacaa
     1381 agaagaagtc caagaaggcg gactgtccca tcgcttgggc caacctcatg ctattcgact
     1441 acaaagatca gctcaagacg ggcgaacggt gcctctacat gtggccctct gtcccagatg
     1501 agaaagggga actgatgaat cctgcgggta cagtacgtgg taaccccaac acagagagtg
     1561 ccgctgccct ggtcatctac ctacctgagg tggctcccca ccctgtgtac ttccctgctc
     1621 tggagaagat cctggagctg gggcgtcacg gggagcgtgg gcgcatcaca gaggaggaga
     1681 tgctctattt gctgtgctcc tggcccgagc ttcctgtgct gagcgccctg gagcttctgg
     1741 actttagttt tcctgactgc tacgtgggtt ccttcgccat caagtcccta cggaagctga
     1801 cggatgacga gcttttccag taccttctgc agctggtaca agtactcaaa tatgagtcct
     1861 acctggactg cgagttgacc aaattcttgt tgggccgagc cctggctaac cgcaagatcg
     1921 ggcacttcct gttctggcac ctccgctctg agatgcatgt accgtccgtg gccctgcgtt
     1981 ttggcctcat catggaagcc tactgcagag gcagcaccca ccacatgaag gtgctgatga
     2041 agcaggggga ggcactgagc aagcttaagg ccctgaatga ctttgtgaag gcgagctcgc
     2101 agaagaccac caagccccag accaaggaga tgatgcatat gtgtatgcgc caggagactt
     2161 acatggaggc gctgtcccac ctgcagtctc ccctcgaccc cagcaccctg ctggaggaag
     2221 tctgtgtgga gcagtgcacc ttcatggact ccaaaatgaa gccattgtgg atcatgtaca
     2281 gcagcgagaa ggcaggcggt gccggcagcg tgggcatcat ctttaagaac ggggatgacc
     2341 tccgccagga catgctgact ctgcagatga tccagctcat ggacttccta tggaagcagg
     2401 agggcctgga cctgaggatg accccctatg gctgcctccc caccggagat cgcacaggcc
     2461 tcattgaggt ggtcctccac tcggacacca tcgccaacat ccagctgaat aaaagcaaca
     2521 tggcagccac ggctgcgttc aacaaggacg ctctgctcaa ctggctcaag tctaagaacc
     2581 ctggggaggc tctggatcgg gccattgagg aattcaccct ctcctgtgct ggctactgtg
     2641 tggccacata tgtgctgggc atcggtgacc ggcacagcga taacatcatg atcagagaga
     2701 gtgggcagct tttccacatt gactttggcc actttctggg gaacttcaag accaagttcg
     2761 ggatcaaccg ggagcgtgtc cccttcattc tcacctacga ctttgtccac gtgatccagc
     2821 aggggaagac taacaacagt gagaaatttg aaaggttccg aggctactgt gaacgagcct
     2881 acaccatcct gcggcgtcac gggctgcttt tccttcatct cttcgccctc atgcgcgcag
     2941 caggtctgcc tgagcttagc tgctccaaag acatccagac tctctggcac tagggaagac
     3001 ggaggaagaa gcactaaagc acttccgggt gaagttcaat gaagctctcc gggagagctg
     3061 gaaaaccaaa gtcaactggc tggcacacaa tgtgtccaag gataacaggc agtaagaggc
     3121 gcccccctgg gcgtcacatt cccctgggcg tcacatggca gttccctggt tccctccggg
     3181 ctctcagcca tagaggtaaa ctgtcagtcc tggagaccag gcatgctcag tggtcatcaa
     3241 aggggcccca gacctgaact gtccctcaca gagaagaacc acacaactgc ttcttgttta
     3301 cactggttat ttatttatga ctcgaaatgt ttaaggaaca gaatagccat aaatggaagt
     3361 gcatttttgt gcaggggagg ggtgctgtcc tcgtgacccc ccctccctca gcactgtaaa
     3421 cagcaccttg aggatcgtac ccctagtctt ccaacctgtg ggtcttggcc ccccaaaggc
     3481 agttttgggg gccaccttcc caggctccca gccggctgcc tagaacaagc ctggcagtca
     3541 cctggtgcct cccacgcaga caggacacct caatcctcag ctcagctcac ctccgccacc
     3601 ttcatgtggc ccaccctcgg cgacctccat ctaccaagcc tccggcagct cctgaggaag
     3661 ccaggagctt ccctctagac tcaggcacac ttgctctgca ctgctgaagt gacaacctct
     3721 tgggtacgga aacaccctca ccttttattt gcgggtaaga acatgattat gtaaactctg
     3781 tatagaatag ccggggtaaa ggacctggct tccactacag atagctgtgt tctgggcctc
     3841 aaaacactag agattggtgc ccgatttagt gcggtgtggt cgtgaatcca gacaaagggc
     3901 aagcctgaac ggagtcctct tcgcaatttg tgtgagaacc gcacacaaag gcagctttct
     3961 ggaaggacag gactgatgtc tcccagagct gccattctca gaaggcagct ggggtcccgg
     4021 gttctgaagt gtgcgcgagg aggaggacca agtttagtag tctgggcgac tggagcatct
     4081 ccagaaatgc agggtctcca ccccctccca ggtatccaaa cctactttgg gctgtagagc
     4141 cagtcacctg gctttttaga gagcccagct cagtggtgca catgcataaa acgtgccatc
     4201 ccgagcccac cgtgatgcat cagctgccgc ctcaggacct ggctctcccg gtaacatcct
     4261 gagacttgca gaaccatcac cgccgtcttg ctggcagccc agaacatggc tgctcaagga
     4321 agccaggtgt ccgctctttc acgatgatga actgagggtc cagcagtggt tggtgcctcc
     4381 agggcacttg ctgaaccctt agtctgcccc aactctgaaa taggaagtgt gcgtgcgtgt
     4441 gcgtgcgtgt gcgcgtgtgt gccgtgttat ttattgaaaa gagtctaggt gctccctggt
     4501 gtggctgcag attctgcaga ggctcagcct ttctgggttg ggtatgtggt ctgtgtacct
     4561 ggctggaaaa gtattttcta tttttttttt ttaaaagttg ttctacgttt ctgtaggggg
     4621 gaaggtagat ttcctctcac tgatgtgggc tgagatcagt ctgtgcaacc ctgacacgtc
     4681 cggtaaagac aggtgaaaag aaataaaaat ctttttatgt tcttacgttc ttggctcaaa
     4741 taataagggg gggcttgggg atacagtgca ttggtaaagt ccttgtct
//
