LOCUS       NM_053481               4509 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit beta (Pik3cb), mRNA.
ACCESSION   NM_053481
VERSION     NM_053481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4509)
  AUTHORS   Wang,J., Zhan,H., Wang,M., Song,H., Sun,J. and Zhao,G.
  TITLE     Sonic hedgehog signaling promotes angiogenesis of endothelial
            progenitor cells to improve pressure ulcers healing by
            PI3K/AKT/eNOS signaling
  JOURNAL   Aging (Albany NY) 15 (19), 10540-10548 (2023)
   PUBMED   37815888
  REMARK    GeneRIF: Sonic hedgehog signaling promotes angiogenesis of
            endothelial progenitor cells to improve pressure ulcers healing by
            PI3K/AKT/eNOS signaling.
            Erratum:[Aging (Albany NY). 2023 Dec 29;15(24):15703-15704. doi:
            10.18632/aging.205458. PMID: 38157439]
REFERENCE   2  (bases 1 to 4509)
  AUTHORS   Mukhomedzyanov,A.V., Popov,S.V., Maslov,L.N., Diez,E.R. and
            Azev,V.N.
  TITLE     Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective
            Effect of Deltorphin II during Cardiac Reperfusion
  JOURNAL   Bull Exp Biol Med 175 (1), 17-19 (2023)
   PUBMED   37338759
  REMARK    GeneRIF: Role of PI3K, ERK1/2, and JAK2 Kinases in the
            Cardioprotective Effect of Deltorphin II during Cardiac
            Reperfusion.
REFERENCE   3  (bases 1 to 4509)
  AUTHORS   Cheng,Q., Wang,M., Jin,R. and Li,G.
  TITLE     Blocking of PI3-kinase beta protects against cerebral
            ischemia/reperfusion injury by reducing platelet activation and
            downstream microvascular thrombosis in rats
  JOURNAL   Sci Rep 13 (1), 2030 (2023)
   PUBMED   36739310
  REMARK    GeneRIF: Blocking of PI3-kinase beta protects against cerebral
            ischemia/reperfusion injury by reducing platelet activation and
            downstream microvascular thrombosis in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4509)
  AUTHORS   Zhang,L., Li,B., Li,W., Jiang,J., Chen,W., Yang,H. and Pan,D.
  TITLE     miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting
            PTEN and Activating the PI3K/AKT Signaling Pathway
  JOURNAL   Cells Tissues Organs 212 (6), 523-534 (2023)
   PUBMED   35717938
  REMARK    GeneRIF: miR-107 Attenuates Sepsis-Induced Myocardial Injury by
            Targeting PTEN and Activating the PI3K/AKT Signaling Pathway.
REFERENCE   5  (bases 1 to 4509)
  AUTHORS   Yang,B., Pan,C.S., Li,Q., Yang,Z., Long,F.X., Fan,J.Y., Wang,C.S.,
            Han,J.Y. and Tang,D.X.
  TITLE     Inhibitory effects of Chanling Gao on the proliferation and liver
            metastasis of transplanted colorectal cancer in nude mice
  JOURNAL   PLoS One 14 (2), e0201504 (2019)
   PUBMED   30789971
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4509)
  AUTHORS   Rajala,R.V., McClellan,M.E., Ash,J.D. and Anderson,R.E.
  TITLE     In vivo regulation of phosphoinositide 3-kinase in retina through
            light-induced tyrosine phosphorylation of the insulin receptor
            beta-subunit
  JOURNAL   J Biol Chem 277 (45), 43319-43326 (2002)
   PUBMED   12213821
  REMARK    GeneRIF: in vivo regulation in retina through light-induced
            tyrosine phosphorylation of the insulin receptor beta-subunit
REFERENCE   7  (bases 1 to 4509)
  AUTHORS   Alpini,G., Glaser,S., Alvaro,D., Ueno,Y., Marzioni,M., Francis,H.,
            Baiocchi,L., Stati,T., Barbaro,B., Phinizy,J.L., Mauldin,J. and
            Lesage,G.
  TITLE     Bile acid depletion and repletion regulate cholangiocyte growth and
            secretion by a phosphatidylinositol 3-kinase-dependent pathway in
            rats
  JOURNAL   Gastroenterology 123 (4), 1226-1237 (2002)
   PUBMED   12360484
  REMARK    GeneRIF: Bile acid depletion and repletion regulate cholangiocyte
            growth and secretion by a phosphatidylinositol 3-kinase-dependent
            pathway in rats.
REFERENCE   8  (bases 1 to 4509)
  AUTHORS   Crljen,V., Volinia,S. and Banfic,H.
  TITLE     Hepatocyte growth factor activates phosphoinositide 3-kinase C2
            beta in renal brush-border plasma membranes
  JOURNAL   Biochem J 365 (Pt 3), 791-799 (2002)
   PUBMED   11931646
  REMARK    GeneRIF: data show a spatial separation of the inositol lipid
            signalling system between brush border membranes (BBM) and
            basolateral membranes (BLM); hepatocyte growth factor causes
            activation of PLC and PI3K in BLM leading to activation of PI3K-C2
            beta in BBM
REFERENCE   9  (bases 1 to 4509)
  AUTHORS   Bi,L., Okabe,I., Bernard,D.J. and Nussbaum,R.L.
  TITLE     Early embryonic lethality in mice deficient in the p110beta
            catalytic subunit of PI 3-kinase
  JOURNAL   Mamm Genome 13 (3), 169-172 (2002)
   PUBMED   11919689
REFERENCE   10 (bases 1 to 4509)
  AUTHORS   Kim,Y.B., Ciaraldi,T.P., Kong,A., Kim,D., Chu,N., Mohideen,P.,
            Mudaliar,S., Henry,R.R. and Kahn,B.B.
  TITLE     Troglitazone but not metformin restores insulin-stimulated
            phosphoinositide 3-kinase activity and increases p110beta protein
            levels in skeletal muscle of type 2 diabetic subjects
  JOURNAL   Diabetes 51 (2), 443-448 (2002)
   PUBMED   11812753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ012482.1, CV117575.1, EV762942.1, EV765206.1, BQ202622.1 and
            AW523465.1.
            
            On Sep 30, 2014 this sequence version replaced NM_053481.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ012482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3213              AJ012482.1         1-3213
            3214-3539           CV117575.1         322-647
            3540-3799           EV762942.1         388-647
            3800-3801           EV765206.1         740-741             c
            3802-3833           EV762942.1         651-682
            3834-4043           EV765206.1         497-706             c
            4044-4232           BQ202622.1         277-465             c
            4233-4509           AW523465.1         1-277               c
FEATURES             Location/Qualifiers
     source          1..4509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4509
                     /gene="Pik3cb"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit beta"
                     /db_xref="GeneID:85243"
                     /db_xref="RGD:620917"
     CDS             1..3213
                     /gene="Pik3cb"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.1.153"
                     /note="catalytic phosphatidylinositol 3-kinase beta; PI3K;
                     PI3Kbeta; ptdIns-3-kinase p110; PI3-kinase p110 subunit
                     beta; PI3K-beta; PI3-kinase subunit beta; ptdIns-3-kinase
                     subunit beta; ptdIns-3-kinase subunit p110-beta;
                     phosphatidylinositol 3-kinase, catalytic, beta
                     polypeptide; p110beta; phosphatidylinositol
                     4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;
                     phosphoinositide-3-kinase, catalytic, beta polypeptide;
                     serine/threonine protein kinase PIK3CB"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit beta isoform"
                     /protein_id="NP_445933.1"
                     /db_xref="GeneID:85243"
                     /db_xref="RGD:620917"
                     /translation="MCFRSIMPPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQL
                     EVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDV
                     RPFLPVLKLVTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKI
                     QSLVGLSWIDWLKHTYPPEHEPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNL
                     NPIKINELAIQKRLTIRGKEEEASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNR
                     TLPHFILVECCKIKKMYEQEMIAIEAAINRNSSSLPLPLPPKKTRVISHVWGNNNPFQ
                     IVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINIC
                     DLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG
                     QLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAENATALHIKFPENKKQPYYYPPF
                     DKIIEKAAEIASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCR
                     ENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV
                     GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEV
                     HTPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKE
                     AMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCRYMDSKMKPLWLVYSNRAFGED
                     AVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVST
                     SETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYV
                     LGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGK
                     TGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLAL
                     GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS"
     exon            1..171
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            172..397
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            398..621
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            622..801
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            802..972
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1050
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1302
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1399
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1530
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1581
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1770
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1892
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2036
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2136
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2315
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2425
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2504
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2672
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2796
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2942
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3075
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..4494
                     /gene="Pik3cb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgcttcc gctctataat gcctcctgct atggcagaca cccttgacat ctgggccgtg
       61 gattcacaga tcgcgtctga tggctccatc tctgtcgatt tccttctgcc cactgggatt
      121 tatatccagt tggaagtacc ccgggaagct accatttctt atattaaaca gatgttatgg
      181 aagcaagttc acaattaccc aatgtttaac ctccttatgg acattgactc ctatatgttt
      241 gcctgtgtga atcaaactgc cgtatatgag gaacttgaag atgaaacacg aagactttgt
      301 gatgtcagac ctttccttcc agttctcaaa ctagtgacta gaagctgtga cccagcagaa
      361 aaattggact caaaaattgg agttcttata ggaaaaggtc ttcatgaatt tgatgccttg
      421 aaggatcctg aagtgaatga atttagaaga aaaatgcgca agttcagcga ggacaagatt
      481 cagtctctgg tggggctgtc ttggattgac tggctcaagc acacgtaccc gcccgagcac
      541 gaaccgtccg tcctggagaa cctggaagac aaactttatg gagggaagct ggttgtggct
      601 gtgcattttg aaaatagcca ggatgtattt agttttcaag tgtctcccaa tttgaatcct
      661 ataaaaataa atgaattggc aatccagaaa cgcctcacta ttcgcgggaa ggaagaggaa
      721 gctagcccct gtgactatgt gttacaggtc agtgggagag tggagtatgt gtttggtgac
      781 catccactga ttcagttcca gtatatccgg aattgtgtaa tgaacaggac cctgccccat
      841 ttcatccttg tggaatgttg taagatcaag aaaatgtatg aacaagaaat gattgccata
      901 gaggctgcca tcaaccgaaa ctcctccagc cttcctctcc ctttaccacc aaagaaaaca
      961 cgagttattt ctcatgtctg gggcaacaac aaccctttcc aaattgtctt ggtaaaagga
     1021 aataagctta acacagaaga aaccgtgaaa gttcatgtca gagccggact ttttcatgga
     1081 accgagctcc tgtgtaaaac cgtcgtaagc tcagagatat caggaaagaa tgaccatatt
     1141 tggaatgaac aactggaatt tgatattaat atttgtgact taccaagaat ggctcgatta
     1201 tgttttgctg tttacgcagt tttggataaa gtaaaaacga agaaatcaac aaaaactatt
     1261 aatccctcta aatatcagac catcaggaaa gcaggaaaag tgcattatcc tgttgcatgg
     1321 gtaaacacca tggtttttga cttcaaagga cagctgaggt ctggagacgt aatattgcac
     1381 agctggtctt cgtttcctga tgagctggaa gaaatgctga accccatggg gactgtgcag
     1441 acgaacccat atgctgagaa tgcaactgcc ttgcacatta agtttccgga gaacaagaag
     1501 cagccttatt attacccccc cttcgataag atcattgaga aggcagctga gattgccagt
     1561 ggagacagtg cgaacgtatc aagtcgtggt gggaaaaagt ttcttgctgt actgaaagaa
     1621 atcttggaca gggaccccct gtctcagctg tgtgagaacg aaatggacct tatttggact
     1681 ctacggcaag actgccgaga aaatttccca cagtcactgc caaaactact cctgtcaatc
     1741 aaatggaata aacttgaaga tgttgctcag cttcaggcgc tcctgcagat ttggcccaaa
     1801 ctgccaccca gggaagcact ggaactcctg gatttcaact atccagacca gtatgtccga
     1861 gagtacgctg taggctgcct gcgacagatg agtgatgaag aactctctca gtatctttta
     1921 cagttggtgc aagttttgaa gtacgagcct tttcttgact gtgccctctc cagattccta
     1981 ttggaaagag cacttgacaa ccggaggatt ggccagtttc tgttttggca tcttaggtca
     2041 gaggtgcaca ctcctgctgt gtccattcag tttggtgtca tcctagaggc atactgtcgg
     2101 ggaagcgtgg ggcacatgaa agtgctttcc aaacaggttg aagcactcaa taaattaaaa
     2161 actttaaata gcttaatcaa attgaatgcg atgaagctga acagagctaa aggaaaggag
     2221 gccatgcaca cgtgcttaaa acagagtgcc taccgggagg cgctctctga cctgcagtca
     2281 cctctgaacc catgtgtcat cctctcagag ctctatgtcg aaaagtgcag atacatggac
     2341 tccaagatga agccgctgtg gctggtctac agcaacaggg cctttggaga ggacgcggtg
     2401 ggagtgatct tcaaaaatgg cgacgatttg cggcaggaca tgctgaccct gcagatgctg
     2461 cgcctgatgg atctgctgtg gaaagaagct ggcttggacc tgcgaatgct cccctatggc
     2521 tgtctagcaa caggagatcg ctctggcctc attgaggttg tgagcacctc tgagacaatc
     2581 gctgacattc agctaaacag tagcaacgtg gctgccacag cagccttcaa caaagatgct
     2641 ctcctgaact ggctcaagga gtacaattct ggggacgacc tggacagagc gattgaggag
     2701 ttcaccctgt cctgtgctgg ctactgtgta gcctcttatg tccttggcat tggtgacagg
     2761 cacagtgaca acatcatggt gaagaaaacc ggccagctct tccacataga ctttgggcat
     2821 attcttggaa atttcaaatc taaatttggc attaaaaggg aacgagtacc ttttattctt
     2881 acttatgact tcattcatgt cattcaacaa ggaaaaacgg gaaacacaga aaaatttggc
     2941 aggttccgcc agtgctgtga agacgcgtac ctgattttac ggcggcatgg gaatctcttc
     3001 attaccctgt ttgcgctgat gttgactgca gggcttcccg agctcacatc agtcaaagat
     3061 atacagtatc ttaaggactc tcttgcctta ggaaagagtg aagaagaagc actcaaacag
     3121 tttaagcaga agtttgatga ggcactcagg gaaagctgga ccactaaggt gaactggatg
     3181 gctcatacag ttcggaaaga ctacaggtct tagcgtccgc tctgctctgc tgcacttgcc
     3241 tgtttgtctc ctttccattt tgcacttgca ctattgaaca tgaccctgcg ggaaatgcca
     3301 agggaatgaa atcctgaagc tcagcgtgaa gttcagaaca cggcatccca cagaagctcg
     3361 tctgaaccac cccaatgccc accctctgta actgagtgct tccaggactc atcatgagtg
     3421 tcagcagcag catggaggac cctttcctgc tgaccttgca cgccgaggaa tgctcctggg
     3481 gactgtttgg ggtctcttct ctcttttctt cagtgtttgg taccttccca gagaggcata
     3541 aatacttctt tccagtgttg accaagtgct gcaactcagc cagcaactta gcacatttgg
     3601 gggctggaaa ctgttctaag aaaggtatct ccctctcctt tttaaattgt gtgagctaca
     3661 aattacattg attatgttga acttattatt tttcaaagga aatattttaa acctgtgaaa
     3721 actcactaat tttgttaata tttatcatga tggcatcatt tcagccagac ttgctgagaa
     3781 tctattggtg ggcaaatata atatatataa tatatatata tatatatata tatgctgcat
     3841 atatatttat aaaatttcta gtgggagttc tatataaaga gatgtttctt tggtagtcct
     3901 cagccttgtt ttacagtttt acagaagcgg agctttttcc taagttactt ttcggttaac
     3961 tgtggatcca gtgcctccag tcgcctcact actgaggcac ctatgaatgt ggcttctctg
     4021 tgtagctctg agagttcatc tcagagaaca caatacttga gcagatgtat ccaaggaagc
     4081 aagcgaatga aaaggaatct atttatggaa taaactcgaa acctaaattt cagtatttta
     4141 gtaatatgcc agctgttctt aatgtattta ttaaaatgta taacattgtg atttttttca
     4201 acggtattag ttcaaatgga agtggatccg cgccacatgg aagtctgtaa cttacttgtt
     4261 gaggtaccac acagttcggg tgctaggcgg cgggtgtgag catgtgcaat agaactactg
     4321 gtttgctgtg tacatggacg tcaggatcca gcaaagctac tgcttcttct ccaaagacac
     4381 atgggagccc tcagtcctca gtggcacggg aaacacaact gagtacttgc cctgagactt
     4441 cagttttcta taggaatttt attaaagagt gtttaatttt gttgtccttc tgaaaaaaaa
     4501 aaaaaaaaa
//
