LOCUS       NM_001105951            5340 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatidylinositol-4-phosphate 3-kinase,
            catalytic subunit type 2 beta (Pik3c2b), mRNA.
ACCESSION   NM_001105951 XM_001060466 XM_213879
VERSION     NM_001105951.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5340)
  AUTHORS   Kozhevnikova,O.S., Telegina,D.V., Devyatkin,V.A. and Kolosova,N.G.
  TITLE     Involvement of the autophagic pathway in the progression of
            AMD-like retinopathy in senescence-accelerated OXYS rats
  JOURNAL   Biogerontology 19 (3-4), 223-235 (2018)
   PUBMED   29492791
  REMARK    GeneRIF: Missense single-nucleotide polymorphism in the Pik3c2b
            gene associated with autophagy regulation in in the progression of
            Age-related macular degeneration was found.
REFERENCE   2  (bases 1 to 5340)
  AUTHORS   Devereaux,K., Dall'Armi,C., Alcazar-Roman,A., Ogasawara,Y.,
            Zhou,X., Wang,F., Yamamoto,A., De Camilli,P. and Di Paolo,G.
  TITLE     Regulation of mammalian autophagy by class II and III PI 3-kinases
            through PI3P synthesis
  JOURNAL   PLoS One 8 (10), e76405 (2013)
   PUBMED   24098492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5340)
  AUTHORS   Das,M., Scappini,E., Martin,N.P., Wong,K.A., Dunn,S., Chen,Y.J.,
            Miller,S.L., Domin,J. and O'Bryan,J.P.
  TITLE     Regulation of neuron survival through an
            intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway
  JOURNAL   Mol Cell Biol 27 (22), 7906-7917 (2007)
   PUBMED   17875942
REFERENCE   4  (bases 1 to 5340)
  AUTHORS   Sindic,A., Crljen,V., Matkovic,K., Lukinovic-Skudar,V., Visnjic,D.
            and Banfic,H.
  TITLE     Activation of phosphoinositide 3-kinase C2 beta in the nuclear
            matrix during compensatory liver growth
  JOURNAL   Adv Enzyme Regul 46, 280-287 (2006)
   PUBMED   16857245
  REMARK    GeneRIF: Activated during compensatory liver growth, which clearly
            demonstrates that different class II PI3K enzymes have different
            subnuclear localization.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213879.4, XM_001060466.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132268, SAMD00132273
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..5340
                     /gene="Pik3c2b"
                     /note="phosphatidylinositol-4-phosphate 3-kinase,
                     catalytic subunit type 2 beta"
                     /db_xref="GeneID:289021"
                     /db_xref="RGD:1306541"
     exon            1..380
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1404
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..5340
                     /gene="Pik3c2b"
                     /EC_number="2.7.1.154"
                     /note="phosphoinositide-3-kinase, class 2, beta
                     polypeptide; nuclear cap binding protein subunit 2"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit beta"
                     /protein_id="NP_001099421.1"
                     /db_xref="GeneID:289021"
                     /db_xref="RGD:1306541"
                     /translation="MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHHK
                     EESRAKQNTEPSLISWDEPALDFYSKPAGRRTELKLLRGLSGSDPTLNYNSISPPEEL
                     PNSTSQDPQPGTDPWPKGSQSGDYLYIFDGSDGRCSLSPVSGDTDGSCKKLSPPPLPP
                     RVSIWDAPPLPPRKGSPSPSKISQPDDINSFSLVEQPSDKLLGAQDPGEGELPNGGGQ
                     RHVLGSVDYDGINDAITRLNLKSTYDSEILSDATRGWKEGRGPLDFSKDTSGKPVARS
                     KTMPPQVPPRTYTPRYANRKNATPGKNRRISAAPVSSRTHTVTNGHELFEVSEERDEE
                     VAAFCHMLDILRTGSDTQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTF
                     TCNCSSTVDLLIYQTLCYTHDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQHCR
                     KFDINIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTISRQALSLLFD
                     TYHNEVDAFLLAEGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQP
                     KIQKKVVEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQEACHFSGALAFTVYG
                     THRIPIIWATSYEEFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIIWDQQICFPVQ
                     VNRLPRETLLCATLYALPIPPPGSSSEANKQKRVPEALGWVTTPLFNFRQVLTCGRKL
                     LGLWPATQENSSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSL
                     REEDQRKLKDITQKESLYWLSDADKKQLWEKRYYCHTEVSSLPLVLASAPSWEWACLP
                     DIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALK
                     YECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIRYQYLLAALLCCCGKG
                     LREEFNRQCWLVNTLAKLAQQVREATPSARQGILRAGLEEVRQFFALNGSCRLPLSPS
                     LLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIM
                     SKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADW
                     LQKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRF
                     LGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLF
                     LNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNF
                     FIHNLAQMKFTGSDDRLTLSFAPRTHTLKSSGRIRDVFLCRHEKVFHPSKGYIYVVKV
                     MRENAHEATYIQRTFEEFQELHNKLRLLFPSSFLPSFPSRFVIGRSRGEAVAERRKEE
                     LNGYIWHLIHAAPEVAECDLVYTFFHPLPRDEKTSGPSPAPKSSDGTWARPVGKVGGE
                     VKLSISYKNNKLFIMVMHIRGLQPLQDGSDPDPYVKIYLLPDPQKATKRKTKVARKTC
                     NPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVHIRLRELDLAQEKTGW
                     FALGSRGHGTL"
     exon            1405..1505
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1660
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1781
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1893
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1973
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2037
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2184
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2378
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2501
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2669
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2781
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2924
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3113
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3207
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3302
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3483
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3591
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3684
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3814
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3951
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4121
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4278
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4388
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4590
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4715
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..4833
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..4915
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..5022
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5023..5151
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
     exon            5152..5340
                     /gene="Pik3c2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccggcggc ctgggccgcg gtcctggcag gagccggtga gcctcgcgcg ccgtgcagtg
       61 cgctggctgt ccgggagatg gcttctcccc gctcgcccgc cgctcgcgct attgtctcac
      121 ccggggctgc ctgactgcga gctcgtgcac gctttcagca gacagcaccg ggccccggac
      181 cgtcccccac gcccgttgct tgcccgtgtg gtcccctgca gcggggatcc cagagccgcg
      241 gtgcgggcga agggagcagg cgacactgaa catcacgcgg gggctggagc cgggagcctc
      301 cgagcgaggc gggtcggcgg agcactagac acccagccac gacagtcagg gtgtcgcggc
      361 agaacccgcg accagcgcag gtcccgagac aacatgtacc tgctgccctc catgccggac
      421 gctggcagga agtagaaggc ttcgtcgtcg tctcctgtgc ccctcgccct catcatgtct
      481 tcgactcagg gcaatgggga gcactggaaa tccctggagt cggtgggcat cagccgcaaa
      541 gagctggcta tggctgaagc cctgcagatg gagtatgatg ctctttcccg gctccgacat
      601 cacaaggagg agagcagggc caagcaaaac acagagccct ctcttatcag ctgggatgag
      661 ccagccttgg acttctacag caagccagca ggcaggcgga cagagctcaa gctcttgcgt
      721 ggtctttctg gctctgatcc caccctaaat tacaactcca tttccccacc agaagagctc
      781 cccaactcta cctcccagga cccacagcct ggcacagatc cctggcccaa gggctcccaa
      841 tctggagact atctctatat ttttgatggc tcagatggga gatgctctct gtctccagta
      901 tcaggtgaca ccgatggctc ttgtaagaaa ctatccccac ctcctctccc tcctcgggtc
      961 tctatctggg atgcccctcc cttgcctcct aggaagggat ctccctcacc ctccaagatc
     1021 tctcagcctg atgacatcaa cagtttctct ttggtggaac agccatctga caaactgcta
     1081 ggggcccagg acccaggaga gggagagcta cccaatggtg ggggacagcg acatgtgctg
     1141 gggtccgtgg actatgacgg catcaatgat gcaatcacga ggctcaactt gaagtccact
     1201 tacgattcgg agatattgtc tgacgctacc aggggctgga aggagggccg aggacccctg
     1261 gactttagca aggacacctc tgggaaacct gtagcccgga gcaagacgat gccccctcaa
     1321 gtgccccctc gaacctatac gccccgatac gccaaccgaa aaaacgcaac acctggcaag
     1381 aaccgccgga tatctgccgc tccggtgagc tctcggaccc acactgtcac caatggccat
     1441 gaattgtttg aggtctcaga ggagagagat gaggaagttg ctgcgttctg ccacatgcta
     1501 gatatcctgc gcacgggctc tgatacccag gactattccc taactgggtg tgtctggagc
     1561 actgtcaccc cgagcccaga gcaccttggg gatgaggtca acctgaaggt gactgtgttg
     1621 tgtgacagtc ttcgggagcc actcaccttt acctgcaact gttcctccac cgtggacttg
     1681 ctcatttacc agaccctctg ctacacccac gacgagctga gggaggtgga tgtgggcgac
     1741 tttgtgctca agccctgtgg gctggaggaa ttcctgcaaa ataagcacgc cttgggaagc
     1801 catgagtata tccaacactg ccgcaagttt gacatcaaca tccgactaca gctgatggag
     1861 cagaaggcta tccggagcga cctggcccgg acggtgaatg atgaccagag cccttccacc
     1921 ttgaactacc tcatccatct tcaagagcgg ccagtcaagc agaccatcag caggcaggcc
     1981 ttgagtcttc tgtttgacac ttaccacaat gaggtggatg ccttcctact ggctgaaggg
     2041 gatttcccac tgaaggctga cagggtggtc cagtctgtga aggccatctg caatgctctg
     2101 gctgctgtgg agactcctga gatcacgagt gctctcaacc agctgcctcc ctgcccgtca
     2161 cgaatgcagc cgaaaatcca gaagaaggtg gtagaagcct tgacagcagc catcttggac
     2221 ttagtggagc tgtactgcag cacattcaat gcagacttcc agacagccgt acctgggagc
     2281 cgaaagcatg atttggttca agaggcctgc cacttctctg gggccctggc cttcactgtc
     2341 tatggcactc accgtattcc catcatctgg gctaccagct atgaagagtt ctacctctcc
     2401 tgctccctca gccacggtgg caaggaactt tgcagccctc tgcagacccg gcgggctcac
     2461 ttctccaagt acctgttcca cctcatcatc tgggaccagc agatctgctt tcccgtgcag
     2521 gtgaacaggc tgcctcggga gaccctgctg tgtgccacac tctatgccct gcccattccc
     2581 cctcccggga gttcctccga agccaataag cagaagcggg tgcctgaagc tctgggttgg
     2641 gtcactaccc ccctcttcaa cttcaggcaa gtcttgacct gtggccgaaa gcttctgggc
     2701 ttgtggccag caacacagga gaactccagt gcccgttgga gtgcaccaaa tttccaccag
     2761 ccagacagtg tcatcctgca gattgacttc cccacctcgg cctttgacat caagttcacc
     2821 agcccccctg gagacaagtt cagcccccgc tatgagtttg gcagtctccg ggaggaggac
     2881 cagcgcaaac ttaaagacat tacgcagaag gagtcccttt actggctctc tgatgccgac
     2941 aagaagcaac tgtgggagaa gcgctattac tgccacactg aggtgagctc gctccccttg
     3001 gtgctcgcca gtgcacccag ctgggagtgg gcttgcctgc cggacatcta tgctctcctg
     3061 caacagtgga ctcacatgaa ccaccaggat gccctgggac tcctgcatgc caccttcccg
     3121 gaccaggagg tgcggcgcat ggccgtgcag tggatcggct ccctctcgga tgctgagctg
     3181 ttggactacc tgccccagct agtacaggcc ctgaagtacg agtgctacct ggatagcccc
     3241 ttggtgcgct ttctcctgaa gcgagccatc tccgacctgc gagtgaccca ctactttttc
     3301 tggttactga aggacagcct caaggactcc cagttcagca tccgttacca atacctgcta
     3361 gcggccctgc tgtgctgctg tggcaaggga ctgagggagg agtttaaccg ccagtgctgg
     3421 cttgtcaata ccctggccaa actggcccag caggtccgag aggccacccc atctgcacgc
     3481 cagggcatcc ttcgtgcggg cttggaggag gtgaggcagt tctttgctct caatggttcg
     3541 tgccgtctgc cgcttagccc cagtctgctg gtgaaaggca ttgtgcccag ggactgttcc
     3601 tatttcaact ccaatgctgt ccccctcaag cttgccttcc aaaatgtgga tccactgggc
     3661 gagaatatca gagtcatctt caagtgtgga gatgaccttc gccaggacat gctcaccctg
     3721 cagatgattc gcatcatgag caagatctgg gtgcaggagg ggctggatat gcgcatggtc
     3781 attttccgct gcttctccac tggccgagga aaagggatgg tggagatgat acccaatgcc
     3841 gagacactgc gtaagatcca ggtggagcat ggggtgaccg gctccttcaa ggaccgtccc
     3901 ctggctgact ggcttcagaa gcacaaccct ggggaggatg aatatgaaaa ggctgtggag
     3961 aacttcatct actcttgtgc cggctgctgt gtggctacat acatcttggg catctgtgac
     4021 agacacaatg acaacatcat gctgaagacc acgggccaca tgttccatat agacttcggc
     4081 cgcttcctgg gccacgcgca gatgttcggt aatatcaaga gggaccgcgc cccgtttgtc
     4141 ttcacctcag acatggcgta tgtcatcaac gggggtgaca agccttccag ccgcttccat
     4201 gattttgttg acctttgctg ccaagcctac aacctcattc gcaagcacac ccatctcttc
     4261 ctcaacctcc tgggcctgat gttgtcctgt gggatccccg agctctcaga cctggaggac
     4321 ctcaagtatg tgtatgatgc cctgagacct caggacacgg aggccaatgc cactacctac
     4381 ttcacaaggt tgattgagtc cagcttgggc agcgtagcta cgaaactcaa ctttttcatc
     4441 cacaacctgg ctcagatgaa gttcacaggc tcagacgacc ggctcaccct ctcctttgcc
     4501 ccccgaacac atactctcaa gagctctggc cgcatccgtg atgtctttct ctgccgacat
     4561 gagaaggtct tccaccctag caagggctat atctatgtgg tgaaggtgat gcgagagaac
     4621 gctcacgagg caacctacat ccagaggacg ttcgaggagt tccaggaact gcacaataag
     4681 ctgcgcctgc tcttcccttc ctccttcctg cccagcttcc ctagtcggtt tgtgattggc
     4741 cgctcccggg gagaggcagt ggctgagagg cggaaggagg agctaaatgg ctacatctgg
     4801 cacttgattc atgcagcccc tgaagtggct gagtgtgacc tggtatatac tttcttccat
     4861 cctctgcccc gcgatgagaa gacttcaggc cctagcccag ccccgaagtc atcagatggg
     4921 acgtgggccc ggccggttgg gaaggtcggt ggggaggtga agctgtccat ttcctacaaa
     4981 aacaacaaac tcttcatcat ggtgatgcat attcggggct tgcaaccgct ccaggatggc
     5041 agtgaccctg acccatatgt aaagatttac ctccttcctg accctcagaa agccacaaag
     5101 aggaaaacca aagtagcccg gaaaacctgc aaccctacct acaatgagat gttggtgtat
     5161 gatgggattc ccaagggaga cctacaacag cgggagctcc agttgagtgt gctaagtgag
     5221 caaggatttt gggagaacgt gcttctcggg gaggtgcaca tccgccttcg ggagctggac
     5281 ctggcccagg agaagaccgg ctggtttgca ctgggatctc gaggtcatgg aaccttatga
//
