LOCUS       NM_001398791            6773 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus phosphoinositide-3-kinase adaptor protein 1
            (Pik3ap1), transcript variant 1, mRNA.
ACCESSION   NM_001398791 XM_008760414
VERSION     NM_001398791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6773)
  AUTHORS   Troutman TD, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan JF
            and Pasare C.
  TITLE     Role for B-cell adapter for PI3K (BCAP) as a signaling adapter
            linking Toll-like receptors (TLRs) to serine/threonine kinases
            PI3K/Akt
  JOURNAL   Proc Natl Acad Sci U S A 109 (1), 273-278 (2012)
   PUBMED   22187460
REFERENCE   2  (bases 1 to 6773)
  AUTHORS   Ni M, MacFarlane AW 4th, Toft M, Lowell CA, Campbell KS and
            Hamerman JA.
  TITLE     B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like
            receptor signaling through activation of PI3K
  JOURNAL   Proc Natl Acad Sci U S A 109 (1), 267-272 (2012)
   PUBMED   22187458
REFERENCE   3  (bases 1 to 6773)
  AUTHORS   Matsumura T, Oyama M, Kozuka-Hata H, Ishikawa K, Inoue T, Muta T,
            Semba K and Inoue J.
  TITLE     Identification of BCAP-(L) as a negative regulator of the TLR
            signaling-induced production of IL-6 and IL-10 in macrophages by
            tyrosine phosphoproteomics
  JOURNAL   Biochem Biophys Res Commun 400 (2), 265-270 (2010)
   PUBMED   20728433
REFERENCE   4  (bases 1 to 6773)
  AUTHORS   Papin J and Subramaniam S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   5  (bases 1 to 6773)
  AUTHORS   Okada T, Maeda A, Iwamatsu A, Gotoh K and Kurosaki T.
  TITLE     BCAP: the tyrosine kinase substrate that connects B cell receptor
            to phosphoinositide 3-kinase activation
  JOURNAL   Immunity 13 (6), 817-827 (2000)
   PUBMED   11163197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000054.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001398791.2.
            
            On Dec 23, 2021 this sequence version replaced XM_008760414.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169055.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132283,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JACYVU010000054.1  1298744-1298888     c
            146-565             JACYVU010000054.1  1289545-1289964     c
            566-702             JACYVU010000054.1  1247305-1247441     c
            703-847             JACYVU010000054.1  1242373-1242517     c
            848-990             JACYVU010000054.1  1241230-1241372     c
            991-1123            JACYVU010000054.1  1240967-1241099     c
            1124-1320           JACYVU010000054.1  1237567-1237763     c
            1321-1510           JACYVU010000054.1  1234676-1234865     c
            1511-1606           JACYVU010000054.1  1221184-1221279     c
            1607-1801           JACYVU010000054.1  1217645-1217839     c
            1802-1867           JACYVU010000054.1  1213499-1213564     c
            1868-2073           JACYVU010000054.1  1211899-1212104     c
            2074-2146           JACYVU010000054.1  1208210-1208282     c
            2147-2302           JACYVU010000054.1  1202051-1202206     c
            2303-2373           JACYVU010000054.1  1197590-1197660     c
            2374-2510           JACYVU010000054.1  1196251-1196387     c
            2511-6773           JACYVU010000054.1  1184895-1189157     c
FEATURES             Location/Qualifiers
     source          1..6773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6773
                     /gene="Pik3ap1"
                     /note="phosphoinositide-3-kinase adaptor protein 1"
                     /db_xref="GeneID:294048"
                     /db_xref="RGD:1307744"
     exon            1..145
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..565
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..702
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..847
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..990
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1123
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1320
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1510
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1606
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1801
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1867
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2073
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2146
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2302
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2373
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2510
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..6773
                     /gene="Pik3ap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtcgcca ctgtcctgag cacagctggg cgccactcct gctccacgcc agcaacgtcg
       61 cccaccgccg ctgcggacgc cggataccgt gctcccgcgc cggccgggga tgcgagctgc
      121 tcccgcgacg gcatggcagc ctcagggtgg ggctggggat gcgacatcct catcttctac
      181 agcccagatg ccgaggaatg gtgccagtac ctacaggatc ttttcgtgtc ctgccggcag
      241 gtccgtagcc agaagattca gacatatcgg ctggtcccgg atgcctgctt ttcctcccag
      301 gacctgtcgg tcttcaggga tgcacgatgc gtgctggtgc tactgtctgc ggggctggtg
      361 gaatgcttcg tccagccagg actgctgccc gtgctccagc gtgcctgcca cccgccacag
      421 cgcgtggtgc gtctgctgtg cggagtgcag cccaacgatg aggacttcca ggccttcttt
      481 cccgactggg cccactggca ggaactgacc tgtgatgacg aaccggagac ctatctggcg
      541 gcggtgagga aggccatttc tgaagattct ggctgtgatt cagtaaccga cacggagccc
      601 gaggacgaga gagctcttcc tttctcaaag catacagacc tgcctctgga gacatcgcct
      661 gggaacctga tggtggtaca gccggaccgc attcgttgtg gggcagaaac cactgtgtat
      721 gtcattgtga gatgcaagct ggacgagaag gtgtcaacag aagtcgagtt ttctcctgag
      781 gattctccct ccgtccggat ggaaggcaca ctggaaaatg agtacacagt ctcggtgaaa
      841 gcaccagacc tctcgtcggg gaatgtttct ctgaaggtct attctgggga cctggtggtc
      901 tgtgaaacca ccatcagcta ttacaccgac atggaggaaa ttgggaactt actctccagt
      961 gctgcaaatc ccgtggagtt tatgtgtcag gcctttaaaa tcgtgcccta caacacagag
     1021 actctcgata aactgctcac ggagtccctg aagaacaaca tccctgcaag tggactgcac
     1081 ctctttggga tcaaccaact ggaagaagac gatatgatga caaatcagag ggatgaggag
     1141 ctgcccaccc tgctgcattt tgctgccaag tacggactga agaacctcac cgccttgctg
     1201 ctcacctgcc caggggctct ccaggcatac agtgtggcca acaagcatgg ccactacccc
     1261 aacaccattg ctgagaaaca cggcttcagg gacctgcgcc agttcatcga cgagtatgtg
     1321 gagaccgtgg acatgctgaa gagtcacatt aaagaggagt tgatgcaggg cgaggaggct
     1381 gacgatgtgt atgagtccat ggcccacctg tccactgact tgctgatgaa atgctccctc
     1441 aaccccggct gtgacgacga gctctatgag tccatggctg ccttcgcccc agcagccaca
     1501 gaagacctct atgtcgaaat gcttcaagcc agtgcaggta accctgtctc tggagaaagt
     1561 ttctctcggc ccactaagga ctcgatgatc cgcaagtttc tagaaggtaa cagtatgaag
     1621 ctggccagtt tggagagaga gcagcaccct ccccacgggg aagaactcta tcacacagtg
     1681 gaggaagatg agaccttctc tgtggacctg gccaacaggc cccctgtccc cgtgcccagg
     1741 ccagagacca gcactcctgg ccctcaccca ctacctgaca atgagccata catttctaaa
     1801 gtttttgcag aaaaaagtca ggaacgggtc gggaatttct atgtttcttc agagagcatc
     1861 aggaaagagc cgcttgtgag gccatggagg gacaggcccc catcgagcat ctacgaccca
     1921 tttgccggga tgaagacgcc gggccagcgg cagctcatca ccctgcagga gcaggtgaag
     1981 ctgggcatcg tcaacgtgga cgaggctgtg ctgcacttca aagagtggca gctcaatcag
     2041 aagaagcggt ccgagtcctt tcgcttccag caggaaaacc ttaaaagact gagagacagc
     2101 atcacccgaa gacagagaga gaagcagaag tcaggaaagc atgcagacct ggagatcaca
     2161 gttccaatcc gacattcgca gcacctgcca gggaaggtgg agttcggtgt gtatgagagc
     2221 gggcccagga agagcgtctt cccagccagg acagagctga gacgcggaga ctggaaaaca
     2281 gacagcacat ccagcacagc aagcagcacg agtaaccgat cgagtacacg gagccttctc
     2341 agcgtgagca gtggaatgga gggcgacaat gaggacaatg aagtccctga aattacccgg
     2401 agtcgtggcc caggtcctac ccaggtggat ggagctccag ttgtaaccgg aacacccgtc
     2461 gggatccttg agagacctcc tagggtgcct cctcgagctg cttcacagag gcctctaacc
     2521 cgggagccct tccatcatcc tcctccgcca gttccaccca gaggtcgctg attccacctc
     2581 ctagatccgg cctacttcgg gacttttaag actagccatt ctcagcctct tgatgaagtc
     2641 ttcatattga gttttctgca tgactatgga cctggagacc cactgtcact ggtgatggtg
     2701 tagccctgct ggtttgggtg atccttgaag acattattaa ggcatgagga aacctgagac
     2761 gaaggcgact ttgttcaatg tcaccaaata tattggttca cattcttatt tgctgaaagg
     2821 atgaaaatac tcacctctcc tatcctagag agggagctta ccaagaccaa tgggcatgtg
     2881 cttaacaagt gagcatactg taggaaacat ctatcagcct gtacagacct ggtagtgcag
     2941 cttaatttct ggaagtgatt atagcccttc cagcagaggt aagaagggac ctaactttga
     3001 agtagttctt tcacagtcta tgtttgtcct gggactggtc acatacgaca agctgaaaag
     3061 ggggttaagc cagactcttg ctccactgtg ccatttgggg tcccccagaa gtgtgaaaca
     3121 ggtggctctg tcatcaccct ctttgaatgt gtatgtgtat ggtgtgtaca tgcagatgtg
     3181 tgtctgtatg tctgtgggca tatgtatgca cctctgtgtg cagactagaa gcaatgttgg
     3241 aagtctctgt cactctctgt tcactgaggc agagccaggc tctcgactga actcagagat
     3301 gactggtaca attagtctag cttgttccag ggatctcctg gctccactct cccggtgctg
     3361 aaatcacagg caggttgcca tgccccctca acatctgtgg gatacttggg atctgaatac
     3421 tggtcctcat gcttggacag caagcacttt atctactgat ccatctcccc agcccctgtc
     3481 agcacacttt gtgtctttaa gaagcccaat cccctccctc tcataagaat tctccaaatg
     3541 tagaaataga gccatacctc actatcagcc ttcttgacat taccctcgtc tgtatctccc
     3601 aggcatggga ctatcagcta ctgccttcac tttgggcttt tgtacctcag aatgctgtca
     3661 aactagttgt gttataggaa atcactgaaa atgatcagaa ccagaatata atatggcctt
     3721 tatatgtctt agttctagct ataaagaagg agcaggaccc ttaattattt ttctctcctg
     3781 aggatcttga agaagtgaca gaaagaagct aaaatatttt ctccccataa caatatactg
     3841 ttactacata ctgttacaat caacctggta aatatgtaga gtacagaact gtaaccattt
     3901 tatgaatgtt gagttcctat tatataaatc taccttcaaa ccacagatcc ttaattttag
     3961 ctatgtacac ggtaaagtta tcagaagggg tccttttaga atacaagtaa tgtcgttgtt
     4021 tctcatgaaa cctttgtcca atcccatata gatatatatt attattgatc tgttcaagtg
     4081 tattcttact ggatcctttt ctcataatta aaggttctcc tttcaatctc tttccatggt
     4141 ccaacacttc ctgggtttaa cttctggggg actcttgagt tgttatataa aacctgccat
     4201 tgatcatgtc caccatggga gagtattttc acaaagtatc tcacagagaa cctggaacat
     4261 ggtagccatt ctggaagtgt ccctcaatcc tcctgtcact tgtttgggag acgtaagaga
     4321 atatcatgta gaagaacaaa gatgacatca gtgtggttgt cctgttcttt atcattcccc
     4381 attttgagag ttttgataaa agagttgtat cttgttatct taagcccctt ttggctacca
     4441 aacttaggct agtatacata ttctggtgaa ctttgataaa taacaacatg gctgtttgtg
     4501 caatgtttgg atatattatt acattttatt cttatatcga aataaataga aaacaaaatt
     4561 caaagtgctt tttgaggagc ctgggtctaa tgaacatgat gcttttggga ggtacataga
     4621 actgatcaga gttgggtgtg gtcagtctta agttctcagg agatattccc tgacccagca
     4681 agctgttgga gattggttct aatgctttga ttcaatcagg agtctgagtg cccaaatgct
     4741 aaataaaggt cctcctcccc aattggtttt tgatcaatcg ttaaagatgc caatagccaa
     4801 tgactaggca tggggtggga cacttagagt tgcacagtct aggatgagag aggaaccaga
     4861 gagattcgtg atggctctgg gaagaagaat ggaacacaga agtggcagga gataaagcca
     4921 agtagtcatg tgagatttca ttcaggtaag tagtcactgg ccacttcccc gattggacct
     4981 ggggtagcag gggaaggctt aggagccttt gaggtagcca agccaaggta tttaaaataa
     5041 actagtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtccgtgt
     5101 gtgtgtgtgt gtgtgtgtgt gcacatgcat gtgcatgcgc atgggtgatc ctccgggagc
     5161 caaagtggtg tagccataac tcctgctaca gcaagctggt tagctgtgtg aggaggaaga
     5221 ggaggaagag gaagaggaag aaggaggagg gagaatccgg atgaatcacc tgtcacctgg
     5281 atggtattac tgaagtttgt tcttaatggt tagaatattc taattaccta gaaagagaac
     5341 catacctgaa gcactcattt attcgtcctt tacatacaga acacatttag gaatgcgtta
     5401 tataaaataa aaacgcggat ttttttctaa tgcaatgagg accagaagct gaaaataaac
     5461 aggtagatga agatggtctc cagatcttct ctggcgcatg gatgatagct tctccactgc
     5521 cttccttcct ccagatttta ccagggagct caacagacag aaaagcaatg gtgatgttca
     5581 ctgcagcctc cgtcaacaca gtctgacagc acttttcctt atcatatgtt cactcctaga
     5641 cacaaacaac caactacaga agcaacaagg tacaaagact gagagactaa gtatgaatga
     5701 gaagttgatg ttccaagcaa atcatttaaa ttggcatatt taacggattc tgatgactcc
     5761 tcctgctttg ctgtagccac acaattatta tgcatctaga ccactctaat gactgatcta
     5821 gcaaatcaaa cagatagtta ctctcccagt cctttgttat taaaaacaaa caaaggcgaa
     5881 ggggagccaa gccaggtcag taacagccct agagctgggg ttttgagatt cctttcccac
     5941 atactccaag gaagcaagtg cgtatcctgc gctcctccgc agggaacagt gtgtgagaaa
     6001 ggcgagtaat taaacctgaa actggaggaa tctgactata agatatttgc tttgggtgca
     6061 tatgtaaatt gttttggttt ccaagcatgt tattaagaat ataaaatagt tttcattcat
     6121 tcctgctggc cagacatgag gcttcccagg gtagtgggag gattagtggg agggtaaaac
     6181 acggatttag aattctcaga cacaacttgg aattcatttt ctcatagaaa aagaaaggtt
     6241 cccaggctag cctgccaacg ctcgtctcat ccacagagtg gaaggcagtt ttatttttct
     6301 gtacccgaag agacagtgtg gtgttaggac gggaatcttt gcttggcaag caggaagctc
     6361 tgcttctagt tcagtcagct gctcactgcg tgagcccaca tcatgatgtc acagctgtgc
     6421 actccatcac ctctgaaact cacagctttg tgcttggtgt ccaggtggct ccaagtctga
     6481 gaagacaagg ccaaggcagg gaaccccttc tgaaggagca tggaggcagc ctattggagt
     6541 catcaccacc taagtagcta ggatctttgt gtgggggtgg gatgggtgag gagaagaaga
     6601 gggcaaggag acggcatcga actcatggcc tactttcctc atgttgtgtg cgtgctctac
     6661 aattgtgaaa cctccagccc cagagcttca tattatgtga cacctggtgt ttcttgcctt
     6721 taatcattgt aatagattaa ttaattaaag aaaaaaacca ctgggtgagg gca
//
