LOCUS       NM_001010966            2429 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis,
            class V (Pigv), mRNA.
ACCESSION   NM_001010966 XM_345586
VERSION     NM_001010966.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Krawitz,P.M., Schweiger,M.R., Rodelsperger,C., Marcelis,C.,
            Kolsch,U., Meisel,C., Stephani,F., Kinoshita,T., Murakami,Y.,
            Bauer,S., Isau,M., Fischer,A., Dahl,A., Kerick,M., Hecht,J.,
            Kohler,S., Jager,M., Grunhagen,J., de Condor,B.J., Doelken,S.,
            Brunner,H.G., Meinecke,P., Passarge,E., Thompson,M.D., Cole,D.E.,
            Horn,D., Roscioli,T., Mundlos,S. and Robinson,P.N.
  TITLE     Identity-by-descent filtering of exome sequence data identifies
            PIGV mutations in hyperphosphatasia mental retardation syndrome
  JOURNAL   Nat Genet 42 (10), 827-829 (2010)
   PUBMED   20802478
REFERENCE   2  (bases 1 to 2429)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 2429)
  AUTHORS   Kang,J.Y., Hong,Y., Ashida,H., Shishioh,N., Murakami,Y.,
            Morita,Y.S., Maeda,Y. and Kinoshita,T.
  TITLE     PIG-V involved in transferring the second mannose in
            glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 280 (10), 9489-9497 (2005)
   PUBMED   15623507
REFERENCE   4  (bases 1 to 2429)
  AUTHORS   Fabre,A.L., Orlean,P. and Taron,C.H.
  TITLE     Saccharomyces cerevisiae Ybr004c and its human homologue are
            required for addition of the second mannose during
            glycosylphosphatidylinositol precursor assembly
  JOURNAL   FEBS J 272 (5), 1160-1168 (2005)
   PUBMED   15720390
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB196341.1.
            
            On Jan 28, 2005 this sequence version replaced XM_345586.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB196341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132300, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2429
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class V"
                     /db_xref="GeneID:366478"
                     /db_xref="RGD:1309526"
     exon            1..334
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /inference="alignment:Splign:2.1.0"
     exon            335..453
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1854
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /EC_number="2.3.1.225"
                     /note="GPI mannosyltransferase II; PIG-V; GPI-MT-II;
                     phosphatidylinositol-glycan biosynthesis class V protein;
                     phosphatidylinositol glycan, class V"
                     /codon_start=1
                     /product="GPI mannosyltransferase 2"
                     /protein_id="NP_001010966.1"
                     /db_xref="GeneID:366478"
                     /db_xref="RGD:1309526"
                     /translation="MGLLDPSQKEVLKFAVSCRILTLVLQALFNIIIPDHHADAFSPP
                     RLAPSGSVDQLVEALLGGLSRWDAEHFLFIAEHGYLYEHNFAFFPGFPLALLMGTELL
                     RPLQGLLSERSCLLVSVALLNSLFSVLAAVALHDLGCLVLHCPRQAFCAALLFCLSPA
                     NVFLAAGYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLLHSQC
                     RGFCSSLVVLDPLKGLVKLMASLCLSVLTVSLPFALFQYYAYTQFCFPGSAHAIPEPL
                     LRLASDRGYRLAGDYEPPWCSRAPPLIYSYIQDVYWNVGLLRYYELRQVPNFLLATPV
                     TVLVVWATWTYVTAHPWLCLTLGLQRTKDRESLEKPHPGFLSAKVFVYLVHAAALLAF
                     GGLCMHVQVLTRLLGSSTPITYWFPAYLLQDREPLLRCVDTAPQKLLENSPPGQKAPR
                     NCVMKLLYNWKTCSPVTKCILVYFLTYWLLGLIMHCNFLPWT"
     exon            454..1575
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..2413
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggattcc cctactttct tctcacccag gcgctgggta ccgctgcttg ccacaaaaac
       61 cccaagaagg ctttcttttg cctattcata ttgtctattg tgtgccaggt cctgtgctga
      121 gctggtgtgg cgggacagga gaggacacgc ggctcaggca gcagtgaaaa ggcctggggc
      181 agtacccggt ccagcctcgg cccacaacga gaagtcagag gctgtttacg gaagggggaa
      241 ctggggcgag agccccgact gggagcgcag cgcccgcgca caaactgatg gcgagcgaag
      301 aggcaaactc ctcaggtgtc accacgccgg gaagaatttg gaagccagag gaagctcagt
      361 cctgatggtg tgaggatggg gctcctggac ccgtcccaga aagaggtgct gaaatttgca
      421 gtgagctgcc gcatcctgac tctagtgcta caggcactct tcaatatcat catcccagac
      481 caccatgccg atgccttttc tcctccccgc ctcgccccct cgggctctgt ggatcagctt
      541 gtggaagctc ttctgggtgg tctgtctcga tgggatgctg aacacttcct gtttattgct
      601 gagcacggct acctttatga gcacaacttt gccttcttcc ctggcttccc cttggccctg
      661 ctgatgggaa ctgaactgct gaggcccctg cagggcctct tgagcgagcg cagttgcctg
      721 ctggtctcag tagcacttct caactccctg ttctctgtgc tggccgcagt tgcacttcat
      781 gacttgggct gtctggtttt gcactgtcct cgccaggcct tttgtgcggc actgctcttc
      841 tgcctcagcc ctgccaatgt tttcttggca gctggttact cggaagcttt gtttgccttc
      901 ctgacattca gtgccatggg gcagctggag aggggccgag gctgggctag tgggctgctc
      961 tttgctcttg ccgctggggt gcgctccaac gggctggtca gcgttggctt cctcctgcat
     1021 tctcagtgca gaggcttttg ttcttctctg gtggtgctgg accccttgaa agggctggtc
     1081 aagctcatgg cctctctgtg cttgtcagta ctcacagtca gccttccttt tgccctcttt
     1141 cagtattatg cctacaccca gttctgtttc ccaggctcag cccatgccat ccctgagccc
     1201 ttgctgcggc tagcttcgga cagaggctac cggcttgcag gagactatga gcccccatgg
     1261 tgctcccggg ctcctccact aatatacagc tatattcagg atgtctactg gaacgttggt
     1321 cttctgcgat actatgagct cagacaggtg ccgaattttc tcctagctac accagtgact
     1381 gtactggttg tgtgggcaac ctggacgtat gtgaccgccc acccttggct ctgccttacc
     1441 cttgggctgc aaaggaccaa ggacagggag agcctggaga agccccatcc tggcttcctc
     1501 agtgcaaagg tgtttgtgta cctggtccac gcggcagcgc tgctggcctt tggaggtctg
     1561 tgcatgcatg tccaggttct cacgcgactt ctgggctctt ccactcccat cacatactgg
     1621 tttccagctt acctgcttca ggatcgagaa ccactgttaa gatgtgtaga cacagcccct
     1681 cagaagcttc ttgagaattc cccaccagga caaaaggccc ccagaaactg tgtcatgaaa
     1741 ctcttataca actggaagac ctgctctcca gtcacaaaat gcatcctagt ctacttcctg
     1801 acctactggc tcctgggact aattatgcat tgcaacttcc tgccttggac ttgacctgga
     1861 atctcagggc aagctggaag ctaatttaag cctgggtctg aaagctgtaa gacaccccaa
     1921 ctaggactgc ctggacactc ctggagcact gtccagtggg atttccccat gtctctctgg
     1981 aggccagtta agaagggaaa atgggagcct ctcatcctgg gcggggtgaa tttaggggag
     2041 taacttcgct gctcagtaga tctgtctcaa atcttcctgg tcaacaagta tgaggcaatc
     2101 ttgaacctac ctctgatcca tgtgtaagtc ttcatctttt tgtttttcca tagagggttt
     2161 ctctgcgtag ccctggcgtc ttggaactca ctctgtaaac cagatttgtg cagaccaggc
     2221 taacctggaa ctcaagagat ccacctgctt ctgcctcctg agtgctagga ttaaagccat
     2281 gagccaccac tgcctggcct ggtgggtaaa tttaaatgtt tgctcaaatc acaggcaaca
     2341 gcctagtcca ttcatgacga tggagatagt gcaatgtaat gactgaagga aaaaggaact
     2401 gcctgctcta aaaaaaaaaa aaaaaaaaa
//
