LOCUS       NP_001010966             492 aa            linear   ROD 24-JUN-2024
DEFINITION  GPI mannosyltransferase 2 [Rattus norvegicus].
ACCESSION   NP_001010966 XP_345587
VERSION     NP_001010966.1
DBSOURCE    REFSEQ: accession NM_001010966.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 492)
  AUTHORS   Krawitz,P.M., Schweiger,M.R., Rodelsperger,C., Marcelis,C.,
            Kolsch,U., Meisel,C., Stephani,F., Kinoshita,T., Murakami,Y.,
            Bauer,S., Isau,M., Fischer,A., Dahl,A., Kerick,M., Hecht,J.,
            Kohler,S., Jager,M., Grunhagen,J., de Condor,B.J., Doelken,S.,
            Brunner,H.G., Meinecke,P., Passarge,E., Thompson,M.D., Cole,D.E.,
            Horn,D., Roscioli,T., Mundlos,S. and Robinson,P.N.
  TITLE     Identity-by-descent filtering of exome sequence data identifies
            PIGV mutations in hyperphosphatasia mental retardation syndrome
  JOURNAL   Nat Genet 42 (10), 827-829 (2010)
   PUBMED   20802478
REFERENCE   2  (residues 1 to 492)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (residues 1 to 492)
  AUTHORS   Kang,J.Y., Hong,Y., Ashida,H., Shishioh,N., Murakami,Y.,
            Morita,Y.S., Maeda,Y. and Kinoshita,T.
  TITLE     PIG-V involved in transferring the second mannose in
            glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 280 (10), 9489-9497 (2005)
   PUBMED   15623507
REFERENCE   4  (residues 1 to 492)
  AUTHORS   Fabre,A.L., Orlean,P. and Taron,C.H.
  TITLE     Saccharomyces cerevisiae Ybr004c and its human homologue are
            required for addition of the second mannose during
            glycosylphosphatidylinositol precursor assembly
  JOURNAL   FEBS J 272 (5), 1160-1168 (2005)
   PUBMED   15720390
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB196341.1.
            
            On Jan 28, 2005 this sequence version replaced XP_345587.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB196341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132300, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..492
                     /product="GPI mannosyltransferase 2"
                     /EC_number="2.3.1.225"
                     /note="GPI mannosyltransferase II; PIG-V; GPI-MT-II;
                     phosphatidylinositol-glycan biosynthesis class V protein;
                     phosphatidylinositol glycan, class V"
                     /calculated_mol_wt=54570
     Region          9..492
                     /region_name="Mannosyl_trans2"
                     /note="Mannosyltransferase (PIG-V); pfam04188"
                     /db_xref="CDD:282094"
     Site            14..34
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            78..98
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            114..134
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            137..157
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            162..182
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            193..213
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            235..255
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            328..348
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            379..399
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     Site            469..489
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KR61.1)"
     CDS             1..492
                     /gene="Pigv"
                     /gene_synonym="RGD1309526"
                     /coded_by="NM_001010966.1:376..1854"
                     /db_xref="GeneID:366478"
                     /db_xref="RGD:1309526"
ORIGIN      
        1 mglldpsqke vlkfavscri ltlvlqalfn iiipdhhada fspprlapsg svdqlveall
       61 gglsrwdaeh flfiaehgyl yehnfaffpg fplallmgte llrplqglls erscllvsva
      121 llnslfsvla avalhdlgcl vlhcprqafc aallfclspa nvflaagyse alfafltfsa
      181 mgqlergrgw asgllfalaa gvrsnglvsv gfllhsqcrg fcsslvvldp lkglvklmas
      241 lclsvltvsl pfalfqyyay tqfcfpgsah aipepllrla sdrgyrlagd yeppwcsrap
      301 pliysyiqdv ywnvgllryy elrqvpnfll atpvtvlvvw atwtyvtahp wlcltlglqr
      361 tkdreslekp hpgflsakvf vylvhaaall afgglcmhvq vltrllgsst pitywfpayl
      421 lqdrepllrc vdtapqklle nsppgqkapr ncvmkllynw ktcspvtkci lvyfltywll
      481 glimhcnflp wt
//
