LOCUS       NM_012723               3929 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus polymeric immunoglobulin receptor (Pigr), mRNA.
ACCESSION   NM_012723
VERSION     NM_012723.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3929)
  AUTHORS   Matsuzaki,K., Sugimoto,N., Islam,R., Hossain,M.E., Sumiyoshi,E.,
            Katakura,M. and Shido,O.
  TITLE     Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor
            Expression in the Submandibular Glands Are Enhanced in
            Heat-Acclimated Rats
  JOURNAL   Int J Mol Sci 21 (3), 815 (2020)
   PUBMED   32012687
  REMARK    GeneRIF: Salivary Immunoglobulin A Secretion and Polymeric Ig
            Receptor Expression in the Submandibular Glands Are Enhanced in
            Heat-Acclimated Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3929)
  AUTHORS   Morzel,M., Chabanet,C., Schwartz,C., Lucchi,G., Ducoroy,P. and
            Nicklaus,S.
  TITLE     Salivary protein profiles are linked to bitter taste acceptance in
            infants
  JOURNAL   Eur J Pediatr 173 (5), 575-582 (2014)
   PUBMED   24248522
REFERENCE   3  (bases 1 to 3929)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 3929)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 3929)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 3929)
  AUTHORS   Aoki,T., Koch,K.S. and Leffert,H.L.
  TITLE     Attenuation of gene expression by a trinucleotide repeat-rich tract
            from the terminal exon of the rat hepatic polymeric immunoglobulin
            receptor gene
  JOURNAL   J Mol Biol 267 (2), 229-236 (1997)
   PUBMED   9096221
REFERENCE   7  (bases 1 to 3929)
  AUTHORS   Koch,K.S., Gleiberman,A.S., Aoki,T., Leffert,H.L., Feren,A.,
            Jones,A.L. and Fodor,E.J.
  TITLE     Discordant expression and variable numbers of neighboring GGA- and
            GAA-rich triplet repeats in the 3' untranslated regions of two
            groups of messenger RNAs encoded by the rat polymeric
            immunoglobulin receptor gene
  JOURNAL   Nucleic Acids Res 23 (7), 1098-1112 (1995)
   PUBMED   7739889
REFERENCE   8  (bases 1 to 3929)
  AUTHORS   Koch,K.S., Fletcher,R.G., Grond,M.P. and Leffert,H.L.
  TITLE     A 43-base-pair complementary DNA sequence homology and triplet
            repeat motif among putative polymeric immunoglobulin receptor
            messenger RNAs in regenerating rat liver
  JOURNAL   Hepatology 18 (1), 226-228 (1993)
   PUBMED   8325615
REFERENCE   9  (bases 1 to 3929)
  AUTHORS   Larkin,J.M. and Palade,G.E.
  TITLE     Transcytotic vesicular carriers for polymeric IgA receptors
            accumulate in rat hepatocytes after bile duct ligation
  JOURNAL   J Cell Sci 98 (Pt 2), 205-216 (1991)
   PUBMED   1676032
REFERENCE   10 (bases 1 to 3929)
  AUTHORS   Banting,G., Brake,B., Braghetta,P., Luzio,J.P. and Stanley,K.K.
  TITLE     Intracellular targetting signals of polymeric immunoglobulin
            receptors are highly conserved between species
  JOURNAL   FEBS Lett 254 (1-2), 177-183 (1989)
   PUBMED   2776882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ104960.1, X15741.1 and U07886.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012723.5.
            
            On May 17, 2013 this sequence version replaced NM_012723.3.
            
            Sequence Note: This RefSeq record was created from transcript data
            from different strains because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X15741.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5756307, SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               FQ104960.1         1-125
            126-3375            X15741.1           20-3269
            3376-3929           U07886.1           670-1223
FEATURES             Location/Qualifiers
     source          1..3929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3929
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /note="polymeric immunoglobulin receptor"
                     /db_xref="GeneID:25046"
                     /db_xref="RGD:3328"
     exon            1..124
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..222
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2489
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /note="polymeric IgA receptor; poly-Ig receptor"
                     /codon_start=1
                     /product="polymeric immunoglobulin receptor precursor"
                     /protein_id="NP_036855.3"
                     /db_xref="GeneID:25046"
                     /db_xref="RGD:3328"
                     /translation="MRLSLFALLVTVFSGVSTQSPIFGPQDVSSIEGNSVSITCYYPD
                     TSVNRHTRKYWCRQGANGYCATLISSNGYLSKEYSGRASLINFPENSTFVINIAHLTQ
                     EDTGSYKCGLGTTNRGLFFDVSLEVSQVPEFPNDTHVYTKDIGRTVTIECRFKEGNAH
                     SKKSLCKKRGEACEVVIDSTEYVDPSYKDRAILFMKGTSRDIFYVNISHLIPSDAGLY
                     VCQAGEGPSADKNNADLQVLEPEPELLYKDLRSSVTFECDLGREVANDAKYLCRKNKE
                     TCDVIINTLGKRDPAFEGRILLTPRDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQE
                     GWPVQAWQLFVNEESTIPNSRSVVKGVTGGSVAIVCPYNPKESSSLKYWCHWEADENG
                     RCPVLVGTQALVQEGYEGRLALFDQPGSGAYTVILNQLTTQDSGFYWCLTDGDSRWRT
                     TIELQVAEATKKPDLEVTPQNATAVIGETFTISCHYPCKFYSQEKYWCKWSNDGCHIL
                     PSHDEGARQSSVSCDQSSQIVSMTLNPVKKEDEGWYWCGVKEGQVYGETTAIYVAVEE
                     RTRGSPHINPTDANARAKDAPEEEAMESSVREDENKANLDPRLFADEREIQNAGDQAQ
                     ENRASGNAGSAGGQSGSSKVLFSTLVPLGLVLAVGAVAVWVARVRHRKNVDRMSISSY
                     RTDISMGDFRNSRDLGGNDNMGATPDTQETVLEGKDEIETTTECTTEPEESKKAKRSS
                     KEEADMAYSAFLFQSSTIAAQVHDGPQEA"
     exon            223..567
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1221
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1554
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1887
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2080
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2202
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2334
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2393
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..3913
                     /gene="Pigr"
                     /gene_synonym="pIgA-R; RNPIGR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtttcag ttttgacagc agtcaccagt gcctccctgg aagcttctag aagggcaggg
       61 gcacacactg gctggcaggc tgtgcccgaa actgaatcac ctggaaagaa ggaagtagct
      121 aaaacatctt atacaagaag tgaaccaaca tgccgcaacc tccttggaag ccacaagcga
      181 tgaggctctc cttgttcgcc ctcttggtaa ctgtcttctc aggggtctcc acacaaagcc
      241 ccatatttgg tccccaggat gtgagtagta ttgaaggtaa ctcggtctcc atcacgtgct
      301 actacccaga cacctctgtc aaccggcaca cccggaaata ctggtgccga caaggagcca
      361 acggctactg cgcaaccctc atctcttcaa atggctacct ctcgaaggag tattcaggca
      421 gagccagcct catcaacttc ccagagaata gcacatttgt gattaacatt gcacatctca
      481 cccaggagga cactgggagc tacaagtgtg gtctgggtac cactaaccga ggcctgtttt
      541 tcgatgtcag cctggaggtc agccaggttc ctgagttccc aaatgacacc catgtctaca
      601 caaaggacat aggcagaact gtgaccatcg aatgccgttt caaagagggg aatgctcata
      661 gcaagaaatc cctgtgtaag aagagaggag aggcctgcga agttgtcatc gactctactg
      721 agtacgtgga ccccagctat aaggacagag caatcctttt tatgaaaggg accagccgcg
      781 atatattcta tgtcaacatt agccacctaa tacccagtga tgctggactg tatgtttgcc
      841 aagctggaga aggccccagt gctgataaaa ataatgctga cctccaggtg ctagagcctg
      901 agccagagct gctttataaa gacctgaggt cctcagtgac ttttgaatgt gacctgggcc
      961 gtgaagtggc aaatgatgcc aaatatctgt gtcggaagaa caaggaaacc tgtgatgtca
     1021 tcatcaacac cctggggaag agagatccag cctttgaagg caggatcctg ctaaccccca
     1081 gggatgacaa tggccgcttc agtgtgttga tcacaggcct gaggaaggag gatgcagggc
     1141 actaccagtg tggagcgcac agttctggtt tgcctcaaga aggctggccc gtccaggctt
     1201 ggcaactctt tgtcaatgaa gagtccacga ttcccaatag tcgctctgtt gtgaagggtg
     1261 tcacaggagg ctctgtggcc atcgtctgtc cctataaccc caaggaaagc agcagcctca
     1321 agtactggtg tcactgggaa gccgacgaga atggacgctg cccggtgctc gtggggaccc
     1381 aggccctggt gcaagaagga tatgaaggcc gactggcact gttcgatcag ccgggcagtg
     1441 gcgcctacac tgtcatcctc aaccagctca ccacccagga ttctggcttc tactggtgtc
     1501 ttaccgatgg tgactctcgc tggagaacca cgatagaact gcaggttgct gaagctacaa
     1561 agaagccaga ccttgaggtg acaccacaga acgcgaccgc ggtgatagga gagaccttca
     1621 caatctcctg ccactatccg tgcaaattct actcccagga gaaatactgg tgcaagtgga
     1681 gcaacgacgg ctgccacatc ctgccgagcc atgatgaagg tgcccgccag tcctctgtga
     1741 gctgtgacca gagcagccag atcgtctcca tgaccctgaa cccggtcaaa aaggaagatg
     1801 aaggctggta ctggtgtggg gtaaaagaag gtcaggtcta tggagaaact acagccatct
     1861 atgtagcagt tgaagagagg accagagggt caccccacat caacccgaca gatgcaaacg
     1921 cacgtgcaaa agatgctcca gaggaagagg caatggaatc ctctgtcagg gaggatgaaa
     1981 acaaggccaa tctggacccc aggctttttg cagacgaaag agagatacag aatgcgggag
     2041 accaagctca ggagaacaga gcatctggga atgctggcag tgctggtgga caaagcggga
     2101 gctccaaagt cctattctcc accctggtgc ccctgggttt ggtgctggca gtgggtgctg
     2161 tggctgtgtg ggtggccaga gtccgacatc ggaagaatgt agaccgcatg tcaatcagca
     2221 gctacaggac agacattagc atgggagact tcaggaactc cagggatttg ggaggcaatg
     2281 acaacatggg cgccactcca gacacacaag aaacagtcct cgaaggaaaa gatgaaatag
     2341 agactaccac cgagtgtacc accgagccag aggaatccaa gaaagcaaaa aggtcatcca
     2401 aggaggaagc tgacatggcc tactcagcat tcctgtttca gtccagcaca atagctgcgc
     2461 aggtccatga tggtccccag gaagcctagg cagtgctgac cacctacccc tgcctgtgac
     2521 aatcaacttg agaatcacat tgatccactc gcagcccacc ctcgcccatc acccaggctc
     2581 ttccctcctg ttctcagagg tgtgctggtt cctccctcag tcgtggaagc ctggcctact
     2641 tatgcctgtt taggagagag cgtgaggagt tctttttgct gttaaagagt aaggtggaaa
     2701 tgagttgagc ccaagaggtg tctctgagag acgagggttc agagcagggg ctcatttcag
     2761 gaggaagagc catttgaagc ctctttatac acatatgcta ggatgtcagg atagctcttc
     2821 tcctccatct ctcctttctt ctcttcttga ttcagacaac agatccgaaa actcactagg
     2881 cttccggtgt ctactaaatg ctgagagtca ggccacagcc tttctataaa catcactgga
     2941 agagacacca cctcgtccca gattctgtct tttccctaag ctatcaatca ttaccgggga
     3001 ttccctttgc ctctgcacct cataggcaac aaaagaaaca taagtcctgc agtctaaggc
     3061 atacccaagc cataagggca ccacgagact cagatgagaa gagatttttc tccagagtac
     3121 tcagtgagat agactagtgt caagccagat ggggcaactc ctggctcttg gcctgggact
     3181 tgtcttcaag atctctgctc ttattagaga aagaacttta gcatgaggaa aagtaagaga
     3241 aaacaagtta catgggcatg gtggtgtgct cctgcaatcc caatattaag aggttaaaaa
     3301 ataggaccag aagtttaaag taatccttgg ctacctagtg agtgtaaggc cagcctggaa
     3361 tcaataagag ttggtttcaa agaagcagga ggagaaggag gaacaggaac aggaggagga
     3421 gcagggggag gagaaaaagg aggaggagga ggaggaggaa gaggaggagg aggaggagga
     3481 ggaggaggag gaggaggagg aggaggagga ggaggaggag aagaagaaga agaagaagaa
     3541 gaagaagaag aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa
     3601 gaagaagaag aagaagaaga agaagaagaa attagaagaa gaaaagaaga aggacaaatg
     3661 gctcttttct ggtctcacct tttcccttcc tgtcactcat gtggacctca gataagagca
     3721 cagatactct cgacctctta catttggaga gttttgagca gacaggaaga agacggagcc
     3781 tgggagcagc tgttctccaa tagtcaaatt aagactgttc ctctctgagc tctgtacttc
     3841 aaccagcacc tttaggcaga agccatcaaa tcagaaatgt ctgttaataa ttaaagtcta
     3901 tgattgccac caaaaaaaaa aaaaaaaaa
//
