LOCUS       NM_001399262             640 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis,
            class P (Pigp), transcript variant 2, mRNA.
ACCESSION   NM_001399262 XM_006248043
VERSION     NM_001399262.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 640)
  AUTHORS   Johnstone,D.L., Nguyen,T.T., Murakami,Y., Kernohan,K.D.,
            Tetreault,M., Goldsmith,C., Doja,A., Wagner,J.D., Huang,L.,
            Hartley,T., St-Denis,A., le Deist,F., Majewski,J., Bulman,D.E.,
            Kinoshita,T., Dyment,D.A., Boycott,K.M. and Campeau,P.M.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Compound heterozygous mutations in the gene PIGP are associated
            with early infantile epileptic encephalopathy
  JOURNAL   Hum Mol Genet 26 (9), 1706-1715 (2017)
   PUBMED   28334793
REFERENCE   2  (bases 1 to 640)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   3  (bases 1 to 640)
  AUTHORS   Choi,D.K., Suzuki,Y., Yoshimura,S., Togashi,T., Hida,M.,
            Taylor,T.D., Wang,Y., Sugano,S., Hattori,M. and Sakaki,Y.
  TITLE     Molecular cloning and characterization of a gene expressed in mouse
            developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down
            syndrome Critical Region gene 5)
  JOURNAL   Mamm Genome 12 (5), 347-351 (2001)
   PUBMED   11331941
REFERENCE   4  (bases 1 to 640)
  AUTHORS   Watanabe,R., Murakami,Y., Marmor,M.D., Inoue,N., Maeda,Y., Hino,J.,
            Kangawa,K., Julius,M. and Kinoshita,T.
  TITLE     Initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-P and is regulated by DPM2
  JOURNAL   EMBO J 19 (16), 4402-4411 (2000)
   PUBMED   10944123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006248043.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166404.1, BF415030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000011.1  47158399-47158585   c
            188-291             JAXUCZ010000011.1  47158088-47158191   c
            292-364             JAXUCZ010000011.1  47155610-47155682   c
            365-483             JAXUCZ010000011.1  47153312-47153430   c
            484-640             JAXUCZ010000011.1  47152601-47152757   c
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..640
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class P"
                     /db_xref="GeneID:288238"
                     /db_xref="RGD:1307205"
     exon            1..187
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            188..291
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..608
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /EC_number="2.4.1.198"
                     /note="phosphatidylinositol glycan, class P; Down syndrome
                     critical region gene 5"
                     /codon_start=1
                     /product="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit P"
                     /protein_id="NP_001386191.1"
                     /db_xref="GeneID:288238"
                     /db_xref="RGD:1307205"
                     /translation="MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSL
                     GLTYWPQKYWAVALPVYLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKS
                     YQEDAIPALRDIPISEVNRMFFLDAKELNT"
     exon            292..364
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            365..483
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            484..640
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaatgggct gagcgccgag gggctgaggg tggggacggg tgggcgttgg tgcttgaagg
       61 actctaggtc cagggctttc ggttttcttt gaacgtcacg taggcaggga gagagccctt
      121 cgtgagcggg caggactcgg gaccttggtc cggcctgggg ccccttcctc gtctcagagg
      181 gtccgagatt gtctaaagcc acagggaaga tggtggaaaa ttcaccgtcg ccattgccag
      241 aaagagcgat ttatggcttt gttcttttcc taagctctca gtttggcttc atactctatc
      301 ttgtgtgggc tttcgttccc gaatcttggc taaactcctt aggcttaact tactggcctc
      361 aaaagtactg ggcagttgcg ttgcctgtct atctcttgat cacggttgta attggttacg
      421 tgctcttatt tggaatcaac atgatgagta cctctccact tgactccatc catacgatca
      481 cagataacta tgctaaaaac caacagagga aaagctacca agaggacgcc atcccagcat
      541 taagagacat tcccattagt gaagtcaaca gaatgttctt cctagacgcc aaagaactca
      601 acacctaaaa ctgagctgtg aataaacatc ctaaaaccaa
//
