LOCUS       NM_001099758             580 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis,
            class P (Pigp), transcript variant 1, mRNA.
ACCESSION   NM_001099758 XM_001055025 XM_213650
VERSION     NM_001099758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 580)
  AUTHORS   Johnstone,D.L., Nguyen,T.T., Murakami,Y., Kernohan,K.D.,
            Tetreault,M., Goldsmith,C., Doja,A., Wagner,J.D., Huang,L.,
            Hartley,T., St-Denis,A., le Deist,F., Majewski,J., Bulman,D.E.,
            Kinoshita,T., Dyment,D.A., Boycott,K.M. and Campeau,P.M.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Compound heterozygous mutations in the gene PIGP are associated
            with early infantile epileptic encephalopathy
  JOURNAL   Hum Mol Genet 26 (9), 1706-1715 (2017)
   PUBMED   28334793
REFERENCE   2  (bases 1 to 580)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   3  (bases 1 to 580)
  AUTHORS   Choi,D.K., Suzuki,Y., Yoshimura,S., Togashi,T., Hida,M.,
            Taylor,T.D., Wang,Y., Sugano,S., Hattori,M. and Sakaki,Y.
  TITLE     Molecular cloning and characterization of a gene expressed in mouse
            developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down
            syndrome Critical Region gene 5)
  JOURNAL   Mamm Genome 12 (5), 347-351 (2001)
   PUBMED   11331941
REFERENCE   4  (bases 1 to 580)
  AUTHORS   Watanabe,R., Murakami,Y., Marmor,M.D., Inoue,N., Maeda,Y., Hino,J.,
            Kangawa,K., Julius,M. and Kinoshita,T.
  TITLE     Initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-P and is regulated by DPM2
  JOURNAL   EMBO J 19 (16), 4402-4411 (2000)
   PUBMED   10944123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jan 5, 2022 this sequence version replaced NM_001099758.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM053953.1, BF285035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000011.1  47158640-47158766   c
            128-231             JAXUCZ010000011.1  47158088-47158191   c
            232-304             JAXUCZ010000011.1  47155610-47155682   c
            305-423             JAXUCZ010000011.1  47153312-47153430   c
            424-580             JAXUCZ010000011.1  47152601-47152757   c
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..580
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class P"
                     /db_xref="GeneID:288238"
                     /db_xref="RGD:1307205"
     exon            1..127
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            128..231
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..548
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /EC_number="2.4.1.198"
                     /note="phosphatidylinositol glycan, class P; Down syndrome
                     critical region gene 5"
                     /codon_start=1
                     /product="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit P"
                     /protein_id="NP_001093228.1"
                     /db_xref="GeneID:288238"
                     /db_xref="RGD:1307205"
                     /translation="MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSL
                     GLTYWPQKYWAVALPVYLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKS
                     YQEDAIPALRDIPISEVNRMFFLDAKELNT"
     exon            232..304
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            305..423
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
     exon            424..580
                     /gene="Pigp"
                     /gene_synonym="Dscr5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgccgcg ccgccccccc cccagctcgg ctgggtgggt ggtgagaccg cggtagcccc
       61 cgctctgcgg acgccgtgcg cctgcgccaa gcggcggggg cgcctggcag cccctgcttt
      121 tcctcagatt gtctaaagcc acagggaaga tggtggaaaa ttcaccgtcg ccattgccag
      181 aaagagcgat ttatggcttt gttcttttcc taagctctca gtttggcttc atactctatc
      241 ttgtgtgggc tttcgttccc gaatcttggc taaactcctt aggcttaact tactggcctc
      301 aaaagtactg ggcagttgcg ttgcctgtct atctcttgat cacggttgta attggttacg
      361 tgctcttatt tggaatcaac atgatgagta cctctccact tgactccatc catacgatca
      421 cagataacta tgctaaaaac caacagagga aaagctacca agaggacgcc atcccagcat
      481 taagagacat tcccattagt gaagtcaaca gaatgttctt cctagacgcc aaagaactca
      541 acacctaaaa ctgagctgtg aataaacatc ctaaaaccaa
//
