LOCUS       NM_138901               1410 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis,
            class L (Pigl), mRNA.
ACCESSION   NM_138901
VERSION     NM_138901.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Ng,B.G., Hackmann,K., Jones,M.A., Eroshkin,A.M., He,P., Wiliams,R.,
            Bhide,S., Cantagrel,V., Gleeson,J.G., Paller,A.S., Schnur,R.E.,
            Tinschert,S., Zunich,J., Hegde,M.R. and Freeze,H.H.
  TITLE     Mutations in the glycosylphosphatidylinositol gene PIGL cause CHIME
            syndrome
  JOURNAL   Am J Hum Genet 90 (4), 685-688 (2012)
   PUBMED   22444671
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Urbaniak,M.D., Crossman,A., Chang,T., Smith,T.K., van Aalten,D.M.
            and Ferguson,M.A.
  TITLE     The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of
            glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme
  JOURNAL   J Biol Chem 280 (24), 22831-22838 (2005)
   PUBMED   15817455
  REMARK    GeneRIF: N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase
            of glycosylphosphatidylinositol biosynthesis is a zinc
            metalloenzyme
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Watanabe,R., Ohishi,K., Maeda,Y., Nakamura,N. and Kinoshita,T.
  TITLE     Mammalian PIG-L and its yeast homologue Gpi12p are
            N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential
            in glycosylphosphatidylinositol biosynthesis
  JOURNAL   Biochem J 339 (Pt 1) (Pt 1), 185-192 (1999)
   PUBMED   10085243
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Nakamura,N., Inoue,N., Watanabe,R., Takahashi,M., Takeda,J.,
            Stevens,V.L. and Kinoshita,T.
  TITLE     Expression cloning of PIG-L, a candidate
            N-acetylglucosaminyl-phosphatidylinositol deacetylase
  JOURNAL   J Biol Chem 272 (25), 15834-15840 (1997)
   PUBMED   9188481
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074020.1.
            
            On Jun 10, 2007 this sequence version replaced NM_138901.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074020.1, CK356582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132290, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..1410
                     /gene="Pigl"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class L"
                     /db_xref="GeneID:192263"
                     /db_xref="RGD:620437"
     exon            1..244
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..768
                     /gene="Pigl"
                     /EC_number="3.5.1.89"
                     /note="PIG-L; phosphatidylinositol-glycan biosynthesis
                     class L protein; phosphatidylinositol glycan, class L"
                     /codon_start=1
                     /product="N-acetylglucosaminyl-phosphatidylinositol
                     de-N-acetylase"
                     /protein_id="NP_620256.1"
                     /db_xref="GeneID:192263"
                     /db_xref="RGD:620437"
                     /translation="MEVVGLLCVAVAVLTWGFLRVWNSAERMRSPEQAGLPGAGSRAL
                     VVIAHPDDEAMFFAPTILGLARLKQQVSLLCFSSGNYYNQGEIRKKELLQSCAVLGIP
                     PSRVMIIDKREFPDDPEVQWDTEHVASTILQHIHANATDLVVTFDAEGVSGHSNHIAL
                     YKAVRALHSGGKLPEGCSVLTLQSVNVLRKYVFLLDLPWTLLSPQGVLFVLTSKEVAQ
                     AKKAMSCHRSQLLWFRHLYTVFSRYMSVNSLQLL"
     exon            245..344
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
     exon            345..435
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
     exon            436..503
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
     exon            504..535
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
     exon            536..669
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1388
                     /gene="Pigl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttacccggca tggaagtggt gggtctcttg tgtgtggccg tggctgtcct gacttggggc
       61 ttcctccggg tttggaactc agcggaacga atgaggtctc cggagcaggc gggcctaccg
      121 ggagccggaa gccgggccct tgtagtgatc gcgcacccgg acgatgaagc catgttcttt
      181 gctcccacga tactaggctt ggcacgcctg aagcagcagg tgtccctgct ctgcttctcc
      241 tcaggaaatt actacaatca aggtgagatt cgaaagaaag aacttctgca gagctgtgct
      301 gtcttgggga ttccaccttc ccgtgtaatg attattgaca agagggagtt tccagatgat
      361 ccagaagtgc agtgggacac agagcatgtg gccagcacca tcctccagca catacatgcc
      421 aatgccaccg acttggtggt gacttttgat gcagaaggag tcagtggtca cagcaaccat
      481 attgccttgt acaaagctgt gagggccctg cactcaggag ggaagctgcc tgaagggtgc
      541 tctgtactta ctctccagtc tgtgaacgtg cttcggaagt atgtcttcct cctggatctc
      601 ccctggactc tactgtcgcc ccagggtgtt ctctttgtgc tcaccagcaa agaagtggca
      661 caggccaaga aagccatgtc ctgccaccgc agtcagctgc tctggttccg ccacctctac
      721 accgtcttct cgagatacat gagcgtcaac tcgctgcagt tgctctgagg cctgagagct
      781 gtcagctcct cggagcaggg gagcagcaga gcaggaagtc ccctggccag acctgggctg
      841 actgacctgc ttgaccaggg agaccccagc aaagcagcct ccgcctaaca ggaaccacat
      901 ggacaatggg tcaccccaac ccagaaggct gcaagtccag aaccaagtta tattggggtg
      961 tccttaggta aacacttgag aatatagaag cagctcccta gttcccaaca accaaaaggc
     1021 taaggagtct ttcagatagc acctgaggcc tacagctgag actcctggct ttcctgtgat
     1081 ctgcctacct gatgttccca ctgtgtgcac gagaaatgcc cgtgtgtgac ttcagttgtc
     1141 ctgctgctac aaaacctcgt ggaactgagg tttacacatt ggaacatgaa actgggtaac
     1201 ctgaatgtgt gtcctgggca ctgtcacata cttcactcca ggataaacta cctcacatcc
     1261 tctttgaagt gaggactgtt actttgttga cagtatcctt tgagtttttt atgatataca
     1321 caacagtaca acctatgaaa aatgttttca aatcctagac gttaaaaaga tgcatagact
     1381 tacaatgaaa aaaaaaaaaa aaaaaaaaaa
//
