LOCUS       NM_001398970            1141 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis,
            class F (Pigf), transcript variant 2, mRNA.
ACCESSION   NM_001398970 XM_017594405
VERSION     NM_001398970.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1141)
  AUTHORS   Zhang,Z.Q., Hong,H., Li,J., Li,X.X. and Huang,X.M.
  TITLE     MicroRNA-214 promotes alveolarization in neonatal rat models of
            bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway
  JOURNAL   Mol Med 27 (1), 109 (2021)
   PUBMED   34530740
  REMARK    Erratum:[Mol Med. 2021 Oct 21;27(1):134. PMID: 34674634]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1141)
  AUTHORS   Zhu,M., Ren,Z., Possomato-Vieira,J.S. and Khalil,R.A.
  TITLE     Restoring placental growth factor-soluble fms-like tyrosine
            kinase-1 balance reverses vascular hyper-reactivity and
            hypertension in pregnancy
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 311 (3), R505-R521 (2016)
   PUBMED   27280428
  REMARK    GeneRIF: Thus, a tilt in the angiogenic balance toward
            anti-angiogenic sFlt-1 is associated with decreased vascular
            relaxation and increased vasoconstriction and BP. Restoring the
            angiogenic/antiangiogenic balance using PlGF enhances endothelial
            NO-cGMP vascular relaxation and decreases vasoconstriction and BP
            in HTN-Preg rats and could offer a new approach in the management
            of PE.
REFERENCE   3  (bases 1 to 1141)
  AUTHORS   Hong,Y., Maeda,Y., Watanabe,R., Inoue,N., Ohishi,K. and
            Kinoshita,T.
  TITLE     Requirement of PIG-F and PIG-O for transferring phosphoethanolamine
            to the third mannose in glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 275 (27), 20911-20919 (2000)
   PUBMED   10781593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1 and BP495818.1.
            
            On Aug 1, 2022 this sequence version replaced NM_001398970.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.332208.1,
                                           SRR26360190.2111788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000006.1  13343134-13343396
            264-512             JAXUCZ010000006.1  13344625-13344873
            513-604             JAXUCZ010000006.1  13346745-13346836
            605-721             JAXUCZ010000006.1  13348341-13348457
            722-830             JAXUCZ010000006.1  13359322-13359430
            831-1141            BP495818.1         3-313               c
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1141
                     /gene="Pigf"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class F"
                     /db_xref="GeneID:681086"
                     /db_xref="RGD:1584658"
     exon            1..263
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            264..512
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..944
                     /gene="Pigf"
                     /EC_number="2.7.8.1"
                     /codon_start=1
                     /product="phosphatidylinositol-glycan biosynthesis class F
                     protein"
                     /protein_id="NP_001385899.2"
                     /db_xref="GeneID:681086"
                     /db_xref="RGD:1584658"
                     /translation="MKDTDIKRLLYTNLLCIFSVFLSIFIPSFFLDNFSILETHLVWL
                     GTCSAFVTGANLLLYLVVKPNVSSKRSSLSHKVARVVRCWLYFLASCFFLHIIFVLYG
                     APLMELVLETFLFAVVLSTFTTVPCLCLLGPNLKAWLRVFSRNGVTSVWENSLQITTV
                     SSFIGAWLGAFPIPLDWERPWQVWPISCTLGATFGYVAGLVISPLWIYWNRKQLTYKN
                     N"
     exon            513..604
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            605..721
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            722..830
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1141
                     /gene="Pigf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgcgcga ggggccatgg cagcctgtcg cacctgaggg tgggaggcgg tggtgtcccc
       61 ttcccttcgg cgggcgggag agttaggtaa gcgggaggga tgcttcctaa gttctcctgg
      121 ggcaggtgca ggtcgctctg cggactgctg ccgtggcttc caaggcgcca cgcttccggc
      181 gggccagagg atgcatggcg cgacggaccc tctgagatcc cggcgtctgt cggcgggacc
      241 gaccctctgt caccgtctct cagatagtta cccaagaaga caccatgaaa gatactgaca
      301 tcaagagact tctatatacc aatcttttgt gcatattttc agttttccta agcattttta
      361 tcccatcctt tttcttggac aacttctcaa tattggaaac tcacttggtc tggttgggca
      421 cttgctctgc ttttgtgact ggtgccaatc tcttgttata cttggtagtg aaaccgaatg
      481 tgtcctctaa aagaagttca ttgtcacata aggtagcccg agttgtcaga tgctggctct
      541 actttctcgc gtcttgtttt ttccttcata taatctttgt tctgtatgga gcaccactga
      601 tggagttggt gctggaaacc tttttatttg cagttgtttt gtctactttt accacagtac
      661 cttgtctgtg tttgttagga ccaaatctca aagcctggct gagagttttc agtagaaatg
      721 gagttacatc tgtttgggag aacagtcttc agattactac agtttctagt ttcataggag
      781 catggcttgg agcatttcct attccactgg attgggaaag accatggcag gtgtggccca
      841 tctcctgtac actcggagcg acctttggct acgtggctgg cctggttatc tcgccactct
      901 ggatatactg gaatagaaag caacttacat acaagaacaa ttaagaggag aagggagaga
      961 agtgatttct ttgtgcagag tccataaggg ctgtgcagaa gtgtacgtgg tcaaagccga
     1021 gccgtccatt tacagcactg tggttttcta aatgtcattt caacatgatg tgattgtagc
     1081 tttttaacta tgaaacccct gagagattgt accttctagt tgaaataaag tatttatagt
     1141 a
//
