LOCUS       NM_001108166            2189 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis,
            class B (Pigb), mRNA.
ACCESSION   NM_001108166 XM_001053705 XM_236397
VERSION     NM_001108166.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Takahashi,M., Inoue,N., Ohishi,K., Maeda,Y., Nakamura,N., Endo,Y.,
            Fujita,T., Takeda,J. and Kinoshita,T.
  TITLE     PIG-B, a membrane protein of the endoplasmic reticulum with a large
            lumenal domain, is involved in transferring the third mannose of
            the GPI anchor
  JOURNAL   EMBO J 15 (16), 4254-4261 (1996)
   PUBMED   8861954
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 20, 2010 this sequence version replaced NM_001108166.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no rat transcripts were available to
            completely represent the gene. The genomic coordinates used for the
            transcript record were based on orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               JAXUCZ010000008.1  82656085-82656323   c
            240-375             JAXUCZ010000008.1  82655263-82655398   c
            376-493             JAXUCZ010000008.1  82653443-82653560   c
            494-598             JAXUCZ010000008.1  82651305-82651409   c
            599-729             JAXUCZ010000008.1  82648970-82649100   c
            730-870             JAXUCZ010000008.1  82646688-82646828   c
            871-922             JAXUCZ010000008.1  82639411-82639462   c
            923-1134            JAXUCZ010000008.1  82638504-82638715   c
            1135-1199           JAXUCZ010000008.1  82637673-82637737   c
            1200-1413           JAXUCZ010000008.1  82634380-82634593   c
            1414-1594           JAXUCZ010000008.1  82634111-82634291   c
            1595-2189           JAXUCZ010000008.1  82632445-82633039   c
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2189
                     /gene="Pigb"
                     /note="phosphatidylinositol glycan anchor biosynthesis,
                     class B"
                     /db_xref="GeneID:315807"
                     /db_xref="RGD:1307251"
     exon            1..239
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1738
                     /gene="Pigb"
                     /EC_number="2.4.1.-"
                     /note="phosphatidylinositol glycan, class B"
                     /codon_start=1
                     /product="GPI mannosyltransferase 3"
                     /protein_id="NP_001101636.3"
                     /db_xref="GeneID:315807"
                     /db_xref="RGD:1307251"
                     /translation="MEPETRDHSTAFRNLHSSSGEMKLRKRKSTQYVIAQEKRSRRRD
                     LLGENTYLVLFTIALRIFNCFLVQTSFVPDEYWQSLEVAHHMVFGYGYLTWEWTERLR
                     GYTYPLIFASIYKILHLLGKDSVQLLIWIPRLGQALLSAVADLRLYSLTKQLENQEVA
                     RWVFFCQLCSWFTWYCCTRTLTNTMETALTAVALFYYPLEGSRSKNSVKYSLLVALAC
                     VVRPTALIPWVPLLFRHLYQEQRKLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQ
                     FNFLKFNVLQNLGTFYGSHPWHWYFSQGFPVVLGTHLPFFIHGCFLAPRRLNILLLAV
                     LWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKAWRKAALSFLLLSNVLLALYT
                     GLVHQRGTLDVMSHIQKVCPRGPDPAPASVFIMMPCHSTPYYSHVHCPLSMRFLQCPP
                     DLTGKTQYLDEADTFYLNPLGWLQQEFHSNVSLPTHLVTFNVLEKEIHAFLTSGNYER
                     TATFFHTHWPERRTGSHIHVYERRLTSRVSTGGN"
     exon            240..375
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            376..493
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            494..598
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            599..729
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            730..870
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            871..922
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1134
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1199
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1413
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1594
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..2189
                     /gene="Pigb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggagcag cgaagcgacg gcggctcgcg gggcccaatc ttagtggcat gtgtccacct
       61 acaagaaagt gaggggcggg caccgtgggc tgcaggtagc caggggagga tggagcccga
      121 gacccgcgat cacagcacgg ccttccgcaa tctccacagc agctctggag agatgaagct
      181 gcggaagagg aagtccacgc agtatgtgat cgctcaggag aagcgctctc ggcgccgtga
      241 tcttcttgga gaaaacactt acctggtctt gtttaccatt gctctgcgaa tatttaactg
      301 cttcttagtc cagacaagtt ttgttcctga tgaatactgg cagtctctgg aagttgcaca
      361 ccacatggtt ttcggttatg gctatttgac ctgggaatgg acagagagac tgagaggtta
      421 cacttatccc ctaatctttg caagcattta caagattctg catcttctgg ggaaagacag
      481 tgttcaatta ctgatctgga ttcccagact tggccaagct cttctgtctg ctgtagcaga
      541 cctaaggctt tactccctca cgaagcagct ggaaaaccag gaagtggcac gatgggtgtt
      601 tttctgccag ctgtgttcct ggttcacgtg gtactgctgt acccgaaccc tcacaaacac
      661 catggagact gccctcactg ccgttgccct tttctactat cctctggaag gctcgaggtc
      721 caagaacagt gtcaagtact ccctcctggt ggcacttgct tgtgtggtcc gccccacagc
      781 acttatcccg tgggtgccgt tactcttcag acatctctac caagaacaga gaaagctcca
      841 cctgacgctg catcattttt tacccgtagg attcattacc ttcagtttgt ctctgataat
      901 tgatcgtatc ttttttggcc aatggacgct ggtccagttt aactttttga aatttaacgt
      961 gctgcagaac ttggggacat tttatggctc tcacccatgg cactggtact tcagtcaagg
     1021 gtttccagtt gtcctgggga cccacttacc cttcttcatt cacggttgct tcctggcccc
     1081 taggaggctc aacatactgc tgctggccgt gctgtggaca ctgctagtgt acagcatgtt
     1141 gggccacaaa gaattcagat ttatctatcc agttttacca ttttgcatgg tgttctgtgg
     1201 ctactcgcta gcccacctga aggcatggag gaaggcagct ctgagcttcc tgctcttgtc
     1261 aaatgtgctg ctggcactct acactggcct agttcatcag agaggcacgc tggacgtcat
     1321 gagtcacatt cagaaagtct gccccagagg ccctgaccca gctccggcct cagtattcat
     1381 catgatgccc tgccactcca cgccttacta cagccatgtt cactgcccac tgtccatgcg
     1441 gtttctccag tgtcccccag acttgactgg aaaaactcag tatcttgatg aagcagatac
     1501 gttctactta aaccccttag gctggttaca acaagagttt cacagcaatg tgtcactccc
     1561 cactcacttg gtcaccttca atgttctgga gaaggagatc catgccttcc tcacctcagg
     1621 gaactatgag aggactgcta ctttcttcca cactcattgg ccagagcgtc gaactggcag
     1681 tcacatacat gtctacgagc ggaggttaac cagcagagtc agcacaggag ggaactgaac
     1741 tgtgaggact tctgcagaga cgttggcata actgagagaa actgcaggtg actcgtgaca
     1801 tgaggggaag ccactgggga cagatgtacc atacactgtc ctgaggcatt ctcagggaac
     1861 atttaattcg gcgccagact tgagagagac ctttagtttt cctcatggtg cagtttattg
     1921 attcttccat agtattcagg tgtgcaagag ttcacaagac aagccagcaa gctcttcaca
     1981 agccaacagg ctcttgaacc cacagaagag acaaaagcat gagagtagaa aacgttagag
     2041 cggagtccca cctcagctta agccctgctg cacacccaca cacggcactg actgccctgt
     2101 gtgagccaag cttgctctaa gctcagctac tcaaacccag ccttgtttca tgcacacaat
     2161 gtctcatgcc tggcttcctg aaaactact
//
