LOCUS       NM_001044253            1915 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PIF1 5'-to-3' DNA helicase (Pif1), mRNA.
ACCESSION   NM_001044253 XM_001076669 XM_346237
VERSION     NM_001044253.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   Paeschke,K., Bochman,M.L., Garcia,P.D., Cejka,P., Friedman,K.L.,
            Kowalczykowski,S.C. and Zakian,V.A.
  TITLE     Pif1 family helicases suppress genome instability at G-quadruplex
            motifs
  JOURNAL   Nature 497 (7450), 458-462 (2013)
   PUBMED   23657261
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Kazak,L., Reyes,A., Duncan,A.L., Rorbach,J., Wood,S.R.,
            Brea-Calvo,G., Gammage,P.A., Robinson,A.J., Minczuk,M. and
            Holt,I.J.
  TITLE     Alternative translation initiation augments the human mitochondrial
            proteome
  JOURNAL   Nucleic Acids Res 41 (4), 2354-2369 (2013)
   PUBMED   23275553
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Snow,B.E., Mateyak,M., Paderova,J., Wakeham,A., Iorio,C.,
            Zakian,V., Squire,J. and Harrington,L.
  TITLE     Murine Pif1 interacts with telomerase and is dispensable for
            telomere function in vivo
  JOURNAL   Mol Cell Biol 27 (3), 1017-1026 (2007)
   PUBMED   17130244
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Zhang,D.H., Zhou,B., Huang,Y., Xu,L.X. and Zhou,J.Q.
  TITLE     The human Pif1 helicase, a potential Escherichia coli RecD
            homologue, inhibits telomerase activity
  JOURNAL   Nucleic Acids Res 34 (5), 1393-1404 (2006)
   PUBMED   16522649
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ489562.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_346237.3, XM_001076669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ489562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1915
                     /gene="Pif1"
                     /note="PIF1 5'-to-3' DNA helicase"
                     /db_xref="GeneID:367645"
                     /db_xref="RGD:1586053"
     exon            1..547
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1915
                     /gene="Pif1"
                     /EC_number="3.6.4.12"
                     /note="PIF1/RRM3 DNA helicase-like protein; Pif1/Rrm3
                     DNA-helicase-like protein; DNA repair and recombination
                     helicase PIF1"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase PIF1"
                     /protein_id="NP_001037718.1"
                     /db_xref="GeneID:367645"
                     /db_xref="RGD:1586053"
                     /translation="MPSSTEVATDECDDTELRCRVAVEELSPGGQPRKRQALRAAELS
                     LGRNERRELMLRLQAPGPEGRPRCFPLRAVRLFTRFAAVGRSTLRLPADGVPRAGSVQ
                     LLLSDCPPERLRRFLRTLRLKLAVAPGPGPASARAQLLGPRPRDFVTISPVQPEELRR
                     AAATKAPDSALEKRPMESQPSMEAPRWPLPVKKLRMPSSKPKLSEEQAAVLRMVLKGQ
                     SIFFTGSAGTGKSYLLKHILGSLPPTGTVATASTGVAACHIGGTTLHAFAGIGSGQAP
                     LAQCVALAHRPGVRQGWLNCQRLVIDEISMVEADFFDKLEAVARAVRQQKKPFGGIQL
                     IICGDFLQLPPVTKGSQHPRFCFQAKSWRKCVPVTLELTEVWRQADQTFISLLKAVRL
                     GRCSDEVTRQLRATAAHKVGRDGIIATRLCTHQDDVALTNEKRLKELPGDVHSFEAID
                     SDPELSRTLDAQCPVGRVLQLKLGAQVMLVKNLAVSRGLVNGARGVVVGFESEGRGLP
                     RVRFLCGITEVIRTDRWTVQVTGGQYLSRQQLPLQLAWAMSIHKSQGMSLDCVEISLG
                     RVFASGQAYVALSRARSLQGLRVLDFDPTVVRCDSRVLQFYATLRQGRGLSLESQDDE
                     EASSDLENMDPNL"
     exon            548..680
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..806
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..960
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1075
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1182
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1322
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1429
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1517
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1663
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1855
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1915
                     /gene="Pif1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgccttct agcactgagg tggcgaccga tgaatgtgat gacaccgagc tgcggtgccg
       61 ggtagccgta gaggagctga gtcctggagg gcaacctcgc aagcgccagg ctctgcgcgc
      121 cgcagagctg agcctaggtc ggaatgaacg ccgcgagttg atgctgcgac tgcaggcacc
      181 cggacccgaa gggcggccac gctgtttccc actgcgcgcc gtgcgcctct tcacccgctt
      241 cgccgcagtt gggcgcagca ctttgcgact cccggccgat ggcgtgcccc gggctggctc
      301 agtgcaactg ctgctctctg actgtccccc ggagcgcttg cgccgcttcc tgcgcaccct
      361 gcgcctgaag ctggcggtcg cccctgggcc gggacccgcc tctgcccgtg cgcaattgct
      421 cggtccgcgg ccccgagact ttgtcacgat cagtccagtg cagccggagg aactgcgccg
      481 tgctgcggcc accaaggctc cagactcagc gctggaaaag cggccaatgg aatcccagcc
      541 tagtatggaa gctccaaggt ggcccctgcc tgtgaagaag ctacgcatgc cctccagcaa
      601 accgaagctt tccgaagagc aggccgctgt gctgcggatg gttctgaaag gccagagcat
      661 attctttacc gggagtgcag ggacagggaa gtcctacctg ctgaaacata tcctgggttc
      721 cctgcctcct actggcactg tggccactgc cagcactggg gtggcagcct gccacattgg
      781 gggcaccacc cttcatgcct ttgcaggcat cggttcaggc caggctcccc tggcccagtg
      841 tgtggctctg gcccatcggc ctggtgtgcg gcagggctgg ctgaactgcc agcgtttggt
      901 cattgatgag atctccatgg tagaggcaga cttctttgac aagttggaag ctgtggccag
      961 agctgtccgg caacagaaga aaccatttgg agggatccag cttattatct gtggggactt
     1021 cctacagttg ccgccagtga ccaaaggttc ccagcatcct cgattctgct ttcaggccaa
     1081 gagctggagg aagtgtgtac cagtgactct ggagctgact gaggtgtgga ggcaagcaga
     1141 ccagaccttc atctctctcc tgaaggctgt gagattaggc agatgttcag atgaagtgac
     1201 ccgccagctc agggccacag ctgcccataa ggtgggacga gatggaatta tagccacgag
     1261 actgtgcacc catcaggatg atgtggccct taccaatgag aagcggctga aggaactacc
     1321 aggtgatgta cacagctttg aggctataga cagtgaccct gagctaagcc ggaccctgga
     1381 tgctcagtgc cctgtaggcc gtgtccttca gttaaagctg ggggctcaag tcatgctggt
     1441 gaagaactta gcagtgtctc ggggcctggt gaatggtgcc cgaggggtgg tagtcgggtt
     1501 tgagtcagaa ggaagagggc ttccccgggt acggttcctg tgtggcatca ctgaggtcat
     1561 ccgcaccgac cgctggacag tacaggtcac tgggggccag tacctcagcc ggcagcagct
     1621 tcccctacag ctagcctggg caatgtccat ccacaaaagc cagggcatgt ctctggactg
     1681 tgtagagatc tctctgggcc gtgtgttcgc cagtggtcaa gcctatgtgg ccctctcccg
     1741 ggcccgtagc ctccagggtc tacgtgtgct agacttcgac cccactgtgg ttcgatgcga
     1801 ctcccgagtg ctgcaattct atgccaccct gcggcagggc aggggcctca gtctggagtc
     1861 gcaagacgat gaggaggcaa gctcagatct ggagaacatg gacccaaacc tctga
//
