LOCUS       NP_001037718             637 aa            linear   ROD 03-APR-2024
DEFINITION  ATP-dependent DNA helicase PIF1 [Rattus norvegicus].
ACCESSION   NP_001037718 XP_001076669 XP_346238
VERSION     NP_001037718.1
DBSOURCE    REFSEQ: accession NM_001044253.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 637)
  AUTHORS   Paeschke,K., Bochman,M.L., Garcia,P.D., Cejka,P., Friedman,K.L.,
            Kowalczykowski,S.C. and Zakian,V.A.
  TITLE     Pif1 family helicases suppress genome instability at G-quadruplex
            motifs
  JOURNAL   Nature 497 (7450), 458-462 (2013)
   PUBMED   23657261
REFERENCE   2  (residues 1 to 637)
  AUTHORS   Kazak,L., Reyes,A., Duncan,A.L., Rorbach,J., Wood,S.R.,
            Brea-Calvo,G., Gammage,P.A., Robinson,A.J., Minczuk,M. and
            Holt,I.J.
  TITLE     Alternative translation initiation augments the human mitochondrial
            proteome
  JOURNAL   Nucleic Acids Res 41 (4), 2354-2369 (2013)
   PUBMED   23275553
REFERENCE   3  (residues 1 to 637)
  AUTHORS   Snow,B.E., Mateyak,M., Paderova,J., Wakeham,A., Iorio,C.,
            Zakian,V., Squire,J. and Harrington,L.
  TITLE     Murine Pif1 interacts with telomerase and is dispensable for
            telomere function in vivo
  JOURNAL   Mol Cell Biol 27 (3), 1017-1026 (2007)
   PUBMED   17130244
REFERENCE   4  (residues 1 to 637)
  AUTHORS   Zhang,D.H., Zhou,B., Huang,Y., Xu,L.X. and Zhou,J.Q.
  TITLE     The human Pif1 helicase, a potential Escherichia coli RecD
            homologue, inhibits telomerase activity
  JOURNAL   Nucleic Acids Res 34 (5), 1393-1404 (2006)
   PUBMED   16522649
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ489562.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XP_346238.3, XP_001076669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ489562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     Protein         1..637
                     /product="ATP-dependent DNA helicase PIF1"
                     /EC_number="3.6.4.12"
                     /note="PIF1/RRM3 DNA helicase-like protein; Pif1/Rrm3
                     DNA-helicase-like protein; DNA repair and recombination
                     helicase PIF1"
                     /calculated_mol_wt=69627
     Region          1..180
                     /region_name="PINT. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HG60.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H611; propagated from
                     UniProtKB/Swiss-Prot (Q1HG60.1)"
     Site            151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H611; propagated from
                     UniProtKB/Swiss-Prot (Q1HG60.1)"
     Region          159..184
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HG60.1)"
     Region          203..500
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Site            order(207,225..232,302,342)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350795"
     Region          <544..589
                     /region_name="SF1_C_RecD"
                     /note="C-terminal helicase domain of RecD family
                     helicases; cd18809"
                     /db_xref="CDD:350196"
     Site            555
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350196"
     Region          618..637
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HG60.1)"
     CDS             1..637
                     /gene="Pif1"
                     /coded_by="NM_001044253.1:2..1915"
                     /db_xref="GeneID:367645"
                     /db_xref="RGD:1586053"
ORIGIN      
        1 mpsstevatd ecddtelrcr vaveelspgg qprkrqalra aelslgrner relmlrlqap
       61 gpegrprcfp lravrlftrf aavgrstlrl padgvprags vqlllsdcpp erlrrflrtl
      121 rlklavapgp gpasaraqll gprprdfvti spvqpeelrr aaatkapdsa lekrpmesqp
      181 smeaprwplp vkklrmpssk pklseeqaav lrmvlkgqsi fftgsagtgk syllkhilgs
      241 lpptgtvata stgvaachig gttlhafagi gsgqaplaqc valahrpgvr qgwlncqrlv
      301 ideismvead ffdkleavar avrqqkkpfg giqliicgdf lqlppvtkgs qhprfcfqak
      361 swrkcvpvtl eltevwrqad qtfisllkav rlgrcsdevt rqlrataahk vgrdgiiatr
      421 lcthqddval tnekrlkelp gdvhsfeaid sdpelsrtld aqcpvgrvlq lklgaqvmlv
      481 knlavsrglv ngargvvvgf esegrglprv rflcgitevi rtdrwtvqvt ggqylsrqql
      541 plqlawamsi hksqgmsldc veislgrvfa sgqayvalsr arslqglrvl dfdptvvrcd
      601 srvlqfyatl rqgrglsles qddeeassdl enmdpnl
//
