LOCUS       NM_053460               1999 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus protein interacting with PRKCA 1 (Pick1), mRNA.
ACCESSION   NM_053460
VERSION     NM_053460.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Erlendsson,S., Thorsen,T.S., Vauquelin,G., Ammendrup-Johnsen,I.,
            Wirth,V., Martinez,K.L., Teilum,K., Gether,U. and Madsen,K.L.
  TITLE     Mechanisms of PDZ domain scaffold assembly illuminated by use of
            supported cell membrane sheets
  JOURNAL   Elife 8, e39180 (2019)
   PUBMED   30605082
  REMARK    GeneRIF: multivalent protein-protein and protein-lipid interactions
            provide critical avidity for the strong binding between the PDZ
            domain scaffold proteins, PICK1 and PSD-95, and their cognate
            transmembrane binding partners
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Herlo,R., Lund,V.K., Lycas,M.D., Jansen,A.M., Khelashvili,G.,
            Andersen,R.C., Bhatia,V., Pedersen,T.S., Albornoz,P.B.C.,
            Johner,N., Ammendrup-Johnsen,I., Christensen,N.R., Erlendsson,S.,
            Stoklund,M., Larsen,J.B., Weinstein,H., Kjaerulff,O., Stamou,D.,
            Gether,U. and Madsen,K.L.
  TITLE     An Amphipathic Helix Directs Cellular Membrane Curvature Sensing
            and Function of the BAR Domain Protein PICK1
  JOURNAL   Cell Rep 23 (7), 2056-2069 (2018)
   PUBMED   29768204
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Lorgen,J.O., Egbenya,D.L., Hammer,J. and Davanger,S.
  TITLE     PICK1 facilitates lasting reduction in GluA2 concentration in the
            hippocampus during chronic epilepsy
  JOURNAL   Epilepsy Res 137, 25-32 (2017)
   PUBMED   28888867
  REMARK    GeneRIF: study found that both GluA2 and PICK1 were down-regulated
            in kainate-treated rats for as long as eight weeks after induction
            of epilepsy; statistical analysis indicates that the functional
            role of PIC 1 in studied material is to increase GluA2
            concentrations in the cells
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Fiuza,M., Rostosky,C.M., Parkinson,G.T., Bygrave,A.M., Halemani,N.,
            Baptista,M., Milosevic,I. and Hanley,J.G.
  TITLE     PICK1 regulates AMPA receptor endocytosis via direct interactions
            with AP2 alpha-appendage and dynamin
  JOURNAL   J Cell Biol 216 (10), 3323-3338 (2017)
   PUBMED   28855251
  REMARK    GeneRIF: PICK1 is a cargo-specific endocytic accessory protein
            required for efficient, activity-dependent AMPAR endocytosis.
REFERENCE   5  (bases 1 to 1999)
  AUTHORS   Koszegi,Z., Fiuza,M. and Hanley,J.G.
  TITLE     Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response
            to oxygen/glucose deprivation in hippocampal but not cortical
            neurons
  JOURNAL   Sci Rep 7 (1), 12318 (2017)
   PUBMED   28951554
  REMARK    GeneRIF: Study shows that oxygen and glucose deprivation (OGD)
            causes endocytosis, lysosomal targeting and consequent degradation
            of GluA2- and GluA3-containing AMPARs, and that PICK1 is required
            for both OGD-induced GluA2 endocytosis and lysosomal sorting.
            GluA1-containing AMPARs resist OGD-induced endocytosis and PICK1
            binding to the endocytic adaptor AP2 is enhanced by OGD in
            hippocampal, but not cortical neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1999)
  AUTHORS   Dev,K.K., Nishimune,A., Henley,J.M. and Nakanishi,S.
  TITLE     The protein kinase C alpha binding protein PICK1 interacts with
            short but not long form alternative splice variants of AMPA
            receptor subunits
  JOURNAL   Neuropharmacology 38 (5), 635-644 (1999)
   PUBMED   10340301
REFERENCE   7  (bases 1 to 1999)
  AUTHORS   Xia,J., Zhang,X., Staudinger,J. and Huganir,R.L.
  TITLE     Clustering of AMPA receptors by the synaptic PDZ domain-containing
            protein PICK1
  JOURNAL   Neuron 22 (1), 179-187 (1999)
   PUBMED   10027300
REFERENCE   8  (bases 1 to 1999)
  AUTHORS   Torres,R., Firestein,B.L., Dong,H., Staudinger,J., Olson,E.N.,
            Huganir,R.L., Bredt,D.S., Gale,N.W. and Yancopoulos,G.D.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (bases 1 to 1999)
  AUTHORS   Staudinger,J., Lu,J. and Olson,E.N.
  TITLE     Specific interaction of the PDZ domain protein PICK1 with the COOH
            terminus of protein kinase C-alpha
  JOURNAL   J Biol Chem 272 (51), 32019-32024 (1997)
   PUBMED   9405395
REFERENCE   10 (bases 1 to 1999)
  AUTHORS   Staudinger,J., Zhou,J., Burgess,R., Elledge,S.J. and Olson,E.N.
  TITLE     PICK1: a perinuclear binding protein and substrate for protein
            kinase C isolated by the yeast two-hybrid system
  JOURNAL   J Cell Biol 128 (3), 263-271 (1995)
   PUBMED   7844141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 24, 2020 this sequence version replaced NM_053460.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.21373.1,
                                           SRR26643284.10520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000007.1  112677545-112677733
            190-293             JAXUCZ010000007.1  112677911-112678014
            294-405             JAXUCZ010000007.1  112678822-112678933
            406-534             JAXUCZ010000007.1  112687938-112688066
            535-601             JAXUCZ010000007.1  112689538-112689604
            602-691             JAXUCZ010000007.1  112690956-112691045
            692-745             JAXUCZ010000007.1  112692708-112692761
            746-808             JAXUCZ010000007.1  112693116-112693178
            809-942             JAXUCZ010000007.1  112693799-112693932
            943-1035            JAXUCZ010000007.1  112694244-112694336
            1036-1086           JAXUCZ010000007.1  112695126-112695176
            1087-1231           JAXUCZ010000007.1  112695945-112696089
            1232-1999           JAXUCZ010000007.1  112696508-112697275
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1999
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /note="protein interacting with PRKCA 1"
                     /db_xref="GeneID:84591"
                     /db_xref="RGD:69437"
     exon            1..189
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            190..293
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1503
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /note="protein kinase C-alpha-binding protein; protein
                     that interacts with C kinase 1; protein interacting with C
                     kinase 1"
                     /codon_start=1
                     /product="PRKCA-binding protein"
                     /protein_id="NP_445912.2"
                     /db_xref="GeneID:84591"
                     /db_xref="RGD:69437"
                     /translation="MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYC
                     PCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYN
                     KLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTA
                     ELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIE
                     KFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYS
                     CIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQL
                     QRFVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGPNQGGFTDGEDEEEEEEDGA
                     AREVSKDARGATGPTDKGRSWCDS"
     exon            294..405
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            406..534
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            535..601
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..691
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            692..745
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            746..808
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            809..942
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1035
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1086
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1231
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1999
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacgcgaca gtcgcggtcg ccgccaggtg gaacggcagg tgggttcagg tgccagcctg
       61 gcccgggcct ggctgtggga cggactctct cggtgagcga ctgaagcggc tcccaagggt
      121 ctggagaccg tggggcgggc tccagaatcc gagcccatcg ccctggcctg gggtcctccc
      181 ctgtaccaaa cccagtttcc tattcccctc ccgaactggg cagttagcca gtcggcccca
      241 gctctcggaa ccatgtttgc agacttagac tatgacatcg aggaggataa attaggaatc
      301 cccactgtgc ccgggaaggt caccctgcag aaggatgctc agaacctgat tggcatcagc
      361 atcggaggag gggcccagta ctgtccttgt ctctacattg tccaggtatt tgataacacg
      421 cctgcagcct tggacggcac tgtggcagct ggtgatgaga tcactggggt caatggccga
      481 tcaatcaaag gaaaaaccaa ggtagaggtg gcgaagatga ttcaggaggt gaagggggag
      541 gtgaccatcc attacaacaa gctgcaggcg gaccctaagc agggcatgtc cctggacatt
      601 gtgttgaaga aagtcaagca ccggctggta gaaaacatga gttcaggcac agctgatgcc
      661 ctgggtctaa gccgtgccat cctgtgtaat gatgggttgg taaagcggct ggaggagctg
      721 gagcgcactg ccgagctgta caaaggaatg acggagcaca ccaagaatct cctacgggcc
      781 ttttatgagc tgtcacagac tcaccgggct tttggggacg tgttctctgt gattggggtg
      841 cgggagccgc agccagcagc aagtgaagca tttgtgaagt ttgctgacgc acaccgcagc
      901 attgagaagt tcggcattcg gctactgaaa accatcaaac cgatgctgac ggatctgaac
      961 acgtacctca ataaggccat ccctgataca cgcctcacca tcaagaagta cctggatgtg
     1021 aagtttgagt acttgtcata ctgtctgaag gtgaaggaga tggacgacga ggagtacagc
     1081 tgcattgccc taggagagcc gctataccga gtgagcacag gcaactatga gtaccgcctt
     1141 atcctgcgct gccgccagga ggctcgagcc cgcttctccc agatgcgcaa ggatgtgctg
     1201 gagaagatgg agctgctgga ccagaagcac gtccaggaca tcgtgttcca gctgcagcgc
     1261 ttcgtgtcta ccatgtccaa gtactataat gactgctatg cggtgctgcg ggacgccgac
     1321 gtcttcccca tcgaggtgga cctggcacac accactctag cctacggccc taaccagggc
     1381 ggctttaccg atggcgaaga tgaggaggag gaggaggagg acggggcagc tagggaagtg
     1441 tccaaggacg cacgtggggc cactgggcct acagacaagg gcagaagctg gtgtgactcc
     1501 tgagtgcccc cctcaagtgg acctgggggc agggtagtgg gaggaccgca gtgggagtgg
     1561 ggccgggcca ctgtaggaca gcgaaggcat atagtggcgc ataaaagcct gctggctcgg
     1621 ggcgcctgcc tccctgctcc tctgtccttg aacagtgaac ccagcctgca gcctgggacc
     1681 tggactctag cccccatcct tccttcccac ctcccagcta gagggagagc tgggccttgg
     1741 acagaaagag aaggggctgg agcaggcaga gcacaggacc tgtccctgtc cctgtgagca
     1801 cctcggtggt gccacgcctg cagggaatgg gagctgggtg gacatccgag gctgtgacca
     1861 gtgtaccagg gcggccccct gagtccatgt gcacacctcg gcagcctata tttatttgtt
     1921 tctggcttag cctcaagggc tggaagctgg gcctgtattg aataaacaga aacccagaca
     1981 gaatggatgg gctcctcgc
//
