LOCUS       NM_001305419            2845 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus progesterone immunomodulatory binding factor 1
            (Pibf1), mRNA.
ACCESSION   NM_001305419 XM_006222044 XM_006252404
VERSION     NM_001305419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2845)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2845)
  AUTHORS   Wheway,G., Schmidts,M., Mans,D.A., Szymanska,K., Nguyen,T.T.,
            Racher,H., Phelps,I.G., Toedt,G., Kennedy,J., Wunderlich,K.A.,
            Sorusch,N., Abdelhamed,Z.A., Natarajan,S., Herridge,W., van
            Reeuwijk,J., Horn,N., Boldt,K., Parry,D.A., Letteboer,S.J.F.,
            Roosing,S., Adams,M., Bell,S.M., Bond,J., Higgins,J.,
            Morrison,E.E., Tomlinson,D.C., Slaats,G.G., van Dam,T.J.P.,
            Huang,L., Kessler,K., Giessl,A., Logan,C.V., Boyle,E.A.,
            Shendure,J., Anazi,S., Aldahmesh,M., Al Hazzaa,S., Hegele,R.A.,
            Ober,C., Frosk,P., Mhanni,A.A., Chodirker,B.N., Chudley,A.E.,
            Lamont,R., Bernier,F.P., Beaulieu,C.L., Gordon,P., Pon,R.T.,
            Donahue,C., Barkovich,A.J., Wolf,L., Toomes,C., Thiel,C.T.,
            Boycott,K.M., McKibbin,M., Inglehearn,C.F., Stewart,F., Omran,H.,
            Huynen,M.A., Sergouniotis,P.I., Alkuraya,F.S., Parboosingh,J.S.,
            Innes,A.M., Willoughby,C.E., Giles,R.H., Webster,A.R., Ueffing,M.,
            Blacque,O., Gleeson,J.G., Wolfrum,U., Beales,P.L., Gibson,T.,
            Doherty,D., Mitchison,H.M., Roepman,R. and Johnson,C.A.
  CONSRTM   UK10K Consortium; University of Washington Center for Mendelian
            Genomics
  TITLE     An siRNA-based functional genomics screen for the identification of
            regulators of ciliogenesis and ciliopathy genes
  JOURNAL   Nat Cell Biol 17 (8), 1074-1087 (2015)
   PUBMED   26167768
REFERENCE   3  (bases 1 to 2845)
  AUTHORS   Kim,K., Lee,K. and Rhee,K.
  TITLE     CEP90 is required for the assembly and centrosomal accumulation of
            centriolar satellites, which is essential for primary cilia
            formation
  JOURNAL   PLoS One 7 (10), e48196 (2012)
   PUBMED   23110211
REFERENCE   4  (bases 1 to 2845)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 2845)
  AUTHORS   Kim,K. and Rhee,K.
  TITLE     The pericentriolar satellite protein CEP90 is crucial for integrity
            of the mitotic spindle pole
  JOURNAL   J Cell Sci 124 (Pt 3), 338-347 (2011)
   PUBMED   21224392
REFERENCE   6  (bases 1 to 2845)
  AUTHORS   Kozma,N., Halasz,M., Polgar,B., Poehlmann,T.G., Markert,U.R.,
            Palkovics,T., Keszei,M., Par,G., Kiss,K., Szeberenyi,J., Grama,L.
            and Szekeres-Bartho,J.
  TITLE     Progesterone-induced blocking factor activates STAT6 via binding to
            a novel IL-4 receptor
  JOURNAL   J Immunol 176 (2), 819-826 (2006)
   PUBMED   16393965
REFERENCE   7  (bases 1 to 2845)
  AUTHORS   Polgar,B., Kispal,G., Lachmann,M., Paar,C., Nagy,E., Csere,P.,
            Miko,E., Szereday,L., Varga,P. and Szekeres-Bartho,J.
  TITLE     Molecular cloning and immunologic characterization of a novel cDNA
            coding for progesterone-induced blocking factor
  JOURNAL   J Immunol 171 (11), 5956-5963 (2003)
   PUBMED   14634107
  REMARK    Erratum:[J Immunol. 2004 Feb 15;172(4):following 2703. Paar,
            Gabriella [corrected to Paar, Christian]]
REFERENCE   8  (bases 1 to 2845)
  AUTHORS   Laskarin,G., Tokmadzic,V.S., Strbo,N., Bogovic,T.,
            Szekeres-Bartho,J., Randic,L., Podack,E.R. and Rukavina,D.
  TITLE     Progesterone induced blocking factor (PIBF) mediates progesterone
            induced suppression of decidual lymphocyte cytotoxicity
  JOURNAL   Am J Reprod Immunol 48 (4), 201-209 (2002)
   PUBMED   12516630
REFERENCE   9  (bases 1 to 2845)
  AUTHORS   Szekeres-Bartho,J., Kilar,F., Falkay,G., Csernus,V., Torok,A. and
            Pacsa,A.S.
  TITLE     The mechanism of the inhibitory effect of progesterone on
            lymphocyte cytotoxicity: I. Progesterone-treated lymphocytes
            release a substance inhibiting cytotoxicity and prostaglandin
            synthesis
  JOURNAL   Am J Reprod Immunol Microbiol 9 (1), 15-18 (1985)
   PUBMED   3863495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1 and FM096888.1.
            
            On or before Mar 11, 2015 this sequence version replaced
            XM_006252404.2, XM_006222044.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.421536.1,
                                           SRR26360172.63460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               JAXUCZ010000015.1  82258473-82258711
            240-507             JAXUCZ010000015.1  82259568-82259835
            508-608             JAXUCZ010000015.1  82263607-82263707
            609-807             JAXUCZ010000015.1  82265620-82265818
            808-927             JAXUCZ010000015.1  82270968-82271087
            928-1061            JAXUCZ010000015.1  82300738-82300871
            1062-1170           JAXUCZ010000015.1  82303984-82304092
            1171-1352           JAXUCZ010000015.1  82304623-82304804
            1353-1478           JAXUCZ010000015.1  82307432-82307557
            1479-1577           JAXUCZ010000015.1  82317015-82317113
            1578-1743           JAXUCZ010000015.1  82357274-82357439
            1744-1894           JAXUCZ010000015.1  82363147-82363297
            1895-2478           FM096888.1         98-681
            2479-2845           JAXUCZ010000015.1  82427180-82427546
FEATURES             Location/Qualifiers
     source          1..2845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..2845
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /note="progesterone immunomodulatory binding factor 1"
                     /db_xref="GeneID:306104"
                     /db_xref="RGD:1305077"
     exon            1..239
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            240..507
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2529
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /codon_start=1
                     /product="progesterone-induced-blocking factor 1"
                     /protein_id="NP_001292348.1"
                     /db_xref="GeneID:306104"
                     /db_xref="RGD:1305077"
                     /translation="MSRKIAKESKKVNISSSLESEDISLETTIHTDDVSSSEEREGKV
                     KITRQLIERKEILHNIQLLKIELSQKNMMIDNLKMDYLTKVEELEEKLNDALHQKQLL
                     TLRLDNQLTIQQKDAKKYQELMKQEMETILLRQKQLEETNHQLREKAGDVRRNLRDLE
                     LTEEQYEKLKSFPEDQLSIPEFVSIRFYELVNPLRKEIHELQVKKNELSEELSTNKGQ
                     LKQLTETYEEARRNHSELLTRCQRLALELADTKQLVQQGDYRQENYDKVKSERDALEQ
                     EVLEVRRKHEVLETSHIAQAKERNELSKEVSTLQQTVTLLQKDKEYLNRQNMELSVRC
                     AHEEDRLERLQVQLEETKRAREEMYEKYVTSRDHYKTEYENKLHDELEQIKLKTNLEI
                     DQLRSASREMYERENRNLREARDNALAEKNRAVTAEKDALEKHEQLLDRYRELQLSTE
                     SKVSEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQAS
                     SEKRITELEAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERILYSYGYGANV
                     PTTAKRRLKQSVHLARRVLQLEKQNSSILKDLDHQKEEVRQLSQELDRANSLLNQSQQ
                     PYRYLIESVRQRDSKIDSLMKCTAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHR
                     EEFAAMKQIIINMCSKHSENNLLLTKVESKSVTENQASRPLTMPREHEENVFIPKPTL
                     FTKKEAQEWPKNQKMKA"
     exon            508..608
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            609..807
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            808..927
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1061
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1170
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1352
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1478
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1577
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1743
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1894
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1985
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2088
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2219
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2304
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2478
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2845
                     /gene="Pibf1"
                     /gene_synonym="RGD1305077"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttccgact gacttccggg agagggtgag cttggtacct gcgcgcccta ggttcttcgg
       61 atttcttctg gggcagggcg ggtggttgtc ttggtgaccg ctcctaacgg tccggtaacc
      121 ccgagatact tgttgagggg ttgcagcctg agctgctgac tgaagacgcc attggttctt
      181 ccaagtgtcc aggtgaagct ggttctagcc ttatatgcgg agttactgac gcttgagaga
      241 agattgattc aaataatgtc tcgaaaaatt gccaaggaat caaaaaaagt taatatctct
      301 agttctctgg aatctgaaga tattagttta gaaacaacca ttcacacaga tgatgtttcc
      361 tcatcagaag agcgagaggg taaagtcaaa atcaccaggc agttaatcga aagaaaagag
      421 atacttcata atattcagtt actgaaaatc gagctatccc aaaaaaatat gatgattgac
      481 aacttaaaaa tggattatct tacaaaggtt gaagagctgg aggaaaaact taatgatgcc
      541 cttcaccaga agcagctgct aactttgaga ttagacaatc aattgactat tcaacagaaa
      601 gacgccaaaa aatatcaaga actaatgaaa caagaaatgg agaccatttt gttgagacag
      661 aagcaactgg aagagacaaa tcatcagcta agagaaaagg ctggcgatgt ccgtcggaat
      721 cttcgagact tggagctaac ggaagagcag tatgagaagc taaaatcttt tcctgaagat
      781 cagctttcta ttcctgaatt tgtctctatt cggttctatg agctagtaaa cccattaaga
      841 aaggaaatcc atgaactaca ggtgaagaag aatgaactat ctgaagagtt aagtacaaat
      901 aaaggccaac tgaagcagct gacggagaca tatgaagaag ctcgaaggaa ccactctgaa
      961 cttctaactc gatgtcaacg tttggcctta gaattagcag acacgaaaca gttagttcag
     1021 caaggagatt accgtcaaga gaactatgac aaagtgaaga gtgaacgcga tgctctcgaa
     1081 caggaagtac tcgaggttag aaggaaacat gaggtacttg aaacctctca catagctcaa
     1141 gctaaagaaa ggaatgaatt atcgaaagag gtaagcacct tgcagcagac agtcaccctg
     1201 ctgcagaaag ataaagaata cctcaatcgc caaaacatgg agctcagtgt acgctgtgcc
     1261 catgaggagg atcgcctgga aaggttgcaa gttcaactgg aagagaccaa aagggctaga
     1321 gaagagatgt atgagaaata tgtcacatcc agagaccatt ataaaacaga atatgaaaat
     1381 aaactacatg atgaactgga acaaatcaaa ttgaaaacta atctagaaat tgatcagctt
     1441 cgaagtgctt ctagggaaat gtatgaacga gaaaacagaa atctccgtga agcaagagat
     1501 aatgctctcg ctgaaaagaa ccgagcagtg acagcggaaa aagacgctct agaaaagcat
     1561 gagcagctcc tagacaggta cagagaactc caacttagta cagaaagcaa agtttccgag
     1621 tttctccatc agagcaagct gaagtccttt gaaagcgagc gtgttcaact cctgcaagag
     1681 gaaacggcaa gaaatctcac acagtgccag ttggaatgtg aaaaatatca gaagaaattg
     1741 gaggttttaa ctaaagaatt ttatagtctc caagcgtctt ctgaaaaacg cattactgaa
     1801 ctcgaggcac agaactcaga gcatcaggca aggttagaca tttacgagaa attggaaaag
     1861 gaacttgatg aaataataat gcagacagca gaaattgaaa atgaagacga ggctgaaaga
     1921 attctttatt cctatggcta tggtgctaac gttcccacaa cagctaagag gcggctaaag
     1981 caaagtgtcc acttggcaag aagagttctt caattagaaa aacaaaattc atcaatttta
     2041 aaagatctgg accatcaaaa ggaggaagta agacagcttt ctcaagagct tgacagagcc
     2101 aattcactgt taaatcagag tcagcaaccc tacagatacc tcatagagtc tgtgagacag
     2161 agggattcca agattgactc actgatgaag tgtactgctc aacttgagaa agatgtcagc
     2221 aacttaaata aagaaaagtc agccctgctg cagacgaaga accagatggc actggatttg
     2281 gagcagcttc taaatcaccg tgaggaattt gcagctatga agcagatcat cattaatatg
     2341 tgtagtaaac attctgagaa caacttactt cttacaaaag tggaatcaaa aagtgtgaca
     2401 gaaaaccaag catcaaggcc tttgactatg ccaagagaac atgaagagaa tgtatttata
     2461 cccaagccaa cgctgtttac taaaaaggaa gcacaagaat ggcccaagaa tcaaaagatg
     2521 aaggcctagt gtttggggtt gaagagagct agcgcctaac ccagctgggc ccctccgtcc
     2581 tcaccgcacc cccagccagg cctccggctc tccactggag tgggcctgtg ttatcatgga
     2641 ctcctgaagt gctatgtttg ttgaggagaa aggttcattt taatcatgta cttgatattt
     2701 tcaaatatac ataacttaat gtttgtttta actaatgtta aattaacaaa tttcagtata
     2761 atcaacatat aaagtacaaa tcgtcatata ctttatatgt ggctttatat attttattat
     2821 aaaataaatg tcttctatct cctga
//
