LOCUS       NM_001100757            2431 bp    mRNA    linear   ROD 19-JUN-2023
DEFINITION  Rattus norvegicus protein inhibitor of activated STAT, 4 (Pias4),
            mRNA.
ACCESSION   NM_001100757 XM_001075850 XM_343155
VERSION     NM_001100757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Wang T, Liu J, Hu C, Wei X, Han L, Zhu A, Wang R, Chen Z, Xia Z,
            Yao S and Mao W.
  TITLE     Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and
            ameliorates ventricular arrhythmias in a rat model of myocardial
            ischemia/reperfusion injury
  JOURNAL   Chin Med J (Engl) 136 (11), 1349-1357 (2023)
   PUBMED   37014755
  REMARK    GeneRIF: Downregulation of cardiac PIASy inhibits Cx43 SUMOylation
            and ameliorates ventricular arrhythmias in a rat model of
            myocardial ischemia/reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Panier S and Durocher D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J,
            Wikstrom M, Bekker-Jensen S and Mailand N.
  TITLE     DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via
            a novel SUMO-binding Zinc finger
  JOURNAL   J Cell Biol 197 (2), 179-187 (2012)
   PUBMED   22508508
REFERENCE   4  (bases 1 to 2431)
  AUTHORS   Cong L, Pakala SB, Ohshiro K, Li DQ and Kumar R.
  TITLE     SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor
            antigen 1 (MTA1) synergistically regulate its transcriptional
            repressor function
  JOURNAL   J Biol Chem 286 (51), 43793-43808 (2011)
   PUBMED   21965678
REFERENCE   5  (bases 1 to 2431)
  AUTHORS   Sun Y, Perera J, Rubin BP and Huang J.
  TITLE     SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase
            activity to cause overexpression of NCOA3 protein
  JOURNAL   J Biol Chem 286 (21), 18623-18632 (2011)
   PUBMED   21454665
  REMARK    GeneRIF: The increase of NCOA3 is essential for SYT-SSX1-mediated
            synovial sarcoma formation. SYT-SSX1 does so by increasing the
            sumoylation of NCOA3 through interaction with a SUMO E3 ligase,
            PIASy, as well as the sumoylation of NEMO.
REFERENCE   6  (bases 1 to 2431)
  AUTHORS   Munarriz E, Barcaroli D, Stephanou A, Townsend PA, Maisse C,
            Terrinoni A, Neale MH, Martin SJ, Latchman DS, Knight RA, Melino G
            and De Laurenzi V.
  TITLE     PIAS-1 is a checkpoint regulator which affects exit from G1 and G2
            by sumoylation of p73
  JOURNAL   Mol Cell Biol 24 (24), 10593-10610 (2004)
   PUBMED   15572666
REFERENCE   7  (bases 1 to 2431)
  AUTHORS   Wormald S and Hilton DJ.
  TITLE     Inhibitors of cytokine signal transduction
  JOURNAL   J Biol Chem 279 (2), 821-824 (2004)
   PUBMED   14607831
  REMARK    Review article
REFERENCE   8  (bases 1 to 2431)
  AUTHORS   Subramanian L, Benson MD and Iniguez-Lluhi JA.
  TITLE     A synergy control motif within the attenuator domain of
            CCAAT/enhancer-binding protein alpha inhibits transcriptional
            synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3
  JOURNAL   J Biol Chem 278 (11), 9134-9141 (2003)
   PUBMED   12511558
REFERENCE   9  (bases 1 to 2431)
  AUTHORS   Sachdev S, Bruhn L, Sieber H, Pichler A, Melchior F and Grosschedl
            R.
  TITLE     PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1
            activity by sequestration into nuclear bodies
  JOURNAL   Genes Dev 15 (23), 3088-3103 (2001)
   PUBMED   11731474
REFERENCE   10 (bases 1 to 2431)
  AUTHORS   Liu B, Gross M, ten Hoeve J and Shuai K.
  TITLE     A transcriptional corepressor of Stat1 with an essential LXXLL
            signature motif
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3203-3207 (2001)
   PUBMED   11248056
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169045.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_343155.3, XM_001075850.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2431
                     /gene="Pias4"
                     /note="protein inhibitor of activated STAT, 4"
                     /db_xref="GeneID:362827"
                     /db_xref="RGD:1308737"
     exon            1..82
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1579
                     /gene="Pias4"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS4"
                     /protein_id="NP_001094227.1"
                     /db_xref="GeneID:362827"
                     /db_xref="RGD:1308737"
                     /translation="MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQ
                     LVQFDCSPELFKKIKELYETRYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYP
                     VLYGKYLNGLGRLPTKALKPEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFA
                     LTPRQVEMIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPG
                     YYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSD
                     LLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAET
                     CAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECEDADEIEFL
                     AEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGMGSGLSGPGGAGGGAGA
                     AGGLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDDDEGPRPKRRCPFQKGLVPAC"
     exon            83..488
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            489..573
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..615
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            616..706
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..835
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            836..941
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1015
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1176
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1307
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..2407
                     /gene="Pias4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcacgtga cgcgacggct ggggcctccc ggcgcggggg acgctagtgg ccaagatggc
       61 ggcagagctg gtggaggcca aaaacatggt gatgagcttc cgagtgtcag acctgcagat
      121 gctgctgggc tttgtaggtc gtagcaagag cgggctgaag catgagctgg tgaccagggc
      181 cttgcagctg gtgcagtttg actgtagccc ggagcttttc aagaagatca aagagctgta
      241 tgagactcgc tatgccaaga agagtgcaga gcccggccca caggcgccac ggcccctgga
      301 tcccctggca ctacactcca tgcccaggac tcccctgtca ggacccaccg tggactaccc
      361 cgtgctgtac gggaagtact tgaatggact ggggcgcctg cccaccaagg cccttaagcc
      421 ggaggtacgc ctggtaaagc tgcctttctt caacatgctg gacgagttgc tgaagcccac
      481 tgagctggtc ccacagagtg ctgagaagct gcaagagagc ccgtgcatct tcgcgctgac
      541 ccctcggcag gtggagatga tccgcaactc cagggagctg cagcctggag tgaaagcagt
      601 gcaggtggta ctgaggatct gttactctga caccagctgt ccacaggagg accagtatcc
      661 acccaacatc gctgtgaaag tcaaccacag ctactgttca gtgccgggct actatccctc
      721 caacaagcct ggtgtggaac ccaagaggcc ctgccgcccc atcaacctta cccacctcat
      781 gtatctgtcc tcggccacca accgcattac tgttacctgg ggcaactatg gcaagagcta
      841 ctctgtggct ttgtacctgg tgcgacagct gacctcctca gacctgctac agaggttgaa
      901 gacgattggg gtgaagcatc ctgagctctg caaggctctg gtcaaggaga agcttcgcct
      961 agaccctgac agcgagatcg ctactaccgg agtgcgagtg tccctcatct gcccactggt
     1021 gaagatgcgg ctctcggtgc cctgccgtgc agagacctgc gcacacctgc agtgctttga
     1081 tgccgtgttc tacctacaaa tgaatgagaa gaagcccacg tggatgtgcc ctgtgtgtga
     1141 caagcccgca gcttatgacc agctcatcat agatgggctg ctgtcgaaga tcctgagtga
     1201 gtgtgaggac gcagatgaga ttgagttcct ggcggaaggt tcatggcgcc caatacgtgc
     1261 agagaaggaa ccaagctgca gcccacaggg ccccatcctg gtgctaggca cctcggacgc
     1321 caacgggctc gcaccagcct ccagcacccc gggcatggga agtggcctga gtggcccagg
     1381 cggcgccggc ggcggggcgg gggcggccgg tggcctggag aacggcaaga caggcgcaga
     1441 cgtggtggac ctcacactgg acagctcgtc gtcctcagaa gatgaggatg aggacgagga
     1501 cgacgatgag gacgatgacg agggcccccg gccgaagcgc cgctgcccgt tccagaaggg
     1561 actggtgccc gcttgctgac gccgctgcgg ggcgctggag ggcgggagcc gctcccgtcc
     1621 atcattccct cgcccacccc tccccggctc ccggctcctg tacttctgga ctctcctctt
     1681 gggggggatt aaaaaaaaag taaaatgaca aaaaaaaaaa aaacaaccaa acaaacaaaa
     1741 aaaaaaacga gaaaataaac acttacacgg gccggcagcc tgcacgccac ctcccggagc
     1801 agcccgcggg gcgcggggac ctcggacact ggacagcggc cggcggctgt ccccgctccc
     1861 tgcgttgagg ccgagccctg accccggagt gctggcctgg tcgcaaccag ttttagttga
     1921 gaagccatgg tggggcggcg ggccggggac ggtggccaca atgtgcaata acgtggtgtc
     1981 ccggggccgg gcgcggcggc agacccgggt ggcatggggg ggtgtcgttt ctagccagct
     2041 acctcggtaa ctccaattca ttcaggttaa cttccccatg gggcagccgg ccgcgggctt
     2101 gggcgctgtc gctctgctct tgtgtggccc gcggcatggg gctccccggc tgcctcctta
     2161 ccctccggag cctcgctctt ccaacgcccc gctgccaggc agacctcggg gcatcctgcc
     2221 gccctcccca cccgactctg tcaggaagca ataccgggtc cggtctggag ctgggcggcc
     2281 tggcggtgtc accgcatgaa ctcgctggga ggccggggcc ctggccagcc acacggcact
     2341 cttttctaat atttgtattc taatttaatt gttttttaaa aatgcaaata aaaaaaaaga
     2401 acgaagaaaa aaaaaaaaaa aaaaaaaaaa a
//
