LOCUS       NM_031784               2902 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein inhibitor of activated STAT, 3 (Pias3),
            mRNA.
ACCESSION   NM_031784
VERSION     NM_031784.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Meng,L., Du,C.P., Lu,C.Y., Zhang,K., Li,L., Yan,J.Z. and Hou,X.Y.
  TITLE     Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required
            for long-term potentiation of synaptic transmission
  JOURNAL   FASEB J 35 (8), e21769 (2021)
   PUBMED   34288124
  REMARK    GeneRIF: Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is
            required for long-term potentiation of synaptic transmission.
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Du,C.P., Wang,M., Geng,C., Hu,B., Meng,L., Xu,Y., Cheng,B.,
            Wang,N., Zhu,Q.J. and Hou,X.Y.
  TITLE     Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is
            Associated with Plasticity of Synaptic Transmission and
            Extracellular Signal-Regulated Kinase 1/2 Signaling
  JOURNAL   Antioxid Redox Signal 32 (1), 18-34 (2020)
   PUBMED   31642335
  REMARK    GeneRIF: Activity-Induced SUMOylation of Neuronal Nitric Oxide
            Synthase Is Associated with Plasticity of Synaptic Transmission and
            Extracellular Signal-Regulated Kinase 1/2 Signaling.
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Wang,S., He,F., Li,Z., Hu,Y., Huangfu,N. and Chen,X.
  TITLE     YB1 protects cardiac myocytes against H2O2-induced injury via
            suppression of PIAS3 mRNA and phosphorylation of STAT3
  JOURNAL   Mol Med Rep 19 (6), 4579-4588 (2019)
   PUBMED   30942400
  REMARK    GeneRIF: YB1 interacts with and promotes PIAS3 mRNA decay to
            facilitate STAT3 phosphorylation.
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Sun,X., Li,J., Dong,F.N. and Dong,J.T.
  TITLE     Characterization of nuclear localization and SUMOylation of the
            ATBF1 transcription factor in epithelial cells
  JOURNAL   PLoS One 9 (3), e92746 (2014)
   PUBMED   24651376
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Cong,L., Pakala,S.B., Ohshiro,K., Li,D.Q. and Kumar,R.
  TITLE     SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor
            antigen 1 (MTA1) synergistically regulate its transcriptional
            repressor function
  JOURNAL   J Biol Chem 286 (51), 43793-43808 (2011)
   PUBMED   21965678
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Rycyzyn,M.A. and Clevenger,C.V.
  TITLE     The intranuclear prolactin/cyclophilin B complex as a
            transcriptional inducer
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6790-6795 (2002)
   PUBMED   11997457
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   Levy,C., Nechushtan,H. and Razin,E.
  TITLE     A new role for the STAT3 inhibitor, PIAS3: a repressor of
            microphthalmia transcription factor
  JOURNAL   J Biol Chem 277 (3), 1962-1966 (2002)
   PUBMED   11709556
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Peiser,C., McGregor,G.P. and Lang,R.E.
  TITLE     Leptin receptor expression and suppressor of cytokine signaling
            transcript levels in high-fat-fed rats
  JOURNAL   Life Sci 67 (24), 2971-2981 (2000)
   PUBMED   11133009
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Kuryshev,Y.A., Gudz,T.I., Brown,A.M. and Wible,B.A.
  TITLE     KChAP as a chaperone for specific K(+) channels
  JOURNAL   Am J Physiol Cell Physiol 278 (5), C931-C941 (2000)
   PUBMED   10794667
REFERENCE   10 (bases 1 to 2902)
  AUTHORS   Wible,B.A., Yang,Q., Kuryshev,Y.A., Accili,E.A. and Brown,A.M.
  TITLE     Cloning and expression of a novel K+ channel regulatory protein,
            KChAP
  JOURNAL   J Biol Chem 273 (19), 11745-11751 (1998)
   PUBMED   9565597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031784.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF032872.2, SRR26643289.7039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000002.1  186922128-186922206
            80-497              JAXUCZ010000002.1  186924253-186924670
            498-582             JAXUCZ010000002.1  186924824-186924908
            583-633             JAXUCZ010000002.1  186924996-186925046
            634-724             JAXUCZ010000002.1  186925271-186925361
            725-859             JAXUCZ010000002.1  186925801-186925935
            860-965             JAXUCZ010000002.1  186926125-186926230
            966-1039            JAXUCZ010000002.1  186926669-186926742
            1040-1200           JAXUCZ010000002.1  186926854-186927014
            1201-1334           JAXUCZ010000002.1  186927723-186927856
            1335-1503           JAXUCZ010000002.1  186927936-186928104
            1504-1637           JAXUCZ010000002.1  186928258-186928391
            1638-1675           JAXUCZ010000002.1  186928553-186928590
            1676-2902           JAXUCZ010000002.1  186929066-186930292
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2902
                     /gene="Pias3"
                     /note="protein inhibitor of activated STAT, 3"
                     /db_xref="GeneID:83614"
                     /db_xref="RGD:708413"
     exon            1..79
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1942
                     /gene="Pias3"
                     /note="potassium channel regulatory protein KChAP;
                     potassium channel-associated protein; protein inhibitor of
                     activated STAT protein 3; E3 SUMO-protein transferase
                     PIAS3"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS3"
                     /protein_id="NP_113972.2"
                     /db_xref="GeneID:83614"
                     /db_xref="RGD:708413"
                     /translation="MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHL
                     LKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPSPLASIPPTLLT
                     PGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHF
                     TFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGK
                     LCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYL
                     VRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRL
                     TVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCS
                     DCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQEGNQSENKKRVEVIDL
                     TIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFL
                     SSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTP
                     PHFLGPLAPTLGSSHRSATPAPAPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDV
                     ISLD"
     exon            80..497
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..582
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..633
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..724
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            725..859
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..965
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1039
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1200
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1334
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1503
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1637
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1675
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2902
                     /gene="Pias3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggtccct gggcctgagc tccggctcgg gctggggcgc ctgcgatgtc tcaagatggc
       61 ggagctgggc gaattaaagc acatggtgat gagtttccgg gtgtctgagc tccaggtgct
      121 ccttggcttc gctggcagga acaagagtgg gcggaagcac gaattgctgg ccaaggccct
      181 gcacctcctc aagtctagct gcgcccccag cgtccagatg aagatcaaag aactttaccg
      241 caggcgcttt ccccggaaga ccctggggcc ttccgatctc tctttgctct ctttgccccc
      301 tggcacctct cctgtaggct cccccagccc ccttgcttcc attcctccca ccctcctgac
      361 ccctggcacc ttgctgggcc ctaagcgtga ggtggacatg caccctcctc tgccccagcc
      421 tgtgcaccct gacgtcacca tgaaaccact gcccttctac gaagtctacg gagagctcat
      481 ccggcccacc acccttgcgt ccacctccag tcagaggttt gaggaagccc actttacctt
      541 tgcactcact ccccagcagc tgcagcagat tctcacatcc agggaggttc tgccaggagc
      601 caagtgcgat tataccatac aagtgcagct caggttctgt ctctgtgaga ccagctgccc
      661 ccaggaggac tatttccccc ctaacctctt tgtcaaggtt aatgggaaac tctgccccct
      721 gccgggttac ctccctccaa ccaagaatgg agctgagccc aagaggccta gtcgtccaat
      781 caacatcaca cccctggctc gtctctcagc cactgttccc aacaccatag tggttaactg
      841 gtcatctgag tttggacgga attactcctt gtctgtgtac ctggtgaggc agttgactgc
      901 agggaccctg ctacaaaagc tcagagccaa gggtatccgg aatccagacc attcccgagc
      961 actgatcaag gagaaattga ctgctgaccc cgacagtgaa gtggctacta caagtctccg
     1021 ggtgtcactc atgtgcccgc tggggaagat gcgcctgact gtcccatgcc gcgctctcac
     1081 ctgtgcccac ctgcagagtt tcgatgctgc cctttatcta cagatgaatg agaaaaagcc
     1141 aacatggacg tgccctgtgt gtgacaagaa ggctccctat gagtcactga ttattgatgg
     1201 tttattcatg gaaattctta attcctgttc ggattgtgat gagatccagt tcatggaaga
     1261 tggatcctgg tgtccaatga aacccaagaa ggaggcatcc gaggtttgcc ccccaccagg
     1321 gtatgggctg gatggtctcc agtatagccc agtccaggag ggaaatcagt cagagaataa
     1381 gaagagggtt gaagtcattg acttgacaat cgaaagctca tcagatgagg aagatctgcc
     1441 ccccaccaag aagcactgcc ctgttacctc ggctgccatt ccagcccttc ctggaagcaa
     1501 aggagccctg acctctggtc accagccgtc ttcggtgctg cggagccctg caatgggtac
     1561 actgggcagt gatttcctgt ctagtctccc actacatgag tacccacctg ccttcccgct
     1621 gggggctgac atccaaggtt tagatttatt ttctttcctt cagactgaga gtcagcacta
     1681 cagcccttca gttatcactt cactagatga gcaggacacc cttggccact tcttccaatt
     1741 ccggggaacc cctccccact tcctgggccc actggccccc acattgggga gctctcaccg
     1801 cagcgccact ccagcacccg ctcctggccg tgtcagcagc attgtggctc ctgggagttc
     1861 cttgagggaa gggcatggag gacccctgcc ttccggtccc tctttgactg gctgtcggtc
     1921 agacgtcatt tccttggact gagttatttg gattgcaaaa tcaatttcta ctggccctag
     1981 cactgagcag atacattgtg ggttcccaac ccctggctgc tctgatccct caggggtcat
     2041 tggtcaaagg ccaggccaga tcttcatgga cacctgcttt tggccttatc actgcctaac
     2101 aaggccagta ctcaaagggt taacatttaa ccttttgaaa aaggacattg gggtctgttt
     2161 ttggaagtgt tctttgatgt agcacattcc tttgggtagg gtaacctagg cagtgggagg
     2221 cagatggaag ggtaggggtt cctcaccctt caccagatct tcagcctctt ggggaaaggg
     2281 cagtttcctg ccccctcccc caggactcct ttccgtaccc aaacccaaac atctgttctt
     2341 tttcgtccat tcccttctct ttggccatac tgtcaggtgg caggtcagag atggacagac
     2401 aactctattt tgggttgcag atttcttttt tgtacataaa taagaaaact ccaaattatc
     2461 caaagatgac ttcccttgcc ttttacttcc cagtgtgact cgaggaggaa acaaggcctt
     2521 agttgtgatc cccaggggct cgggaacagg gcgtggcctg cctactgcct gggtctctct
     2581 atttatatat ttaagttcac aatgttttta tgctaaacag tcaagggcct aagcttctag
     2641 tgacctgtgc tcaggcctag attgttcttg caccttttat gggacatggg ggctctgttc
     2701 tccttcccaa tactcaggcc ccttcagggc caaagccctg tgatgtgatt tcacttttta
     2761 tccccagagc tgtagcagag ttctcgccta caataaaggt tgtgaatgtt ctgtgagcgt
     2821 catggagggg agagatgttg taccttgttt tccagaccca tggtttgtgg ggcagagggt
     2881 ccatgttcta tcctttcact ta
//
