LOCUS       NM_001393764            9974 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus protein inhibitor of activated STAT, 2 (Pias2),
            transcript variant 1, mRNA.
ACCESSION   NM_001393764
VERSION     NM_001393764.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9974)
  AUTHORS   Gupta,S., Wang,M., Azuma,Y. and Muma,N.A.
  TITLE     Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and
            PIASxalpha
  JOURNAL   Int J Mol Sci 22 (24), 13176 (2021)
   PUBMED   34947973
  REMARK    GeneRIF: Regulation of Serotonin 1A Receptor SUMOylation by SENP2
            and PIASxalpha.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9974)
  AUTHORS   Chen,P., Wang,W., Zhang,Y., Yuan,Y. and Wu,Y.
  TITLE     Decreased MIZ1 Expression in Severe Experimental Acute
            Pancreatitis: A Rat Study
  JOURNAL   Dig Dis Sci 61 (3), 758-766 (2016)
   PUBMED   26581215
  REMARK    GeneRIF: Decreasing MIZ1 expression was closely correlated with
            inflammatory response, and development of acute necrotizing
            pancreatitis.
REFERENCE   3  (bases 1 to 9974)
  AUTHORS   Buyandelger,B., Mansfield,C., Kostin,S., Choi,O., Roberts,A.M.,
            Ware,J.S., Mazzarotto,F., Pesce,F., Buchan,R., Isaacson,R.L.,
            Vouffo,J., Gunkel,S., Knoll,G., McSweeney,S.J., Wei,H., Perrot,A.,
            Pfeiffer,C., Toliat,M.R., Ilieva,K., Krysztofinska,E.,
            Lopez-Olaneta,M.M., Gomez-Salinero,J.M., Schmidt,A., Ng,K.E.,
            Teucher,N., Chen,J., Teichmann,M., Eilers,M., Haverkamp,W.,
            Regitz-Zagrosek,V., Hasenfuss,G., Braun,T., Pennell,D.J., Gould,I.,
            Barton,P.J., Lara-Pezzi,E., Schafer,S., Hubner,N., Felkin,L.E.,
            O'Regan,D.P., Brand,T., Milting,H., Nurnberg,P., Schneider,M.D.,
            Prasad,S., Petretto,E. and Knoll,R.
  TITLE     ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a
            Novel Candidate Gene for Cardiomyopathy and Heart Failure
  JOURNAL   Circ Cardiovasc Genet 8 (5), 643-652 (2015)
   PUBMED   26175529
  REMARK    GeneRIF: functions for ZBTB17 in the heart, a transcription factor
            that may play a role as a novel cardiomyopathy gene
REFERENCE   4  (bases 1 to 9974)
  AUTHORS   Rabellino,A., Carter,B., Konstantinidou,G., Wu,S.Y., Rimessi,A.,
            Byers,L.A., Heymach,J.V., Girard,L., Chiang,C.M.,
            Teruya-Feldstein,J. and Scaglioni,P.P.
  TITLE     The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its
            oncogenic counterpart PML-RARA
  JOURNAL   Cancer Res 72 (9), 2275-2284 (2012)
   PUBMED   22406621
REFERENCE   5  (bases 1 to 9974)
  AUTHORS   Widagdo,J., Taylor,K.M., Gunning,P.W., Hardeman,E.C. and
            Palmer,S.J.
  TITLE     SUMOylation of GTF2IRD1 regulates protein partner interactions and
            ubiquitin-mediated degradation
  JOURNAL   PLoS One 7 (11), e49283 (2012)
   PUBMED   23145142
REFERENCE   6  (bases 1 to 9974)
  AUTHORS   Takahashi,K., Taira,T., Niki,T., Seino,C., Iguchi-Ariga,S.M. and
            Ariga,H.
  TITLE     DJ-1 positively regulates the androgen receptor by impairing the
            binding of PIASx alpha to the receptor
  JOURNAL   J Biol Chem 276 (40), 37556-37563 (2001)
   PUBMED   11477070
REFERENCE   7  (bases 1 to 9974)
  AUTHORS   Cho,S.Y., Jeon,J.W., Lee,S.H. and Park,S.S.
  TITLE     p67 isoform of mouse disabled 2 protein acts as a transcriptional
            activator during the differentiation of F9 cells
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 645-650 (2000)
   PUBMED   11104669
REFERENCE   8  (bases 1 to 9974)
  AUTHORS   Kotaja,N., Aittomaki,S., Silvennoinen,O., Palvimo,J.J. and
            Janne,O.A.
  TITLE     ARIP3 (androgen receptor-interacting protein 3) and other PIAS
            (protein inhibitor of activated STAT) proteins differ in their
            ability to modulate steroid receptor-dependent transcriptional
            activation
  JOURNAL   Mol Endocrinol 14 (12), 1986-2000 (2000)
   PUBMED   11117529
REFERENCE   9  (bases 1 to 9974)
  AUTHORS   Moilanen,A.M., Karvonen,U., Poukka,H., Yan,W., Toppari,J.,
            Janne,O.A. and Palvimo,J.J.
  TITLE     A testis-specific androgen receptor coregulator that belongs to a
            novel family of nuclear proteins
  JOURNAL   J Biol Chem 274 (6), 3700-3704 (1999)
   PUBMED   9920921
REFERENCE   10 (bases 1 to 9974)
  AUTHORS   Wu,L., Wu,H., Ma,L., Sangiorgi,F., Wu,N., Bell,J.R., Lyons,G.E. and
            Maxson,R.
  TITLE     Miz1, a novel zinc finger transcription factor that interacts with
            Msx2 and enhances its affinity for DNA
  JOURNAL   Mech Dev 65 (1-2), 3-17 (1997)
   PUBMED   9256341
  REMARK    Erratum:[Mech Dev 1997 Dec;69(1-2):219]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.51965.1,
                                           SRR26643295.56872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000018.1  72901707-72901906
            201-675             JAXUCZ010000018.1  72927408-72927882
            676-760             JAXUCZ010000018.1  72937671-72937755
            761-811             JAXUCZ010000018.1  72945948-72945998
            812-902             JAXUCZ010000018.1  72946103-72946193
            903-1037            JAXUCZ010000018.1  72952650-72952784
            1038-1143           JAXUCZ010000018.1  72954903-72955008
            1144-1217           JAXUCZ010000018.1  72955766-72955839
            1218-1378           JAXUCZ010000018.1  72959045-72959205
            1379-1512           JAXUCZ010000018.1  72959533-72959666
            1513-1684           JAXUCZ010000018.1  72961460-72961631
            1685-1824           JAXUCZ010000018.1  72970721-72970860
            1825-1862           JAXUCZ010000018.1  72975651-72975688
            1863-9974           JAXUCZ010000018.1  72978167-72986278
FEATURES             Location/Qualifiers
     source          1..9974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..9974
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /note="protein inhibitor of activated STAT, 2"
                     /db_xref="GeneID:83422"
                     /db_xref="RGD:71056"
     exon            1..200
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2042
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     SUMO-protein ligase PIAS2; DAB2-interacting protein;
                     msx-interacting-zinc finger protein; protein inhibitor of
                     activated STAT x; androgen receptor-interacting protein 3;
                     E3 SUMO-protein transferase PIAS2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS2 isoform 1"
                     /protein_id="NP_001380693.1"
                     /db_xref="GeneID:83422"
                     /db_xref="RGD:71056"
                     /translation="MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHL
                     LKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGSSSPVEPDLAVAGIH
                     SLPSTSIAPHSPSSPVASVLLQDTKPTFEMQQPSPPIPPVHPDVQLKTLPFYDVLDVL
                     IKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAET
                     SCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ
                     ISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSE
                     IATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKA
                     AYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVF
                     SKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQ
                     PSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGLDFLSLIPVDPQYCPP
                     MFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSETGVITSSGSNIPDVISLD"
     exon            201..675
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            676..760
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            761..811
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            812..902
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1037
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1143
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1217
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1378
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1512
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1684
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1824
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1862
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..9974
                     /gene="Pias2"
                     /gene_synonym="ARIP3; DIP; Miz1; PiasX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcaggtca cgtgaggggc ccggtggagg tggtggaggt ggtggcgcgg cggcggcggc
       61 ggccgcggcg tctagagcgg cgcccagtgc aggatgttgc aggagacggc ggcggtgtcg
      121 ttggcggtag cgggcggagg agcggtgacg gctgaggcgc ccgcgggcgg gataaaatgg
      181 cggatttcga ggagttgagg aatatggttt ctagttttag ggtttctgaa ttacaagtgt
      241 tactgggctt tgctggacgg aataaaagtg ggcgcaagca tgacctcctg atgagggcgt
      301 tgcatttact gaagagtggc tgcagccctg cggttcagat taaaattcga gaattataca
      361 gacgccgata cccacggaca cttgaaggac tttctgatct atccacaatc aaatcttcag
      421 ttttcagttt ggatggtagc tcatcaccag tagagcctga cttggccgtg gctgggatcc
      481 actcgttgcc ttctacttcc attgcacctc attcaccgtc atctcctgtc gcttctgtgc
      541 tgcttcaaga cactaagccc acgtttgaga tgcagcaacc atctcctccc attcctcctg
      601 tccatcctga cgtgcagtta aaaacgctgc ccttctatga cgtccttgat gttctcatca
      661 agcccacaag tttagttcaa agcagtattc agcggtttca agagaagttt tttatttttg
      721 ctttgacacc ccagcaagtt agagagatat gcatttcaag ggattttttg ccaggtggca
      781 ggagagacta cacagtccaa gtccagctgc gactttgctt ggcagagacc agttgccctc
      841 aagaagataa ctatcccaat agtttgtgta taaaagtaaa tgggaaactc tttcctttgc
      901 ctggctatgc accaccacct aaaaatggga tcgaacagaa gcgtcctgga cgccccctga
      961 atattacatc tttagtgaga ttgtcttcag ctgtgccaaa tcagatttct atttcttggg
     1021 catctgaaat tggaaagaat tactccatgt ctgtgtatct tgtacgacag cttacatcag
     1081 ccatgttatt acagagatta aaaatgaaag gtattagaaa tcctgatcat tccagagcac
     1141 tcattaaaga aaaacttact gcagatcctg atagtgaaat tgctacaact agtcttcgag
     1201 tgtccttgat gtgcccttta ggaaaaatga ggctgacaat cccgtgccgc gcagtgacgt
     1261 gtacacatct gcagtgcttt gatgctgccc tgtatcttca gatgaatgag aagaagccca
     1321 cctggatttg tcctgtttgt gacaaaaagg ctgcctatga gagtctgata ctagatgggc
     1381 tttttatgga aattctcaat gactgttctg atgtggatga gatcaaattc caggaagatg
     1441 gttcctggtg ccccatgaga cctaagaaag aagctatgaa agtaaccagc cagccctgta
     1501 caaaagtaga aagttcaagt gtctttagta aaccttgttc agtgactgta gccagtgatg
     1561 caagcaagaa gaagattgat gttattgatc taacaataga gagctcttct gatgaagagg
     1621 aagaccctcc cgccaaaagg aaatgcatct ttatgtcaga aacacaaagc agtccaacca
     1681 aaggggttct catgtatcag ccatcttctg taagggtgcc cagtgtgact tcagttgatc
     1741 ctgctgctat tccaccttca ttaacagact actcagtacc attccaccac acgccagtgt
     1801 cgagcatgtc atcagatttg ccaggtttgg attttctttc ccttattcca gttgatcccc
     1861 agtactgtcc tcctatgttt ttggatagtc tcacctcacc cttaacagca agcagtacgt
     1921 ctgtcaccac caccagcccc catgaaagca gtactcacgt tagttcatcc agcagcagga
     1981 gtgagacagg ggtcataacc agcagtggga gtaacattcc tgacgtcatc tctttggact
     2041 aaaggcggac atacttgatt ctgggaatca ttcatcaaaa ctctttcttg gatgtctagt
     2101 ccatggaagc taatttttgc aacttaatat ttattgaaat gtcaaatgga tcctttgctt
     2161 tctgagagat gaacatggat gactccagca ggaaccagat gacatgccag gaggactctc
     2221 ctcacgctgt ccatgagcat cggatacggt gagcattgga tacggtgagc attggatacg
     2281 gttcatccaa gcgactgtct ttggagcggt tgacttcagg tcctacactg tggatggagt
     2341 ctacacacca ggcaaccttt tgttacaata aacagcaata aagttatgta aatagttaaa
     2401 cttttctaat taaagatgta atcactgata tagactaaca gcaacttctg tttaatccag
     2461 tatgaaggaa ggatagctgg gagaagtctt gtttcctgag tgaatacttt ctatggagat
     2521 ctgttctatt ttgttgaagt aatgaagttt gaataactgg ccagaatttg ggttctactt
     2581 ttcttcttca ggttttctgt tcttcatgat cccatcaaag caaatgatct ttgtgctgtg
     2641 catttccctc ttgtcgtcca cgctttgatg tttgctgatg tgtgccgagt gaaatgtgga
     2701 tttggttgcc ctttataatg attatgttca agaatactgc ccagattttg ttctgatata
     2761 aagtgttatt ttgggttact gtacattctt gtagaatttt ctacagattt gagacttttt
     2821 ttttccggaa agtcaaccct ttgagtaaaa tgtgcttgag ttaagatgtg gctagaatac
     2881 tggtacggtt ttctttacaa tattcagaaa tatttaatgt tgggaaacac cagaacatac
     2941 ttaggagagg tggaaataac tgatttcctc ctaagaattt aactgatttc atatatttta
     3001 taggataata cagtatactg tcttggttgg aactcttcac attttaatgg cactgataca
     3061 caaattatat ttaaggtctc tgatcataat ccttaccaat gtaatttcaa tttcagcagt
     3121 gactttcaag tttaaagaaa aaagtcaatg gtaaatgata gaaggaagta ttagatctca
     3181 ctttcctaaa cgtcttttgt gaaaacacac acacacacac acacacacac acacacacac
     3241 acacacacac acacacacac acacgagatt atatttgaaa tgaaatgagg acaagtgccc
     3301 aaagtcccac ttgatgctgc ctttaaaaca caccactcac gtcgctatgc caggtgcact
     3361 tatcacttgc ttcctttagg ttccttaatt tttagttttc tagaatttag ttaattttcc
     3421 tgatgcctag tgttctctgc ctttgttata tcgacttaaa gctttttttt tttttttaaa
     3481 gtggctactc ttaacttctc aaatgtgttt taacataatg attctacttc tgctccaggg
     3541 acatggtccc cacttcagca ttggtggggt tgtattgtac tggctcaagc tttcatggcc
     3601 tttgtgcacc ttttgtataa atgcctatgc agttgtccac gctgttccta ctcagccttc
     3661 agctcctcgt tttaatgatc tttccttttg gtagggcttc agagacatca aagatatggg
     3721 aagcaaagcc agcccctgtg accacagcgg gcactgcatt gtggcccctg gcttgcttga
     3781 ccttagccag tccagataaa gattccttcc tctaggatgt tacgttgttg ctgctttagg
     3841 tacagatgca gtttctgttg cctatgtaac cagaaaaata acctggcttc tgtggtatgg
     3901 tgtgttcata aagaagtggt gcagcctgtt tacccagtag agtctcaaag gatcactgaa
     3961 gtcctttaag tactgaaggt tggagtagac attatttcct tagctctcat aacatgcctc
     4021 tgcttttgta gttgtactac atatgtcaat gagctcgtca acagttcatg aaattacaaa
     4081 agagtcactt tagatgactg acgcctttga aatagatgta agtgtttaat attaaattgg
     4141 ggttactttg cagctatctt tgaaggtctg tacttttctt tctgcacttg gctctgtatt
     4201 tacatggttg ttgcaaagcc attctttcct caatgtcaca ttttatgaag atcctgataa
     4261 gcagagtctc tgtaatgcag atatctgttt aaccagatag actagaataa agaggtcatc
     4321 ttggtgttac ttagatggca gccacctccc attatctgag atatctacac ccagcgagcg
     4381 gtggctaatg cttacagtca cttggccaac ctggtttgca tccccacccc caacccacat
     4441 agacactgaa gggtttcctt gctttattaa ttccaggcag tgtagctgca cagaactcca
     4501 ctcatgacaa cggcttttac tacctagctt tctgactcct ttctgcctcg aaagtatcaa
     4561 tacttggcct ctgttctagg acaattgtaa aggcaagtga gataggtctg ttttagaaca
     4621 ctgatgcaca catgatgctt aggtaaggag taatgagtgt gatccagcct gtcataaccc
     4681 ttatatcaaa cacgcttcca ttagagtagt aggaatgagt ttgaaggaag gtgttgaact
     4741 ttaaacagtt atgttgaatg gagttagata gcctattttg acttctaatg tgtcttcaat
     4801 cagtcctgga tactcacctt tgtcttttgc aaataaagac attcattagt tgcgcttgtc
     4861 tttgtaagta aggttggttt tcataaaagt tttaagttgc ctttgcttat ttaaaaggag
     4921 aaaagtacgt tagtaacttt tttcttgcaa gtttgcctcc agttctatgg aaaatcataa
     4981 tttatttccc acattatttt catcttaaaa ataaaaatca gtgcccattt aatttgagtc
     5041 tgatagtgat tttagtaggt ctggatccag gtagtgtggg aatggggagt agccatttag
     5101 aggctgtggg ttgttgagtc gttatgggta tacttcatgc actgtgatga agcttgtggg
     5161 gacagtctca gagactgctg ctcttggtgg gcgactggtc gtagctggct gctgttggag
     5221 ctgcatcatg acttacaaaa ccagcaggta caggcccatc agaacctagt atcttatccc
     5281 tcagccaatg agacgaatac tggtatgctt tctgacacac agggtgaatg aatactgacc
     5341 tagggagtct gatgtaaact aactgaagaa aagagtcctt cctctcaagg tgatgctgat
     5401 ttgtggtgtt taggagaggg gagtaggact gcagacgagg actggttcag atggtgacca
     5461 cagtaactga aggttctgtc ctgctcttgt catcaggagg gttatgtttg ctgatgttgg
     5521 caggcacagt gcaagtcatt tatggagaca gttcagtgta aactgtcttg ccaaccattt
     5581 tgccttttct ctgttactct attctttctc tccttaacca gccttgctac attttacctc
     5641 tctcctgaaa tcactttcct gcttcatggt accaagcagt accacccaga gcccttcagc
     5701 cccacagttt attcactagt attttttatt ctctttactc aagaggtagt tgctgacctg
     5761 ctgttgtaaa gtctgcctct aggaggggag gcataactga atggccttgt gaaataacac
     5821 tgaagagctt cctatgaata ctatattagt tcctttctgt tgttttgtta aaatacctcc
     5881 aacagaaagc aagctaagaa agaaaggatt tattttgctt taaatttaca aaatatatac
     5941 agtcatcttg gccagaaagt cacagagaca tttcatctga gcacaggaaa tagggcaagg
     6001 gctacgaaac ctcaaagctg gcaatgaatg ctctttctcc aacagtgctc cacctcaaag
     6061 tctgtaacct ttcccaccag catcaagggc agaaggctaa acattcaaat agatgagcat
     6121 gagagacagt ttttcaaact acaatgaact gtaacaattt gttgtaaact tatgtcattt
     6181 tctctacatt aaaaataggg acggggctgg ggatttagct cagtggtaga gcgcttacct
     6241 aggaagcaca aggccctggg ttcggtcccc agctccgaaa aaaagaatca aaaaaaaaaa
     6301 atagggagat agtcaaaata acttgtctaa tatcgtgcat ctaagtactg attggttttt
     6361 aacatctgtt caggggcctt gctagatatt ttccttgggt ttctttcccc cctcactagt
     6421 gcagaaattt aaatcccatg gcctctgaac cttcactcca acgctgagct acactcctat
     6481 ttcctcatca tatcagtaag cacttctata gtatcttttt tttttaagat tttttaaaaa
     6541 tatttattta ttttatgtac agcattctgc ctgcatatgt gactgcaggc cagaagaggg
     6601 caccaggtct cattacagat ggttgtgagc caccatgtgg ttcctgggaa tcaaactcat
     6661 gacctctgga agagcagtca gtgctcttaa ccgctgagcc atctctccag cccgtagtat
     6721 ctttatcctg tttatattct gctaatagtg gttatgctac tgtcagcctc tgctaaactg
     6781 caagctccgt gacagcacag tggctttgct tgtatcccac agtaacagta tgccatgctt
     6841 ggttggtata ccatatttgc taatgaagaa acagtggtaa ccatttgtac ttggcttggg
     6901 ttgagtatgg aaatttaata cttgttgaat attcatgtag cagcagacat ttaccagaag
     6961 aaagtgcaaa caaaacaagc caaaaacaaa aaaacaaacc aacaacaaca acaaaaaccc
     7021 aaataaccca aaaggcaaac atatttagag tgggtagcaa aagtgtggtt agttggaggg
     7081 aaggtagctt gtataagtaa aatttattta cttacttatt tttagccttg aggctggcaa
     7141 actgacccac ttttagactc agaactttaa atagaaacaa gaatttaacc tgatgaccct
     7201 agatattatt agacaagata tagatacgtt gtcattcaac aggctgaaag gacaccaaac
     7261 tgaatagcac cacccttcct aatttctcca tcacactata cataccctca ccaagttcta
     7321 gcaccaactt gttaacctgt cttaggtgcc tgtttcaaat ttttgtgtac attgagtcag
     7381 aatatgtggt gattaatggc aactttagtt tagcctaggt gttcaaggat cacccaagct
     7441 gtagtaagtg tatgtgcttt gttcttttct tataaaaaat tatatatata tatatatatg
     7501 tatatatata tatatatata tatatacaca cacacacaca cacatataca cacatacata
     7561 cacatttgtt tccctataat ctcatcatag acatttgagc tatctcctat gcttgctgtt
     7621 aggaatagcg ttgctatgct catccatgaa cacagtatcg tgcacatgtg ttactgggtt
     7681 gatatatgtg tatgtctgtg gagaccagag tataggagca gtgtaccttg ttttctctta
     7741 ccctcttgtc ttctctcccc catcctcccc tctccctcct ttctgataca aggtctccca
     7801 ctggaaccca gggctcaagg attagtcaat gacagctggc aaagtcctaa gaaactaccc
     7861 gcatttctgc cacctctcca gtgctggaat tacaagcacg cactaccata tctggctttt
     7921 tacatggatg ctgggaattg aactcaggtc tgataagcta gtcagttgca tgtattcttt
     7981 gggaaagtgt attcagatcc attgcccaca tttttattgg gctatttgtc ttactgcatt
     8041 gtaccagttg tgtttgttat ttaatatgta tatatttttt tcctgtctga ggagtatctt
     8101 ttcaattcct tgataccctt gaaatacatg ttttacattt tgataggatc tagtttattt
     8161 ctttcccatg ctgcttatgc ttttggtttc atggttaaga ttccattacc aaatccaagg
     8221 tagttttgct ggctaactct tgtgttaaca caaggcagtg ttacctggga tgaaggaata
     8281 ttaatgaaga aaaagtctca gtatgattga tctgtaggca agtctgttga acattttttt
     8341 ggttgatgat ttatggtggc taccctggcc cactgtgagt ggtgtcactc ctgggcaggt
     8401 agttctgggt ttcataagaa agcaggctgt gcaaaccatt gatagcaagt cagtaaacag
     8461 aattccttcg tggattctac tgctgttcct gcgtccaggt tctacccttg attgcctgtc
     8521 ctgactaccc tctatgatgg actcttatcc tgtaccgtag gctgaaataa gccctttctt
     8581 ccccaagttg cttttgatca tggtgtttat catagcagtt gaaaccctga gtagtataat
     8641 aatgaaatta attgtatttc ttgaaagaat tttttaattt tatcttaaat ttgcaactga
     8701 tccattatga gttaactttt ttgaatcttt tagtttattg aaaatattac tttcgtatat
     8761 atcttgatta cagtttctcc tctactcctc actttctcta ttttctctcc tcacttccct
     8821 tacccctgga tctacttttc tgtctctcat tagaagagca aactcatatg caataacaac
     8881 taaacatagc agaataaaat atgatataaa acaaagacca tcacattgtg gttagacaaa
     8941 gcaacccaag agaaaaagaa ctccaagagc aggcacaaga gtcagagacc cactcaaagg
     9001 ctaagctgaa agtgtatgtt ctataaatca gaatatgtgt atgatattgc tatgctgtgt
     9061 actgtgtgcc agcctatctg ggtttgaagg atgcctctgt cacttgggat ttttgccaag
     9121 atagttactg tgactctggt tccttgtgta aaatggggtt tatagaatct ttgtttcttg
     9181 attagggtta ctattgctgt gatgaaacac catgaccaaa gaaacttggg ggaaggaaag
     9241 ggtttgactt acatttccac atcacggttt gtcaaaggaa gtcaggacag aaacttggca
     9301 gggcaagaac cccgaagcag gagctggcac agagaccatg gaggggtgct gcttactgac
     9361 ttgcttcacc tggcttgctc agcctacttt cttatagaac ctaggaacca gcccaggggt
     9421 ggcaccatct acgatgtgct gagccctcct caatcacaaa ttaagaaaat gccctacaga
     9481 cttgcctaca gccttatctt attgaggtat tttcttaatt agaattcttc ttctcacatg
     9541 acaatatctt gtatcaagct gacataaagc tatccagcac agggggcctt gtcgtttttg
     9601 agaatgggat ggaaacgcat gtaacaatat tcagttcgaa ttcagcaact gtaaaggctg
     9661 tactcttaac ttggagaagt gaccaacaga taatggatta taaggtctgt gttgtaataa
     9721 atggtgctca tttacctagc cctcaagtta gcccacacat tattttctac tttcatgagg
     9781 gctatgaatg catctgaact gataaagtag tgaagcagca aaatctgata aaattaacag
     9841 atccaatgtg tgaaagtata tgtcagttgt attcatgtga acctagaatt taaaagtaaa
     9901 ctcgttctaa actgcttatt agtgtgatgc aatatcaatt tatatttttc atgtaataaa
     9961 cttactgtat ttta
//
