LOCUS       NM_001106829            5640 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus protein inhibitor of activated STAT, 1 (Pias1),
            mRNA.
ACCESSION   NM_001106829 XM_001074210 XM_217188
VERSION     NM_001106829.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5640)
  AUTHORS   Chen,Y.C., Hsu,W.L., Ma,Y.L., Tai,D.J. and Lee,E.H.
  TITLE     CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory
  JOURNAL   J Neurosci 34 (29), 9574-9589 (2014)
   PUBMED   25031400
  REMARK    GeneRIF: This study provide the first evidence that CREB could be
            SUMO-modified by the E3 ligase PIAS1 and that CREB SUMOylation
            plays an important role in spatial memory formation
REFERENCE   2  (bases 1 to 5640)
  AUTHORS   Liu,Y., Zhang,Y.D., Guo,L., Huang,H.Y., Zhu,H., Huang,J.X., Liu,Y.,
            Zhou,S.R., Dang,Y.J., Li,X. and Tang,Q.Q.
  TITLE     Protein inhibitor of activated STAT 1 (PIAS1) is identified as the
            SUMO E3 ligase of CCAAT/enhancer-binding protein beta (C/EBPbeta)
            during adipogenesis
  JOURNAL   Mol Cell Biol 33 (22), 4606-4617 (2013)
   PUBMED   24061474
REFERENCE   3  (bases 1 to 5640)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   4  (bases 1 to 5640)
  AUTHORS   Liu,S.Y., Ma,Y.L. and Lee,E.H.
  TITLE     NMDA receptor signaling mediates the expression of protein
            inhibitor of activated STAT1 (PIAS1) in rat hippocampus
  JOURNAL   Neuropharmacology 65, 101-113 (2013)
   PUBMED   22982248
  REMARK    GeneRIF: PIAS1 may function as an immediate early gene in an
            activity-dependent manner: its expression is rapidly induced upon
            NMDA receptor activation in rat hippocampus.
REFERENCE   5  (bases 1 to 5640)
  AUTHORS   Belaguli,N.S., Zhang,M., Brunicardi,F.C. and Berger,D.H.
  TITLE     Forkhead box protein A2 (FOXA2) protein stability and activity are
            regulated by sumoylation
  JOURNAL   PLoS One 7 (10), e48019 (2012)
   PUBMED   23118920
REFERENCE   6  (bases 1 to 5640)
  AUTHORS   Ling,Y., Sankpal,U.T., Robertson,A.K., McNally,J.G., Karpova,T. and
            Robertson,K.D.
  TITLE     Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1
            modulates its interaction with histone deacetylases (HDACs) and its
            capacity to repress transcription
  JOURNAL   Nucleic Acids Res 32 (2), 598-610 (2004)
   PUBMED   14752048
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5640)
  AUTHORS   Wormald,S. and Hilton,D.J.
  TITLE     Inhibitors of cytokine signal transduction
  JOURNAL   J Biol Chem 279 (2), 821-824 (2004)
   PUBMED   14607831
  REMARK    Review article
REFERENCE   8  (bases 1 to 5640)
  AUTHORS   Kadare,G., Toutant,M., Formstecher,E., Corvol,J.C., Carnaud,M.,
            Boutterin,M.C. and Girault,J.A.
  TITLE     PIAS1-mediated sumoylation of focal adhesion kinase activates its
            autophosphorylation
  JOURNAL   J Biol Chem 278 (48), 47434-47440 (2003)
   PUBMED   14500712
REFERENCE   9  (bases 1 to 5640)
  AUTHORS   Yan,W., Santti,H., Janne,O.A., Palvimo,J.J. and Toppari,J.
  TITLE     Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during
            spermatogenesis in the rat
  JOURNAL   Gene Expr Patterns 3 (3), 301-308 (2003)
   PUBMED   12799075
REFERENCE   10 (bases 1 to 5640)
  AUTHORS   Sapetschnig,A., Rischitor,G., Braun,H., Doll,A., Schergaut,M.,
            Melchior,F. and Suske,G.
  TITLE     Transcription factor Sp3 is silenced through SUMO modification by
            PIAS1
  JOURNAL   EMBO J 21 (19), 5206-5215 (2002)
   PUBMED   12356736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 25, 2020 this sequence version replaced NM_001106829.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY644724.1, SRR26360194.1713295.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000008.1  72334276-72334311   c
            37-481              JAXUCZ010000008.1  72306539-72306983   c
            482-566             JAXUCZ010000008.1  72277370-72277454   c
            567-614             JAXUCZ010000008.1  72277112-72277159   c
            615-705             JAXUCZ010000008.1  72275095-72275185   c
            706-840             JAXUCZ010000008.1  72274176-72274310   c
            841-946             JAXUCZ010000008.1  72267361-72267466   c
            947-1020            JAXUCZ010000008.1  72256743-72256816   c
            1021-1181           JAXUCZ010000008.1  72250673-72250833   c
            1182-1312           JAXUCZ010000008.1  72248344-72248474   c
            1313-1493           JAXUCZ010000008.1  72246915-72247095   c
            1494-1636           JAXUCZ010000008.1  72242527-72242669   c
            1637-1674           JAXUCZ010000008.1  72240189-72240226   c
            1675-5640           JAXUCZ010000008.1  72233566-72237531   c
FEATURES             Location/Qualifiers
     source          1..5640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5640
                     /gene="Pias1"
                     /note="protein inhibitor of activated STAT, 1"
                     /db_xref="GeneID:300772"
                     /db_xref="RGD:1307843"
     exon            1..36
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1968
                     /gene="Pias1"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase PIAS1"
                     /protein_id="NP_001100299.3"
                     /db_xref="GeneID:300772"
                     /db_xref="RGD:1307843"
                     /translation="MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHL
                     LKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGH
                     PASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDN
                     SQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPN
                     LCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGR
                     TYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLL
                     CPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLF
                     MEILKYCTDCDEIQFKEDGSWAPMRSKKEVQEVTASYNGVDGCLSSTLEHQVASHNQS
                     SNKNKKVEVIDLTIDSSSDEEEEEPPAKRTCPSLSPTSPLSNKGILSLPHQASPVSRT
                     PSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAA
                     AVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPATNGSSSGSNSSLVSSNSLRES
                     HGHGVASRSSADTASIFGIIPDIISLD"
     exon            37..481
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..566
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..614
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..705
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..840
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..946
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1020
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1181
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1312
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1493
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1636
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1674
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..5640
                     /gene="Pias1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagacgca agatggcgga cagtgcggaa ctaaagcaaa tggttatgag ccttagagtt
       61 tctgaactcc aagtactgtt gggctacgct gggagaaaca agcacggacg caaacacgaa
      121 cttcttacaa aagccctgca tttgttaaag gctggctgta gtcctgctgt acaaatgaaa
      181 attaaagaac tctacaggcg gcggttccct cagaaaatta tgacacctgc ggacttgtct
      241 atccccaacg tacattcaag tcctatgcca gcgactcttt ctccatccac cattccacag
      301 ctcacttacg atggtcaccc tgcatcgtcc ccattactcc ctgtttctct tctgggacct
      361 aaacatgaac tggaactccc acatctcaca tcagcgctgc acccagtcca tccggacata
      421 aagctgcaaa agctaccatt ctatgacctg ctggacgaac tgatcaaacc caccagtcta
      481 gcttcagaca acagccagcg ctttcgggaa acctgttttg catttgcctt gacaccacaa
      541 caggtgcagc agatcagcag ctccatggat atttctggga ccaaatgtga cttcacagtg
      601 caggtccaat taaggttttg tttatcagaa accagttgtc cacaagaaga tcacttccca
      661 cccaatcttt gtgtaaaagt gaatacaaaa ccttgcagcc ttccaggtta ccttccacct
      721 actaaaaatg gtgtggaacc aaagcgacct agccgaccaa ttaatatcac ctcacttgtc
      781 cgattgtcca cgacagtacc aaataccatt gttgtttctt ggactgcaga aattggaaga
      841 acctattcca tggcagtata tcttgtaaaa cagttgtcct caacagttct tcttcagagg
      901 ttacgagcaa aggggataag gaatccggat cattctagag ctttaattaa agagaagtta
      961 actgcagatc cagatagtga gatagctact accagcctac gggtttcgct gctgtgtcca
     1021 cttgggaaaa tgcgactgac aattccatgt cgggcactta cctgttccca cctccagtgt
     1081 tttgatgcaa ctctttatat tcaaatgaat gagaaaaagc caacatgggt ttgtcctgtg
     1141 tgtgataaga aggccccata tgaacacctc attattgatg ggttgtttat ggaaatccta
     1201 aagtactgta cagactgtga cgagatacag tttaaggagg atggctcgtg ggctccgatg
     1261 aggtcaaaaa aggaagtgca agaagtcact gcctcctaca atggggtcga tggatgcttg
     1321 agctccacat tggagcatca ggtggcttcc cacaaccagt cttcaaataa aaacaagaaa
     1381 gtggaggtga ttgacctaac cattgacagt tcatcagatg aagaggagga agaaccccct
     1441 gccaagagga cctgtccttc cctgtctcct acgtcaccac taagtaataa aggcatctta
     1501 agtcttcctc atcaagcatc gcctgtgtcc cgcaccccaa gccttcctgc tgtagataca
     1561 agctacatca acacctccct catccaggac tacagacacc ctttccacat gacgcccatg
     1621 ccttatgact tacaaggatt agatttcttt cctttcttat caggagacaa tcagcattac
     1681 aacacctccc tgcttgccgc agcggcagct gcggtctcag atgaccagga cctcctgcac
     1741 tcctcccgat ttttcccgta tacctcctcg cagatgtttc tcgatcagct aagtgcagga
     1801 gggagcactt ctctgccagc caccaatgga agcagtagtg gcagcaacag cagccttgtg
     1861 tcttccaaca gtctgaggga gagccatggc catggtgtgg ccagcaggag cagcgcagac
     1921 acggcatcca tctttggcat cataccagac attatctcgt tggactgacg ccctcaccct
     1981 gctgctccca ccccatccca gattaaatga cttggcagaa gagaactcta tgctctgttt
     2041 taccttatcc tgtttagaaa agtatacagc gtgttttttt tttccttttt tttagggaaa
     2101 aaaaattaaa agaaatgtac agagaacaaa actatatttt cagttttact tttgtatata
     2161 aatctaagac tgcctgtctg ataaaacact tgttaaaaaa aaaaagaaaa agaaaagaaa
     2221 aaaacaagca cccacaaacc ttcagttcat tttttctgga ttctgaagac ttttcaccat
     2281 ttgtcctatg gtttgggttt tattttactt caatggcatt atctttcttg caataatgga
     2341 aacagttgca tgtatgaggt taaatcgttg gctttgttgt ggggaagggg ttgggatagc
     2401 tttgatttcc atttttaaaa gtgacagact tggattctgt ttgtgtgtgt gtgtgggttt
     2461 tgccagcctt aagttatgaa actcgtctat ctcactgctt cccctttgtt ttcagaacag
     2521 agctcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgcgcatgct
     2581 ctcgtgtgct gtgcacctgt gtgtactgtt ctgtcatcac tgtcccctcc tcctcagttt
     2641 gcatttgctt aatatcagtt cctacttctt tcaaaatgtt tccgaggtct tgaactcttg
     2701 tgtgagcatc tttctcaact ctccccaggt gcatgttctc catcacagat cccctgtgat
     2761 ctgctgtcta ccctctacga gtgtgtttcc cagaagtgct ggagtaaaag ctgcctggat
     2821 aagcaatctg tgggcaggcc ctcgaatgac aatacacttt ggttgactct aaatctgaat
     2881 tgccagtggt ccatatgtaa gccaaggctg tgagcacctg cattttggcc atagggtaac
     2941 aagttttcct tgaggatctt cataccgaaa tgggatctga aagaaccctc gtagccccgt
     3001 ggggtgtgga gtgccatttg cagctggcag aggacgttcc attccatcga aagaaaagga
     3061 aggaaggaaa gaagtcagtt actctaaagt taacagttca gcacatgtgg attcatagca
     3121 aatctatttg ataaacagtt gaaactcaaa aataacctta gttattttgt ttttgaggct
     3181 ctgagtatac tttttattct tagctgtgtt ctttttttcc ttcacttttt agtggcaagc
     3241 atgacatagg aagccttttt ttttttttta attgaagaat cgattggtct tacctaatct
     3301 caatagcaga atatgtaaat atattaaaat gttttcgaga tgattaaggg tcaaaggaag
     3361 gaacaagtgc ttctcatact tgagcagaga agaaagcatg ctcttacagt ggagaataga
     3421 tgacgcgtgg ctaatggggg gtgcgggcct aactgcagag agccaaggca tgccaccacc
     3481 aggtcctgca actggctttt tagattacac cctcgtgttt tcagagttgg tgaaggacca
     3541 gctttgtgta tagtaaactt gttttcaagc cttgcatcag tacagaagga ccgatactaa
     3601 tccagggaga agtcaagatg gctgtgtctt cagttatatg ataaagcaag tggttcatat
     3661 gacagtgtgg catctaaaaa taatatgttt tatagtgtct ctctgctact aaaatgtcaa
     3721 cttgaatttt tgaaaaaagt tggtgttgat atgtatatgt gtgtgtgtgt atatatgtat
     3781 ttataaataa gtgtgtgtga gtaacatcgt tgtcttcccc tacgcatgtg tgttccacac
     3841 aaacagctgt gttagagtca caaaacaatt cgcaataaaa caagacattt gttgtcagtt
     3901 caaaccagaa atagttacgt ttttaaattc atctggtgtt gtgagtacat gttctcccag
     3961 ttctcattac tgtattaatt tagactcgtt tcagatacca taatttgttg cattgggatt
     4021 agaatgggaa tcactaaaat tttgaggggt ttctgttaat atagcaatag gaaacatttt
     4081 attattttaa ctgagataga atgaatagtg ttctttgtcc ttggttttgt ttggttgttt
     4141 tggtttggtt tgcttttggt tctgttagtg gttttcggat attgatccat agttttttgt
     4201 gtctgatgct aaattacaaa cttagaacca tccagtgtaa accagctctc tgcattcttc
     4261 atgccagtta tagaggggtc actctccttc tgtgtcctgc cttgtaccag cctaagggga
     4321 aagtgggtaa ttggagaact agatgtcctg tggctctggt catgtcccca caggagaaca
     4381 tggtggtcta tgtattttgt tccttccact tactgaggag ttcatttctt cagtattgac
     4441 tttctaaaat gttgcatgtg gtcaaggtga gtcagagact ttcccaaccc ttaataacta
     4501 ttagagtcat gtactacttt atctcctaca tttaaaagaa aaagtgcatg gtcgctttgt
     4561 ccctttttgt tgttgttttt ccttagcctg ccctcactcc ctagccttgc caatcttgat
     4621 aggctgcaga caaactctgc actcagcagc tttcgttcag caagttgcca ggagcccctt
     4681 ccttagtctt tcttactagc atgtacacgt gtgctctgta cagtaccaca tgttctgtac
     4741 agtaccgtgt gtgtgctcct gtctatctgt atgtaagcac acatcatcaa taaagtagcc
     4801 attcaaccag gagggtggag gtggctttta atttactctg tgggcattac tggacaggtt
     4861 ttttaaaata tgaaacttaa ccatgcatac tctgttgacc aattcatttt gagtattaaa
     4921 gttgttccat tgctaattta gatgttatac atctaaattt agatgtactg acttaatcac
     4981 tcagttttga aaaatgtggg ttcttttgtt ggtggtggtg gtggtggcat attttttgtt
     5041 gctttttgtt ttgttctttt tttcagccaa ttctcctttg agacaagtct gtgaaaatga
     5101 ataaaaatat accccaattg taaatggata gatgtagaaa gaacctagtt tttaaagcaa
     5161 tttcaatttt aaatacatga gactttctga atcttcagga ctcttaaaag cacatttgaa
     5221 tttattttgg taagaatttt gttttgtgac tgcacattga attctgtttg tttgtttttt
     5281 taaataaatg caaagcatag atttcaagga gggagggaga gtagccggtg gtcccagtgc
     5341 gctgctgctg ttttattaac aaaggggaag atgtatataa atagataaag attaccataa
     5401 attccatgaa cttaaatctg tgattcattg ccttaagact ttctctctta gaatttccat
     5461 accgcatgcc aaaccagtaa aatggctttt aaaagatgta tagtagacca atgtcagttt
     5521 gtataaaagt accaagtgaa aatatttatt acatgcattg gagaaaagtt gtttccctgt
     5581 tgaatgttac ctgtttctgt agagctcttt agatgtaata aaaaagaagc cttcagttaa
//
