LOCUS       NM_031083               3205 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphatidylinositol 4-kinase beta (Pi4kb), mRNA.
ACCESSION   NM_031083
VERSION     NM_031083.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3205)
  AUTHORS   Klima,M., Toth,D.J., Hexnerova,R., Baumlova,A., Chalupska,D.,
            Tykvart,J., Rezabkova,L., Sengupta,N., Man,P., Dubankova,A.,
            Humpolickova,J., Nencka,R., Veverka,V., Balla,T. and Boura,E.
  TITLE     Structural insights and in vitro reconstitution of membrane
            targeting and activation of human PI4KB by the ACBD3 protein
  JOURNAL   Sci Rep 6, 23641 (2016)
   PUBMED   27009356
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3205)
  AUTHORS   Bojjireddy,N., Sinha,R.K., Panda,D. and Subrahmanyam,G.
  TITLE     Sanguinarine suppresses IgE induced inflammatory responses through
            inhibition of type II PtdIns 4-kinase(s)
  JOURNAL   Arch Biochem Biophys 537 (2), 192-197 (2013)
   PUBMED   23899475
  REMARK    GeneRIF: These results suggest that the anti-inflammatory effects
            of sanguinarine on PtdIns 3-kinase signaling pathway are more
            likely an indirect effect and emphasize the importance of the cross
            talk between type II PtdIns 4-kinases and PtdIns 3-kinases.
REFERENCE   3  (bases 1 to 3205)
  AUTHORS   Greninger,A.L., Knudsen,G.M., Betegon,M., Burlingame,A.L. and
            DeRisi,J.L.
  TITLE     ACBD3 interaction with TBC1 domain 22 protein is differentially
            affected by enteroviral and kobuviral 3A protein binding
  JOURNAL   mBio 4 (2), e00098-e00013 (2013)
   PUBMED   23572552
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3205)
  AUTHORS   Jeganathan,S., Morrow,A., Amiri,A. and Lee,J.M.
  TITLE     Eukaryotic elongation factor 1A2 cooperates with
            phosphatidylinositol-4 kinase III beta to stimulate production of
            filopodia through increased phosphatidylinositol-4,5 bisphosphate
            generation
  JOURNAL   Mol Cell Biol 28 (14), 4549-4561 (2008)
   PUBMED   18474610
  REMARK    GeneRIF: Work suggests an important role for both eEF1A2 and
            PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin
            remodeling.
REFERENCE   5  (bases 1 to 3205)
  AUTHORS   Jeganathan,S. and Lee,J.M.
  TITLE     Binding of elongation factor eEF1A2 to phosphatidylinositol
            4-kinase beta stimulates lipid kinase activity and
            phosphatidylinositol 4-phosphate generation
  JOURNAL   J Biol Chem 282 (1), 372-380 (2007)
   PUBMED   17088255
  REMARK    GeneRIF: there is a physical and functional relationship between
            eEF1A2 and PI4KIIIbeta
REFERENCE   6  (bases 1 to 3205)
  AUTHORS   Kapp-Barnea,Y., Melnikov,S., Shefler,I., Jeromin,A. and
            Sagi-Eisenberg,R.
  TITLE     Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta
            regulate IgE receptor-triggered exocytosis in cultured mast cells
  JOURNAL   J Immunol 171 (10), 5320-5327 (2003)
   PUBMED   14607934
  REMARK    GeneRIF: Overexpression of a PI4K beta mutant in rat mast cells
            inhibits IgE receptor-triggered phosphatidylinositol
            4,5-bisphosphate (PIP2) hydrolysis and exocytosis.
REFERENCE   7  (bases 1 to 3205)
  AUTHORS   Einicker-Lamas,M., Wenceslau,L.D., Bernardo,R.R., Nogaroli,L.,
            Guilherme,A., Oliveira,M.M. and Vieyra,A.
  TITLE     Sphingosine-1-phosphate formation activates phosphatidylinositol-4
            kinase in basolateral membranes from kidney cells: crosstalk in
            cell signaling through sphingolipids and phospholipids
  JOURNAL   J Biochem 134 (4), 529-536 (2003)
   PUBMED   14607979
  REMARK    GeneRIF: phosphatidylinositol-4 kinase in basolateral membranes
            from kidney cells is activated by sphingosine-1-phosphate
REFERENCE   8  (bases 1 to 3205)
  AUTHORS   Taverna,E., Francolini,M., Jeromin,A., Hilfiker,S., Roder,J. and
            Rosa,P.
  TITLE     Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta
            interact in neuronal cells and are translocated to membranes during
            nucleotide-evoked exocytosis
  JOURNAL   J Cell Sci 115 (Pt 20), 3909-3922 (2002)
   PUBMED   12244129
  REMARK    GeneRIF: NCS-1 protein and 1-phosphatidylinositol 4-kinase b
            interact in neuronal cells and are translocated to membranes during
            nucleotide-evoked exocytosis.
REFERENCE   9  (bases 1 to 3205)
  AUTHORS   Cuozzo,F.P., Mishra,S., Jiang,J. and Aukema,H.M.
  TITLE     Overexpression of kidney phosphatidylinositol 4-kinasebeta and
            phospholipase C(gamma1) proteins in two rodent models of polycystic
            kidney disease
  JOURNAL   Biochim Biophys Acta 1587 (1), 99-106 (2002)
   PUBMED   12009430
REFERENCE   10 (bases 1 to 3205)
  AUTHORS   Nakagawa,T., Goto,K. and Kondo,H.
  TITLE     Cloning and characterization of a 92 kDa soluble
            phosphatidylinositol 4-kinase
  JOURNAL   Biochem J 320 (Pt 2) (Pt 2), 643-649 (1996)
   PUBMED   8973579
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031083.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84667.1, SRR26643429.8996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000002.1  185229392-185229729
            339-1275            JAXUCZ010000002.1  185238043-185238979
            1276-1320           JAXUCZ010000002.1  185243305-185243349
            1321-1548           JAXUCZ010000002.1  185247155-185247382
            1549-1776           JAXUCZ010000002.1  185248195-185248422
            1777-1886           JAXUCZ010000002.1  185250162-185250271
            1887-1991           JAXUCZ010000002.1  185250980-185251084
            1992-2115           JAXUCZ010000002.1  185251255-185251378
            2116-2381           JAXUCZ010000002.1  185253382-185253647
            2382-2514           JAXUCZ010000002.1  185259293-185259425
            2515-2635           JAXUCZ010000002.1  185259693-185259813
            2636-3144           JAXUCZ010000002.1  185260831-185261339
            3145-3205           JAXUCZ010000002.1  185261359-185261419
FEATURES             Location/Qualifiers
     source          1..3205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3205
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /note="phosphatidylinositol 4-kinase beta"
                     /db_xref="GeneID:81747"
                     /db_xref="RGD:621214"
     exon            1..338
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            339..1275
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..2817
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /EC_number="2.7.1.67"
                     /note="PI4Kbeta; PI4K-beta; ptdIns 4-kinase beta;
                     phosphatidylinositol 4-kinase, catalytic, beta
                     polypeptide; catalytic phosphatidylinositol 4-kinase beta"
                     /codon_start=1
                     /product="phosphatidylinositol 4-kinase beta"
                     /protein_id="NP_112345.1"
                     /db_xref="GeneID:81747"
                     /db_xref="RGD:621214"
                     /translation="MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVID
                     PEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEED
                     EMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYI
                     GNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGA
                     YSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSK
                     SDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMA
                     IGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSK
                     DKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVP
                     NYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRR
                     RLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCG
                     DDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKK
                     QSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE
                     GHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAA
                     RKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMR
                     SITTKLYDGFQYLTNGIM"
     exon            1276..1320
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1548
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1776
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1886
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1991
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2115
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2381
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2514
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2635
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..3205
                     /gene="Pi4kb"
                     /gene_synonym="Pik4cb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttactatggc atcggtagtg tcctgacagt tcggaaagca ggaaagcaag cgccgagaag
       61 aaaggctcgg gcccagcgga ctcttacatc gcaacccatc aaggaattgt tattttgggt
      121 cctgcaagtg gggtccggtc caacttgagg tagcgtgaag gccccttcag gcggcgccgc
      181 gggcagcccc gcagccgggg cctggtgcag ccgccgcggc cgctgtcagg gaagcgcagg
      241 cggccaatgg aacccgggag cggccgctgc tgctgaggcg gcggtgtcgg cagtccgacc
      301 ccgaccgcct gcaccccctc cgcgagggtc ccccggagct tggaagctcg aagtctggct
      361 gtagccatgg gagacatggt agtggagcct gccaccctga agccaacttc tgagcctact
      421 cctagcccat cagggaataa cgggggctcc ctactaagcg tcatcacgga gggggtcggg
      481 gaactgtcag tgattgaccc tgaggtggcc cagaaggcct gccaggaggt actggagaaa
      541 gtcaagcttt tgcatggagg tgtagccatc tctagcaaag gcagcccact ggagttggtt
      601 aatggggatg gtgtggacaa tgagatccgt tgcctagatg atccacctac cgagatcagg
      661 gaggaagaag atgagatgga gcctggtgtg gtctctggca cagccaaagg aacaagaaga
      721 agacgacaga acaactcagc caaacagtct tggctcctga ggctgtttga atcaaaacta
      781 tttgacatct ctatggccat ttcatacttg tataactcca aggagccggg agtgcaagcc
      841 tacattggca accggctctt ctgctttcgc aatgaggatg tggacttcta tttgccccag
      901 ttgcttaaca tgtatatcca tatggatgag gatgtgggtg atgccattaa accctacata
      961 gtccaccgtt gtcgccagag catcaacttt tccctccagt gtgccctgtt gcttggggcc
     1021 tactcttcag acatgcacat ttctactcaa cgacactccc gagggaccaa gttacggaag
     1081 ctaatcctct cagatgagct gaagccagct caccgaaaga gggagctgcc aactttaagc
     1141 ccagcccctg acacaggact gtctccctct aaaaggactc accagcgctc taagtcagat
     1201 gccacggcca gcataagtct cagcagcaac ctgaaacgaa cagccagcaa ccctaaagtg
     1261 gagaatgagg atgaggagct ctcctccagc accgagagta ttgataattc attcagttcc
     1321 cctgtccggc tggcccctga gcgagaattc atcaagtcct tgatggcaat cggcaaacgg
     1381 ctggccacgc tccccactaa agagcaaaaa acacaaaggc tgatctcaga actttccctg
     1441 ctcaaccata agctccctgc ccgagtctgg ctgcccacag ctggctttga ccaccacgtg
     1501 gtccgtgtgc cccacacaca agctgttgtc ctcaattcca aggataaggc tccctacctg
     1561 atctatgtgg aagttcttga atgtgaaaac ttcgacacaa ctaatgttcc tgcccggatt
     1621 cctgaaaacc gaattcggag tacgaggtct gtggagaacc tgccggaatg tggtatcact
     1681 cacgagcagc gggctggcag cttcagcact gtgcccaatt atgacaatga cgatgaagcc
     1741 tggtcggtgg atgacatagg cgagctgcag gtggagctcc cagaagtgca caccaacagc
     1801 tgtgacaaca tctctcagtt ctcggtggac agcatcacca gccaggagag caaggagcct
     1861 gtgttcattg cggcagggga catcagacgg cgcctttcag aacagctggc tcacactccc
     1921 acagccttca aacgagaccc tgaagaccct tctgcagtcg ccctcaaaga gccctggcag
     1981 gagaaagtgc ggaggatcag agaaggttcc ccgtatggcc atcttcccaa ttggcgactc
     2041 ctttcagtca ttgtcaagtg tggagatgac cttcgccagg agctgctggc tttccaggtg
     2101 ttgaaacaac tgcagtccat ttgggaacag gagcgagtgc ctctttggat caagccatat
     2161 aagattcttg tgatttcagc tgacagtggc atgattgaac cagtagtcaa cgctgtgtcc
     2221 atccaccagg tgaagaaaca gtcacagctc tccttgctcg attacttcct gcaggagcat
     2281 ggcagttaca ccactgaggc attcctcagt gcccagcgca attttgtgca aagttgtgct
     2341 ggctactgct tggtctgcta cctattacaa gtcaaggaca ggcacaatgg gaacatcctt
     2401 ctggacgcag aaggtcacat catccacatc gactttggct tcatcctttc cagctcaccc
     2461 cgaaacctgg gcttcgagac gtcagccttt aagctgacca cagaatttgt ggatgtaatg
     2521 ggcggcctga acggtgatat gttcaactac tataagatgc tcatgctgca agggctgatc
     2581 gctgctcgca aacacatgga caaggtggta cagattgtgg agatcatgca gcaaggttct
     2641 cagcttcctt gcttccatgg ctccagcacc attcgcaacc tcaaagagag gttccacatg
     2701 agcatgactg aggagcagct gcagctgctg gtggagcaga tggtggacgg cagcatgagg
     2761 tccatcacca ccaaactcta cgatggcttc cagtacctca ccaatggcat catgtgacac
     2821 cactttcagg cccagaagtg gtgggattga aggcaccctc cttaggagga cccttgccta
     2881 agaaaaccta aatcacaaaa tcccacctac ctaaccacct acccaaggga aatggaaggc
     2941 aaaaaacaca aaggatcatg tggtaaccat gagagctggc caaagggtag gagagccaac
     3001 catggggtcc agacttgctg gggcttcccc acctcttgct gtgtcagtat tgccacctga
     3061 cagatcccag gactcactgc cctccagaga acagagatga tgaacatgag gaggactgga
     3121 accttcttcc cctcggggat ctcatctttt actttccctg ggtcccagca agatgggagg
     3181 agtgggttct tggtacttag gactt
//
