LOCUS       NM_001415014            6619 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phosphatidylinositol 4-kinase alpha (Pi4ka),
            mRNA.
ACCESSION   NM_001415014 NM_022301 XM_008768902
VERSION     NM_001415014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6619)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6619)
  AUTHORS   Dowdle,W.E., Nyfeler,B., Nagel,J., Elling,R.A., Liu,S.,
            Triantafellow,E., Menon,S., Wang,Z., Honda,A., Pardee,G.,
            Cantwell,J., Luu,C., Cornella-Taracido,I., Harrington,E.,
            Fekkes,P., Lei,H., Fang,Q., Digan,M.E., Burdick,D., Powers,A.F.,
            Helliwell,S.B., D'Aquin,S., Bastien,J., Wang,H., Wiederschain,D.,
            Kuerth,J., Bergman,P., Schwalb,D., Thomas,J., Ugwonali,S.,
            Harbinski,F., Tallarico,J., Wilson,C.J., Myer,V.E., Porter,J.A.,
            Bussiere,D.E., Finan,P.M., Labow,M.A., Mao,X., Hamann,L.G.,
            Manning,B.D., Valdez,R.A., Nicholson,T., Schirle,M., Knapp,M.S.,
            Keaney,E.P. and Murphy,L.O.
  TITLE     Selective VPS34 inhibitor blocks autophagy and uncovers a role for
            NCOA4 in ferritin degradation and iron homeostasis in vivo
  JOURNAL   Nat Cell Biol 16 (11), 1069-1079 (2014)
   PUBMED   25327288
REFERENCE   3  (bases 1 to 6619)
  AUTHORS   Nakatsu,F., Baskin,J.M., Chung,J., Tanner,L.B., Shui,G., Lee,S.Y.,
            Pirruccello,M., Hao,M., Ingolia,N.T., Wenk,M.R. and De Camilli,P.
  TITLE     PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its
            impact on plasma membrane identity
  JOURNAL   J Cell Biol 199 (6), 1003-1016 (2012)
   PUBMED   23229899
REFERENCE   4  (bases 1 to 6619)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 6619)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 6619)
  AUTHORS   Berger,K.L., Cooper,J.D., Heaton,N.S., Yoon,R., Oakland,T.E.,
            Jordan,T.X., Mateu,G., Grakoui,A. and Randall,G.
  TITLE     Roles for endocytic trafficking and phosphatidylinositol 4-kinase
            III alpha in hepatitis C virus replication
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7577-7582 (2009)
   PUBMED   19376974
REFERENCE   7  (bases 1 to 6619)
  AUTHORS   Barylko,B., Mao,Y.S., Wlodarski,P., Jung,G., Binns,D.D., Sun,H.Q.,
            Yin,H.L. and Albanesi,J.P.
  TITLE     Palmitoylation controls the catalytic activity and subcellular
            distribution of phosphatidylinositol 4-kinase II{alpha}
  JOURNAL   J Biol Chem 284 (15), 9994-10003 (2009)
   PUBMED   19211550
  REMARK    GeneRIF: palmitoylation is critical for targeting PI4KIIalpha to
            the trans-Golgi network and for enhancement of its association with
            low buoyant density membrane fractions
REFERENCE   8  (bases 1 to 6619)
  AUTHORS   Kakuk,A., Friedlander,E., Vereb,G. Jr., Kasa,A., Balla,A.,
            Balla,T., Heilmeyer,L.M. Jr., Gergely,P. and Vereb,G.
  TITLE     Nucleolar localization of phosphatidylinositol 4-kinase PI4K230 in
            various mammalian cells
  JOURNAL   Cytometry A 69 (12), 1174-1183 (2006)
   PUBMED   17131383
  REMARK    GeneRIF: These experiments suggest the participation of PI4K230 in
            a DNase and RNase sensitive complex with a unique localization and
            function in the nucleolus.
REFERENCE   9  (bases 1 to 6619)
  AUTHORS   Nakagawa,T., Goto,K. and Kondo,H.
  TITLE     Cloning, expression, and localization of 230-kDa
            phosphatidylinositol 4-kinase
  JOURNAL   J Biol Chem 271 (20), 12088-12094 (1996)
   PUBMED   8662589
REFERENCE   10 (bases 1 to 6619)
  AUTHORS   Westrup,D. and Ragg,H.
  TITLE     Secondary thrombin-binding site, glycosaminoglycan binding domain
            and reactive center region of leuserpin-2 are strongly conserved in
            mammalian species
  JOURNAL   Biochim Biophys Acta 1217 (1), 90-92 (1994)
   PUBMED   8286422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Dec 20, 2022 this sequence version replaced
            NM_022301.2, XM_008768902.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.27478.1,
                                           SRR26643292.46573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000011.1  97113390-97113635
            247-363             JAXUCZ010000011.1  97127923-97128039
            364-457             JAXUCZ010000011.1  97130603-97130696
            458-546             JAXUCZ010000011.1  97135760-97135848
            547-619             JAXUCZ010000011.1  97136838-97136910
            620-879             JAXUCZ010000011.1  97138139-97138398
            880-946             JAXUCZ010000011.1  97141289-97141355
            947-1095            JAXUCZ010000011.1  97144806-97144954
            1096-1161           JAXUCZ010000011.1  97148195-97148260
            1162-1258           JAXUCZ010000011.1  97151548-97151644
            1259-1450           JAXUCZ010000011.1  97152961-97153152
            1451-1551           JAXUCZ010000011.1  97153673-97153773
            1552-1681           JAXUCZ010000011.1  97154338-97154467
            1682-1814           JAXUCZ010000011.1  97155912-97156044
            1815-1910           JAXUCZ010000011.1  97156977-97157072
            1911-2094           JAXUCZ010000011.1  97157670-97157853
            2095-2198           JAXUCZ010000011.1  97159020-97159123
            2199-2367           JAXUCZ010000011.1  97160944-97161112
            2368-2418           JAXUCZ010000011.1  97163474-97163524
            2419-2527           JAXUCZ010000011.1  97185978-97186086
            2528-2664           JAXUCZ010000011.1  97186520-97186656
            2665-2798           JAXUCZ010000011.1  97186798-97186931
            2799-2881           JAXUCZ010000011.1  97189146-97189228
            2882-2952           JAXUCZ010000011.1  97192231-97192301
            2953-3077           JAXUCZ010000011.1  97192385-97192509
            3078-3159           JAXUCZ010000011.1  97193428-97193509
            3160-3243           JAXUCZ010000011.1  97193758-97193841
            3244-3333           JAXUCZ010000011.1  97194893-97194982
            3334-3453           JAXUCZ010000011.1  97198379-97198498
            3454-3546           JAXUCZ010000011.1  97200853-97200945
            3547-3703           JAXUCZ010000011.1  97202054-97202210
            3704-3831           JAXUCZ010000011.1  97202448-97202575
            3832-3990           JAXUCZ010000011.1  97208352-97208510
            3991-4142           JAXUCZ010000011.1  97208742-97208893
            4143-4250           JAXUCZ010000011.1  97210063-97210170
            4251-4378           JAXUCZ010000011.1  97212141-97212268
            4379-4498           JAXUCZ010000011.1  97213981-97214100
            4499-4578           JAXUCZ010000011.1  97214353-97214432
            4579-4772           JAXUCZ010000011.1  97214579-97214772
            4773-4863           JAXUCZ010000011.1  97215329-97215419
            4864-5031           JAXUCZ010000011.1  97216713-97216880
            5032-5085           JAXUCZ010000011.1  97217753-97217806
            5086-5206           JAXUCZ010000011.1  97219085-97219205
            5207-5336           JAXUCZ010000011.1  97221874-97222003
            5337-5407           JAXUCZ010000011.1  97223283-97223353
            5408-5480           JAXUCZ010000011.1  97223800-97223872
            5481-5551           JAXUCZ010000011.1  97223945-97224015
            5552-5661           JAXUCZ010000011.1  97225198-97225307
            5662-5766           JAXUCZ010000011.1  97225664-97225768
            5767-5892           JAXUCZ010000011.1  97225853-97225978
            5893-6013           JAXUCZ010000011.1  97226207-97226327
            6014-6173           JAXUCZ010000011.1  97226565-97226724
            6174-6263           JAXUCZ010000011.1  97227441-97227530
            6264-6347           JAXUCZ010000011.1  97227747-97227830
            6348-6619           JAXUCZ010000011.1  97227924-97228195
FEATURES             Location/Qualifiers
     source          1..6619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..6619
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /note="phosphatidylinositol 4-kinase alpha"
                     /db_xref="GeneID:64161"
                     /db_xref="RGD:621213"
     exon            1..246
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..6399
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /EC_number="2.7.1.67"
                     /note="phosphatidylinositol 4-kinase, catalytic, alpha
                     polypeptide; phosphatidylinositol 4-kinase a; leuserpin 2;
                     PI4-kinase alpha; ptdIns-4-kinase alpha"
                     /codon_start=1
                     /product="phosphatidylinositol 4-kinase alpha"
                     /protein_id="NP_001401943.1"
                     /db_xref="GeneID:64161"
                     /db_xref="RGD:621213"
                     /translation="MAAAGARGGGGAGAAGARGGGGAGAGTGGSGSSSGSSTSRGFYF
                     NTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDL
                     QHKDCIVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPS
                     LRDEILEALLQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISRSFGRYSNSEESLLS
                     KLFPKVPPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQV
                     SPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPEYYFSTISSSFSVSPLFNGITYKEF
                     YIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEANPSADLYYTTFSDPVYLTMFKM
                     LRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQAN
                     AACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERF
                     PVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPG
                     KKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLI
                     PDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQY
                     IYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDE
                     LLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKE
                     AKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSV
                     LQYNSAMKNDTVTPAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYM
                     RVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKEN
                     EEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLS
                     LSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVT
                     KSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGVTQLTERPACVKK
                     DYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQA
                     MFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMR
                     EMAGAWHMTVEQKFGLFSAETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEI
                     AKYCSSDQVEIFSSLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVP
                     NATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTAS
                     QLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLH
                     KYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQW
                     KDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHT
                     IDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQ
                     IVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQ
                     LVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQP
                     GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTED
                     ECRRQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVA
                     TAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAY
                     SLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIM
                     GGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFS
                     PNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIPY"
     exon            247..363
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            364..457
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            458..546
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            547..619
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            620..879
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            880..946
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1095
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1161
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1258
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1450
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1551
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1681
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1814
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1910
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2094
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2198
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2367
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2418
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2527
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2664
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2798
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2881
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2952
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3077
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3159
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3243
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3333
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3453
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3546
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3703
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3831
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3990
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4142
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4250
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4378
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4498
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4499..4578
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4772
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4863
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..5031
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5085
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5086..5206
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5207..5336
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5337..5407
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5480
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5481..5551
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5552..5661
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5662..5766
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5767..5892
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            5893..6013
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            6014..6173
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            6174..6263
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            6264..6347
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
     exon            6348..6619
                     /gene="Pi4ka"
                     /gene_synonym="PI4K-alpha; Pik4ca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcagtc ccagagctac aaacccggcc gcctgcgccc ggacgcgcgc tgtgatggcg
       61 gctgctgggg cccggggagg cggcggcgcc ggcgccgctg gggcccgggg aggcggcggc
      121 gccggcgccg gcaccggcgg ctcggggtcc agctctggtt ccagcacctc ccgaggtttt
      181 tatttcaaca cagtgctttc actggcccgc tccctggctg tgcagagacc tgcatcctta
      241 gagaaggttc aaaagctgct gtgcatgtgc ccagtagatt ttcatggaat cttccagcta
      301 gatgaaagac ggagagatgc agtgattgct ctgggcattt ttctcattga gtctgatctt
      361 cagcacaaag attgtattgt tccttatctt cttcgacttc tcaggggtct tccaaaagtc
      421 tattgggtag aagaaagcac agctcggaaa ggcagaggta acctcccggt tgcagaaagc
      481 ttcagcttct gcctggtgac cttgctgtct gatgtggctt gcagggaccc ctcacttagg
      541 gatgagattt tagaggcact tttgcaggtt ttacatgtcc ttctgggaat gtgccaggcc
      601 ctggagattc aagagaaaga atacctttgc aagtatgcaa tcccatgcct gatagggatc
      661 tcgagatctt ttggacgtta cagcaattca gaagaatctc tcctctcaaa gctttttccc
      721 aaagtccctc ctcattccct gagaatcccc gaagagctag aaggtgtccg aaggcgttcc
      781 tttaatgact tccgctccat cctgcccagc aacctgctga ctgtctgtca ggagggcaca
      841 ctgaagagga aaaccagcag tgtgtccagc atctctcagg ttagcccaga acgtggcatg
      901 ccccctccca gctcccctgg aggatctgct tttcactatt ttgaagcctc ttgcctgcct
      961 gatggaacca ccttggagcc cgaatactac ttctctacca tcagctccag tttttctgtc
     1021 tctcccctgt tcaatggtat cacctataag gagttctata ttccactgga aatgcttcga
     1081 gaactcttaa acttggtaaa gaagattgtt gaggagcctg ttctcaagtc cttagatgca
     1141 gctgtagcca gagtgatgga ggccaatccc agtgctgacc tatactacac gaccttcagt
     1201 gatcccgtct acctgaccat gttcaagatg cttcgagaca ctctgtacta tatgaaagac
     1261 ttacccacct cctttgtgaa agagatccat gattttgtgt tggagcagtt caacatgagc
     1321 caaggggaac tccaaaagat tctccatgat gcagacagga tccacagtga gatgagccca
     1381 ctcaaactgc gctgccaagc aaatgctgcc tgcgtagacc tcatggtgtg ggctgtgaag
     1441 gatgagcagg gtgcagaaaa cctttgcatc aagctgtctg aaaagctgca gtccaagaca
     1501 tccagcaagg tcatcatcgc ccatttgccc ttgctgatct gctgcctaca gggtctgggc
     1561 cgcctatgtg aacggttccc ggtggtggtc cactcagtga caccatcttt gagagacttt
     1621 ctggtgattc catccccagt gctggtgaag ctctataagt accacagtca gtaccacaca
     1681 gttgctggca gtgatataaa aattagtgtc accaatgagc attctgagtc aactctgaat
     1741 gtcttgcccg gcaagaagaa ccagccatcc atgtatgagc agctccggga catcgccatt
     1801 gacaacatct gcaggtgcct gaaggccggc ctcaccgtgg accctgtgat cgtggaggcc
     1861 ttcctggcca gcctctccaa ccggctctat atctcccagg agagcgataa ggatgctcac
     1921 ttgattcctg accataccat tcgtgccttg ggacacattg cagtggctct gagggatacc
     1981 ccaaaggtca tggagccaat tctgcagatc ctgcagcaga aattttgcca gcccccctca
     2041 cccctcgatg tgctcatcat cgaccagctg ggctgcctgg ttatcactgg aaatcaatac
     2101 atttatcagg aagtgtggaa tctcttccaa caaatcagtg tgaaggccag ttcagttgta
     2161 tattcagcca ccaaagacta caaagaccat ggctacaggc actgctccct cgcagtcatc
     2221 aatgccctgg ccaacatcgc agccaacatt caggaggagc accttgtgga tgagctgttg
     2281 atgaacctgc tggaactgtt tgtgcagctg gggctggagg ggaagagagc cagtgagagg
     2341 gccagcgaga aggggcccgc cctgaaggct tccagcagtg cagggaattt gggagtgctc
     2401 attcctgtaa tagccgtgct cacccgacga ttgccaccca tcaaagaagc taaacctagg
     2461 ctacaaaagc ttttccgaga cttctggctc tactctgtgc taatgggatt cgctgtggaa
     2521 ggctcagggc tctggccgga agagtggtat gaaggagtct gtgaaatagc aaccaagtca
     2581 cctctgctta cctttcccag caaagagcct cttcgatcag tcctccagta caactcagcc
     2641 atgaaaaatg atacagtgac cccggctgag ctgaatgagc tccgaagtac catcatcaac
     2701 ttgctagatc ctcctcctga ggtgtctgcc ctcatcaaca agctggactt tgccatgtcc
     2761 acctatctct tgtctgtgta tcggctggaa tacatgaggg tgctgcgttc tacagatcca
     2821 gatcgcttcc aggtaatgtt ctgctacttc gaggataaag ctattcagaa agacaaatct
     2881 gggatgatgc agtgtgtcat cgctgttgct gacaaagtat ttgatgcctt cctgaacatg
     2941 atggcagaaa aagccaagac caaggagaat gaagaggagt tggagcggca tgcccagttt
     3001 ctgctggtga acttcaacca cattcacaag aggatacgca gagtggctga caagtacctg
     3061 tctggtctgg tggataagtt tccacacttg ctctggagtg ggactgtgct gaagaccatg
     3121 ttggacattc tgcagaccct gtcactatca ctaagtgctg atattcacaa ggaccaacct
     3181 tattatgaca ttcctgacgc cccctatcgg atcacggttc ctgacacgta tgaagcccgg
     3241 gagagcatcg tgaaagactt tgctgcacgc tgtgggatga tcctgcagga agccatgaag
     3301 tgggcaccca cggtcactaa gtcccacctg caggaatatc tgaacaagca tcagaactgg
     3361 gtgtcaggac tgtcccagca cacgggattg gccatggcca ctgagagcat ccttcacttt
     3421 gccggctaca acaagcagaa cacaactctt ggggtaactc agctcactga gcgcccggcc
     3481 tgtgtgaaga aagactactc caacttcatg gcatccttga atttgcgcaa ccgctatgcc
     3541 ggcgaggtgc acgggatgat tcggttctca ggtgccacag gccagatgtc cgacctgaac
     3601 aaaatgatgg tccaggatct gattacagct ctggaccaca gtcatcctca gcactatacc
     3661 caagccatgt tcaaattgac ggccatgctc attagcagca aagattgtga cccacagctc
     3721 cttcatcatc tgtgttgggg tcccctccgg atgttcaacg agcatggcat ggagactgca
     3781 ctagcctgct gggagtggct gctggctggc aagaatggag tggaagtgcc gttcatgcgg
     3841 gagatggcag gagcctggca catgacagtg gagcagaagt tcggcctctt ctctgcagaa
     3901 acaaaggaag cagatcccct ggcagcgtca gaagcaagtc agccacgacc ctgtccccct
     3961 gaagtgacac ctcactacat ctggattgat ttcctggtgc agcggtttga gattgccaag
     4021 tactgtagct ctgaccaggt ggagatcttc tcaagcctgc tgcagcgctc catgtccctc
     4081 cacatcggtg gagccagggg gagcatgaac aggcatgtgg cagccattgg accacgtttc
     4141 aaactgctga ccctggggct gtccctccta cacgctgatg tggttccaaa tgcaaccatt
     4201 cgaaacgtgc ttcgagagaa gatctactca acagcctttg actatttcag ttgtccacca
     4261 aagttcccta ctcaaggaga aaagaggctg cgtgaagata taagcatcat gattaagttt
     4321 tggactgcca tgttctcaga taagaagtac ctgactgcca gccaactcgt tcccccagat
     4381 aaccaggaca cccgaagcaa cttggatata actgtgggct ctcgacaaca ggctacacag
     4441 ggatggatca acacataccc cctctccagt ggcatgtcaa ctatctccaa aaaatcaggc
     4501 atgtctaaga aaaccaaccg aggttcccag ctgcacaagt actacatgaa gcgtaggacg
     4561 ctgctgctgt cactgttggc cactgagatc gagcgcctca tcacttggta caacccgctg
     4621 tcagccccag agctagagct ggaccaggca ggtgagaaca gtgttgccaa ctggaggtcc
     4681 aagtatatca gcctgagtga gaagcagtgg aaggacaacg tgaaccttgc ctggaccatc
     4741 tctccatacc tcgctgtgca gctgccagcc aggttcaaga atacagaagc cattggaaat
     4801 gaagtgaccc gtctcgttcg cctggaccca ggagctgtta gtgatgtccc tgaagctatc
     4861 aagttccttg tcacctggca caccatcgat gctgatgctc cagagcttag ccatgtgtta
     4921 tgctgggcac ccacggaccc gcccacgggc ctctcctact tctccagcat gtacccccca
     4981 caccctctca ctgcacagta tggggtgaaa gtcctgcggt ccttccctcc ggatgccatt
     5041 ctgttctaca tcccccagat tgtgcaggcc ctcagatatg acaagatggg ctatgtgcgc
     5101 gagtacattc tctgggctgc agccaaatcc cagcttctgg cacaccagtt tatttggaat
     5161 atgaaaacta acatctacct tgatgaagaa gggcaccaga aagaccctga cattggtgac
     5221 cttctggagc agttagtaga agaaatcaca gggtctctat caggcccagc caaagatttc
     5281 tatcaacggg aatttgattt ctttaacaag atcaccaacg tgtcagccat catcaagccc
     5341 taccctaaag gcgatgaaag aaagaaggct tgtctgtcag ccctgtctga agtgaaggtg
     5401 cagcctggct gctacctgcc cagcaaccct gaagcaattg tgctagacat tgactacaag
     5461 tcagggacac caatgcagag tgctgcaaaa gcgccgtatc ttgccaagtt taaggtgaag
     5521 cgatgcggag tgagtgaact tgaaaaagaa ggtctgcagt gccgctcaga cacagaggat
     5581 gagtgccgca ggcaagaggc tgatggcaag aagatctgct ggcaagcagc catcttcaaa
     5641 gtgggggatg actgccgaca ggacatgcta gccctgcaga tcatcgacct tttcaagaac
     5701 atcttccagc tggttggcct ggacctcttc gtttttccct atcgggtagt ggctactgcc
     5761 cctgggtgtg gggtgattga gtgcattcca gactgtacct cccgagacca gctaggccgc
     5821 cagactgact tcggcatgta tgactacttt acacgccagt atggggacga gtctaccttg
     5881 gccttccagc aggcacgcta caactttatc agaagcatgg cggcctacag cctcctgctg
     5941 ttcctgctgc agatcaagga caggcacaac ggcaacatca tgctggacaa gaagggacac
     6001 atcatccaca tagactttgg cttcatgttt gaaagctcac cgggtggcaa ccttggctgg
     6061 gagccagaca tcaagctgac agacgagatg gtgatgatta tggggggcaa gatggaagcc
     6121 acacccttca agtggttcat ggagatgtgc gtccgaggtt atctggctgt gcgcccctat
     6181 atggatgcag tcgtctccct ggttacactc atgttggaca caggcctgcc ctgtttccgt
     6241 ggccagacaa tcaaactttt gaaacacagg ttcagcccga acatgacaga gcgggaggct
     6301 gcaaatttta tcatgaagat catccaaaac tgtttcctca gcaacaggag ccggacctac
     6361 gacatgatcc agtactacca gaatgatatc ccctactgag gagactgtac ctgaagcctt
     6421 gagtgtcaca gagcagcttg tactgtcacc ataagcctgg gtgtggaggt gacaggcaca
     6481 tggaacttgg atgcacaggt gtgagtcttt ttcacactgg atacattccc tatttgttca
     6541 cccatcttac tatgttggta catgaagtat tttcctgtgt aaacatgaga aattgacata
     6601 aaaaataaga accctaaaa
//
