LOCUS       NM_001170481            1992 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus peptidase inhibitor 16 (Pi16), transcript variant
            1, mRNA.
ACCESSION   NM_001170481 XM_001078697 XM_215351
VERSION     NM_001170481.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1992)
  AUTHORS   Deng,M., Yang,S., Ji,Y., Lu,Y., Qiu,M., Sheng,Y., Sun,W. and
            Kong,X.
  TITLE     Overexpression of peptidase inhibitor 16 attenuates angiotensin
            II-induced cardiac fibrosis via regulating HDAC1 of cardiac
            fibroblasts
  JOURNAL   J Cell Mol Med 24 (9), 5249-5259 (2020)
   PUBMED   32227584
  REMARK    GeneRIF: Overexpression of peptidase inhibitor 16 attenuates
            angiotensin II-induced cardiac fibrosis via regulating HDAC1 of
            cardiac fibroblasts.
REFERENCE   2  (bases 1 to 1992)
  AUTHORS   Frost,R.J. and Engelhardt,S.
  TITLE     A secretion trap screen in yeast identifies protease inhibitor 16
            as a novel antihypertrophic protein secreted from the heart
  JOURNAL   Circulation 116 (16), 1768-1775 (2007)
   PUBMED   17909105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 16, 2021 this sequence version replaced NM_001170481.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.77949.1,
                                           SRR26360186.1656662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               JAXUCZ010000020.1  7377953-7378266
            315-536             JAXUCZ010000020.1  7381171-7381392
            537-646             JAXUCZ010000020.1  7384216-7384325
            647-735             JAXUCZ010000020.1  7384612-7384700
            736-1467            JAXUCZ010000020.1  7385220-7385951
            1468-1597           JAXUCZ010000020.1  7386152-7386281
            1598-1992           JAXUCZ010000020.1  7386609-7387003
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1992
                     /gene="Pi16"
                     /note="peptidase inhibitor 16"
                     /db_xref="GeneID:294312"
                     /db_xref="RGD:1304760"
     exon            1..314
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1577
                     /gene="Pi16"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protease inhibitor 16"
                     /codon_start=1
                     /product="peptidase inhibitor 16 isoform 1 precursor"
                     /protein_id="NP_001163952.1"
                     /db_xref="GeneID:294312"
                     /db_xref="RGD:1304760"
                     /translation="MHSSCSPWVMLPQLPLLLLLLLLLLTATGPATALTEDEKQTMVE
                     LHNHYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEG
                     MDVPLAVGNWHEEHEYYNLSTATCDPGQMCGHYTQVVWSKTERIGCGSHFCETLQGVE
                     EANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGYSCVNSLCEPERKPEKAQDSPPR
                     VTEVPGSRETGIPSLATSESLHFSSVTKVSDSLATEPSPAVETKAPPSLATEGPSSMA
                     TEAQSFLTEVPSVSATHIQPSLDEGPVNFLTSTHIPVPKSTDKEASSKSRAASVSPEK
                     SLYPKMSPTETGESPPQIQEEAEPKAELPEREDELPEAEVELPEAEAELPEAKAELPV
                     SSEALVPVLPAQERGGPKASLEHSSYPVPTYLPNFPSASGNATGGRTLALQSSRTGAE
                     DPEKASWDSKNSAPVWGPFPGLLLPLLLLAGIF"
     exon            315..536
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
     exon            537..646
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
     exon            647..735
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1467
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1597
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1992
                     /gene="Pi16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggctgg gcctccagac acagcccctg ccgccccacc ccagccaggg tggtgcttgt
       61 gtgggaagga ctttaagtcc agccgccaga cccctgatcg ggagaggcag agagggctgg
      121 ccactatgca cagctcctgc agcccgtggg tgatgctgcc ccagctgcca ctgctgctcc
      181 tgttgcttct gctgctgctg actgccactg gccccgccac agccctcaca gaggacgaga
      241 agcaaaccat ggtggagctt cacaaccact accgcgccca ggtgtccccg ccagcctcag
      301 acatgctgca gatgaggtgg gacgacgagc tggccgcctt cgccaaggcc tacgctcaga
      361 agtgcgtgtg gggacacaac aaggagcgcg ggcggcgcgg agagaacctg tttgccatca
      421 cggacgaggg catggatgta ccgctggccg tggggaactg gcacgaggag catgaatatt
      481 acaatctcag cacagccacc tgtgatccgg gccagatgtg cggccactac actcaggtag
      541 tgtggagcaa aactgagaga atcggctgtg gttcccactt ctgcgagacg ctccagggag
      601 tggaggaagc taacatccat ttgctggtgt gcaactatga gcccccgggg aacgtgaagg
      661 gccggaagcc ctaccaggag gggacgcctt gctcccagtg ccctcttggc tacagctgcg
      721 tgaactctct ctgtgagccg gagagaaaac cggaaaaagc gcaggattcg cctccaaggg
      781 tgactgaagt cccaggctcc agggaaaccg gtattccatc cctagcaacc tctgaatctc
      841 tacatttctc ctcggtaaca aaggtctcgg actccctggc aaccgagccc tcacctgcgg
      901 tagaaacaaa ggccccacct tccttagcaa ccgaaggccc ctcctccatg gcaacagagg
      961 ctcagtcttt tctaactgag gtcccctcgg tttctgcaac gcacatccag ccttcactgg
     1021 atgaagggcc agttaacttc ctcacatcaa cacacatccc tgtccccaaa tctacggaca
     1081 aagaagccag cagcaagtcg agagcagcct ccgtgagccc agagaaatct ctgtacccca
     1141 agatgtcccc gacagagaca ggagagtccc caccccaaat ccaggaggag gctgagccca
     1201 aggccgagtt gcctgagcgg gaggacgagt tgcccgaggc agaggtcgaa ttgcctgagg
     1261 cagaggccga gttgccagag gccaaggccg agttgcctgt ttccagtgag gctttggtcc
     1321 cagttcttcc agctcaggag cgcggtgggc cgaaggcctc actggaacac tccagctacc
     1381 ctgtccccac atatctgccc aacttcccta gtgcctcggg caatgccaca ggtgggcgca
     1441 ccctggccct acaatcatcc cggacaggtg cagaggaccc tgaaaaggcc agctgggatt
     1501 cgaagaactc tgctcctgtg tggggccctt tcccgggact gctgctgcct ctcctgctgt
     1561 tggctggcat attctgaggg ggacactcaa aggcctggga gaagagctca gatgcccaac
     1621 tgctgtgttc tcctatcctg tccctcaagc aagatatcac ccctggctaa agcccctctg
     1681 gaagggaaag gctgtgggct catcagtaac tgcacaccgg ggcccttcct gcccctcaca
     1741 gtggagttct acggaggaca tgattctgat gatacttgtc tgctccacgg ggtggggtgg
     1801 ggcgggtggg ctgctgtctg cctgcaggct ctagggctcc ccatctccaa gtggtgccca
     1861 ttggcttgga cagcagggac tcggggtagg taaagaacaa gccccaacca aagtggggtt
     1921 ctgtgggtgg ggaggcgggg agcagggaac gaagagaggc agctttgact cctgaataaa
     1981 gcctgtctga ga
//
