LOCUS       NM_001106558             578 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphohistidine phosphatase 1 (Phpt1), mRNA.
ACCESSION   NM_001106558 XM_001074086 XM_216013
VERSION     NM_001106558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 578)
  AUTHORS   Kamath,V., Kyathanahalli,C.N., Jayaram,B., Syed,I., Olson,L.K.,
            Ludwig,K., Klumpp,S., Krieglstein,J. and Kowluru,A.
  TITLE     Regulation of glucose- and mitochondrial fuel-induced insulin
            secretion by a cytosolic protein histidine phosphatase in
            pancreatic beta-cells
  JOURNAL   Am J Physiol Endocrinol Metab 299 (2), E276-E286 (2010)
   PUBMED   20501872
  REMARK    GeneRIF: these data implicate regulatory roles for PHPT1 in a G
            protein-sensitive step involved in nutrient-induced insulin
            secretion
REFERENCE   2  (bases 1 to 578)
  AUTHORS   Reni,M., Sartori,N., Mambrini,A., Berardi,R., Passardi,A.,
            Milella,M., Cereda,S., Tronconi,M.C., Aprile,G., Cordio,S.,
            Pasetto,L.M., Rognone,A., Pederzoli,P. and Falconi,M.
  TITLE     An Italian study on treatment trends and outcomes of patients with
            stage III pancreatic adenocarcinoma in the gemcitabine era: is it
            time to change?
  JOURNAL   Anticancer Drugs 21 (4), 459-464 (2010)
   PUBMED   20110805
REFERENCE   3  (bases 1 to 578)
  AUTHORS   Xu,A., Hao,J., Zhang,Z., Tian,T., Jiang,S., Hao,J., Liu,C.,
            Huang,L., Xiao,X. and He,D.
  TITLE     14-kDa phosphohistidine phosphatase and its role in human lung
            cancer cell migration and invasion
  JOURNAL   Lung Cancer 67 (1), 48-56 (2010)
   PUBMED   19344975
REFERENCE   4  (bases 1 to 578)
  AUTHORS   Klumpp,S., Faber,D., Fischer,D., Litterscheid,S. and Krieglstein,J.
  TITLE     Role of protein histidine phosphatase for viability of neuronal
            cells
  JOURNAL   Brain Res 1264, 7-12 (2009)
   PUBMED   19138678
  REMARK    GeneRIF: results suggest that an increased activity of protein
            histidine phosphatase (PHP) impairs neuron cellular function
            whereas downregulation of PHP does not
REFERENCE   5  (bases 1 to 578)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 578)
  AUTHORS   Krieglstein,J., Lehmann,M., Maurer,A., Gudermann,T., Pinkenburg,O.,
            Wieland,T., Litterscheid,S. and Klumpp,S.
  TITLE     Reduced viability of neuronal cells after overexpression of protein
            histidine phosphatase
  JOURNAL   Neurochem Int 53 (5), 132-136 (2008)
   PUBMED   18656514
REFERENCE   7  (bases 1 to 578)
  AUTHORS   Srivastava,S., Zhdanova,O., Di,L., Li,Z., Albaqumi,M., Wulff,H. and
            Skolnik,E.Y.
  TITLE     Protein histidine phosphatase 1 negatively regulates CD4 T cells by
            inhibiting the K+ channel KCa3.1
  JOURNAL   Proc Natl Acad Sci U S A 105 (38), 14442-14446 (2008)
   PUBMED   18796614
REFERENCE   8  (bases 1 to 578)
  AUTHORS   Ma,R., Kanders,E., Sundh,U.B., Geng,M., Ek,P., Zetterqvist,O. and
            Li,J.P.
  TITLE     Mutational study of human phosphohistidine phosphatase: effect on
            enzymatic activity
  JOURNAL   Biochem Biophys Res Commun 337 (3), 887-891 (2005)
   PUBMED   16219293
REFERENCE   9  (bases 1 to 578)
  AUTHORS   Ek,P., Pettersson,G., Ek,B., Gong,F., Li,J.P. and Zetterqvist,O.
  TITLE     Identification and characterization of a mammalian 14-kDa
            phosphohistidine phosphatase
  JOURNAL   Eur J Biochem 269 (20), 5016-5023 (2002)
   PUBMED   12383260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI276995.1 and BI276399.1.
            
            On Jan 12, 2008 this sequence version replaced NM_001106558.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD373006.1, CF115205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               BI276995.1         1-521               c
            522-578             BI276399.1         1-57                c
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..578
                     /gene="Phpt1"
                     /note="phosphohistidine phosphatase 1"
                     /db_xref="GeneID:296571"
                     /db_xref="RGD:1311355"
     exon            1..169
                     /gene="Phpt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..387
                     /gene="Phpt1"
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /product="14 kDa phosphohistidine phosphatase"
                     /protein_id="NP_001100028.2"
                     /db_xref="GeneID:296571"
                     /db_xref="RGD:1311355"
                     /translation="MAADLGQIPDVDIDSDGIFKYVLIRVHLAEPSGDPARECKEIVR
                     GYKWAEYHADIYDKVSGELQKNGYDCECLGGGRISHQSQDRKIHVYGYSMGYGRAQHS
                     VSTEKIKAKYPDYEVTWADDGY"
     exon            170..294
                     /gene="Phpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..561
                     /gene="Phpt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttggcga acatggcggc ggacctcggt cagattcctg atgtggacat tgattcagat
       61 ggtatcttca agtacgtgct gattcgagtc cacttagcag agccttccgg ggatccggcg
      121 agggagtgca aggaaatcgt gcgtggctac aaatgggctg aataccacgc ggacatctat
      181 gacaaagtgt caggcgaact gcaaaagaat ggctatgact gcgagtgcct aggcggcggg
      241 cgcatctccc atcagagcca ggacaggaag atacacgtgt atggctattc tatgggttac
      301 ggccgtgccc agcactctgt ttcaactgag aagatcaaag ccaagtatcc tgattatgag
      361 gtcacctggg ctgatgatgg ctactgaagc tctccccacc agcatctaag tcaggactct
      421 gctctccctg tattctgtct tgaggggctg gccctgtgtt ctccttttgt accttgggca
      481 acacaccacc tgccaggcct tagaggccag agcaatctga tccataggaa ttaaagtatt
      541 gatatgccta ctagcccctg aaaaaaaaaa aaaaaaaa
//
