LOCUS       NM_001105833            1999 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus phosphoethanolamine/phosphocholine phosphatase 1
            (Phospho1), mRNA.
ACCESSION   NM_001105833 XM_001081325 XM_220877
VERSION     NM_001105833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Huesa C, Yadav MC, Finnila MA, Goodyear SR, Robins SP, Tanner KE,
            Aspden RM, Millan JL and Farquharson C.
  TITLE     PHOSPHO1 is essential for mechanically competent mineralization and
            the avoidance of spontaneous fractures
  JOURNAL   Bone 48 (5), 1066-1074 (2011)
   PUBMED   21272676
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Yadav MC, Simao AM, Narisawa S, Huesa C, McKee MD, Farquharson C
            and Millan JL.
  TITLE     Loss of skeletal mineralization by the simultaneous ablation of
            PHOSPHO1 and alkaline phosphatase function: a unified model of the
            mechanisms of initiation of skeletal calcification
  JOURNAL   J Bone Miner Res 26 (2), 286-297 (2011)
   PUBMED   20684022
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Ciancaglini P, Yadav MC, Simao AM, Narisawa S, Pizauro JM,
            Farquharson C, Hoylaerts MF and Millan JL.
  TITLE     Kinetic analysis of substrate utilization by native and TNAP-,
            NPP1-, or PHOSPHO1-deficient matrix vesicles
  JOURNAL   J Bone Miner Res 25 (4), 716-723 (2010)
   PUBMED   19874193
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Roberts SJ, Stewart AJ, Sadler PJ and Farquharson C.
  TITLE     Human PHOSPHO1 exhibits high specific phosphoethanolamine and
            phosphocholine phosphatase activities
  JOURNAL   Biochem J 382 (Pt 1), 59-65 (2004)
   PUBMED   15175005
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001081325.1, XM_220877.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169002.1, CV118920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1999
                     /gene="Phospho1"
                     /note="phosphoethanolamine/phosphocholine phosphatase 1"
                     /db_xref="GeneID:287644"
                     /db_xref="RGD:1306182"
     exon            1..215
                     /gene="Phospho1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..327
                     /gene="Phospho1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..1999
                     /gene="Phospho1"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1204
                     /gene="Phospho1"
                     /EC_number="3.1.3.75"
                     /note="phosphatase, orphan 1"
                     /codon_start=1
                     /product="phosphoethanolamine/phosphocholine phosphatase"
                     /protein_id="NP_001099303.1"
                     /db_xref="GeneID:287644"
                     /db_xref="RGD:1306182"
                     /translation="MCQRPWLWPANQPLPGRLPPRRLSLAPSSCSSSPCSQDGRMAAP
                     GAPRFLLTFDFDETIVDENSDDSIVRAAPGQQLPESLRATYREGYYNEYMQRVFKYLG
                     EQGVRPRDLRAVYETIPLSPGMGDLLQFIAKQGSCFEVILISDANTFGVESALRAAGH
                     HSLFRRILSNPSGPDARGLLTLRPFHTHSCSRCPANMCKHKVLSEYLRERARDGVHFE
                     RLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRAHVVPWETAA
                     DVRQHLQQVLKMC"
ORIGIN      
        1 tgggcccggg tgctgcggct gccgcagcgc ccgccgcggc tcgggctctg gctccccggc
       61 atttaaaggg gacgcggcgg cggccccggg gatggggggc aggtggaagg gacggagcag
      121 aagcacatca tccacggtcc ctcggggctg gagggacgcg tgagccggag ctcagaaatc
      181 cgggggtgga taagaccgcg tcccccccaa ttcccgagct ctggatgaca actggagacc
      241 aaccaagttt ctaaaggtgg aactcaggat aatacactga caatgagtgg gtgctttccg
      301 gttgttggat tgcgatgcct gtctagggtc ttggatgtgc cagcgaccct ggctgtggcc
      361 cgctaatcag cctctccctg gccggctccc gccgcgccgc ctctcgcttg ccccctcctc
      421 ctgctcctct tccccctgct cccaggacgg caggatggcc gcgccgggcg cgcctcgctt
      481 cctcctgacc ttcgacttcg atgagaccat tgtggatgag aacagcgacg actcgatcgt
      541 gcgtgctgcg ccaggccagc aactgcccga gagcctgcgt gccacctatc gggagggcta
      601 ctacaatgag tacatgcaac gcgtcttcaa gtacctgggt gagcagggag tacggccccg
      661 ggacctgcgc gctgtctacg agaccatccc cctgtcgcca ggcatgggcg atttgttgca
      721 gttcatagcc aaacagggct cctgcttcga ggttattctc atttcggatg ccaacacctt
      781 cggtgtggag agtgccctgc gtgccgctgg ccaccacagt ttattccgcc gcatcctcag
      841 caacccgtcg gggcccgatg cgcggggact gctgacgctg cggcccttcc acacgcacag
      901 ctgctcgcgc tgccccgcca acatgtgcaa gcacaaggtg ctcagcgaat acctgcgtga
      961 gcgggcccgc gacggcgtgc acttcgagcg cctcttctat gtgggtgatg gtgcaaatga
     1021 cttctgcccc atggggctgc tagcgggcgg ggatgtagcc ttcccacgcc gcggctaccc
     1081 catgcaccgc ctcatccaag aggcacagaa ggctgagccc agttccttcc gcgcccacgt
     1141 ggtgccctgg gaaacggccg ccgacgtgcg ccaacatctg caacaggtgc tgaagatgtg
     1201 ctgaagacca tcgcctgcaa ggggtgcccg ggacaaccag cggaggaggg gcgggactgg
     1261 gaattggtta ggaccaccta gttttactac cctccctctt tcctttccgc tttgctgtgc
     1321 tcctctggtc ggttctgaaa ttcggtccgc ttgtggctgg gagctggggc ttcagagccg
     1381 tccctgtctc tgcagttaac acagctcagc tgccttccct ccagggaggt gagcacccct
     1441 tggaaggcag gcagtgtccc tcgaactgag aggaacgggc tcctagaagt tgggagaaaa
     1501 aacatctccc acttacttta gctgctgcat aacctcctct gcccagcctt tcaaacggac
     1561 tcaggatccc ccaatccgca tgccagcacc agatttcctc gcggcagacc tatgatgctc
     1621 tcagaagaca actctaggtc tctcggtctt gcttcagcca acgcaaccct atactgccgc
     1681 tgcgctggct gcgccttgtt tccttcccac ccccccacct cacccccgcc agacacacac
     1741 accccccccc aaggaagaaa aagccagaag gaacaaccgc ctcttgctgg tggaacgagg
     1801 taaagccaac caatgacctc ggagagtgtg atgacaaatc ctcgcactcc ggcaagagac
     1861 cagggacttc accaaagtcg tccccgcctc atccccctcc acccctatgg aacagaaagc
     1921 catgttttta agcagagcca gggaaaccca agcccctccc ctctctggag tttcagacca
     1981 ataaaggagg tgaaggggg
//
