LOCUS       NM_001109131            4151 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus PH domain and leucine rich repeat protein
            phosphatase 2 (Phlpp2), mRNA.
ACCESSION   NM_001109131 XM_001077164 XM_574238
VERSION     NM_001109131.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Yeh,S.T., Zambrano,C.M., Koch,W.J. and Purcell,N.H.
  TITLE     PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2)
            regulates G-protein-coupled receptor kinase 5 (GRK5)-induced
            cardiac hypertrophy in vitro
  JOURNAL   J Biol Chem 293 (21), 8056-8064 (2018)
   PUBMED   29628444
  REMARK    GeneRIF: Loss of Phlpp2 expression is associated with cardiac
            hypertrophy.
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Toker,A. and Marmiroli,S.
  TITLE     Signaling specificity in the Akt pathway in biology and disease
  JOURNAL   Adv Biol Regul 55, 28-38 (2014)
   PUBMED   24794538
  REMARK    Review article
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Rizvi,F., Shukla,S. and Kakkar,P.
  TITLE     Essential role of PH domain and leucine-rich repeat protein
            phosphatase 2 in Nrf2 suppression via modulation of
            Akt/GSK3beta/Fyn kinase axis during oxidative hepatocellular
            toxicity
  JOURNAL   Cell Death Dis 5 (3), e1153 (2014)
   PUBMED   24675471
  REMARK    GeneRIF: Cellular PHLPP2 levels may aggravate oxidative toxicity by
            suppressing Nrf2/ARE transcriptional regulation via
            Akt(Se473)/GSK3beta/Fyn kinase axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Jackson,T.C., Verrier,J.D., Semple-Rowland,S., Kumar,A. and
            Foster,T.C.
  TITLE     PHLPP1 splice variants differentially regulate AKT and PKCalpha
            signaling in hippocampal neurons: characterization of PHLPP
            proteins in the adult hippocampus
  JOURNAL   J Neurochem 115 (4), 941-955 (2010)
   PUBMED   20819118
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Kanan,Y., Matsumoto,H., Song,H., Sokolov,M., Anderson,R.E. and
            Rajala,R.V.
  TITLE     Serine/threonine kinase akt activation regulates the activity of
            retinal serine/threonine phosphatases, PHLPP and PHLPPL
  JOURNAL   J Neurochem 113 (2), 477-488 (2010)
   PUBMED   20089132
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Gao,M.H., Miyanohara,A., Feramisco,J.R. and Tang,T.
  TITLE     Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2)
            by agonist stimulation in cardiac myocytes expressing adenylyl
            cyclase type 6
  JOURNAL   Biochem Biophys Res Commun 384 (2), 193-198 (2009)
   PUBMED   19450723
  REMARK    GeneRIF: increased Akt activity was associated with inhibition of
            PHLPP2 activity by adenylyl cyclase type 6.
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Brognard,J. and Newton,A.C.
  TITLE     PHLiPPing the switch on Akt and protein kinase C signaling
  JOURNAL   Trends Endocrinol Metab 19 (6), 223-230 (2008)
   PUBMED   18511290
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001109131.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.61412.1,
                                           SRR26643429.55953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000019.1  54744581-54744750
            171-463             JAXUCZ010000019.1  54752564-54752856
            464-597             JAXUCZ010000019.1  54770011-54770144
            598-788             JAXUCZ010000019.1  54776710-54776900
            789-914             JAXUCZ010000019.1  54780026-54780151
            915-1069            JAXUCZ010000019.1  54781855-54782009
            1070-1216           JAXUCZ010000019.1  54784477-54784623
            1217-1447           JAXUCZ010000019.1  54785008-54785238
            1448-1650           JAXUCZ010000019.1  54786381-54786583
            1651-1711           JAXUCZ010000019.1  54790928-54790988
            1712-1807           JAXUCZ010000019.1  54793460-54793555
            1808-1963           JAXUCZ010000019.1  54795415-54795570
            1964-2164           JAXUCZ010000019.1  54797669-54797869
            2165-2327           JAXUCZ010000019.1  54801802-54801964
            2328-2458           JAXUCZ010000019.1  54802574-54802704
            2459-2569           JAXUCZ010000019.1  54803226-54803336
            2570-2764           JAXUCZ010000019.1  54804105-54804299
            2765-2996           JAXUCZ010000019.1  54805473-54805704
            2997-4151           JAXUCZ010000019.1  54810104-54811258
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4151
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /note="PH domain and leucine rich repeat protein
                     phosphatase 2"
                     /db_xref="GeneID:498949"
                     /db_xref="RGD:1562857"
     exon            1..170
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..4151
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="PH domain leucine-rich repeat-containing protein
                     phosphatase 2"
                     /protein_id="NP_001102601.2"
                     /db_xref="GeneID:498949"
                     /db_xref="RGD:1562857"
                     /translation="MGEVEPVPAGSLEPPEPPEAAAPRRPGGIRVLKRNMKHNGSRNC
                     LNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTSSSSSSSSSSSSSDLHLVL
                     CTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFEDPVRIQE
                     EATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLI
                     VSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQ
                     RQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKF
                     SQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNV
                     LTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRM
                     NHVKHVDLRMNHLKTVIIENLEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQL
                     RELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEIL
                     DISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDVQHNTLSRLPDT
                     LFSKALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTNNLLTDQCIPVLVGHPHL
                     RVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLKAIPTTIANCKRLHTLVAHANNIS
                     IFPEILQLPQIQFVDLSCNDLTEILIPETLPATLQDLDLTGNTNLVLEHKTLDMFSHI
                     TTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYGMFD
                     GDRNEELPRLLQCTMADVLLEEVQHSTSDTVFMANTFLVSHRKLGMAGQKLGSSALLC
                     YIRPDTADPTSSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAI
                     ITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYL
                     EAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMHGLALPGP
                     VGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVGSTASDEHNTVGLETSL
                     LPRPERRCSLHPVPSAGTFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVE
                     VDIHCCRGRESENSPTLPKNSSYPCSEEHARGLGFGIRRQNSVNSGILLPVNKDKMEL
                     QKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVP
                     RDLEDEVKEQMKQHQESRPEPEPREEDRTEPLQEFDTAL"
     exon            171..463
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            464..597
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            598..788
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            789..914
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1069
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1216
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1447
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1650
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1711
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1807
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1963
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2164
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2327
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2458
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2569
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2764
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2996
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..4151
                     /gene="Phlpp2"
                     /gene_synonym="Phlppl; RGD1562857"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctcgcg cgcgcctccg aggctctcgc tgtcgcgccg gccgagcgtc tctgtaaagc
       61 cttggccgcc aatgggggag gtggagcccg tgcccgcggg ctcgctggag cccccggagc
      121 cacctgaagc ggcggcgcct cgccggcccg gaggtattcg ggtcctaaag aggaatatga
      181 aacacaatgg gagcagaaat tgtttgaata gaagaagtag gtttggctct cgagaaagag
      241 actggctaag agaagatgtg aagagaggct gtgtttacct ttatggagcg gacacgacca
      301 ctgccactac aaccaccacc tcctcctcct cctcctcctc ctcctcctcc tcctcctctg
      361 atttacatct tgtcctttgc acagtggaga caccagcgtc agaaatatgt gctggagagg
      421 gaagagaaag tctctatcta cagcttcatg gagatctggt caggagactg gagcccactg
      481 aacggcctct ccagattgtt tacgactact tatccaggct ggggtttgaa gatcccgtgc
      541 gcatacagga ggaggctacg aaccctgatc tcagctgtat gattcgattt tatggtgaaa
      601 agccatgcca gatggatcat ctggaccgaa tcctgctgtc tggcatctat aacgtccgca
      661 aagggaagac ccagctgcac aaatgggctg agcgcctcgt tgttctctgt ggcacctgcc
      721 ttattgtctc ctcagtgaag gattgccaaa ctggaaagat gcacatcttg ccactggttg
      781 ggggaaagat agaagaagtg aagcgccggc aacactccct tgctttcagc tcagctggag
      841 cccaagctca gacctatcat gtcagcttcg agactttggc tgagtaccag agatggcagc
      901 ggcaggcgtc taaggtggtg tcccagagga tcagcaccgt ggacctctcg tgttacagcc
      961 ttgaggaggt tcctgagcat ctcttctaca gtcaagacat cacctacctc aacctgcgac
     1021 acaacttcat gcagttagaa agaccagggg gccttgacac actctacaaa ttttctcaac
     1081 tgaagggcct gaacttgtcc cataataagc ttggactgtt tcctgtgttg ctgtgtgaga
     1141 tttctaccct gactgaactc aacctttctt gtaatggatt tcatgacttg ccaagtcaga
     1201 ttggtaatct gttaaatctt cagaccctct gccttgatgg caatgttctc acagctctac
     1261 cagatgaatt gggaaacctg cagcagctta cttctctggg aatttccttc aacaatttta
     1321 gtcaaattcc tgaagttttg gagaaactca ccatgttaga taaagtggtt atggcaggaa
     1381 accgtttgga aatcctgaac ctaggggtgc tgaccaggat gaaccatgtt aagcatgtgg
     1441 atctaaggat gaaccacttg aaaacggtga ttattgaaaa tctggaggga aataaacaca
     1501 tcactcacat ggatttgcgg gacaatcagt tgactgattt ggaccttagc tccttatgta
     1561 gcttggagca gctgcattgt gagcggaacc agttgagaga gctgacactc agtggcttct
     1621 cccttcgaaa cctctacgcc aattggaaca agctgacagc agtgaatgtc tatccagtac
     1681 caagcctgct cacttctttg gaactctccc gaaacttgct agaatgtatc cctgactggg
     1741 cctgtgaagc aaaaaagcta gaaatactag atataagcta caatctgctt acagaggttc
     1801 ccatgagaat tctgagtagt ctgagtcttc ggaaactgat ggtaggacac aaccacatcc
     1861 atgtccttcc ggcactggtg gagcacattc ccctcgaggt actggatgtc cagcataaca
     1921 ctctgtccag gctgccggac acactgttct ccaaggcctt aaatctcagg tacttgaatg
     1981 catccgcaaa tagtctggag tctttgcctt ctgcgtgtgc tggagaggag agtctgagtg
     2041 tgctgcagct gctgtacctg accaacaacc ttctgacaga ccagtgcata cctgttttgg
     2101 tcgggcaccc acacctgcgt gttctgcacc ttgcaaacaa ccagctacag acctttcctg
     2161 caagcaaact aaacaaattg gagcaactgg aagaactgaa tctaagtggg aacaagctta
     2221 aagctattcc cacaaccata gcaaactgca aaagactgca cacccttgtc gcacatgcca
     2281 acaacatcag cattttccca gagatcctgc agctgcctca gattcagttt gttgacctga
     2341 gttgcaatga tttgacagaa atactaattc cagagactct gcctgccact ttacaagacc
     2401 ttgatcttac aggaaataca aatctggttc tggaacacaa gactttggac atgtttagcc
     2461 atatcacaac actgaaaatt gatcagaaac ctttaccgac cacagattct acagttacat
     2521 caaccttctg gagccatgga ctggccgaga tggctgggca gaggaataaa ctctgtgtgt
     2581 ctgctctggc tatggataac tttgcagagg gcgtgggggc tgtgtacggc atgtttgatg
     2641 gggacaggaa tgaggaactc ccccgtctgc tgcagtgtac aatggcagac gtgcttttgg
     2701 aagaggtaca gcactcaaca agtgacaccg ttttcatggc caataccttc ctggtgtctc
     2761 acaggaaatt aggaatggct ggccagaagc taggttcctc tgctctcctg tgctatattc
     2821 gacctgacac tgccgaccca acaagtagtt ttagcttgac tgtagccaat gttggcacgt
     2881 gccaagctgt cctgtgccga ggtggaaagc cagtacctct ttctaaagtc ttcagcttgg
     2941 agcatgaccc agaggaggca cagagggtga aggaccagaa agctatcata acagaggaca
     3001 acaaggtgaa tggggttacc tgctgcaccc ggatgctggg atgtacatac ctctacccct
     3061 ggatcctccc caagcctcac atatcctcca ctccgcttac cattcaagat gaattgctga
     3121 ttttgggaaa caaagcactg tgggaacact tgtcctatct agaagctgtc agtgcagtcc
     3181 gtcatgtgca agacccatta gctgctgcta agaagctgtg cacattagca cagagctatg
     3241 gttgtcagga caatgtgggg gcaatggtgg tttatttgaa cattggtgaa gaaggctgta
     3301 cctgtgaaat gcatgggctt gcccttccag gccctgtggg atttgcttca acagcaacca
     3361 tcaaggatgc ccccaagcca accactccct cctctagcag tgggattgcc tcagagctga
     3421 gcagtgaggt gtcgacctca gaggtgagca gtgaggtggg ttccacagcg tctgacgaac
     3481 acaacactgt gggcctggag acgagcttgc ttcccaggcc tgagaggcgc tgtagtctgc
     3541 accctgtgcc ctctgcaggc actttccagc gccagccttc ttgtgctacc ttttccagca
     3601 atcagtctga caatggactg gacagtgacg atgaccagcc tgttgaaggc gtcataacca
     3661 atggcagcag ggttgaggta gaggtagaca ttcattgctg ccgaggcaga gagtctgaga
     3721 actcccctac tctcccgaag aattcttcct acccctgttc agaggaacat gctagggggt
     3781 tgggttttgg gatccgaaga cagaacagtg tgaatagtgg tatacttctg ccagtgaaca
     3841 aagacaagat ggagttacag aagtctccct ccacttcttg tttgtatgga aagaaactct
     3901 ccaatggctc cattgtgccc ctagaagaca gcctgaacct cattgaggtg gccacagaag
     3961 cacccaagag gaaaactggc tattttgctg cccccactca gctggaacca gaggatcaat
     4021 ttgttgtccc ccgtgacctg gaagacgaag tgaaggagca aatgaagcag caccaggaga
     4081 gcaggcctga gcctgaaccc agggaagagg accggacaga gcccctgcag gagtttgata
     4141 cagcactgtg a
//
