LOCUS       NM_001191578            5491 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pleckstrin homology-like domain, family B, member
            1 (Phldb1), transcript variant 1, mRNA.
ACCESSION   NM_001191578 XM_002729916
VERSION     NM_001191578.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5491)
  AUTHORS   Nakaya,Y., Sukowati,E.W. and Sheng,G.
  TITLE     Epiblast integrity requires CLASP and Dystroglycan-mediated
            microtubule anchoring to the basal cortex
  JOURNAL   J Cell Biol 202 (4), 637-651 (2013)
   PUBMED   23940118
REFERENCE   2  (bases 1 to 5491)
  AUTHORS   Levi,L., Hanukoglu,I., Raikhinstein,M., Kohen,F. and Koch,Y.
  TITLE     Cloning of LL5, a novel protein encoding cDNA from a rat pituitary
            library
  JOURNAL   Biochim Biophys Acta 1216 (2), 342-344 (1993)
   PUBMED   8241284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 1, 2022 this sequence version replaced NM_001191578.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000008.1  53948209-53948285   c
            78-158              JAXUCZ010000008.1  53941254-53941334   c
            159-282             JAXUCZ010000008.1  53940267-53940390   c
            283-453             JAXUCZ010000008.1  53939244-53939414   c
            454-579             JAXUCZ010000008.1  53931683-53931808   c
            580-1928            JAXUCZ010000008.1  53928752-53930100   c
            1929-2210           JAXUCZ010000008.1  53924966-53925247   c
            2211-2351           JAXUCZ010000008.1  53924506-53924646   c
            2352-2489           JAXUCZ010000008.1  53924283-53924420   c
            2490-2645           JAXUCZ010000008.1  53921208-53921363   c
            2646-2756           JAXUCZ010000008.1  53917808-53917918   c
            2757-2846           JAXUCZ010000008.1  53917593-53917682   c
            2847-2987           JAXUCZ010000008.1  53914770-53914910   c
            2988-3128           JAXUCZ010000008.1  53913363-53913503   c
            3129-3231           JAXUCZ010000008.1  53913148-53913250   c
            3232-3526           JAXUCZ010000008.1  53911755-53912049   c
            3527-3617           JAXUCZ010000008.1  53911581-53911671   c
            3618-3764           JAXUCZ010000008.1  53909747-53909893   c
            3765-3881           JAXUCZ010000008.1  53907257-53907373   c
            3882-3984           JAXUCZ010000008.1  53906900-53907002   c
            3985-4070           JAXUCZ010000008.1  53902641-53902726   c
            4071-4103           JAXUCZ010000008.1  53902437-53902469   c
            4104-5491           JAXUCZ010000008.1  53900338-53901725   c
FEATURES             Location/Qualifiers
     source          1..5491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..5491
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /note="pleckstrin homology-like domain, family B, member
                     1"
                     /db_xref="GeneID:171434"
                     /db_xref="RGD:620878"
     exon            1..77
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            78..158
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..4244
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein LL5-alpha"
                     /codon_start=1
                     /product="pleckstrin homology-like domain family B member
                     1 isoform 1"
                     /protein_id="NP_001178507.1"
                     /db_xref="GeneID:171434"
                     /db_xref="RGD:620878"
                     /translation="MATLNRNQLGPGCKTQAVVQKGPLDLIETGQGLKVQTDKPHLVS
                     LGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNA
                     CTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGSTYSPGS
                     AESESLVNGNHTAQPATRAPPACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAA
                     TSPLSPVANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQE
                     PGPSVPPLVPARSSSYHLALQPPQSRPSGSRSSESPRLGRKGGHERPPSPGLRGLLTD
                     SPAATVLAEARRTTESPRLGGQLPVVAISLSEYPSSGARSQPTSIPGSPKFQSPVPAP
                     RNKIGTLQDRPPSPFREPPGTERVLTTSPSRQLVGRTFSDGSATRTLQPPESPRLGRR
                     GLDSMRELPPLSPSLSRRALSPLPARTAPDPKLSREVAESPRPRRWAAHGTSPEDFSL
                     TLGARGRRTRSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPHAQRKLSSG
                     DLRVPIPRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAE
                     YSRADGGPETGELPSIGEATAALALAGRRPSRGLAGAIVVSGRSGEESGGASQRLWES
                     MERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLAVEEERAQVLGRVEQLKVRVKE
                     LEQQLQEAAREAEMERALLQGEREAERALLQKEQRAMDQLQEKLVALETGIQKERDKE
                     ADALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSVSKRKERLAVLD
                     SQAGQIRAQAVQESERLAREKNAVLQLLQKEKEKLTVLERRYHSLTGGRSFPKTTSTL
                     KEMEKLLLPAVDLEQWYQELMAGLGTGLAAASPRSSPPPLPAKASRQLQVYRSKMNGD
                     MASPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNGTSSLPRNLAATL
                     QDIETKRQLALQQKGHQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAAFPAGPSGFP
                     TLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG
                     LDMGKIEEMEKMLKEAHAEKSRLMESREREMELRRQALEEERRRREQVERRLQSESAR
                     RQQLVEKEVKLREKQFSQARPLTRYLPNRKEDFDLKTHIESSGHGVDTCLHVVLSSKV
                     CRGYLIKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLR
                     SAAKKRFFHFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQ
                     FMN"
     exon            159..282
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            283..453
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            454..579
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1928
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2210
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2351
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2489
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2645
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2756
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2846
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2987
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3128
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3231
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3526
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3617
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3764
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3881
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..3984
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..4070
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4103
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..5491
                     /gene="Phldb1"
                     /gene_synonym="Ll5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtgtcc tcgccagcct gaggctgccg cggcccactt gggcgaaggg gccggtatcc
       61 ctccaactcc ccacaaggag ctctggagcc ctaggaccat ggctactctt aataggaacc
      121 agctaggccc tggatgcaag acccaggctg tggtgcagaa agggccgttg gatctgattg
      181 agacgggtca aggactgaag gtgcagacag acaaacctca tcttgtgagc ctgggcagcg
      241 gcaggctcag cacagcaatc actctcctgc cgctggagga agggaggaca gtgattggtt
      301 cagcagccag ggacatctca ctgcaaggtc caggccttgc tccagaacac tgctacatcg
      361 agaatctgag gggcactctc accctgtacc cttgtggcaa tgcctgcact attgatgggc
      421 tccctgttcg gcagcccacc cggctcactc agggctgcat gttgtgtctg ggtcagtcca
      481 ccttcctgcg ctttaaccac ccagccgaag ccaagtggat gaagagtatg attccagcag
      541 ggggccgggc cccagggtcc acgtacagtc ctggctctgc tgaatcagag agcttggtca
      601 atgggaacca cacagcacag cccgcaaccc gggcacctcc agcctgtgcc agccacagtt
      661 ccctggtgag ctccattgaa aaggacctgc aggaaatcat ggactcgttg gtgctagagg
      721 agcccggagc tgcaggcaag aagcctgcag ccacatcccc gttgtcgcca gtggctaatg
      781 gtggacgcta cctgttgtcc cctccaacca gcccaggagc catgtctgtg ggctccagct
      841 atgagaacac ctctccggcc ttctctccac tgtcctcacc agccagcagt ggaagctgtg
      901 ctagccactc tcccagtggg caggagccag gaccttctgt gcccccgctc gtgcctgccc
      961 gttcctccag ctaccatttg gctctgcaac ccccacagtc ccgcccaagt ggttcccgct
     1021 cctctgagag tccccggctg ggcaggaaag ggggtcatga gagacctccc agccctggtc
     1081 tccgaggtct tctgactgac agtcctgcag ctacagtctt ggctgaggcc cgcagaacca
     1141 ctgagagtcc caggctaggt gggcagctgc ctgtggtggc tatcagcctg agtgaatatc
     1201 catcttccgg tgcccgcagc caacccacca gtattcctgg cagccctaag ttccagtctc
     1261 cagtgcctgc tccccgaaac aagatcggca cactccagga ccgccctccc agtcctttcc
     1321 gtgagccccc aggcacagag cgggtactaa caaccagccc ctctcgacag cttgtgggca
     1381 gaacattttc agatgggtca gcaactcgta ccctccagcc accggagagt ccccgcttgg
     1441 gccggcgggg cctggacagt atgcgggaac tgcccccgtt gagtccatct ctgtctcgaa
     1501 gggctctgtc cccactgcca gcccggactg ccccagatcc caaactaagc agggaagtgg
     1561 cagagagccc ccggccccgg cgctgggcag cccatgggac ttcacctgag gacttctccc
     1621 tgacactagg agcacggggc cgcaggactc ggagtccttc gcccacactc ggggagtccc
     1681 tggcacctcg caagggcagc ttcagtggca ggctaagccc agcctacagt ctgggctctc
     1741 ttactggggc ttcacctcgc cagagccccc atgctcaaag gaagctttcc agtggggact
     1801 tgcgggtgcc catcccaagg gagaggaaaa atagcatcac ggagatcagc gacaatgagg
     1861 acgatctcct ggagtaccac aggcggcagc gccaagagcg gctccgggag caggagatgg
     1921 agaggctgga acgccagcgc ctggagacca tcctgaacct gtgtgctgag tacagccgag
     1981 ctgacggggg acctgagact ggggaactgc ccagtatagg agaggccacg gcagcactgg
     2041 ctttggcagg caggaggccc tcaagaggct tggcaggagc catagtagtg tctggaagga
     2101 gtggtgagga gtctggaggt gcctcgcagc gcctgtggga gagcatggag cgctctgatg
     2161 aagagaatct caaagaggag tgcagcagca cagagagcac ccagcaggag cacgaagatg
     2221 ctcctagcac gaagctccaa ggagaggtgc tggctgtgga agaggagcgg gctcaggttc
     2281 tggggcgcgt agagcagctg aaggtccgag tgaaggagct ggaacagcag ctgcaggagg
     2341 cagcccgaga ggctgaaatg gagagagcac tgctgcaggg ggagagggag gcggagcgag
     2401 cattgctgca gaaggaacaa agagctatgg accagctgca ggagaagttg gtggccttgg
     2461 agacaggcat ccagaaggag agggacaagg aggcagacgc tctagagact gagacaaagc
     2521 tctttgagga cctggagttc cagcagctgg agcgggagag tcgcgtggag gaggagcggg
     2581 agttggccgg ccaagggctg cttcgcagca aggctgagtt gctgcgcagc gtgagcaaga
     2641 gaaaggagcg cctagctgta ctggacagtc aggctgggca gatccgggcc caagcagtac
     2701 aggagtcaga gcgtctggcc cgggaaaaga atgctgtcct gcagctactg caaaaggaga
     2761 aggagaagct gactgtgctt gagaggagat atcattcgct cacgggtggc aggtcttttc
     2821 cgaagaccac ctcaaccctc aaagagatgg agaaactgct gctccctgct gtagacttag
     2881 agcagtggta ccaggagttg atggccgggc tggggactgg ccttgctgca gcctcccctc
     2941 gctcctctcc cccgcctctg cctgccaaag cttctcgtca gctgcaggtt taccgctcca
     3001 agatgaatgg tgacatggcc agccccctgc ccaggacccg tagtggccct ctcccctcct
     3061 cctcaggctc ctcatcctct tcttcacagc tcagcgtggc taccctgggc cgtagtcctt
     3121 ccccaaagag tgccctgctc gcccagaatg gcaccagtag tctccctcga aacctggcag
     3181 ccacgctgca ggacattgag accaagcgcc agctggccct acagcaaaag gggcaccaag
     3241 tgatcgagga gcaacggcga cggctggctg agctgaagca gaaagcagcg gcagaggctc
     3301 agtgccagtg ggatgccttg catggtgcag ccgcctttcc agcaggcccg tctggcttcc
     3361 ccacactcat gcaccattct atcctgcacc acctgccagc aggcagggaa cgtggagagg
     3421 agggcgagca cgcttacgac accctgagcc tggagagttc ggacagcatg gagaccagca
     3481 tctctacggg gggcaactcc gcctgttccc ctgacaacat gtccagcgct agtggtctgg
     3541 acatgggcaa gatagaggaa atggagaaga tgctaaagga agctcacgcg gagaagagcc
     3601 ggctcatgga gtccagggag cgggagatgg agctacggag gcaggccctg gaggaggaac
     3661 gtcggaggcg ggagcaagtg gagcggaggc tgcagagtga gagcgcccgc aggcagcagc
     3721 tggtggagaa agaagtcaag ctgagggaga agcagttttc ccaggctcga cctctgacac
     3781 gttatcttcc caaccggaag gaggactttg atttgaagac ccacatagag tcgtcaggcc
     3841 atggggtgga cacctgccta catgtggtgc ttagcagcaa ggtctgccgt ggctacttaa
     3901 tcaagatggg tggcaagatt aaatcgtgga agaagcgctg gtttgtcttt gaccggctga
     3961 agcgcaccct ttcctactat gtggacaaac acgagacgaa gctgaagggg gtcatctact
     4021 tccaggccat cgaggaagtg tactatgacc acctgcgcag cgcagccaag aaaaggtttt
     4081 tccacttcac catggtgact gagagtccga atccagccct caccttctgt gtgaagaccc
     4141 atgaccggct gtactacatg gtggccccat ctgcagaggc catgcgcatc tggatggatg
     4201 tcatcgtcac gggagctgag ggctacactc aattcatgaa ctaactacca ggcacctcct
     4261 gggtccccca ggtcagcccc aggacaccat gccctgccac ttgctgctct gcttgtccct
     4321 ggagacagag gcacactggg cacgggccac aaagggtcag gatgtagttg agtaccccag
     4381 ggcttttgtg caagaaaacg aaattgttct atgaggagtt tggtgcttgg gaatcaggct
     4441 ccggtcccta aagagccagc agagaggaaa ggaagaggga gggccttgtc gcctcctggg
     4501 agtccagaag tgcaggattc cctcctgggt ccagcaggct gaagaggcat agctgagctg
     4561 tgactctcag ctctgtcctg gtacccactt agcccagctt actttctctc tgtaaaggac
     4621 aaattatggt accagaatct gccaaagatc ccctttctca tctcatcccc tctacagggg
     4681 tctggggggt cctgagcaga gccacgtgta gaacagggga gaggctcagg cctgcacttc
     4741 ccgcccccgg tctgcctcct tctcctccca cctcccactt ttcactactt agctcaagga
     4801 ccagagacct caagtgtcat tctcgaggtc cagccccgta atcatgttac aagcccatca
     4861 tccttgtctc catggtggct gcttcctcac catggttaca cactaattgc catggccact
     4921 ctgtggctct gcccactgct tcggctgtgg gccacatgag ggtacatgcc acccatctct
     4981 ccaacccagg cctgggggcc tgtcacatgg tgggaggaga tagagttcct cccggctgca
     5041 gtgtgtctcc agcccccagc ccagccctct cccttttact gtgccttgct tagagccaga
     5101 agggatgatg tccagagatc caagaccaga gagcagcatc actgagggga gaggaagcta
     5161 agaggtctgc cctcccattc tgacaggact agttcccaat aaggaacgag ggtggtagct
     5221 cagagtgtct ggaaagaagc ctgagttggg agcagggcgg gcagaagcag aggccctgag
     5281 ctgtggtaac ctcccttcag tttcccaaag gtgacgggaa agaaggacag aggatcaagt
     5341 ctccagctgg ctggcctcag ccttgcgcct taacactaag ccaccttccc tgccctcccc
     5401 agcactgggc ccttggttgc tgggcctggc tgggtgtttt gcagtatttg taagcatttc
     5461 agcagaacaa taaaagcatt ttgactatgt a
//
